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  1. #1
    Easy, Alpha is not Autino's Avatar
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    AI vs SERM - whats the difference

    Still reading as much as I can but In the mean time, I would like to know the differnec between and AI and a SERM and why each is benificial over the other in specific situations

    Thanks
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  2. #2
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    use the search button. THere are pages about this topic you just have to look.
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  3. #3
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    google, wikipedia, or the search function all have more than sufficient info on this
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  4. #4
    Easy, Alpha is not Autino's Avatar
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    I already did a search guys.
    Not one thread the explains the difference between the 2.

    I am not only writing this thread to learn more, but also so that anyone else with the same questions can find it with a quick search.

    How about some answers for me and future member searches?
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  5. #5
    Registered User SinewySam's Avatar
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    AI= Aromatase inhibitor. It prevents the aromatase enzyme from acting on testosterone and turning the test into estrogen.

    SERM= Selective Estrogen Receptor Modulator. These chemicals act on your estrogen receptors, not estrogen itself. SERMs prevent estrogen from exerting their cellular effects.

    SERMs block estrogen from acting on certain sites in the body, while AIs prevent your body from synthesizing estrogen, two very different actions.

    This is rudimentary at best, but gives you an idea. Definitely do more research outside of BB.com forums if your planning a post cycle therapy.
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  6. #6
    Easy, Alpha is not Autino's Avatar
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    Thank you.

    And is it suggested to use one over the other in certain situations?
    Both at times?
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  7. #7
    On Sabbatical Xc's Avatar
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    Originally Posted by Autino View Post
    Thank you.

    And is it suggested to use one over the other in certain situations?
    Both at times?
    Of course
    Currently: Attending BB.com School of Medicine.
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  8. #8
    Improve your Mind CognitiveNutrition's Avatar
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    Plus there is the newer SERDs (Selective estrogen-receptor downregulators).
    www.cognitivenutrition.com
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  9. #9
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    Originally Posted by Autino View Post
    Thank you.

    And is it suggested to use one over the other in certain situations?
    Both at times?
    Well, they are both used post-cycle. AI's, however, can be used stand-alone as an indirect but still powerful way to increase your testosterone levels. SERMS, on the other hand, would never be used unless you were sure you had unnaturally high estrogen (IE after a cycle of hormonal anabolics)

    Now I may be mistaken but a SERM is somewhat healthier because it allows estrogen to remain in your body and exert its beneficial effects, but without giving you boobs etc etc. AIs can bring estrogen to undesirably LOW levels if not used carefully I believe.
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  10. #10
    Easy, Alpha is not Autino's Avatar
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    Are they both used post cycle at the same time?
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  11. #11
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    A review in progress

    Estrogen modulation is a growing target for bodybuilders. This is a short review of various targets and drugs available. This will be updated and expanded as needed.

    Aromatase inhibitors:

    AIs are categorized into two types:

    Type 1: Irreversible steroidal inhibitors such as exemestane form a permanent bond with the aromatase enzyme complex.
    Type 2: Non-steroidal inhibitors (such as anastrozole, letrozole) inhibit the enzyme by reversible competition.

    Aromatase inhibitors work by inhibiting the action of the enzyme aromatase, which converts androgens into estrogens by a process called aromatization. By inhibiting aromatase they increase Testosterone and reduce Gynecomastia.

    1. Letrozole (common brand name Femara) is a type 2 AI.

    Letrozole has shown to reduce estrogen levels by 98 percent while raising testosterone levels. The anti-estrogen action of letrozole is preferred by bodybuilders for use during a steroid cycle to reduce bloating due to excess water retention and prevent the formation of gynecomastia related breast tissue that is a side effect of some anabolic steroids. Usage above 2.5 mg/day is known to potentially temporarily kill sex drive. Above 5mg/day for extended periods may cause kidney problems.


    SERM (Selective Estrogen Receptor Modulaters):

    Are a class of compounds that acts on the estrogen receptor. A characteristic that distinguishes these substances from pure receptor agonists and antagonists is that their action is different in various tissues, thereby granting the possibility to selectively inhibit or stimulate estrogen-like action in various tissues


    1. Tamoxifen (brand name Nolvadex).

    In men, tamoxifen is sometimes used to treat gynecomastia which arises for example as a side effect of antiandrogen prostate cancer treatment.Tamoxifen is also used by bodybuilders to prevent or reduce drug-induced gynecomastia caused by the estrogenic metabolites of anabolic steroids.

    2. Clomifene or clomiphene (brand name Clomid)

    Clomifene acts by inhibiting the action of estrogen on the gonadotrope cells in the anterior pituitary gland. In response to low estrogen levels, follicle-stimulating hormone (FSH) release is increased. Clomifene is commonly used by male anabolic steroid users to bind the estrogen receptors in their bodies, thereby blocking the effects of estrogen, i.e., gynecomastia. It also restores the body's natural production of testosterone. It is commonly used as a "recovery drug" and taken toward the end of a steroid cycle.

    3. Toremifene citrate (brane name Fareston).


    SERD (Selective Estrogen Receptor Downregulator):

    1. Fulvestrant (brand name Faslodex) It is an estrogen receptor antagonist with no agonist effects, which works both by down-regulating and by degrading the estrogen receptor. It some studies is stronger than anastrozole.

    http://www.mindandmuscle.net/forum/i...howtopic=30673
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  12. #12
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    excellent post ^^
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  13. #13
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    Originally Posted by AConrad00 View Post
    excellent post ^^
    Thanks man I should have a full review from our MD in 1-2 weeks.
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  14. #14
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    examples of SERMS???
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  15. #15
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    Do you know what you get when you search for information
    about PH's and PCT's?

    Hundreds of posts saying "Do a search."

    Yes, I'm serious.

    Originally Posted by Autino View Post
    I already did a search guys.
    Not one thread the explains the difference between the 2.

    I am not only writing this thread to learn more, but also so that anyone else with the same questions can find it with a quick search.

    How about some answers for me and future member searches?
    Last edited by B P Spin; 10-07-2007 at 10:42 PM.
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  16. #16
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    Originally Posted by ponshoe View Post
    examples of SERMS???
    Clomifene (Clomiphene)
    Tamoxifen
    Toremifene citrate
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  17. #17
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    My issue being I am not aware of any OTC serm's
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    Originally Posted by scrag View Post
    My issue being I am not aware of any OTC serm's
    Just saw one on TV today, I think, I'll have to look in to it. Estrogenx or something like that, we'll see. Searching...Estroven...searching for more info on it...nope that **** is garbage.
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  19. #19
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    Originally Posted by scrag View Post
    My issue being I am not aware of any OTC serm's
    So just buy some online.
    www.cognitivenutrition.com
    www.bodybuilding.com/store/uniq/uniq.htm

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  20. #20
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    Originally Posted by uniquenutrition View Post
    So just buy some online.
    Not where I live you cant just order stuff online unfortunately or if you try to import it customs will seize it.
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    Originally Posted by scrag View Post
    Not where I live you cant just order stuff online unfortunately or if you try to import it customs will seize it.
    SERMS are controlled there?
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    Easy, Alpha is not Autino's Avatar
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    In the above post it says that steroid users use AIs during a cycle to prevent bloating and gyno.
    So am I correct to say that Ai us used during cycle and Serm is used post cyclt, or am I not reading well enough?
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    Originally Posted by Autino View Post
    In the above post it says that steroid users use AIs during a cycle to prevent bloating and gyno.
    So am I correct to say that Ai us used during cycle and Serm is used post cyclt, or am I not reading well enough?
    That is one way.
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    Transresverstol sp? might be a SERM?
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    Originally Posted by Doughboy View Post
    Transresverstol sp? might be a SERM?
    LOL zero human studies...so far.
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    Originally Posted by uniquenutrition View Post
    LOL zero human studies...so far.
    Just mentioning an otc product that MAY help, not comparing to other products mentioned above.
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    Originally Posted by Doughboy View Post
    Just mentioning an otc product that MAY help, not comparing to other products mentioned above.
    Thats why I said so far. It could be of some benefit in the future. But with no human studies on it's use in any condition it's falls down the cracks sadly. PA used it a few product but i think he decided not to recommend it anymore. Need to find his postings in it again.
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    Originally Posted by uniquenutrition View Post
    SERMS are controlled there?
    They're controlled most places without a prescription for human use.
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    Originally Posted by eatingisfun View Post
    They're controlled most places without a prescription for human use.
    Glad I'm in the US.
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    Originally Posted by uniquenutrition View Post
    Glad I'm in the US.
    You need a prescription in the US to get them legally(for human use). The only reason you can get them now is because of a loophole in the laws allowing it for research purposes.
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