Novedex XT Research, Hot Off the Press!

[mues97]

This is from the INTERNATIONAL SOCIETY OF SPORTSNUTRITION CONFERENCE PROCEEDINGS .

Any comments?


Ziegenfuss T.N., Mendel R.W., and Hofheins J.E. Safety and Efficacy of a Commercially- Available, Naturally-Occurring, Aromatase Inhibitor in Healthy Men.
Ohio Research Group of Exercise Science and Sports Nutrition. Wadsworth, Ohio 44281, USA.tim@ohioresearchgroup.com

Rationale:In healthy eugonadal men, it is known that blocking estrogen formation stimulates thehypothalamic-pituitary-testicular (HPT) axis to increase in vivo androgen production. Recently, a new class of dietary supplements has appeared that claim to inhibit the aromatase enzyme (i.e., decrease the transformation of aromatizable androgens [androstenedione, DHEA, testosterone] into estrogens [estriol, estrone, estradiol]), leading to an increase in androgen and testosterone formation. Purpose: As the first step in a series of experiments on a popular, over-the-counter aromatase inhibitor, the purpose of this pilot study was to examine the effects of Novedex XT™(NOV-XT) administration on selected hormonal responses (total testosterone [TT], bioavailable testosterone [BT] and estradiol [E2]), as well as serum and plasma markers of renal, hepatic, andhematological function. Methods: Using an open-label, proof-of-concept design, five eugonadal men (mean ± SD age, height, weight, body fat: 31.0 ± 5.3 yr, 177.0 ± 3.8 cm, 86.6 ± 8.7 kg, 15.2 ± 5.4 %) ingested 4 capsules of NOV-XT prior to bed for 28 consecutive days. According to themanufacturer, each capsule of NOV-XT contains 60 mg of a proprietary blend of three naturally-occurring aromatase inhibitors: 6, 17-keto-etiocholene-3-ol tetrahydropyranol ether, 3, 17-keto-etiochol-triene, and 3’,5,7-trihydroxy-4’-methoxyflavone (supplements were provided by an FDA-registered, pharmaceutically licensed manufacturer; confirmation by an external laboratory is pending). Blood samples obtained at baseline (prior to supplementation), and at weekly intervals thereafter for 28 days, were analyzed for TT, BT, and E2 by radioimmunometric and chemilluminetric assays. Subjects were required to maintain their normal dietary and training patterns during the study. All blood samples were obtained at the same time of day (0700-0900) to minimize diurnal variation. Hormone concentrations were statistically analyzed by ANOVA and Tukey’s HSD post-hoc test. Dependent t-tests were used to compare changes in blood chemistries. Statistical significance was accepted at p<0.05. Results: Compared to baseline, NOV-XTadministration rapidly and significantly increased TT and BT. Mean changes from baseline for TT (Figure 1) after one, two, three, and four weeks of NOV-XT administration were: +145% (p<0.006), +183% (p<0.0005), +232% (p<0.0002), and +240% (p<0.0002), respectively. Meanchanges from baseline for BT (Figure 2) after one, two, three, and four weeks of NOV-XTadministration were: +300% (p<0.01), +402% (p<0.0009), +511% (p<0.0002), and +528% (p<0.0002), respectively. Despite these large increases in TT and BT, no significant aromatization to estradiol was observed (i.e., E2 concentrations remained 3-6 pg/mL below baseline at all timepoints). No statistically significant changes in clinical blood chemistries (fasting glucose, BUN, creatinine, bilirubin, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, sodium, potassium, chloride, calcium, albumin, globulin, CO2, total protein, total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, VLDL-cholesterol) or systemic hemodynamics (heart rate, systolic blood pressure, diastolic blood pressure) were observed, nor were any adverse events reported during the study.

Conclusions: Within the framework of the current experimental design, these preliminary data indicate that four weeks of NOV-XT administration significantly elevates serum TT and BT, likelyvia the inhibition of estradiol formation and the shifting of the HPT axis towards androgen/testosterone production. In healthy, eugonadal men, supplementation with NOV-XT does not appear to result in any deleterious effects on blood chemistry or systemic hemodynamics. Ongoing research is being conducted to confirm and refine these results in a larger sample size, aswell as examine the impact of NOV-XT on androgenic and estrogenic metabolites, bodycomposition, and muscular performance. Supported in part by a research grant from Gaspari Nutrition (Neptune, NJ).

[BringnIt]

Good post.

[size]

Very good results.

[ellipticer]

I'm awaiting the data that shows any change in body composition over time. While searching for the original paper on Novedex XT, I found this was also published in the same issue:


Trimmer R1, RD, Johnson R2, Effects of Two Naturally Occurring Aromatase Inhibitors on
Male Hormonal and Blood Chemistry Profiles 1North Florida Sports Nutrition Consultants,
Jacksonville, FL rtNFSNC@yahoo.com 2Kilosports, Inc, Phoenix AZ
ryan.johnson@kilosports.com

Low testosterone levels have been postulated as a factor in age-related physiological deterioration in
males, notably decreased muscle mass and strength, increased fat mass, frailty, osteopenia,
osteoporosis, loss of energy, reduced metabolism, glucose intolerance, depressed mood, decreased
libido and erectile dysfunction, among others. Aromatase inhibitors have been shown to decrease
estradiol and increase testosterone levels in males. We investigated the impact of a combination of
two naturally occurring aromatase inhibitors (AI) on endogenous testosterone, estradiol and blood
chemistry profiles when given orally to a cohort of 15 males over a 28-day period. All subjects
were between the ages of 21 and 72 with a mean age of 39.9 years (median 35) and had taken no
testosterone-boosting supplements or medications in the three months prior to study initiation.
Both AIs were combined together in one capsule and were dosed orally as 3 capsules once daily.
Blood samples were collected at baseline prior to starting AI therapy, at 10 days and at 28 days after
entering the study. Mean baseline total testosterone for the cohort (N=15) was 489 ng/dL (range
218-712 pg/ml). Mean baseline free testosterone was 91.6 pg/ml (range 45.7-171.6 pg/ml). At ten
days, mean total testosterone and free testosterone increased by 244% (range 509-2153 ng/dL) and
358% (204-502 pg/ml) respectively from baseline. At 28 days, mean total testosterone levels had
increased 314% (range 884-2487 ng/dL); mean free testosterone increased 492% (range 266-685
pg/ml) from baseline measurements. Mean estradiol levels were suppressed to undetectable levels
(<20 pg/ml) by day 10 in 10/15 study entrants and below limit of detection in 13/15 patients at day
28. No significant changes from baseline ( > or < than 15%) were observed in blood chemistry
levels for any subject during the 28-day study duration. Three patients agreed to the collection of
additional blood samples on Day 56 after the discontinuation of AI therapy on Day 29. Analysis of
samples in this small sub-study is pending and will be presented at the conference. Results of this
pilot study of 15 patients found that this proprietary blend of two naturally occurring aromatase
inhibitors significantly increased total and free testosterone levels from baseline measurements at
both 10 and 28 days. No significant alterations in lipid, liver or other blood chemistry parameters
were noted during the 28-day study period. Additional studies are needed to confirm the long-term
efficacy and safety of this combination of naturally occurring aromatase inhibitors.

[ShadowOne]

Impressive. With the recall of Rebound XT, this is sure a boost for Gaspari's product. What the study should have also described were just gross observation in androgenic effects. Like, "test subject X reported a mild increase in acne..." "test subject X did not report any noticeable hairloss..." etc etc. Obviously it would be all subjective, but still useful anectodal information. Many clinical trials for drugs will usually have a section where they'll say something like, "treatment was generally well tolerated, with side effects generally being minor such as flu-like symptoms, mild rash...).

[ellipticer]

A graph showing TT and FT levels; from the original study about Novedex XT:

[ShadowOne]

Originally Posted by ellipticer

A graph showing TT and FT levels; from the original study about Novedex XT:

Someone correct me if I'm wrong. But these numbers rival or even beat the levels found in people who are directly injecting 250mg/week of Test Enth or Test Cyp.

[ironLifeBG]

Originally Posted by ShadowOne

Someone correct me if I'm wrong. But these numbers rival or even beat the levels found in people who are directly injecting 250mg/week of Test Enth or Test Cyp.

you aren't wrong, this is some seriously strong ****.

[JV@Gaspari]

These results are just the beginning of the good news. Stay tuned... later this year, Gaspari Nutrition will release the results of our groundbreaking study from a well known sports nutrition research facility.

JV

[Peter LeDrew]

I was wondering why more people weren't talking about this product before after reading some on it.
Hopefully we'll get some good logs going.

[supaflash]

Didnt I read somewhere the nolvadex XT had the same ingredients as RXT meanings its basically the same stuff just diff labels. With the exception of the recall , wouldnt it just be smart to get either since they both have the same junk in em? Hell if rxt doesnt work for pube induced gyno what makes ppl think nolvaxt would??? All the results I see are ppl saying it worked on their PH gyno.

[size]

Originally Posted by Peter LeDrew

I was wondering why more people weren't talking about this product before after reading some on it.

Because people dislike Bruce ******* and enjoy bashing him due to internet attitudes. This is a very good product. I have used a similar product, ALRI's Ultra HOT, and I was extremely pleased.

[PHbalanced]

I'm starting a log here.
http://forum.bodybuilding.com/showthread.php?t=512924
Don't know when my NOV-XT will come in, though. May be awhile before I have any info.

[ironLifeBG]

Originally Posted by supaflash

Didnt I read somewhere the nolvadex XT had the same ingredients as RXT meanings its basically the same stuff just diff labels. With the exception of the recall , wouldnt it just be smart to get either since they both have the same junk in em? Hell if rxt doesnt work for pube induced gyno what makes ppl think nolvaxt would??? All the results I see are ppl saying it worked on their PH gyno.

i am staring at both bottles right now and they don't have the same ingredients.
look

this is NXT -- http://www.bodybuilding.com/store/gn/nxt.html

this is RXT -- http://www.bodybuilding.com/store/design/reb.html

[freakie]

They're not formulated exactly the same but the main AI in both Rebound and Novedex is ADT.

[JV@Gaspari]

Originally Posted by supaflash

Didnt I read somewhere the nolvadex XT had the same ingredients as RXT meanings its basically the same stuff just diff labels. With the exception of the recall , wouldnt it just be smart to get either since they both have the same junk in em? Hell if rxt doesnt work for pube induced gyno what makes ppl think nolvaxt would??? All the results I see are ppl saying it worked on their PH gyno.

ABSOLUTELY NOT.......... ReboundXT and NovedexXT DO NOT share the same ingredients. The only thing they share is the XT in the name. The claims we make on NovedexXT are backed by clinical trials and medical research.

Additional info on NovedexXT can be found in the BREAKING NEWS section of our website at http://www.gasparinutrition.com

[size]

Originally Posted by JV@Gaspari

ABSOLUTELY NOT.......... ReboundXT and NovedexXT DO NOT share the same ingredients. The only thing they share is the XT in the name. The claims we make on NovedexXT are backed by clinical trials and medical research.

Well, do they not both include ATD but Novedex XT has some good additions? Anyway, I think Novedex XT is a good product (besides the name) and I look forward to seeing more good products from Gaspari.

[ellipticer]

Originally Posted by JV@Gaspari

ABSOLUTELY NOT.......... ReboundXT and NovedexXT DO NOT share the same ingredients. The only thing they share is the XT in the name. The claims we make on NovedexXT are backed by clinical trials and medical research.

And we appreciate the medical research backing it up. I just ordered 3 bottles. Now, since the weight and body fat of the subjects were measured to start the trial, could you find out the end results of the weight and body fat across the sample at the end of the trial?

[RepubCarrier]

Gaspari, do we have your assurances that the proprietary blend in Novadex XT that I can buy right now at bb.com will be the same as what was used in the above clinical trial?

I may try it.

[Peter LeDrew]

Originally Posted by size

Because people dislike Bruce ******* and enjoy bashing him due to internet attitudes. This is a very good product. I have used a similar product, ALRI's Ultra HOT, and I was extremely pleased.

Oh.

[JV@Gaspari]

Originally Posted by RepubCarrier

Gaspari, do we have your assurances that the proprietary blend in Novadex XT that I can buy right now at bb.com will be the same as what was used in the above clinical trial?

I may try it.

ABSOLUTELY. Gaspari Nutrition is a growing company and Rich stands behind his pledge to Purity, Quality and Potency 100%.

[BringnIt]

I would wait for PA's product, Peter.

[ckohl23]

I think all of this brings out a very important point. DS has always pointed to the large amount of positive feedback as a reason to choose their product over others.

With the recent news of the lack of active in a sizeable batch of Rebound XT, some of this user feedback is now pretty much invalid and can be attributed to placebo effect rather than real results.

Don't get me wrong, I like DS and I think they are still a leader in the industry when it comes to new and innovative products and standing behind the customer.

However, this news should change the buying attitudes of intelligent people out there - we should demand relevant scientific research, third-party studies, actual blood tests and proof of quality/potency before laying down our hard earned money - placing less emphasis on logs, feedback and other anecdotal evidence. Hard science and numbers take precedence over hype any day in my book and I applaud Gaspari for making steps in this direction. I'm sure the new attention on this product will work in their favor and I hope it sets a new standard for future supplement evaluation around here.

[ShadowOne]

Originally Posted by JV@Gaspari

ABSOLUTELY. Gaspari Nutrition is a growing company and Rich stands behind his pledge to Purity, Quality and Potency 100%.

I guess it helps that PA also mentioned in another thread that he tested NXT and said it had good ATD in it.

[Syr]

Originally Posted by JV@Gaspari

ABSOLUTELY. Gaspari Nutrition is ...

Advertising apart, we know that there was a change in the composition of Novedex XT. Size question is legitimate: that study uses the new or the old formula?

[PHbalanced]

Originally Posted by JV@Gaspari

ABSOLUTELY NOT.......... ReboundXT and NovedexXT DO NOT share the same ingredients. The only thing they share is the XT in the name.

Not directly asking JV, but anybody know where to find what's really in Rebound XT? The only ingredient I see is the trademark name of "Diene-3", while NOV-XT has some long chemical compounds listed as their ingredients. I'd like to know what specific part of Rebound's compound is so effective against gyno. And, my apologies if I sound naive, but I had a horrible chemistry teacher.

[Growin Guns]

I believe you can see a better list if you go to the BB.com store and look up the product. The description has more of the science side in it. It is written by the makers so it also has a heavy dose of propaganda, but it should help with your question.
GG

[PHbalanced]

Nevermind, I found it. Here are the ingredients:

Rebound XT:
(1,4-androstadiene - 3,6,17-dione)

NOV-XT:
[6, 17-keto-etiocholeve-3-ol tetrahydropyranol],
[3, 17-keto-etiochol-triene],
[3’,5,7-trihydroxy-4’-methoxyflavone].

They really are totally different products.

[ellipticer]

Originally Posted by PHbalanced

Not directly asking JV, but anybody know where to find what's really in Rebound XT? The only ingredient I see is the trademark name of "Diene-3", while NOV-XT has some long chemical compounds listed as their ingredients. I'd like to know what specific part of Rebound's compound is so effective against gyno. And, my apologies if I sound naive, but I had a horrible chemistry teacher.

The most informative thread on what is in these similar, but different, products.

[4amWorkouts]

Not trying to discount anything, but are sample sizes of 5 and 15 people a little low to draw any conclusions from?