Effectiveness of DHB (6,7-dihydroxybergamottin)

**pu12en12g** · 03-22-2005, 10:49 AM

For those that have used DHB (6,7-dihydroxybergamottin) as a anabolic amplifier, please post your thoughts.

Thanks.

**JB20** · 03-22-2005, 10:53 AM

i am interested as well
http://www.bodybuilding.com/store/ids/dhb.html

**<^>** · 03-22-2005, 12:57 PM

bump i want to hear about this product more !!?? I want to know if it worked for ppl or what ??

**Black_Spit** · 03-22-2005, 01:40 PM

never heard of it... It sure seems cheap though.

**pu12en12g** · 03-23-2005, 03:41 PM

Well I ordered some... so I guess I'll be the test subject in a few months.

**acecombact1** · 03-23-2005, 03:47 PM

Dihydroxybergamottin caproate as a potent and stable CYP3A4 inhibitor, but its not an anabolic agent!

**pu12en12g** · 03-23-2005, 08:26 PM

Originally Posted by acecombact1

Dihydroxybergamottin caproate as a potent and stable CYP3A4 inhibitor, but its not an anabolic agent!

I think that's why it's sold as a "anabolic amplifier".

**SwingGuru** · 03-24-2005, 06:41 AM

I think it would depend on what you were taking. Some products break down into something more potent I believe when undergoing first pass. It has been theorized that it is actually a metabolite of dbol that is actually so anabolically potent. This product would have the same functionality as eating grapefruit I believe.

**acecombact1** · 03-24-2005, 01:21 PM

Originally Posted by pu12en12g

I think that's why it's sold as a "anabolic amplifier".

this stuff is in grap fruit, that why they tell you drink grape fruit juice with orall AAS

**G.W. Hayduke** · 03-24-2005, 01:24 PM

Yes, that's why it is paired up in some PH's. It is only useful to increase the length of time that a drug spends in your system. It can enhance EC stack for example.

**pu12en12g** · 03-28-2005, 07:33 AM

Originally Posted by Aeternitatis

Yes, that's why it is paired up in some PH's. It is only useful to increase the length of time that a drug spends in your system. It can enhance EC stack for example.

**glsa17** · 04-01-2005, 08:06 AM

Originally Posted by acecombact1

this stuff is in grap fruit, that why they tell you drink grape fruit juice with orall AAS

Both, juice and these pills, would do nothing for transdermals right, only oral?

**Lok7y** · 04-01-2005, 08:08 AM

Originally Posted by glsa17

Both, juice and these pills, would do nothing for transdermals right, only oral?

Correct.

**EricTheRed** · 04-01-2005, 08:08 AM

bump

dont know much about this stuff

**CHUCK DIESEL** · 04-01-2005, 08:37 AM

Originally Posted by acecombact1

this stuff is in grap fruit, that why they tell you drink grape fruit juice with orall AAS

So its probably just naringin

**G.W. Hayduke** · 04-01-2005, 08:50 AM

I was thinking it was similar to the stuff that's in Earl Grey tea, bergamot. I believe that is derived from bitter orange.

**Lok7y** · 04-03-2005, 12:10 PM

DHB (6,7-dihydroxybergamottin) is a furanocoumarin found in grapefruit (and subsequently grapefruit juice).

I know grapefruit juice intact does act as an orally-administered substance-amplifier, in that it inhibits presystemic drug metabolism mediated by CYP P450 3A4. I'm not sure if DHB can do it by itself however--there are other flavanoids in grapefruit that seems to work synergistically with DHB in suppressiong cytochrome-system metabolizaiton of drugs.

According to "Grapefruit juice and drugs: a hazardous combination?" [translated from French] by Lohezic-Le Devehat et. al., they administered patients 42 different drugs either with grapefruit juice or without, and found that of the 42 all but 12 were metabolized differently when administered with GFJ. But another study I saw showed that when just bergamottin was administered, they found it not correlated with CYP P450 inhibition.

I general I'm pretty sure that DHB would only be able to affect the hydroxylation reactions involved in steroid hormone metabolism. However, it still would not have any influence on the oxidoreductases, which, according to PA, "are by far the most important pathways for deactivation of androgens."

So my guess is DHB might improve the oral bioavailability of steroids, particularly methylated ones.

Now grapefruit juice on the other hand? Grapefruit juice can be kind of fun...

**pu12en12g** · 04-13-2005, 10:37 AM

Originally Posted by IDS

Bergamottin has been shown in clinical studies to block the body's ability to down regulate caffeine. Thus the addition of Bargamottin enhances the effect of caffeine by extending its life span in the body.

This is interesting too

**pu12en12g** · 09-22-2005, 09:26 AM

Also see this thread on bioperine:

http://forum.bodybuilding.com/showthread.php?t=583962

**DaRk_StAr** · 09-22-2005, 09:32 AM

Originally Posted by pu12en12g

Well I ordered some... so I guess I'll be the test subject in a few months.

when you say you are going to be the test subject what you mean by this? You turning to the dark side?

**pu12en12g** · 09-22-2005, 09:35 AM

Originally Posted by DaRk_StAr

when you say you are going to be the test subject what you mean by this? You turning to the dark side?

In 2006 probably... I'm hoping to hit 260lbs at around 12% naturally... but I've been a supplement test subject for a couple years now... lol I think it started with Now Foods glycerine....

**DaRk_StAr** · 09-22-2005, 09:54 AM

Originally Posted by pu12en12g

In 2006 probably... I'm hoping to hit 260lbs at around 12% naturally... but I've been a supplement test subject for a couple years now... lol I think it started with Now Foods glycerine....

lol haha good luck mate you will do it i know you will................im going to be like you as well trying to try out other supplements and stuff and try and achieve gains naturally with my low testosterone levesl as mentioned before....Hopefully i can proof the uneed for that much testosterone.....You think this is possible?

**pu12en12g** · 09-26-2005, 12:07 AM

Originally Posted by DaRk_StAr

Hopefully i can proof the uneed for that much testosterone.....You think this is possible?

I'm not sure what you mean there.... ? ?

**DaRk_StAr** · 09-26-2005, 01:35 AM

Originally Posted by pu12en12g

I'm not sure what you mean there.... ? ?

meaning i can build muscle with my low testosterone all the way

**pu12en12g** · 09-26-2005, 01:48 AM

Originally Posted by DaRk_StAr

meaning i can build muscle with my low testosterone all the way

Yeah definately.... it's just harder to stay lean.

**DaRk_StAr** · 09-26-2005, 01:55 AM

Originally Posted by pu12en12g

Yeah definately.... it's just harder to stay lean.

alright cheers.....yeh i find that quite difficult to stay lean.Low testosterone still can build muscle easily right but harder to retain and hard to stay lean

**Andy K** · 09-26-2005, 03:19 AM

Pu12, how big and at what bf % would you like to end up after your eventual cycles in the future?

**pu12en12g** · 09-26-2005, 05:57 AM

Originally Posted by Andy K

Pu12, how big and at what bf % would you like to end up after your eventual cycles in the future?

This is my inspiration and my ultimate goal:

Dave Gulledge @ 265 lbs:

<img src="http://www.midwestbarbell.com/~midwestmd/Strongman/DSCN0115.JPG">

**EricTheRed** · 09-26-2005, 12:20 PM

Originally Posted by pu12en12g

This is my inspiration and my ultimate goal:

Dave Gulledge @ 265 lbs:

<img src="http://www.midwestbarbell.com/~midwestmd/Strongman/DSCN0115.JPG">

da amn

thats some serious motivation right there for me

**Dimitar** · 09-26-2005, 02:32 PM

man, I have the same non-symmetric pecs as that guy...there aren't too many like us

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