Acetyl -L l carnitine dosage.

[linverson]

I've read through many carnitine threads from my carnitine searcch. However, i can not find a proper dosage figure.

I managed to get a hold of pure Wildbull BRONX Acetyl-L-carnitine that contains no fillers. Clumped when i opened it and smelt like vinegar, store said because it contained no fillers thats why its like that.

Anyhow, if this shtuff is 100% pure, would half a teaspoon be enough before cardio in the morning? Half teaspoon would be about 1-2 grams (would that be right?) is that too much?

[Elliptical Envy]

You should get a scale to measure it out. I normally use about 750mg to 1500mg at a time.

[Zachattack43]

I've read through many carnitine threads from my carnitine searcch. However, i can not find a proper dosage figure.

I managed to get a hold of pure Wildbull BRONX Acetyl-L-carnitine that contains no fillers. Clumped when i opened it and smelt like vinegar, store said because it contained no fillers thats why its like that.

Anyhow, if this shtuff is 100% pure, would half a teaspoon be enough before cardio in the morning? Half teaspoon would be about 1-2 grams (would that be right?) is that too much?

yea the real stuff clumps, no biggie. I believe its more like 1/2teaspoon = 570mg. so yea, about 2grams per teaspoon

[cakedonkey]

Whatever you do, take it with carbs.

[cakedonkey]

1: J Physiol. 2007 Jun 1;581(Pt 2):431-44. Epub 2007 Mar 1.

New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle.

Stephens FB, Constantin-Teodosiu D, Greenhaff PL.

Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK. francis.stephens@nottingham.ac.uk

In skeletal muscle, carnitine plays an essential role in the translocation of long-chain fatty-acids into the mitochondrial matrix for subsequent beta-oxidation, and in the regulation of the mitochondrial acetyl-CoA/CoASH ratio. Interest in these vital metabolic roles of carnitine in skeletal muscle appears to have waned over the past 25 years. However, recent research has shed new light on the importance of carnitine as a regulator of muscle fuel selection. It has been established that muscle free carnitine availability may be limiting to fat oxidation during high intensity submaximal exercise. Furthermore, increasing muscle total carnitine content in resting healthy humans (via insulin-mediated stimulation of muscle carnitine transport) reduces muscle glycolysis, increases glycogen storage and is accompanied by an apparent increase in fat oxidation. By increasing muscle pyruvate dehydrogenase complex (PDC) activity and acetylcarnitine content at rest, it has also been established that PDC flux and acetyl group availability limits aerobic ATP re-synthesis at the onset of exercise (the acetyl group deficit). Thus, carnitine plays a vital role in the regulation of muscle fuel metabolism. The demonstration that its availability can be readily manipulated in humans, and impacts on physiological function, will result in renewed business and scientific interest in this compound.

PMID: 17331998 [PubMed - indexed for MEDLINE]

[Elliptical Envy]

Whatever you do, take it with carbs.

Good point. I know people are going to use ALCAR with their WMS now.

[Zachattack43]

Good point. I know people are going to use ALCAR with their WMS now.

I just use it with my mod - high carb meals

[Elliptical Envy]

I just use it with my mod - high carb meals

You wouldn't use it at all.

[Zachattack43]

You wouldn't use it at all.

negged for lack of evidence

[Elliptical Envy]

negged for lack of evidence

Aye man.......why you gotta be all cold like that?

[Zachattack43]

Aye man.......why you gotta be all cold like that?

that was quick, you were standing by for my response, huh?

[Elliptical Envy]

that was quick, you were standing by for my response, huh?

Just browsing the forums until I get off work.

[devilzfan300]

Whatever you do, take it with carbs.

I thought you were supposed to take it first thing in the morning on an empty stomach. Why do you say take it with carbs?

[cakedonkey]

I thought you were supposed to take it first thing in the morning on an empty stomach. Why do you say take it with carbs?

This is why: http://forum.bodybuilding.com/showpo...93&postcount=5.


Read the full-text if you can.

[CognitiveNutrition]

I've read through many carnitine threads from my carnitine searcch. However, i can not find a proper dosage figure.

I managed to get a hold of pure Wildbull BRONX Acetyl-L-carnitine that contains no fillers. Clumped when i opened it and smelt like vinegar, store said because it contained no fillers thats why its like that.

Anyhow, if this shtuff is 100% pure, would half a teaspoon be enough before cardio in the morning? Half teaspoon would be about 1-2 grams (would that be right?) is that too much?

1,500-3,000 mg ideally with R-Lipoic acid.

[NO HYPE]

1,500-3,000 mg ideally with R-Lipoic acid.

Steve. Do you have any references in which you based that dosage on, that you could link me to? All I have is this one....




L-Carnitine
PHARMACOKINETICS -

About 60 to 75% of L-carnitine from food is absorbed. The percentage absorbed from supplements appears to be lower. In one study only 20% of a 2-gram dose of L-carnitine was found to be absorbed following ingestion. Most of an ingested dose of L-carnitine is absorbed by the small intestine, apparently by facilitative diffusion and active transport. Following the administration of a dose of L-carnitine of 1,980 milligrams twice daily, the maximum plasma concentration level (Cmax) was 80 nanomoles per milliliter, and the time to maximum concentration (Tmax) occurred at 3.3 hours. The bioavailability of oral L-carnitine is about 15%. L-carnitine is not bound to plasma protein or albumin. http://www.pdrhealth.com/drug_info/n...lca_0060.shtml

[Zachattack43]

This is why: http://forum.bodybuilding.com/showpo...93&postcount=5.


Read the full-text if you can.

Dana Houser seems to disagree with you on timing of ALCAR, he prefers 5g in the morning and 5g at night.

[devilzfan300]

This is why: http://forum.bodybuilding.com/showpo...93&postcount=5.


Read the full-text if you can.

Didnt really understand. Can you elaborate?

[djaeger3]

Is ALCAR useless on a diet such as the Anabolic since carbs are limited during the week? Should I still take it daily or only on the weekend carb-up days? I thought it would be useful since the ANabolic diet is so high in fat..

[Zachattack43]

Is ALCAR useless on a diet such as the Anabolic since carbs are limited during the week? Should I still take it daily or only on the weekend carb-up days? I thought it would be useful since the ANabolic diet is so high in fat..

its useless for brain function and possible LH production