I've read through many carnitine threads from my carnitine searcch. However, i can not find a proper dosage figure.
I managed to get a hold of pure Wildbull BRONX Acetyl-L-carnitine that contains no fillers. Clumped when i opened it and smelt like vinegar, store said because it contained no fillers thats why its like that.
Anyhow, if this shtuff is 100% pure, would half a teaspoon be enough before cardio in the morning? Half teaspoon would be about 1-2 grams (would that be right?) is that too much?
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Thread: Acetyl -L l carnitine dosage.
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08-31-2007, 09:06 PM #1
Acetyl -L l carnitine dosage.
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08-31-2007, 09:12 PM #2
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08-31-2007, 09:19 PM #3
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08-31-2007, 09:51 PM #4
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08-31-2007, 09:58 PM #5
1: J Physiol. 2007 Jun 1;581(Pt 2):431-44. Epub 2007 Mar 1.
New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle.
Stephens FB, Constantin-Teodosiu D, Greenhaff PL.
Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK. francis.stephens@nottingham.ac.uk
In skeletal muscle, carnitine plays an essential role in the translocation of long-chain fatty-acids into the mitochondrial matrix for subsequent beta-oxidation, and in the regulation of the mitochondrial acetyl-CoA/CoASH ratio. Interest in these vital metabolic roles of carnitine in skeletal muscle appears to have waned over the past 25 years. However, recent research has shed new light on the importance of carnitine as a regulator of muscle fuel selection. It has been established that muscle free carnitine availability may be limiting to fat oxidation during high intensity submaximal exercise. Furthermore, increasing muscle total carnitine content in resting healthy humans (via insulin-mediated stimulation of muscle carnitine transport) reduces muscle glycolysis, increases glycogen storage and is accompanied by an apparent increase in fat oxidation. By increasing muscle pyruvate dehydrogenase complex (PDC) activity and acetylcarnitine content at rest, it has also been established that PDC flux and acetyl group availability limits aerobic ATP re-synthesis at the onset of exercise (the acetyl group deficit). Thus, carnitine plays a vital role in the regulation of muscle fuel metabolism. The demonstration that its availability can be readily manipulated in humans, and impacts on physiological function, will result in renewed business and scientific interest in this compound.
PMID: 17331998 [PubMed - indexed for MEDLINE]SAN Nutrition
sann.net / pumpedmag.com / starmarklabs.com
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08-31-2007, 09:59 PM #6
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08-31-2007, 10:03 PM #7
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08-31-2007, 10:04 PM #8
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08-31-2007, 10:08 PM #9
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08-31-2007, 10:09 PM #10
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08-31-2007, 10:09 PM #11
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08-31-2007, 10:10 PM #12
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09-29-2007, 11:17 PM #13
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09-29-2007, 11:30 PM #14
This is why: http://forum.bodybuilding.com/showpo...93&postcount=5.
Read the full-text if you can.SAN Nutrition
sann.net / pumpedmag.com / starmarklabs.com
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09-30-2007, 12:03 AM #15
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09-30-2007, 04:45 AM #16
Steve. Do you have any references in which you based that dosage on, that you could link me to? All I have is this one....
L-Carnitine
PHARMACOKINETICS -
About 60 to 75% of L-carnitine from food is absorbed. The percentage absorbed from supplements appears to be lower. In one study only 20% of a 2-gram dose of L-carnitine was found to be absorbed following ingestion. Most of an ingested dose of L-carnitine is absorbed by the small intestine, apparently by facilitative diffusion and active transport. Following the administration of a dose of L-carnitine of 1,980 milligrams twice daily, the maximum plasma concentration level (Cmax) was 80 nanomoles per milliliter, and the time to maximum concentration (Tmax) occurred at 3.3 hours. The bioavailability of oral L-carnitine is about 15%. L-carnitine is not bound to plasma protein or albumin. http://www.pdrhealth.com/drug_info/n...lca_0060.shtml~
Wherever progression lacks.... regress can be found in abundance.
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09-30-2007, 09:41 AM #17
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09-30-2007, 02:48 PM #18
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10-04-2007, 12:25 AM #19
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10-04-2007, 05:14 AM #20
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