Still reading as much as I can but In the mean time, I would like to know the differnec between and AI and a SERM and why each is benificial over the other in specific situations
Thanks
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10-07-2007, 02:04 PM #1
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10-07-2007, 02:10 PM #2
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10-07-2007, 02:15 PM #3
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10-07-2007, 02:25 PM #4
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10-07-2007, 02:36 PM #5
AI= Aromatase inhibitor. It prevents the aromatase enzyme from acting on testosterone and turning the test into estrogen.
SERM= Selective Estrogen Receptor Modulator. These chemicals act on your estrogen receptors, not estrogen itself. SERMs prevent estrogen from exerting their cellular effects.
SERMs block estrogen from acting on certain sites in the body, while AIs prevent your body from synthesizing estrogen, two very different actions.
This is rudimentary at best, but gives you an idea. Definitely do more research outside of BB.com forums if your planning a post cycle therapy.
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10-07-2007, 03:30 PM #6
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10-07-2007, 03:40 PM #7
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10-07-2007, 03:42 PM #8
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10-07-2007, 03:56 PM #9
Well, they are both used post-cycle. AI's, however, can be used stand-alone as an indirect but still powerful way to increase your testosterone levels. SERMS, on the other hand, would never be used unless you were sure you had unnaturally high estrogen (IE after a cycle of hormonal anabolics)
Now I may be mistaken but a SERM is somewhat healthier because it allows estrogen to remain in your body and exert its beneficial effects, but without giving you boobs etc etc. AIs can bring estrogen to undesirably LOW levels if not used carefully I believe.
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10-07-2007, 09:38 PM #10
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10-07-2007, 09:41 PM #11
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A review in progress
Estrogen modulation is a growing target for bodybuilders. This is a short review of various targets and drugs available. This will be updated and expanded as needed.
Aromatase inhibitors:
AIs are categorized into two types:
Type 1: Irreversible steroidal inhibitors such as exemestane form a permanent bond with the aromatase enzyme complex.
Type 2: Non-steroidal inhibitors (such as anastrozole, letrozole) inhibit the enzyme by reversible competition.
Aromatase inhibitors work by inhibiting the action of the enzyme aromatase, which converts androgens into estrogens by a process called aromatization. By inhibiting aromatase they increase Testosterone and reduce Gynecomastia.
1. Letrozole (common brand name Femara) is a type 2 AI.
Letrozole has shown to reduce estrogen levels by 98 percent while raising testosterone levels. The anti-estrogen action of letrozole is preferred by bodybuilders for use during a steroid cycle to reduce bloating due to excess water retention and prevent the formation of gynecomastia related breast tissue that is a side effect of some anabolic steroids. Usage above 2.5 mg/day is known to potentially temporarily kill sex drive. Above 5mg/day for extended periods may cause kidney problems.
SERM (Selective Estrogen Receptor Modulaters):
Are a class of compounds that acts on the estrogen receptor. A characteristic that distinguishes these substances from pure receptor agonists and antagonists is that their action is different in various tissues, thereby granting the possibility to selectively inhibit or stimulate estrogen-like action in various tissues
1. Tamoxifen (brand name Nolvadex).
In men, tamoxifen is sometimes used to treat gynecomastia which arises for example as a side effect of antiandrogen prostate cancer treatment.Tamoxifen is also used by bodybuilders to prevent or reduce drug-induced gynecomastia caused by the estrogenic metabolites of anabolic steroids.
2. Clomifene or clomiphene (brand name Clomid)
Clomifene acts by inhibiting the action of estrogen on the gonadotrope cells in the anterior pituitary gland. In response to low estrogen levels, follicle-stimulating hormone (FSH) release is increased. Clomifene is commonly used by male anabolic steroid users to bind the estrogen receptors in their bodies, thereby blocking the effects of estrogen, i.e., gynecomastia. It also restores the body's natural production of testosterone. It is commonly used as a "recovery drug" and taken toward the end of a steroid cycle.
3. Toremifene citrate (brane name Fareston).
SERD (Selective Estrogen Receptor Downregulator):
1. Fulvestrant (brand name Faslodex) It is an estrogen receptor antagonist with no agonist effects, which works both by down-regulating and by degrading the estrogen receptor. It some studies is stronger than anastrozole.
http://www.mindandmuscle.net/forum/i...howtopic=30673www.cognitivenutrition.com
www.bodybuilding.com/store/uniq/uniq.htm
PEA 750 mg caps: http://www.bodybuilding.com/store/uniq/peaultra.html
PEA Dosing: http://forum.bodybuilding.com/showpost.php?p=261217881&postcount=1379
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10-07-2007, 09:50 PM #12
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10-07-2007, 09:52 PM #13
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10-07-2007, 10:30 PM #14
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10-07-2007, 10:39 PM #15
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10-07-2007, 11:04 PM #16
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10-07-2007, 11:45 PM #17
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10-08-2007, 12:04 AM #19
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10-08-2007, 12:38 AM #20
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10-09-2007, 09:19 AM #22
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10-09-2007, 10:05 AM #24
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10-09-2007, 10:07 AM #25
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10-09-2007, 10:12 AM #26
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10-09-2007, 10:18 AM #27
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Thats why I said so far. It could be of some benefit in the future. But with no human studies on it's use in any condition it's falls down the cracks sadly. PA used it a few product but i think he decided not to recommend it anymore. Need to find his postings in it again.
www.cognitivenutrition.com
www.bodybuilding.com/store/uniq/uniq.htm
PEA 750 mg caps: http://www.bodybuilding.com/store/uniq/peaultra.html
PEA Dosing: http://forum.bodybuilding.com/showpost.php?p=261217881&postcount=1379
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10-09-2007, 10:28 AM #28
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10-09-2007, 10:29 AM #29
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10-09-2007, 10:34 AM #30
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