New Arachidonic Acid Study/Info

[jjohn]

From www.bodyofscience.com

This is the full article for the corresponding NEWS headline.

New Paper on Arachidonic Acid Supplementation

A paper on the supplementation of arachidonic acid (AA) was recently published in the British Journal of Nutrition (British Journal of Nutrition (2007), 98, 451?453). This article is of interest to the athletic community supplementing arachidonic acid for a number of reasons, most notably its focus on safety, its close examination of the buildup and depletion of arachidonic acid in the body, and its use of AA combined with a high intake of Omega-3 fatty acids. Key to this review was a study published in the same journal in April of 2007 by Kusumoto et al. (Br J Nutr. 2007 Sep;98(3):626-35. Epub 2007 Apr 20), which involved the supplementation of arachidonic acid (840mg/d) in a group of 24 healthy Japanese men that consumed high amounts of fish in their diet. This is the first paper of its kind, as most previous investigations of arachidonic acid supplementation safety involved Westerners with low daily intakes of Omega-3 fatty acids. Habitual daily intakes of DHA and EPA in this study ranged from 42 to 691mg and 98 to 991mg, respectively. The average intakes were about 310mg and 550 mg per day. Among the findings were the following.

2-Week Buildup Window:

It took 2 weeks for maximum arachidonic acid levels to be achieved in serum phospholipids. This was the first study to closely examine the time it took to reach peak levels with AA supplementations, and reinforces anecdotal observations of a 2-3 week ?loading? window before significant results are noted with supplementation in bodybuilders/athletes.

4-Week Washout:

Arachidonic acid levels remained elevated for a few weeks after supplementation was discontinued. They reached their pretreated levels after 4 weeks. This may also explain why some continue to notice progress in the immediate weeks following AA discontinuation.

Omega-3?s Had No Effect:

Peak arachidonic acid levels were similar in this study to other studies where AA was given to subjects with low dietary levels of Omega-3 fatty acids. At these levels there did not appear to be any significant Omega-3 antagonism of arachidonic acid. This study reinforces the anecdotal observations that low doses of fish oil or regular fish consumption do not appear to appreciably diminish the results of arachidonic acid supplementation.

Arachidonic Acid Supplementation is Safe:

This paper one again takes a review of the safety of arachidonic acid supplementation, with interest in its effects on many areas of health including inflammation, immune functioning, lipids, blood pressure, platelet aggregation, glucose concentrations, liver function, and bleeding time, and notes that arachidonic acid supplementation appears to be perfectly safe in healthy subjects. When noting the inclusion of the most recent AA study (Kusumoto), the British Journal of Nutrition review states:

?Taken together with earlier studies, this study suggests that, rather than being harmful, moderately increased arachidonic acid intake is probably harmless in healthy adults, although the effect of intakes above 1.5g/d are not known and the effect of increased intake in diseased individuals is not known.?

[leonidas300]

Great news, thanks for posting that study. This bodes well for Molecular Nutrition and they deserve it.

[jjohn]

Thanks buddy we appreciate it

[BiggerWeighter]

breakthrough discovery right here. If I don't win I might seriously consider buying it for my next stack.

[leonidas300]

breakthrough discovery right here. If I don't win I might seriously consider buying it for my next stack.

I am currently logging it but I have been so impressed with it I actually already ordered another cycle of X-factor and Activate Xtreme. This is the best natural stack you are going to come across. You will not be disappointed.

[Apostle X]

I just ordered 2 cycles of it. I am looking forward to next year!

[JHICKS3301]

With all the new studies coming out about AA i'm looking forward to trying Xfactor

Might be getting some in the near future

[njmuscle66]

I am currently logging it but I have been so impressed with it I actually already ordered another cycle of X-factor and Activate Xtreme. This is the best natural stack you are going to come across. You will not be disappointed.

Glad to hear the positive results.........I am going to be running it in a few weeks myself

[getbustered]

4-Week Washout:

Arachidonic acid levels remained elevated for a few weeks after supplementation was discontinued. They reached their pretreated levels after 4 weeks. This may also explain why some continue to notice progress in the immediate weeks following AA discontinuation.

I personally like that part of the paper. It puts a more specific number on something that I was wondering, and also explains some things I have noticed personally.

[jjohn]

I just ordered 2 cycles of it. I am looking forward to next year!

In case you aren't aware, bb.com cycles sold will get a free t-shirt. Check in the supp section

[jjohn]

I personally like that part of the paper. It puts a more specific number on something that I was wondering, and also explains some things I have noticed personally.

Yepper! Hence why everyone keep their gains, and even continue to gain after cessation of the fatty acid!

[extremenergy3]

Can't wait to try the stuff if i can

[jjohn]

Can't wait to try the stuff if i can

If you can?? Why couldn't ya?

[cakedonkey]

Always good to see new lit. on this stuff. Molecular Nutrition is among the Elite in my books.

[Hoomgar]

Wow! What a n00b I am. So I fully understand the findings from the study but my question would then be...

What are the benefits of supplementing with Arachidonic Acid? What does it do when taken by a body builder?

[jjohn]

Wow! What a n00b I am. So I fully understand the findings from the study but my question would then be...

What are the benefits of supplementing with Arachidonic Acid? What does it do when taken by a body builder?

Arachidonic is the ingredient found in X Factor. It is an omega 6 fatty acid. It has has a lot of roles in the body. I can't really summarize this in a few lines, so a little research-browsing through the forums would help you out greatly Let me know if some things are unclear to you

[Hoomgar]

Arachidonic is the ingredient found in X Factor. It is an omega 6 fatty acid. It has has a lot of roles in the body. I can't really summarize this in a few lines, so a little research-browsing through the forums would help you out greatly Let me know if some things are unclear to you

I am familiar with what the Omega FAs are good for so that is good. I'll have to have a peek at X-Factor. Always looking for new and better nutrition and supplements.

[jjohn]

I am familiar with what the Omega FAs are good for so that is good. I'll have to have a peek at X-Factor. Always looking for new and better nutrition and supplements.

Just look around, and you'll find a lot of info on this supplement! Send me a PM with whatever you need, I'm there to help!

[jmil]

I am currently logging it but I have been so impressed with it I actually already ordered another cycle of X-factor and Activate Xtreme. This is the best natural stack you are going to come across. You will not be disappointed.

Completely agreed! I still take pride in the fact that I was a part of the very first time that the "X-factor/Activate" stack was recommended, when we (when I was with Molec) started the logs in conjunction with Designer Supps. This stack is STILL BADASS!! Definitely agree that it don't get any better for a natural stack!

[bigla2004]

You mean this stuff works.. I was thinking the past studies and all the rave reviews from reputable members about x-factor (aa supplementation) were all a bunch of bs .

Christmas list-
4 bottles X-Factor
2 bottles Activate Xtreme

[jjohn]

4 XF bottles and 2 AX will be something nice to have!

[Big Poppa S]

4 XF bottles and 2 AX will be something nice to have!

Sounds good! Feel free to send me it as a present....LOL

[DRP7]

Omega-3?s Had No Effect:

Peak arachidonic acid levels were similar in this study to other studies where AA was given to subjects with low dietary levels of Omega-3 fatty acids. At these levels there did not appear to be any significant Omega-3 antagonism of arachidonic acid. This study reinforces the anecdotal observations that low doses of fish oil or regular fish consumption do not appear to appreciably diminish the results of arachidonic acid supplementation.

Omega3's did not antagonize what exactely?
- the levels of AA (blood levels? tissue levels?) or
- the levels of AA metabolites (prostglandines)
- the effect of AA on body parameters (strength, size, etc)





a few more questions:

1. what parameters of inflammation and immune function have been measured?

2. how long did the subjects take AA (840 mg/d)?


thanks to anybody who can answer these questions!

[DustinX]

I was reading some information about AA. I know the prostate growth has been discussed, but I just read an article about how taking an NSAID kept the growth in check. I can't find a link to the actual study, but I read this on about.com. Sorry if this is a stupid post, I just thought it was interesting info about the NSAID and stopping the growth. Here is a link.

http://prostatecancer.about.com/od/p...rachidonic.htm

Scientists have found that a common omega 6 fatty acid known as arachidonic acid signals increased growth of prostate cancer cells in culture.

Also of interest: The introduction of a non-steroidal inflammatory to the culture kept the growth in check.

This has triggered a further study with laboratory animals to see if increased amounts of arachidonic acid causes increased tumor growth in them.

[Docta J]

I was reading some information about AA. I know the prostate growth has been discussed, but I just read an article about how taking an NSAID kept the growth in check. I can't find a link to the actual study, but I read this on about.com. Sorry if this is a stupid post, I just thought it was interesting info about the NSAID and stopping the growth. Here is a link.

http://prostatecancer.about.com/od/p...rachidonic.htm

But then wouldn't an NSAID waste the arachidonic acid's extra-inflammatory abilities?

[dan7681]

Omega3's did not antagonize what exactely?
- the levels of AA (blood levels? tissue levels?) or
- the levels of AA metabolites (prostglandines)
- the effect of AA on body parameters (strength, size, etc)





a few more questions:

1. what parameters of inflammation and immune function have been measured?

2. how long did the subjects take AA (840 mg/d)?


thanks to anybody who can answer these questions!

4 weeks, here's the study, good read and should answer all your questions
http://journals.cambridge.org/downlo...062d1042e9273c

[DRP7]

4 weeks, here's the study, good read and should answer all your questions
http://journals.cambridge.org/downlo...062d1042e9273c

thanks, Dan, but the link doesn't work for me. here is what I get:

File not available. [S0007114507761779a.pdf].

[Bane]

You have to have journal access to get this it seems

[dan7681]

thanks, Dan, but the link doesn't work for me. here is what I get:

You have to have journal access to get this it seems

Strange I was literally able to access it bout 2 days ago. Now it's not available anywhere Man I wish I would have copied it to my computer for you guys, but I was at college and was in a hurry.

Omega3's did not antagonize what exactely?
- the levels of AA (blood levels? tissue levels?) or
- the levels of AA metabolites (prostglandines)
- the effect of AA on body parameters (strength, size, etc)

From what I remember it was referring to in cell membranes

[G.W. Hayduke]

I don't get it.