CLA (Conjugated Linoleic Acid)????????

[TXMade86]

I heard this works pretty well with burning fat and improving muscle tone. Are there any immediate or later side effects with this product. Does it stunt growth? What stores can I find this at?

[PSKlifter]

Not worth it. A sound diet combined w/ a solid strength training and cardio routine will do 10x more.

[freakie]

I heard this works pretty well with burning fat and improving muscle tone. Are there any immediate or later side effects with this product. Does it stunt growth? What stores can I find this at?

Studies have confirmed that CLA works for improving body composition. Unfortunately, experiences by most people don't back up the studies' claims.

[BringnIt]

That's probably because most people don't use CLA standardized to the same percentage of isomers that the studies use...

[freakie]

That's probably because most people don't use CLA standardized to the same percentage of isomers that the studies use...

A study published this year used a 50/50 Cis-9, Trans-11/Trans-10, Cis-12 isomer split. IIRC, around 3.5g per day. NOW CLA has the same isomer profile.

[pu12en12g]

Not worth it. A sound diet combined w/ a solid strength training and cardio routine will do 10x more.

Agreed.

TXMade86,

Please use the search button in the future.

[BringnIt]

"A study published this year used a 50/50 Cis-9, Trans-11/Trans-10, Cis-12 isomer split. IIRC, around 3.5g per day. NOW CLA has the same isomer profile."

Good. I happen to like CLA as a long-term supplement.

[DaRk_StAr]

apparently when people take CLA and report nothing its because of the too low dosages....maybe a higher dosage will work

[pu12en12g]

apparently when people take CLA and report nothing its because of the too low dosages....

Unfortunately, that isn't the case

[PSKlifter]

Unfortunately, that isn't the case

Do you happen to remember off the top of your head what the toxicity level of cla is? Isnt it very very close to the supposed "effective" dose?

[freakie]

What is strange about all the studies is that the weight/fat loss was quite extreme. Sometimes 5%-9% BF reductions.
The only thing I can conclude is that the CLA is really making up for some type of serious nutrition deficit in the study subjects that does not exist in the healthier, athletically trained set around here. Most (all) of the studies are conducted using obese and morbidly obese subjects. Perhaps if we had 50%-60% BF to start with we would see the dramatic results of the studies.

[armz_ha]

cla is meant to prevent more new fat cells from forming; that's why its better to use it when you're bulking not cutting.

[BringnIt]

Out of curiosity, were you cutting or bulking when you unsuccessfully tried CLA? I assumed you used the NOW Brand. What were your dosages?

[DelToro]

A study published this year used a 50/50 Cis-9, Trans-11/Trans-10, Cis-12 isomer split. IIRC, around 3.5g per day. NOW CLA has the same isomer profile.

that's the brand I bough

waste of money

even tried freezing them like the guy in the forum said

I was taking 9 a day (in the bottle it said 6)

what a worthess piece of **** supp

[freakie]

Out of curiosity, were you cutting or bulking when you unsuccessfully tried CLA? I assumed you used the NOW Brand. What were your dosages?

I guess I'm one of the stupid people that hasn't completely given up on CLA. I've used NOW CLA in the past at 6g (4.8g CLA) per day. Currently I'm taking BN bulk CLA, 10g (7g CLA) per day. I used to be extremely overweight with very high BF so I look at anything I can do to keep from gaining fat as a good thing. If the CLA helps any at all it's all good to me. Besides, CLA has shown some other benefits outside of weight/fat loss.

[BringnIt]

Thanks. I'm stupid right along with you. Have you seen the research indicating that CLA and sesathin have synergistic benefits?

[freakie]

Thanks. I'm stupid right along with you. Have you seen the research indicating that CLA and sesathin have synergistic benefits?

No, but I'm taking both! <a <img src='http://smileys.smileycentral.com/cat/36/36_1_11.gif' border=0></a>

[BringnIt]

http://www.lef.org/magazine/mag2005/...ort_cla_01.htm

[freakie]

<a <img src='http://smileys.smileycentral.com/cat/23/23_30_114.gif' border=0></a>

[pu12en12g]

My advice to all CLA users is to start megadosing leucine pre, during, and post workout.

If you don't see noticable results, I'll buy your (unopened) bulk leucine from you.

[BringnIt]

I could do both, you know.

[freakie]

My advice to all CLA users is to start megadosing leucine pre, during, and post workout.

If you don't see noticable results, I'll buy your (unopened) bulk leucine from you.

What do you consider a megadose of leucine?
I was taking EAA's before, during, and after workout. That amounted to about 8g-10g of leucine.

[ironstrife]

im going to try CLA myself.. im not expecting any jaw dropping results.. but im massively bulking as of now and i hope it helps me keep off the fat..

however, im split between the two..

Ultimate Nutrition CLA
&
NOW CLA

Ultimate Nutrition CLA has "Patented CLAPure".. i wonder if it'd be better..

[user12jf]

tried it
its bull****
dont botherrr

[deserusan]

CLA is not a wonder supplement but does serve a purpose. Combined with a healthy diet this can help with a leaner body composition. To say it doesn't work is rather ingnorant considering you are basing claims from "forum rumors" or out of your own failed experience. Here some studies which show the effectiveness of CLA on altering body composition. Until you gain a PhD or even an undergraduate degree for that matter I suggest you keep your baseless opinions to yourself. There is a ton of research which gives positive support towards CLA.

Bhattacharya A, Rahman MM, Sun DX, Lawrence R, Mejia W, McCarter R, O'Shea M, Fernandes G. The combination of dietary conjugated linoleic acid and treadmill exercise lowers gain in body fat mass and enhances lean body mass in high fat-fed male Balb/C mice. J. Nutr. 135(5):1124–1130 (2005).

Borys B, Borys A, Pajak JJ. The fatty acid profile of meat of suckling lambs from ewes fed rapeseed and linseed. J. Anim. Feed Sci. 14:223-226 Suppl. 1 (2005).

Borys B, Pajak JJ, Borys A. The effect of rapeseed fed to suckled ewes on the fatty acid profile of lamb meat. J. Anim. Feed Sci. 14:231-234 Suppl. 1 (2005).

Brownbill RA, Petrosian M, Ilich JZ Association between dietary conjugated linoleic acid and bone mineral density in postmenopausal women. J. Am. College Nutr. 24(3):177–181 (2005).

Cherian G, Ai W, Goeger MP. Maternal dietary conjugated linoleic acid alters hepatic triacylglycerol and tissue fatty acids in hatched chicks. Lipids 40(2):131–136 (2005).

Choi SH, Song MK. Effect of C18-polyunsaturated fatty acids on their direct incorporation into the rumen bacterial lipids and CLA production in vitro. Asian-Australiasian J. Anim. Sci. 18(4):512–515 (2005).

Chung SY, Brown JM, Sandberg MB, McIntosh M. Trans-10,cis-12 CLA increases adipocyte lipolysis and alters lipid droplet-associated proteins: role of mTOR and ERK signaling. J. Lipid Res. 46(5):885–895 (2005).

Corino C, Di Giancamillo A, Rossi R, Domeneghini C. Dietary conjugated linoleic acid affects morphofunctional and chemical aspects of subcutaneous adipose tissue in heavy pigs. J. Nutr. 135(6):1444–1450 (2005).

Cossignani L, Simonetti MD, Damiani P. Biocatalyzed acidolysis of olive oil triacylglycerols with 9c,11t and 10t,12c isomers of conjugated linoleic acid. European Food Res. Technol. 220(3–4):267–271 (2005).

Cusack S, Jewell C, Cashman KD. The effect of conjugated linoleic acid on the viability and metabolism of human osteoblast-like cells. Prostaglandins Leukotriens Essential Fatty Acids 72(1):29–39 (2005).

Czauderna M, Kowalczyk J, Korniluk K, Wasowska I, Pastuszewska B. Dietary conjugated linoleic acid isomers and selenium affect the fatty acid profile in rat liver. J. Anim. Feed Sci. 14: 533–536 Suppl. 1 (2005).

Czauderna M, Kowalczyk J, Korniluk K, Wasowska I. Improving the analysis of fatty acids using a combination of gas chromatography and Ag+ liquid chromatography. 14:563–566 Suppl. 1 (2005).

Czauderna M, Kowalczyk J, Pisulewski PM, Korniluk K. Influence of dietary conjugated linoleic acid (CLA) on the fatty acid content and CLA profile of egg yolks in laying hens. J. Anim. Feed Sci. 14:435–438 Suppl. 1 (2005).

Czauderna M, Kowalczyk J, Bulskaz E, Boldizarova K, Niedzwiedzka KM, Ruszczynska A, Leng L. Effect of dietary CLA isomers on selenium, zinc, copper, chromium, magnesium and calcium levels in rat liver. J. Anim. Feed Sci. 14:529–532 Suppl. 1 (2005).

Dannenberger D, Nuernberg K, Nuernberg G, Scollan N, Steinhart H, Ender K. Effect of pasture vs. concentrate diet on CLA isomer distribution in different tissue lipids of beef cattle. Lipids 40(6):589–598 (2005).

De la Torre A, Gruffat D, Chardigny JM, Sebedio JL, Durand D, Loreau O, Bauchart D. In vitro metabolism of rumenic acid in bovine liver slices. Reproduction Nutr. Develop. 45(4):441–451 (2005).

de Roos B, Rucklidge G, Reid M, Ross K, Duncan G, Navarro MA, Arbones-Mainar JM, Guzman-Garcia MA, Osada J, Browne J, Loscher CE, Roche HM. Divergent mechanisms of cis9, trans11-and trans10, cis12-conjugated linoleic acid affecting insulin resistance and inflammation in apolipoprotein E knockout mice: a proteomics approach. FASEB J. Express Article doi:10.1096/fj.05-3953fje (Published online July 29, 2005).

Delmonte P, Kataoka A, Corl BA, Bauman DE, Yurawecz MP. Relative retention order of all isomers of cis/trans conjugated linoleic acid FAME from the 6,8- to 13,15-positions using silver ion HPLC with two elution systems. Lipids 40(5):509–514 (2005).

Destaillats F, Angers P. Thermally induced formation of conjugated isomers of linoleic acid. European J. Lipid Sci. Technol. 107(3):167–172 (2005).

Destaillats F, Japiot C, Chouinard PY, Arul J, Angers P. Short communication: Rearrangement of rumenic acid in ruminant fats: A marker of thermal treatment. J. Dairy Sci. 88(5):1631–1635 (2005).

Dhiman TR, Zaman S, Olson KC, Bingham HR, Ure AL, Pariza MW. Influence of feeding soybean oil on conjugated linoleic acid content in beef. J. Agric. Food Chem. 53(3):684–689 (2005).

Giudetti AM, Beynen AC, Lemmens AG, Gnoni GV, Geelen MJH. Hepatic lipid and carbohydrate metabolism in rats fed a commercial mixture of conjugated linoleic acids (Clarinol G-80 (TM)). European J. Nutr. 44(1):33–39 (2005).

Gonthier C, Mustafa AF, Ouellet DR, Chouinard PY, Berthiaume R, Petit HV. Feeding micronized and extruded flaxseed to dairy cows: Effects on blood parameters and milk fatty acid composition. J. Dairy Sci. 88(2):748–756 (2005).

Granlund L, Larsen LN, Nebb HI, Pedersen JI. Effects of structural changes of fatty acids on lipid accumulation in adipocytes and primary hepatocytes. Biochim. Biophys. Acta Mol. Cell. Biol. Lipids 1687(1–3):23–30 (2005).

Granlund L, Pedersen JI, Nebb HI. Impaired lipid accumulation by trans 10, cis 12 CLA during adipocyte differentiation is dependent on timing and length of treatment. Biochim. Biophys. Acta Mol. Cell. Biol. Lipids 1687(1–3):11–22 (2005).

Graves E, Hitt A, Pariza MW, Cook ME, McCarthy DO. Conjugated linoleic acid preserves gastrocnemius muscle mass in mice bearing the colon-26 adenocarcinoma. Res. Nursing Health 28(1):48–55 (2005).

Gruffat D, De La Torre A, Chardigny JM, Durand D, Loreau O, Bauchart D. Vaccenic acid metabolism in the liver of rat and bovine. Lipids 40(3):295–301 (2005).

Hao XY, Mir PS, Shah MA, Travis GR. Influence of canola and sunflower diet amendments on cattle feedlot manure. J. Environ. Quality 34(4):1439–1445 (2005).

He ML, Mir PS, Beauchemin KA, Ivan M, Mir Z. Effects of dietary sunflower seeds on lactation performance and conjugated linoleic acid content of milk. Can. J. Anim. Sci. 85(1):75–83 (2005).

Herzallah SM, Humeid MA, Al-Ismail KM. Effect of heating and processing methods of milk and dairy products on conjugated linoleic acid and trans fatty acid isomer content. J. Dairy Sci. 88(4):1301–1310 (2005).

Hoffmann K, Blaudszun J, Brunken C, Hopker WW, Tauber R, Steinhart H. New application of a subcellular fractionation method to kidney and testis for the determination of conjugated linoleic acid in selected cell organelles of healthy and cancerous human tissues. Analytical Bioanalytical Chem. 381(6):1138–1144 (2005).

Hoffmann K, Blaudszun J, Brunken C, Hopker WW, Tauber R, Steinhart H. Distribution of polyunsaturated fatty acids including conjugated linoleic acids in total and subcellular fractions from healthy and cancerous parts of human kidneys. Lipids 40(3):309–315 (2005).

House RL, Cassady JP, Eisen EJ, Eling TE, Collins JB, Grissom SF, Odle J. Functional genomic characterization of delipidation elicited by trans-10, cis-12-conjugated linoleic acid (t10c12-CLA) in a polygenic obese line of mice. Physiol. Genomics 21(3):351–361 (2005).

Ide T. Interaction of fish oil and conjugated linoleic acid in affecting hepatic activity of lipogenic enzymes and gene expression in liver and adipose tissue. Diabetes 54(2):412–423 (2005).

Jang ES, Jung MY, Min DB. Hydrogenation for low trans and high conjugated fatty acids. Comp. Rev. Food Sci. Food Safety 4(1):22–30 (2005).

Jewell C, Cusack S, Cashman KD. The effect of conjugated linoleic acid on transepithelial calcium transport and mediators of paracellular permeability in human intestinal-like Caco-2 cells. Prostaglandins Leukotrienes Essential Fatty Acids 72(3):163–171 (2005).

Jones EL, Shingfield KJ, Kohen C, Jones AK, Lupoli B, Grandison AS, Beever DE, Williams CM, Calder PC, Yaqoob P. Chemical, physical, and sensory properties of dairy products enriched with conjugated linoleic acid. J. Dairy Sci. 88(8):2923–2937 (2005).

Keating AF, Stanton C, Murphy JJ, Smith TJ, Ross RP, Cairns AT. Isolation and characterization of the bovine Stearoyi-CoA desaturase promoter and analysis of polymorphisms in the promoter region in dairy cows. Mammalian Genome 16(3):184–193 (2005).

Kennedy SR, Campbell PJ, Porter A, Tocher DR. Influence of dietary conjugated linoleic acid (CLA) on lipid and fatty acid composition in liver and flesh of Atlantic salmon (Salnio salar). Comp. Biochem. Physiol. B-Biochem. Molec. Biol. 141(2):168–178 (2005).

If you want more sources I can provide them or give the e-mail address of the worlds leading researcher Dr. Pariza. He's a professor here at the Univeristy of Wisconsin-Madison and I had the priviledge of taking a food science class he taught a few years back. Can you provide one shred of evidence that points to the ineffectiveness of CLA?

http://www.wisc.edu/fri/clarefs.htm

[pu12en12g]

http://forum.bodybuilding.com/showpo...9&postcount=36

[Phosphate bond]

http://forum.bodybuilding.com/showpo...9&postcount=36

That is a good post.

And I don't think either isomer is terribly good for you from a health standpoint.

^^^^^^ Agreed.

I took this stuff many years ago. Of course I bought the "marked down" GNC branded CLA (which might have made my CLA experience even worse actually).

Compared to the EFAS I was taking it actually made me feel kind of sick. In all fairness that cheap GNC stuff might have been partly to blame.

[nightfly71]

I've been using 3-5 grams per day of CLA from Twinlab over the past 2 or 3 mos. in combo w/ a couple of other things. Namely, ECA or yohimbine. I've taken off approx. 5 bodyfat percentage points.
Not sure exactly what did it, but something's working. I think CLA is solid, but takes time. Everything I've heard about it's effectiveness is dependent upon at least 3 mos of continuous use.
I end up getting it pretty cheap, so I plan to continue to use it during this last month of slow cutting and also into my upcoming bulking phase. I figure if it's slowly, but steadily reducing BF, I'll stick w/ it...certainly can't hurt.

[xGhostinGx]

I've been using 3-5 grams per day of CLA from Twinlab over the past 2 or 3 mos. in combo w/ a couple of other things. Namely, ECA or yohimbine. I've taken off approx. 5 bodyfat percentage points.

in combo w/ a couple of other things. Namely, ECA or yohimbine. I've taken off approx. 5 bodyfat percentage points.

I dont even know how to respond to a post this ignorant.

[deserusan]

J Nutr. 2005 Apr;135(4):778-84.

Supplementation with conjugated linoleic acid for 24 months is well tolerated by and reduces body fat mass in healthy, overweight humans.

After 12 mo in a randomized, double-blind, placebo-controlled trial of conjugated linoleic acid (CLA) supplementation (2 groups received CLA as part of a triglyceride or as the free fatty acid, and 1 group received olive oil as placebo), 134 of the 157 participants who concluded the study were included in an open study for another 12 mo. The goals of the extension study were to evaluate the safety [with clinical chemistry analyses and reported adverse events (AEs)] and assess the effects of CLA on body composition [body fat mass (BFM), lean body mass (LBM), bone mineral mass (BMM)], body weight, and BMI. All subjects were supplemented with 3.4g CLA/d in the triglyceride form. Circulating lipoprotein(a) and thrombocytes increased in all groups. There was no change in fasting blood glucose. Aspartate amino transferase, but not alanine amino transferase, increased significantly. Plasma total cholesterol and LDL cholesterol were reduced, whereas HDL cholesterol and triglycerides were unchanged. The AE rate decreased compared with the first 12 mo of the study. Body weight and BFM were reduced in the subjects administered the placebo during the initial 12 mo study (-1.6 +/- 3.2 and -1.7 +/- 2.8 kg, respectively). No fat or body weight changes occurred in the 2 groups given CLA during the initial 12 mo. LBM and BMM were not affected in any of the groups. Changes in body composition were not related to diet and/or training. In conclusion, this study shows that CLA supplementation for 24 mo in healthy, overweight adults was well tolerated. It confirms also that CLA decreases BFM in overweight humans, and may help maintain initial reductions in BFM and weight in the long term.