i got my blood results today and found elevated AST and ALT results..
does anyone know what these enzymes do and if this is bad?
i am trying to do my research on google
Aspartate transaminase (AST) also called Serum Glutamic Oxaloacetic Transaminase (SGOT) or aspartate aminotransferase (ASAT) is similar to ALT in that it is another enzyme associated with liver parenchymal cells. It is raised in acute liver damage, but is also present in red cells, and cardiac and skeletal muscle and is therefore not specific to the liver. The ratio of AST to ALT is sometimes useful in differentiating between causes of liver damage.
Alanine transaminase (ALT), also called Serum Glutamic Pyruvate Transaminase (SGPT) or Alanine aminotransferase (ALAT) is an enzyme present in hepatocytes (liver cells). When a cell is damaged, it leaks this enzyme into the blood, where it is measured. ALT rises dramatically in acute liver damage, such as viral hepatitis or paracetamol (acetaminophen) overdose. Elevations are often measured in multiples of the upper limit of normal (ULN).
10-14-2007, 11:25 PM #1
I have elevated liver enzymes (AST / ALT)? bad?
10-14-2007, 11:25 PM #2
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10-14-2007, 11:33 PM #3
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Common Agents That Can Cause Liver Transaminase Elevations
Amoxicillin- clavulanic acid
Jin bu huan
Nonsteroidal anti-inflammatory drugs
10-15-2007, 03:30 AM #6
10-15-2007, 04:42 AM #7
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10-15-2007, 06:03 AM #8
Abnormal levels of protein/albumin/globulin, albumin/globulin ratio, bilirubin, alkaline phosphatase, lactic dehydrogenase (LDH), AST (SGOT), ALT (SGPT), iron, cholesterol, and cholesterol lipoproteins are indications of potential liver/biliary problems. These may include liver damage induced by alcohol or drug use, liver cancer, or obstruction of the bile duct, among others. Together, ALT and AST allow for differential diagnosis of disorders associated with the hepatobiliary system and the pancreas. High levels of alkaline phosphatase may also indicate abnormally high levels of vitamin D.
Gamma glutamyl transpeptidase (GGT)
GGT is a biliary enzyme that is useful for diagnosing diseases of the liver and pancreas. It may also be used to distinguish abstinent alcoholics from alcoholics who continue to drink. Levels are commonly elevated in patients with liver inflammation (due to viral hepatitis, alcohol abuse, mononucleosis, cytomegalovirus/ CMV, myocardial infarction, diabetes mellitus, neurologic disease, trauma, and sepsis) or obstruction of the bile ducts (from pancreatic disease, gallstones, or tumors). Decreased levels of GGT may be found in hypothyroid patients or in patients with low magnesium levels or hypothalamic malfunction. GGT is a very specific indicator of liver damage or biliary obstruction, and will be the first hepatobiliary marker to indicate any increases in the blood. GGT, CEA, and alkaline phosphatase, used together, are useful markers to detect liver metastasis from the breast and colon. GGT should be tested along with AST and ALT to diagnose liver and biliary dysfunction.
BLOOD TEST NORMAL VALUES
How to interpret your blood test results
YANA: Interpreting the Results of Your Blood Tests
Hope that helps,
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10-15-2007, 06:08 AM #9