ATD - Site Specific Androgen Receptor Modulation

[Hrobjartz]

Hi, just found this on bb.com.

Site Specific Androgen Receptor Modulation
http://www.bodybuilding.com/fun/core_may_7.htm

Recently many readers have been writing in asking questions about how to use one of the hottest new supplements to hit the market - ATD (3,17-dioxo-etiochol-1,4,6-triene).

ATD is possibly the greatest recent supplement breakthrough allowing for tremendous natural testosterone production and HPTA up-regulation. And no, I'm not talking about another "tribulus" or "deer antler velvet" supplement.

Natural athlete can benefit from significant increases (over 400%) in natural testosterone production as a result of ATD supplementation...

Anybody tried this stuff or know anything about it?

Just curious...

[size]

****'s Ultra HOT is an excellent product. Results/feedback from users has been overwhelmingly positive.

[Hrobjartz]

Originally Posted by size

****'s Ultra HOT is an excellent product. Results/feedback from users has been overwhelmingly positive.

Thanks for the feedback!
Looks interesting.

I´m currently on a SD cycle. Was planning on using Nolva and Rebound for PCT. Would Ultra Hot be better than Rebound for PCT? Or could you use them together?

[RepubCarrier]

ATD is in ultra hot, rebound XT, and gaspari novadex (just fyi)

[Hrobjartz]

Originally Posted by RepubCarrier

ATD is in ultra hot, rebound XT, and gaspari novadex (just fyi)

Yea my bad.
I somehow thought the article said that Ultra Hot was the only product containing ATD, but obviously not.

Currently there are very few products I am aware of containing ATD. Whichever brand you choose, be aware that taking the correct dose is key. My own bias of course is ****'s Ultra H.O.T, which contains ATD plus other natural aromatase inhibitors and estrogen clearing compounds.

Thanks for the clarification.

[pu12en12g]

Bump for more discussion, now that the price on ATD dropped like a rock.

[PSKlifter]

Originally Posted by pu12en12g

Bump for more discussion, now that the price on ATD dropped like a rock.

pa's atd in his giant nutrition line......like 19$.... gonna be hard to beat that.

[kendog]

Originally Posted by PSKlifter

pa's atd in his giant nutrition line......like 19$.... gonna be hard to beat that.

Only prob is the near $8 shipping, which puts it right up there with the rest. I ordered some anyways for a stand alone cycle.

[PSKlifter]

Originally Posted by kendog

Only prob is the near $8 shipping, which puts it right up there with the rest. I ordered some anyways for a stand alone cycle.

damn, actually did not notice that as i have not ordered yet. that sucks....

[dbish77]

Originally Posted by PSKlifter

pa's atd in his giant nutrition line......like 19$.... gonna be hard to beat that.

Sig

[pu12en12g]

Originally Posted by PSKlifter

damn, actually did not notice that as i have not ordered yet. that sucks....

Damn $8... that does suck... still considering it though...

[PSKlifter]

Originally Posted by dbish77

Sig

haha, good call

[PSKlifter]

its currently ups only, thats the reason for the cost. im sure fed ex and usps will eventually be added and the prices should be better..... (im sure = im hoping)

[UberBerzerker]

Originally Posted by size

****'s Ultra HOT is an excellent product. Results/feedback from users has been overwhelmingly positive.

Put me down for a NEGative response...I bought a bottle, did 3 a night for all of the 20 days it would last. Only thing I noticed was a messed up sleep pattern. I would fall asleep easier, sleep deep, wake up at wierd hours, sit up, then go right back to sleep. Weird stuff. I almost felt as if I bought a $40 bottle of ZMA, but with ZMA I never noticed the strange sleep patterns. I've noticed no other benefits from the Ultra HOT. I would however, give it one more shot, but make sure I did before/after testing of T levels, but that would be a ways off. I want to try the Giant Nutrition of Gaspari stuff first, see if I *notice* any differences.

[RepubCarrier]

Originally Posted by UberBerzerker

Put me down for a NEGative response...I bought a bottle, did 3 a night for all of the 20 days it would last. Only thing I noticed was a messed up sleep pattern. I would fall asleep easier, sleep deep, wake up at wierd hours, sit up, then go right back to sleep. Weird stuff. I almost felt as if I bought a $40 bottle of ZMA, but with ZMA I never noticed the strange sleep patterns. I've noticed no other benefits from the Ultra HOT. I would however, give it one more shot, but make sure I did before/after testing of T levels, but that would be a ways off. I want to try the Giant Nutrition of Gaspari stuff first, see if I *notice* any differences.

you definetely would have noticed 75mg of ATD for 20 days. By the 5-7th day you would have sex drive comperable to a 500mg test cycle.

[freakie]

Does anybody really know how much ATD is in each capsule of Ultra Hot?
The ingredients show a proprietary blend of 250mg split across 5 ingredients.
You could have to take 6 capsules of Ultra Hot to get 75 mg of ATD.

[matpal]

Originally Posted by PSKlifter

pa's atd in his giant nutrition line......like 19$.... gonna be hard to beat that.

BB.com will have an ATD formula soon from a company I am hleping get off thr ground (but have no ownership in).

Should retail for $20 or under.

[PSKlifter]

Originally Posted by matpal

BB.com will have an ATD formula soon from a company I am hleping get off thr ground (but have no ownership in).

Should retail for $20 or under.

so its not going to be an omega product? i do luv me some omega

[pu12en12g]

Originally Posted by PSKlifter

so its not going to be an omega product? i do luv me some omega

:werd:

I can't wait to hear more feedback on the pure ATD products

[Robboe]

Originally Posted by freakie

Does anybody really know how much ATD is in each capsule of Ultra Hot?
The ingredients show a proprietary blend of 250mg split across 5 ingredients.
You could have to take 6 capsules of Ultra Hot to get 75 mg of ATD.

18mg per cap, i believe.

[Krzna]

I sure hope matpal and his boyz bring out some ATD themselves.When it comes to a pct product i trust no one but *** or IBE. Hell am neva buying anything from bb.com after the HP's.

[Kraftydog]

Originally Posted by RepubCarrier

you definetely would have noticed 75mg of ATD for 20 days. By the 5-7th day you would have sex drive comperable to a 500mg test cycle.

how do your rectify your statements with this. Have you actually taken 500mg of test?

Horm Behav. 1989 Mar;23(1):10-26.


Effects of ATD on male sexual behavior and androgen receptor binding: a reexamination of the aromatization hypothesis.

Kaplan ME, McGinnis MY.

Department of Anatomy, Mount Sinai School of Medicine, CUNY, New York 10029.

The aromatization hypothesis asserts that testosterone (T) must be aromatized to estradiol (E2) to activate copulatory behavior in the male rat. In support of this hypothesis, the aromatization inhibitor, ATD, has been found to suppress male sexual behavior in T-treated rats. In our experiment, we first replicated this finding by peripherally injecting ATD (15 mg/day) or propylene glycol into T-treated (two 10-mm Silastic capsules) or control castrated male rats. In a second experiment, we bilaterally implanted either ATD-filled or blank cannulae into the medial preoptic area (MPOA) of either T-treated or control castrated male rats. With this more local distribution of ATD, a lesser decline in sexual behavior was found, suggesting that other brain areas are involved in the neurohormonal activation of copulatory behavior in the male rat. To determine whether in vivo ATD interacts with androgen or estrogen receptors, we conducted cell nuclear androgen and estrogen receptor binding assays of hypothalamus, preoptic area, amygdala, and septum following treatment with the combinations of systemic T alone. ATD plus T, ATD alone, and blank control. In all four brain areas binding of T to androgen receptors was significantly decreased in the presence of ATD, suggesting that ATD may act both as an androgen receptor blocker and as an aromatization inhibitor. Competitive binding studies indicated that ATD competes in vitro for cytosol androgen receptors, thus substantiating the in vivo antiandrogenic effects of ATD. Cell nuclear estrogen receptor binding was not significantly increased by exposure to T in the physiological range. No agonistic properties of ATD were observed either behaviorally or biochemically. Thus, an alternative explanation for the inhibitory effects of ATD on male sexual behavior is that ATD prevents T from binding to androgen receptors.

[Kraftydog]

Originally Posted by Hrobjartz

Hi, just found this on bb.com.

Site Specific Androgen Receptor Modulation
http://www.bodybuilding.com/fun/core_may_7.htm

most of the claims in that article are not supported by science. I am surprised that no citations were posted since there is a significant amount of research on ATD

[ironLifeBG]

i just finished a 28day cycle of m1t and did a 28 day PCT using 6-0x0, novadex XT and some tribolan

i am experienced zero sides and survived with my gains intact

this stuff is gooood.

[bg330]

Originally Posted by Kraftydog

most of the claims in that article are not supported by science. I am surprised that no citations were posted since there is a significant amount of research on ATD

Its ****, NOTHING he says is supported by science. Have you read chemical enhancement???

[IronPimper]

I won't defend ALR. However, there is some science that verifies his claims,

http://www.ncbi.nlm.nih.gov/entrez/q...480&query_hl=3

Notice that in this study atd was able to block test binding in the hypothalamus, which is exactly what the poster was referring to.

This article shows that atd administered in conjunction with test still inhibited its effects in the poa, but did not effect mounting behavior (sex drive)

http://www.ncbi.nlm.nih.gov/entrez/q...576&query_hl=3

This study shows that monkeys injected with atd showed considerable decreases in aromatase activity in the hypothalamus. In the non-castrated males, this led to a corresponding increase in lh and t levels.

http://www.ncbi.nlm.nih.gov/entrez/q...136&query_hl=6

With that said, these are animal studies, and it is hard to determine how the drug will work in humans. The bloodwork and anecdotal evidence I have seen so far seems to be overwhelmingly positive

[RepubCarrier]

Originally Posted by Kraftydog

how do your rectify your statements with this. Have you actually taken 500mg of test?

No, but a ****load of 4-derm didn't come close to this. I compared my anecdotal experiences with the experiences of those who've pinned 500mg/week, and they were pretty much the same. There was a definite increase in DHT as well.

[Kraftydog]

Originally Posted by RepubCarrier

No, but a ****load of 4-derm didn't come close to this. I compared my anecdotal experiences with the experiences of those who've pinned 500mg/week, and they were pretty much the same. There was a definite increase in DHT as well.

500mg of test a week is the equivalent of about 70mg of test a day. thats 700% more than high normal test production. Its just my opinion but unless you have actually used injectable test you should not make the comparison. 4derm is not injectable test and there are very few people that would say that it is comparable.

[spoonman]

Originally Posted by matpal

BB.com will have an ATD formula soon from a company I am hleping get off thr ground (but have no ownership in).

Should retail for $20 or under.

Could you be more specific on the date?? Are we talking months or days?

[pu12en12g]

Thanks to velikimajmun for scanning the following document:

<img src="http://technologyorgasm.com/upload/atd1.jpg">
<img src="http://technologyorgasm.com/upload/atd2.jpg">
<img src="http://technologyorgasm.com/upload/atd3.jpg">
<img src="http://technologyorgasm.com/upload/atd4.jpg">
<img src="http://technologyorgasm.com/upload/atd5.jpg">