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  1. #1
    Banned HalpMe's Avatar
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    cort bloc worth it?

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  2. #2
    Registered User PumpingIron4Him7's Avatar
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    no...
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  3. #3
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    Nothing can naturally block your cortisol levels to a point that would actually make a difference.
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  4. #4
    nevigsawkufelgnisaton in10city's Avatar
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    Originally Posted by HalpMe View Post
    Well given that the dose of Phosphatidylserine purportedly needed to attenuate cortisol is 800 mg / day, that's 8 capsules... So $30 bucks for about a weeks supply ... PS is very expensive.

    You don't mention why you want to take this... but @ 17 there should be no compelling reason to take it, as diet, training, and recovery are probably in need of correction to start with to deal with reasoned cortisol / overtraining issues.
    It is the mark of an educated mind to be able to entertain a thought without accepting it.
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  5. #5
    No struggle, No progress niiick's Avatar
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    AX: Retain2
    ★ Hard Work Beats Genetics ★ When Genetics Don't Work Hard ★
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    nevigsawkufelgnisaton in10city's Avatar
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    Originally Posted by niiick View Post
    AX: Retain2
    He's 17 years old
    It is the mark of an educated mind to be able to entertain a thought without accepting it.
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  7. #7
    Ear Responsible GeneGnomeX's Avatar
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    Thumbs up

    hm cortisol needs to be looked at in a different light. If reading this goes over your head it suggests beneficial adaptations in times of stress- EVEN CHRONIC, as long as you have times of low stress. A cortisol blocker can be BAD FOR YOUR HEALTH and potentially LIMIT MUSCLE GROWTH.


    Ann N Y Acad Sci. 2007 Apr;1100:449-54.

    Prior chronic in vivo glucocorticoid excess leads to an anabolic phenotype and an extension of cellular life span of skin fibroblasts in vitro.

    Kletsas D, Pratsinis H, Gioni V, Pilichos K, Yiacoumettis AM, Tsagarakis S.

    Laboratory of Cell Proliferation and Ageing, Institute of Biology, National Centre for Scientific Research Demokritos, 15310 Athens, Greece.

    Intense stress can be detrimental for tissue homeostasis and accelerates aging. On the other hand, repeated mild stresses can have beneficial and even life-prolonging effects. Hypersecretion of glucocorticoids (GCs) represents the major hormonal response to stress. However, besides its life-sustaining role, GC excess can promote a "catabolic" phenotype. Accordingly, we have studied the effect of long-lasting exposure to high GC levels in vivo on several parameters of tissue homeostasis, as well as cellular senescence, in cells removed from the high-GC milieu in vivo and then cultured in vitro. To this end, we have used human skin fibroblasts from (a) Cushing's syndrome patients that are characterized by chronic endogenous GC excess and (b) patients treated with exogenous GC administration. Interestingly, when Cushing's syndrome fibroblasts were cultured in vitro under standard conditions they express an "anabolic" phenotype, i.e., they restore their ability for collagen synthesis, secrete reduced levels of metalloproteases, and have an increased proliferative capacity and contractility. Furthermore, these cells exhibit a significant extension of their proliferative life span, while they respond better to exogenous stress by producing significantly higher levels of heat-shock protein-70 (HSP70). In addition, preliminary results with fibroblasts from patients subjected to chronic exogenous GC administration indicate that they express a similar behavior in vitro, at least with regard to the restoration of collagen expression. These data suggest that prior exposure to elevated GC concentrations is not associated with persisting adverse effects on fibroblasts and may also have a beneficial outcome in some aspects of cell physiology, including longevity in vitro.
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  8. #8
    Ear Responsible GeneGnomeX's Avatar
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    btw there are studies suggesting HSP70 is involved in protein synthesis by essentially stabilizing the cell
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  9. #9
    Registered User nbb2474's Avatar
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    EndoAmp

    Originally Posted by in10city View Post
    Well given that the dose of Phosphatidylserine purportedly needed to attenuate cortisol is 800 mg / day, that's 8 capsules... So $30 bucks for about a weeks supply ... PS is very expensive.

    You don't mention why you want to take this... but @ 17 there should be no compelling reason to take it, as diet, training, and recovery are probably in need of correction to start with to deal with reasoned cortisol / overtraining issues.
    I agree. Two Cort-Bloc capsules only provide 200mg of phosphatidylserine and there are only 60 capsules per bottle. Do the math. You'd need four bottles per month to meet the 800mg level.

    One serving of EndoAmp is 800mg of phosphatidyserine+154mg of phosphatidycholine. And it is "only" $50 per bottle for a month. Like in10city pointed out, no 17yo needs to worry about cortisol as you've got so much testosterone and growth hormone racing through your veins that they far overwhelm the modest output of cortisol your body produces.
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