First the study that it raises cholesterol and now this study.
Why are people still putting this in supplements?
Mol Pharmacol. 2005 Mar;67(3):948-54. Epub 2004 Dec 15. Related Articles, Links
The hypolipidemic natural product guggulsterone is a promiscuous steroid receptor ligand.
Burris TP, Montrose C, Houck KA, Osborne HE, Bocchinfuso WP, Yaden BC, Cheng CC, Zink RW, Barr RJ, Hepler CD, Krishnan V, Bullock HA, Burris LL, Galvin RJ, Bramlett K, Stayrook KR.
Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA. burris@lilly.com
Guggulsterone (GS) is the active substance in guggulipid, an extract of the guggul tree, Commiphora mukul, used to treat a variety of disorders in humans, including dyslipidemia, obesity, and inflammation. The activity of GS has been suggested to be mediated by antagonism of the receptor for bile acids, the farnesoid X receptor (FXR). Here, we demonstrate that both stereoisomers of the plant sterol, (E)- and (Z)-GS, bind to the steroid receptors at a much higher affinity than to FXR. Both stereoisomers bind to the mineralocorticoid receptor (MR) with a Ki value of approximately 35 nM, which is greater than 100 times more potent than their affinity for FXR. Both (E)- and (Z)-GS also displayed high affinity for other steroid receptors, including the androgen (AR), glucocorticoid (GR), and progesterone receptors (PR) with Ki values ranging from 224 to 315 nM. In cell-based functional cotransfection assays, GSs behaved as antagonists of AR, GR, and MR, but as agonists of PR. Agonist activity was also demonstrated with estrogen receptor (ER) alpha; however, the potency was very low (EC50 > 5000 nM). In addition, GS displayed activity in functional assays in cell lines expressing endogenous AR, GR, ER, and PR. These data suggest that the variety of pharmacological effects exhibited by GS may be mediated by targeting several steroid receptors.
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Thread: the guggulsterone issue
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04-25-2005, 03:12 PM #1
the guggulsterone issue
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04-25-2005, 03:15 PM #2
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04-25-2005, 03:19 PM #3Originally Posted by derekmac
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04-25-2005, 03:24 PM #4
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04-26-2005, 02:46 PM #5
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04-26-2005, 02:49 PM #6
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04-26-2005, 02:50 PM #7
Reminds me somewhat of the glutamine issue....there has yet to be a study showing the oral efficacy of glutamine in non burn patients, or people who have diseases, and yet glutamine is still highly touted, despite the science to the contrary.
People would do well to do a little research for themselves....knowledge is power.
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04-26-2005, 02:53 PM #8
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04-26-2005, 10:29 PM #9
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04-27-2005, 12:45 PM #10
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04-27-2005, 09:16 PM #11
That sucks. Although I still think that everyone will one day get there wish and be able to take a pill that has no side effects and will allow you to drop to 8% bf overnight with no lean mass loss, without modifing their diet or having to work out. (I am a smart ass, I know)
Thanks for the info.
B)
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04-28-2005, 10:54 AM #12
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04-28-2005, 10:57 AM #13
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04-28-2005, 11:24 PM #14
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04-28-2005, 11:42 PM #15
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"That sucks. Although I still think that everyone will one day get there wish and be able to take a pill that has no side effects and will allow you to drop to 8% bf overnight with no lean mass loss, without modifing their diet or having to work out. (I am a smart ass, I know)"
Take DNP. I mean, aside from that death issue, no real side effects there...Speller Extraordinaire. Don't believe the lies.
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04-29-2005, 01:07 AM #16
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04-29-2005, 05:16 AM #17
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05-01-2005, 07:09 PM #18
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05-03-2005, 08:03 PM #19
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05-04-2005, 09:04 AM #20
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05-04-2005, 03:33 PM #21
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05-04-2005, 09:05 PM #22
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05-05-2005, 09:11 AM #23
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Originally Posted by korexite
Finished a bottle of a syntrax product with guggle a bit ago, and recently had bloodwork done. LDL was normal.
-krazy|
Currently featuring VMax Weightvest review. http://blog.bodybuilding.com/krazykarl
"a liver is like a DUI - you don't need to worry till you've had a couple of them"
-Slated
"The Misc is the closest thing the human race has to a natural predator. Charles Darwin and myself applaud you all."
-PeonLover
goal: 215 lbs/7% bf/6 min mile
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05-05-2005, 09:30 AM #24
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05-05-2005, 10:07 AM #25
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05-05-2005, 12:29 PM #26
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05-07-2005, 07:34 PM #27
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05-09-2005, 03:45 PM #28
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05-10-2005, 07:14 AM #29
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05-10-2005, 02:06 PM #30Originally Posted by nni
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