Anyone here supplement with Garlic?

[mbcrump]

Been reading some very good things about garlic and started supplementing with it yesterday. Is it all hype? I bought a bottle for 3.88 so no loss if its just hype. What are your opinions on it?

[in10city]

Originally Posted by mbcrump

Been reading some very good things about garlic and started supplementing with it yesterday. Is it all hype? I bought a bottle for 3.88 so no loss if its just hype. What are your opinions on it?

It's great for keeping people from asking to "work in" with you at the gym

What are you using it for?

[fresh00]

i currently am before bed for my immune system along with all its other health benefits

[rusmuscle]

Originally Posted by in10city

It's great for keeping people from asking to "work in" with you at the gym

What are you using it for?

haha nice



i know garlic helps keep cholesterol levels at a norm, and just good for well being. I've also heard rumors it somehow helps with 'abnominal fat'

what are you taking it for?

[Skull Crusher Chris]

Originally Posted by fresh00

i currently am before bed for my immune system along with all its other health benefits

x2 but with breakfast as well for me.

[LL SquatButt J]

anyone using a non oderless garlic supp? im using kyolic 103 ryte now...

[DFA]

i swallow a clove..whole..never get sick

[teebirdhyzer]

I take it 2 to 3 times per day. Odorless type.

[dan7681]

Originally Posted by mbcrump

Been reading some very good things about garlic and started supplementing with it yesterday. Is it all hype? I bought a bottle for 3.88 so no loss if its just hype. What are your opinions on it?

Garlic is a staple for me now, it has many positive effects and is priced relatively cheap. IMO go with the eccentric coated tablets and also use one standardized for Allin/Allicin

[kappaz]

Originally Posted by dan7681

Garlic is a staple for me now, it has many positive effects and is priced relatively cheap. IMO go with the eccentric coated tablets and also use one standardized for Allin/Allicin

Enteric Coatings

Some manufacturers have enteric-coated their garlic powder so that it would bypass the stomach. Assuming the best, that a high quality garlic powder is used initially (one that is not exposed to high temperatures which can deactivate alliinase), this form of garlic could potentially deliver alliin and alliinase to the intestinal tract. However, simulated intestinal fluids have been shown to inhibit 40% of the allicin production. The remaining allicin may exert anti-microbial effects on bad bacteria, however, it may also destroy friendly bacteria. Both allicin and raw garlic preparations which contain allicin have been shown to decrease the bacteria flora. Further, being a strong oxidizing agent allicin may irritate the sensitive cells which line the intestinal tract as it has been shown to irritate the cells lining the stomach. Finally, if organically grown garlic is not used as a starting material, enteric-coatings may assist in delivering pesticides and other contaminants in the garlic directly into the intestinal tract for absorption.

Allicin: Not Found in Top Garlic Products

For years, allicin has been deemed as the compound responsible for the benefits of garlic. It has shown an ability to kill bacteria and fungus in test tubes and topically crushed raw garlic has been used in wars to fight infections. However, no clinical trials have been performed with allicin and it has not become a commercial product, mainly because of its chemical instability but also because of its pungent odor and irritating nature.

Allicin is produced by an enzymatic reaction when raw garlic is either crushed or somehow injured. The enzyme, alliinase, combines with a compound called alliin in raw garlic and produces allicin. Because allicin is so unstable, once it is generated it readily changes into other compounds. Thus cooking, aging, crushing and otherwise processing garlic causes the allicin to be decomposed into other compounds. According to two studies of garlic preparations, allicin decreased to nondetectable amounts within one to six days (20-144 hours) This could explain why a study of various products on the market showed that they all contained an undetectable amount (<1 ppm) of allicin.

"Allicin Potential" of Questionable Value

To prevent the typical loss of allicin, some manufacturers have attempted to stabilize alliin and alliinase so that these compounds would not come together until after they enter the body in hopes of producing allicin inside of the body. Such "allicin potential" is measured by adding water to garlic products which contain both alliin and alliinase to determine how much allicin can be produced. However, the actual production of allicin inside the body is not the same as that produced in a test tube for the following reasons:

Intestinal Conditions Hinder the Generation of Allicin:

- Stomach acid destroys alliinase, preventing allicin production.
- Intestinal fluids further diminish the amount of allicin that can be produced.

Simulated stomach fluids and simulated intestinal fluids have commonly been used to determine the effects of typical digestion on nutrients or chemicals in question. Interestingly, alliinase, the enzyme which catalyzes the conversion of alliin to allicin, has been shown to be irreversibly deactivated at pH 3 or below, an acidic environment typically found in the stomach.Further, a 99% loss in allicin production was observed following consecutive exposure to simulated stomach fluids and simulated intestinal fluids which would occur when one takes a garlic powder orally.Therefore, it appears that unless a garlic powder bypasses the stomach, the amount of allicin produced is negligible.

Allicin Is Not Bioavailable:

No allicin found in the body following oral intake.

A study in which participants consumed a large amount of allicin (approximately 90,000 mcg) via crushed raw garlic (25 grams; roughly 10 cloves) revealed that neither allicin nor 16 of its daughter compounds could be detected in blood or urine from one to 24 hours after consumption. Due to its high reactivity allicin was shown to be completely metabolized in the liver. If allicin could even make it to the blood (to be delivered throughout the body), studies have shown that it changes into other compounds within five minutes and in the process may oxidize the blood cells causing them to lose their ability to carry oxygen.

"Allicin is not biologically active inside of the body"

Yukihiro Kodera, at the Designer Foods III Symposium: Research Update on Phytochemicals in Garlic, Soy and Licorice held in May, 1994 in Washington, D.C. found the following:

"Under simulated digestive conditions, little allicin was released from a garlic powder which contained both alliin and alliinase. When allicin was mixed with blood, it disappeared very rapidly, and the formation of trace amounts of allylmercaptan and diallyl disulfide were observed. Allicin also converted the hemoglobin in red blood cells to methemoglobin. Furthermore, allicin has been shown to disappear upon contact with the liver; no allicin could be detected in the effluent when allicin was perfused into an isolated liver."

"Though allicin was considered to be a key compound in garlic in the past, recent scientific findings, including the pharmacokinetics and metabolism of organosulfur compounds in garlic, have revealed that allicin is not biologically active inside of the body"

Allicin has not been conclusively proven to be responsible for garlic's known health benefits.

Following are some conclusions drawn about allicin from garlic scientists at the "First World Congress on the Health Significance of Garlic and Garlic Constituents" held in August 1990 in Washington, D.C.:

Contrary to the popular myth that a garlic product must contain allicin to be beneficial, allicin has not been conclusively proven to be responsible for garlic's known health benefits. Most of the garlic or garlic products that have been based to demonstrate garlic health effects do not contain significant amounts of allicin. (Allicin is an odorous and transient garlic compound.)

Equally untrue is the myth that if garlic or a garlic product does not have a garlic odor it does not provide benefits. A major part of the data on the benefits of garlic is derived from studies of cooked garlic, pickled garlic, aged garlic, and aged garlic extract. All of them have little typical garlic odor.

Other Compounds Must Be Responsible for the Benefits of Garlic

Various forms of garlic, which contain no allicin (e.g., cooked, steamed, microwaved and aged garlic extract), have demonstrated an array of benefits in studies. Therefore, it is logical that compounds other than allicin are responsible for such benefits. To date, well over 100 compounds have been identified in garlic preparations. Presently, S-allyl cysteine appears to be a very promising compound with good absorption. Again, according the research of Kodera et al:

"The pharmacokinetic studies of S-allyl cysteine demonstrated rapid absorption and almost 100% bioavailability after oral administration. In addition, since both the safety and effectiveness of S-allyl cysteine have been reported, this compound appears to play an important role in garlic's medicinal effects."

Though individual compounds, such as S-allyl cysteine, have shown activity in studies and are absorbed by the body, it is likely that a synergism of various compounds provide the benefits of garlic. This is in agreement with Dr. Koch, a renowned Austrian scientist who stated that the activity of various sulfur compounds could not alone be responsible for the benefits of garlic and fixation on a single group of components can lead to mistakes and wrong conclusions.

[MegaPump]

Im not sure if an old friend at work said he ate a whole garlic each day of if he supplemented it, but he said he never gets sick. Iv known him for 4 years and he never took one day off sick. Im pretty sure he said he ate it. Iv recently considered garlic supplementation. I do know that garlic is acidic. Let us know how you go.

[Motley_Muscle]

Originally Posted by kappaz

Enteric Coatings

Some manufacturers have enteric-coated their garlic powder so that it would bypass the stomach. Assuming the best, that a high quality garlic powder is used initially (one that is not exposed to high temperatures which can deactivate alliinase), this form of garlic could potentially deliver alliin and alliinase to the intestinal tract. However, simulated intestinal fluids have been shown to inhibit 40% of the allicin production. The remaining allicin may exert anti-microbial effects on bad bacteria, however, it may also destroy friendly bacteria. Both allicin and raw garlic preparations which contain allicin have been shown to decrease the bacteria flora. Further, being a strong oxidizing agent allicin may irritate the sensitive cells which line the intestinal tract as it has been shown to irritate the cells lining the stomach. Finally, if organically grown garlic is not used as a starting material, enteric-coatings may assist in delivering pesticides and other contaminants in the garlic directly into the intestinal tract for absorption.

Allicin: Not Found in Top Garlic Products

For years, allicin has been deemed as the compound responsible for the benefits of garlic. It has shown an ability to kill bacteria and fungus in test tubes and topically crushed raw garlic has been used in wars to fight infections. However, no clinical trials have been performed with allicin and it has not become a commercial product, mainly because of its chemical instability but also because of its pungent odor and irritating nature.

Allicin is produced by an enzymatic reaction when raw garlic is either crushed or somehow injured. The enzyme, alliinase, combines with a compound called alliin in raw garlic and produces allicin. Because allicin is so unstable, once it is generated it readily changes into other compounds. Thus cooking, aging, crushing and otherwise processing garlic causes the allicin to be decomposed into other compounds. According to two studies of garlic preparations, allicin decreased to nondetectable amounts within one to six days (20-144 hours) This could explain why a study of various products on the market showed that they all contained an undetectable amount (<1 ppm) of allicin.

"Allicin Potential" of Questionable Value

To prevent the typical loss of allicin, some manufacturers have attempted to stabilize alliin and alliinase so that these compounds would not come together until after they enter the body in hopes of producing allicin inside of the body. Such "allicin potential" is measured by adding water to garlic products which contain both alliin and alliinase to determine how much allicin can be produced. However, the actual production of allicin inside the body is not the same as that produced in a test tube for the following reasons:

Intestinal Conditions Hinder the Generation of Allicin:

- Stomach acid destroys alliinase, preventing allicin production.
- Intestinal fluids further diminish the amount of allicin that can be produced.

Simulated stomach fluids and simulated intestinal fluids have commonly been used to determine the effects of typical digestion on nutrients or chemicals in question. Interestingly, alliinase, the enzyme which catalyzes the conversion of alliin to allicin, has been shown to be irreversibly deactivated at pH 3 or below, an acidic environment typically found in the stomach.Further, a 99% loss in allicin production was observed following consecutive exposure to simulated stomach fluids and simulated intestinal fluids which would occur when one takes a garlic powder orally.Therefore, it appears that unless a garlic powder bypasses the stomach, the amount of allicin produced is negligible.

Allicin Is Not Bioavailable:

No allicin found in the body following oral intake.

A study in which participants consumed a large amount of allicin (approximately 90,000 mcg) via crushed raw garlic (25 grams; roughly 10 cloves) revealed that neither allicin nor 16 of its daughter compounds could be detected in blood or urine from one to 24 hours after consumption. Due to its high reactivity allicin was shown to be completely metabolized in the liver. If allicin could even make it to the blood (to be delivered throughout the body), studies have shown that it changes into other compounds within five minutes and in the process may oxidize the blood cells causing them to lose their ability to carry oxygen.

"Allicin is not biologically active inside of the body"

Yukihiro Kodera, at the Designer Foods III Symposium: Research Update on Phytochemicals in Garlic, Soy and Licorice held in May, 1994 in Washington, D.C. found the following:

"Under simulated digestive conditions, little allicin was released from a garlic powder which contained both alliin and alliinase. When allicin was mixed with blood, it disappeared very rapidly, and the formation of trace amounts of allylmercaptan and diallyl disulfide were observed. Allicin also converted the hemoglobin in red blood cells to methemoglobin. Furthermore, allicin has been shown to disappear upon contact with the liver; no allicin could be detected in the effluent when allicin was perfused into an isolated liver."

"Though allicin was considered to be a key compound in garlic in the past, recent scientific findings, including the pharmacokinetics and metabolism of organosulfur compounds in garlic, have revealed that allicin is not biologically active inside of the body"

Allicin has not been conclusively proven to be responsible for garlic's known health benefits.

Following are some conclusions drawn about allicin from garlic scientists at the "First World Congress on the Health Significance of Garlic and Garlic Constituents" held in August 1990 in Washington, D.C.:

Contrary to the popular myth that a garlic product must contain allicin to be beneficial, allicin has not been conclusively proven to be responsible for garlic's known health benefits. Most of the garlic or garlic products that have been based to demonstrate garlic health effects do not contain significant amounts of allicin. (Allicin is an odorous and transient garlic compound.)

Equally untrue is the myth that if garlic or a garlic product does not have a garlic odor it does not provide benefits. A major part of the data on the benefits of garlic is derived from studies of cooked garlic, pickled garlic, aged garlic, and aged garlic extract. All of them have little typical garlic odor.

Other Compounds Must Be Responsible for the Benefits of Garlic

Various forms of garlic, which contain no allicin (e.g., cooked, steamed, microwaved and aged garlic extract), have demonstrated an array of benefits in studies. Therefore, it is logical that compounds other than allicin are responsible for such benefits. To date, well over 100 compounds have been identified in garlic preparations. Presently, S-allyl cysteine appears to be a very promising compound with good absorption. Again, according the research of Kodera et al:

"The pharmacokinetic studies of S-allyl cysteine demonstrated rapid absorption and almost 100% bioavailability after oral administration. In addition, since both the safety and effectiveness of S-allyl cysteine have been reported, this compound appears to play an important role in garlic's medicinal effects."

Though individual compounds, such as S-allyl cysteine, have shown activity in studies and are absorbed by the body, it is likely that a synergism of various compounds provide the benefits of garlic. This is in agreement with Dr. Koch, a renowned Austrian scientist who stated that the activity of various sulfur compounds could not alone be responsible for the benefits of garlic and fixation on a single group of components can lead to mistakes and wrong conclusions.

Great post!

Time to go make salmon burgers with garlic powder on 'em. mmmmm