muscle break through cont'd

[sicosico]

15 lbs of mass and 5 % decrease in bf: compound from ( muira puama extract)

Plant Derived Compound
Aimed At Reducing Body Fat and Increasing Lean Muscle

BDC 03, PhytoMedical’s first plant derived compound from the muira puama plant, has pharmacologically active elements that have been successful in reducing body fat percentage, increasing lean muscle mass and lowering cholesterol in animal studies, which resulted in the issuance of US patent # 5,516,516.

Native to the Brazilian Amazon and other parts of the Amazon rainforest, the muira puama plant has long been used by indigenous people for the treatment of asthenia, dyspepsia, menstrual disturbances, chronic rheumatism, sexual impotence, ataxia and central nervous system disorders.

Learning of the indigenous uses, early European explorers brought the plant back to Europe, where it became part of herbal medicine for the treatment of impotence, infertility, neurasthenia, menstrual disturbances, hookworms, rheumatism and dysentery. Today, muira puama, with no known health risks associated with its use and no known drug or nutrient interactions, is still listed in the British Herbal Pharmacopoeia, a noted source of herbal medicine.

Pure scientific interest into muira puama’s efficacy and pharmacological properties dates back to the early 1920s, when researchers discovered a bark and root system rich in fatty acids, fatty acid esters, essential oils, plant sterols and triterpenes. More recent studies have indicated that the plant’s active constituents include novel alkaloids, free long chain fatty acids, sesquiterpenes and monoterpenes.

Muira puama’s various ethnobotanical claims by indigenous people have been well documented and researched, including two human trails in France that confirmed that muira puama was effective in improving libido and treating erectile dysfunction. Other clinical research has reported to have in vivo adaptogenic, antifatigue, antistress and CNS effects in humans and animals, as well as animal studies that demonstrated that an extract of muira puama was effective at reducing body fat and cholesterol levels, as well as increasing lean body mass. The latter studies, conducted by noted research scientist Dr. Bruce Cherksey, resulted in a US patent being issued, to which PhytoMedical Technologies has an exclusive worldwide license.

The two most important therapeutic components covered under PhytoMedical’s licensed muira puama based patent – decreasing body fat and increasing lean body mass – directly impact two of the leading causes of mortality in North America, obesity and cachexia.

In determining the efficacy of the muira puama derived composition, animal studies were conducted using Wistar rats (mean weight of 230 grams). Randomly divided into four groups of six rats, two of the groups were allowed to feed at will, while the other two received a restricted amount of food. One group of rats each from the ad libitum and calorie restricted food populations received a daily dose of the patented muira puama derived composition, while the other remaining two groups served as the control, each receiving an equal amount of sesame oil on a daily basis.

After approximately four weeks, rat body weights and perirenal pad weights were measured, as well as blood chemistry analyzed. As expected, restricted food animals showed lower body weight gains than the ad libitum fed animals (about 50 grams versus 160 gram gains). In the ad libitum groups, both the group that received the muira puama derived composition and the one that did not showed virtually the same weight gain (161 grams versus 162 grams). When compared to the calorie restricted animals, the group receiving the muira puama derived composition gained slightly more weight than the group not receiving the composition, however, the difference (55 grams versus 46 grams) was statistically insignificant.

The fat gain versus lean body mass gain in the animals was measured by weighing the perirenal fat pads. In the ad libitum groups, the control animals had perirenal fat pad weights of 1.25 grams, while the muira puama treated animals had pad weights of .96 grams. The perirenal fat pad weight in the calorie restricted groups was approximately .45 grams for both the muira puama composition group and the control group.

These results demonstrate that, in ad libitum fed animals showing overall weight gain, the muira puama derived composition had the effect of decreasing the deposition of fat, while at the same time shifting the overall weight gain towards lean body mass gain.

Additionally, blood chemistry analysis showed a substantial reduction in total cholesterol levels in muira puama treated animals, both in the ad libitum (25% reduction) and restricted diet (15% reduction) populations. In all cases, the cholesterol/HDL ratios were not altered. Further blood chemistry analyses show minimal effect on blood urea nitrogen and creatinine levels in muira puama treated animals, which is consistent with the preservation or anabolism of muscle.

The same muira puama derived composition used in the animal studies was administered to a healthy male subject, forty five years of age, who had maintained a stable weight of 105 pounds for over ten years. Prior to the study, and with the exception of slightly elevated cholesterol with an HDL of approximately 50, the subject had normal blood pressure, normal baseline blood chemistries, normal liver function tests and a body fat percentage of 18%, as measured using the girth measurement. Throughout the study period, neither the subject’s daily exercise regiment of walking two to three miles per day nor his diet changed significantly.

After ingesting the muira puama derived composition over a three month period, the male subject’s weight increased by fifteen pounds, his blood chemistries remained normal, his cholesterol level decreased slightly and his HDL level rose from 50 to 75. The subject’s body fat percentage, as measured using the girth measurement method, was 13%, a 5% reduction, indicating that the fifteen pound weight gain had been preferentially shifted toward lean muscle mass.

The subject continued ingesting the muira puama derived composition for a further three months, again with dietary and exercise levels remaining constant. After three months, the subject gained a further ten pounds, while his body fat percentage remained at 13%. Just as importantly, the subject’s blood chemistries remained normal, while his HDL level remained at approximately 75.

After discontinuing the ingestion on a daily basis for three months, the subject’s weight was within two pounds of the weight measured prior to discontinuation, however, his body fat percentage increased 5% to 18%. The subject then reinstituted his daily ingestion routine, and within 30 days, the subject lost three to five pounds of body weight, while his body fat percentage returned to 13%. After another 90 days, the subject’s weight returned to the value it was four months previously, while the body fat percentage remained at 13%.

Additionally, the male subject did not experience any alterations in facial or body hair, exacerbation of acne or alterations in liver function tests, which are androgenic symptoms commonly experienced after treatment with anabolic steroids.

http://www.phytomedical.com/

[sicosico]

http://patft.uspto.gov/netacgi/nph-P...S=PN/5,516,516

Method of preparing muira puama extract and its use for decreasing body fat percentage and increasing lean muscle mass

Abstract

A method, and related compositions, for reducing body fat percentage, increasing lean muscle mass and/or lowering cholesterol levels in individuals. The method consists of the ingestion of an extract derived from muira puama root, bark or other wood material. A method of preparing the muira puama extract into an easily ingestible and manipulatable solid form, and pharmaceutical compositions for use by mammalian subjects, are also disclosed.

I claim:

1. A solid-form extract of muira puama produced by the steps of (1) extracting a muira puama resin from muira puama wood material by mixing said wood material with an extraction solvent capable of solubilizing said resin, (2) removing non-solubilized wood materials from the extraction solvent mixture, (3) removing said extraction solvent to yield a muira puama resin extract, (4) washing said resin extract in a second solvent in which said resin is substantially insoluble, and (5) drying said washed resin extract to yield a solid-form extract of muira puama.

2. A solid-form extract of muira puama according to claim 1 wherein said extraction solvent comprises an alcohol solvent.

3. A solid-form extract of muira puama according to claim 1 wherein said second washing solvent comprises water.

4. A pharmaceutical composition comprising the solid-form muira puama extract of claim 1 and a pharmaceutically acceptable carrier.

5. The pharmaceutical composition of claim 4, wherein the composition is in a unit dosage form containing from about 10 to about 500 mg of said solid-form muira puama extract per unit dose.

6. A pharmaceutical composition comprising, in combination with a pharmaceutically acceptable carrier, an extract of muira puama produced by the steps of (1) extracting a muira puama resin from muira puama wood material by mixing said wood material with an extraction solvent capable of solubilizing said resin, (2) removing non-solubilized wood materials from the extraction solvent mixture, and (3) removing said extraction solvent to yield a muira puama resin extract.

7. A pharmaceutical composition for oral ingestion comprising a measured portion of an extract of muira puama and a pharmaceutically acceptable carrier.

8. The pharmaceutical composition of claim 7, wherein the composition is a solid-form composition selected from the group consisting of capsules, tablets, pills or powder form compositions.

9. The pharmaceutical composition of claim 7 further comprising a solid binder as an additive.

10. The pharmaceutical composition of claim 7, wherein the composition is in a unit dosage form containing from about 10 to about 500 mg of muira puama extract per unit dose.

11. A method of decreasing body fat percentage in a mammalian subject comprising administering to the subject a repeated series of doses of the solid-form muira puama extract of claim 1.

12. A method of decreasing body fat percentage in a mammalian subject comprising administering to the subject a repeated series of doses of the pharmaceutical composition of claim 7.

13. A method of increasing lean muscle mass in a mammalian subject comprising administering to the subject a repeated series of doses of the solid-form muira puama extract of claim 1.

14. A method of increasing lean muscle mass in a mammalian subject comprising administering to the subject a repeated series of doses of the pharmaceutical composition of claim 7.

15. A method of lowering the cholesterol level of a mammalian subject comprising administering to the subject a repeated series of doses of the solid-form muira puama extract of claim 1.

16. A method of lowering the cholesterol level of a mammalian subject comprising administering to the subject a repeated series of doses of the pharmaceutical composition of claim 7.

17. A kit for use in decreasing body fat percentage, increasing lean muscle mass or lowering the cholesterol level of a mammalian subject, comprising (1) a measured portion of a solid-form muira puama extract and (2) instructions directing the ingestion by the subject of said extract in a repeated series of doses over a period of time sufficient to decrease body fat, increase muscle mass or lower cholesterol levels.

18. The kit according to claim 17 wherein said muira puama extract is in a unit dosage form.

FIELD OF THE INVENTION

This invention relates to compositions derived from muira puama and their use for reducing body fat and/or increasing lean muscle mass.

BACKGROUND OF THE INVENTION

Muira puama is the wood derived from Liriosma ovata Miers, Oleaceae, also known as Acanthea virilis Wehmer, Acanthaceae, a shrub or small tree found in the region around the Amazon and Orinoco river basins. The roots and woody stems of muira puama are popularly known for their astringent quality as a treatment for diarrhea. R. C. Wren, Potter's New Cyclopaedia of Botanical Preparations (1988). In addition, muira puama is included in a number of commercial formulations that purport to contain aphrodisiac activity. Clarence Meyer, Herbal Aphrodisiacs from World Sources (1986) (hereinafter "Meyer"). Miller has recognized that muira puama contains an unidentified resin that has a strong stimulating effect upon the human central nervous system and, assertedly, the libido. R. A. Miller, The Magical and Ritual Use of Aphrodisiacs (1985) (hereinafter "Miller", which is incorporated by reference herein). Astringency and sexual stimulation are believed to be the only reported activities derived from muira puama.

The muira puama root is commercially available and it usually occurs as light-brown to pink-brown hard, tough, fibrous, woody splinters. The root is odorless and has a slightly astringent taste.

The chemical constituents of muira puama are not well characterized, but it has been reported that muirapaumine, esters of benzoic acid, lupeol, and phytosterols are present. Merck Index (11th Ed. 1989); Auterhoff and Pankow, 301 Arch. Pharm. (Weinheim) 481 (1968); Auterhoff and Parkow, 302 Arch. Pharm. (Weinheim) 209 (1969); A. Heinz, Drogenkunos (1975). The root's supposed aphrodisiac activity is thought to reside in an aromatic resin of unknown composition. W. H. Lee & L. L. Lee, Herbal Love Potions (1991); G. W. Griffin, Aphrodisiacs for Men (1991) (hereinafter "Griffin"). Although it has been claimed that the active ingredient is testosterone, this claim has not been substantiated by chemical analyses. T. Fahey, Steroid Alternative Handbook (1993). Even if this claim were substantiated, it could not be the source of the root's purported aphrodisiac activity because oral ingestion of the root would cause any such testosterone to be rapidly degraded by the liver.

The aromatic resin is not considered to be sufficiently active when muira puama is ingested in powder form. The resin is not water soluble, therefore it cannot be extracted into water. Miller (1985); Meyer (1986); Griffin (1991). In order to prepare active quantities of muira puama, the root or bark material must be extracted with alcohol. Miller (1985) describes a typical "home use" extraction procedure consisting of mixing the powdered root with boiling vodka and straining the resulting extract before consumption. Alternatively, the resin may be extracted from the root or bark with hot isopropanol, or other alcohol, whereafter the extract is strained and evaporated. A small portion of the residue is then dissolved in the mouth to obtain the purported sexual stimulation.

Up until the present invention, muira puama has not been reported as having any use for the treatment of obesity or for increasing lean muscle mass.

There is a great need for a method of reducing body fat. Excess body fat is a known risk to good health. Obesity, or excess body fat, is an independent heart disease risk equal to that of smoking, high blood pressure, and elevated plasma lipids. The National Institutes of Health have found that obesity should be viewed as a disease. In an eight year study which included over 100,000 female nurses, the NIH found that even subjects that were slightly overweight were at an increased risk for myocardial infarction and coronary artery disease. Subjects of average weight were found to experience about 30% more heart attacks than the thinnest subjects. The risk of heart attacks for those subjects that were moderately overweight was 80% higher than that for the thin subjects. J. E. Manson et al., New England J. Med. 822 (1990).

Obesity is also associated with impairment of cardiac function due to an increase in the heart's mechanical workload, hypertension, stroke, diabetes, renal disease, gallbladder disease, pulmonary disease, problems in the administration of anesthesia during surgery, osteoarthritis, degenerative joint disease, gout, abnormal plasma lipid and lipoprotein concentration, menstrual irregularities, and psychological problems. S. W. Rabkin, et al., 39 Am. J. Cardiology 452 (1977).

[sicosico]

Many factors may predispose a person to excessive body fat, which may be quantified as a percentage of total weight. These include: eating patterns, environment, psychological factors such as body image, and biochemical differences related to resting metabolic rate, dietary-induced thermogenesis, levels of spontaneous activity, basal temperature, levels of cellular adenosine triphosphatase, lipoprotein lipase and other enzymes, and metabolically active brown adipose tissue. K. D. Brownell & J. P. Foreyt, Handbook of Eating Disorders (1986); R. T. Frankel and M-W Yang, Obesity and Weight Control (1988).

As people age, the body fat percentage of the body increases while the important lean muscle mass decreases. K. Imamura et al., 33 J. Gerontology 678 (1983). The maintenance of lean muscle mass is considered extremely important as the loss of muscle strength is directly related to limited mobility and physical performance as well as to increases in the incidence of accidents suffered by the elderly. R. Goldman & M. Bockstein, Physiology and Pathology of Aging (1975). In addition, a number of other muscle-wasting disease conditions exist, such as late stage cancer or AIDS, in which compositions to improve lean muscle mass would be desirable.

Substances and techniques believed or reported to increase lean muscle mass and thereby decrease the percentage of body fat include alcohol, amphetamines, epinephrine, aspartates, red cell reinfusion, caffeine, protein, phosphates, oxygen-rich breathing mixtures, gelatin, lecithin, wheat-germ oil, vitamins, herbs such as ginseng, sugar, minerals, ionized air, music, hypnosis, marijuana, *******, anabolic steroids, and human growth hormone. F. R. Hatfield, Ultimate Sports Nutrition (1987). Few, if any, of these substances or techniques have been scientifically proven to be of any value, and a number, such as anabolic steroids, amphetamines, and illicit compounds, potentially have dangerous side effects.

As an example, anabolic steroids have become popular among many professional and amateur athletes. Not only have few studies documented any significant positive effects from these drugs, but they have severe adverse side effects including hirsutism, hair loss, sterility, liver disease, cancer induction, decrease in serum HDL, and development of a hostile/aggressive personality. E. E. Yesalis, Anabolic Steroids in Sport and Exercise (1993).

The present invention provides methods and compositions for reducing total body fat percentage while increasing lean muscle mass, and for decreasing blood cholesterol levels, by ingestion of an extract derived from muira puama. This extract does not have the severe side effects present in other known treatments.

SUMMARY OF THE INVENTION

It is a general object of the present invention to provide a method for decreasing total body fat percentage in individuals, particularly humans or other mammals.

It is another object of the present invention to provide a method for increasing lean muscle mass in individuals in need thereof, such as in cancer or acquired immune deficiency syndrome patients.

It is another object of the present invention to provide a method for decreasing one or more blood cholesterol levels in individuals.

It is a further object of the present invention to provide an extract capable of reducing total body fat percentage, increasing lean muscle mass, and/or decreasing blood cholesterol levels in individuals.

It is a further object of the present invention to provide a method for decreasing total body fat percentage, increasing lean muscle mass and/or decreasing blood cholesterol levels without the dangerous side effects of anabolic steroids.

It is another object of the present invention to provide a method of extracting a resin from muira puama and, preferably, obtaining a water washed or other solid-form extract that may be used to decrease body fat percentage, increase lean muscle mass and/or decrease blood cholesterol levels in individuals.

It is another object of the present invention to provide a method for decreasing total body fat percentage, increasing lean muscle mass and/or decreasing one or more blood cholesterol levels by treatment with muira puama resin, or a washed or other solid-form extract of muira puama, in an easily ingestible form such as in capsule form.

It is yet another object of the present invention to provide pharmaceutical compositions, preferably in unit dosage form, comprising an extract of muira puama and, especially, a washed or other solid-form extract of muira puama.

These and other objects are readily achieved by providing a method of preparing an easily ingested extract of muira puama and related pharmaceutical compositions which, when taken regularly, have the effect of decreasing body fat percentage, increasing lean muscle mass and/or decreasing blood cholesterol levels. This extract does not have the known dangerous side effects of anabolic steroids.

DETAILED DESCRIPTION OF THE INVENTION

a. Extraction procedures

Muira puama root, which may be obtained commercially (for example, from herbologists or other stores that sell herbs for medicinal uses; lists of such sources may be found in Miller (1985) and in Michael Tierra, The Way of Herbs (1990)) in the form of chips or splinters, was used for preparation of the resins and other muira puama extracts of the present invention. In a typical extraction procedure, one pound of the root was placed in four liters of 95% ethanol for thirty days at room temperature to produce a tincture. The solution was then filtered (Whatman #1 filters; other filters of similar grade may be used) to remove root fragments. The alcohol was then allowed to slowly evaporate at room temperature for approximately one week. This extraction process produced a resin extract that had the appearance of an opaque, highly viscous, yellow-brown to black, sticky resin.

Other methods of extraction will be apparent to those skilled in the art given the present disclosure, and include distillation of the root, bark or other muira puama wood material in ethanol overnight and collection of the reflux. In addition, other alcohols, or other solvents (especially organic solvents) known to those skilled in the art, including, but not limited to ethers (e.g. ethyl ether), ketones (e.g. acetone), and esters (e.g. ethyl acetate), which are capable of extracting the muira puama resin, and which preferably are non-toxic, or at least readily removable from the product resin, may be used. The extraction solvent may be removed by alternative means, as for example by placing the extract solution in a commercial desiccator or vacuum evaporator in order to remove some or preferably all of the remaining extraction solvent.

[sicosico]

It has been discovered by the inventor that the resin extract may be further processed into a more easily manipulatable and ingestible form by washing with water. Thus, a resin extract as prepared above was resuspended into hot water and washed by shaking for one hour. The solution was then filtered and the washed extract residue collected. The washed extract residue was thereafter allowed to dry at room temperature.

Other solutions may also be used to wash the resin extract. An important consideration is that the solution not solubilize the active component of the resin. Routine experimentation by those skilled in the art, taking into account characteristics such as polarity, will easily identify which solutions may be used to yield the desired final product. The resin may also be washed by applying heat during the washing process. The resulting solid-form extract may be dried in a desiccator or by other conventional means.

Unexpectedly, the washed residue as obtained above was a solid material which, as reported below, retained the same activity as the precursor resin extract. Moreover, as described hereinafter, the washed extract was found to have a form which, in contrast to the resin extract, could conveniently be handled and apportioned into pharmaceutically conventional dosage units, for example capsules.

The solid-form muira puama extract obtained in this manner constitutes a pharmaceutically convenient form which retains muira puama activity. The washed residue is granular and can be easily measured into required dosages, as opposed to the sticky resin form of muira puama extract. By concentrating the muira puama activity into a granular form, and encapsulating the residue into capsules, muira puama may be administered in a much more palatable manner than the resin extract. Another advantage of the granular or other solid form of muira puama extract is that it can be easily stored and shipped.

In one example of a pharmaceutical composition of the present invention, the granular muira puama extract as obtained above was mixed with ascorbic acid (which served both as a purification agent and as a binder) and encapsulated in capsules as follows. Ascorbate solution was added to the washed solid-form extract; the mixture contained an equal weight of ascorbate to extract. The mixture was stirred and the precipitate was collected by filtration. The ascorbate/washed extract precipitate had a more powder-like composition and had a lighter brown-yellow color than the original washed extract, suggesting that the ascorbate had solubilized inactive ingredients. This step should yield a higher degree of purity of muira puama activity and is a likely step to its further purification.

Other binders, stabilizers, preservatives, carriers, encapsulants, excipients or other additives (particularly solid additives) that are known to those of skill in the pharmaceutical art may be substituted for ascorbic acid. Similarly, given the present disclosure, it will be recognized that other pharmaceutical forms may be utilized to formulate compositions containing the solid-form muira puama extract of the present invention. Such forms include, for example, tablets, capsules, pills, powders, sustained release formulations, salts and the like. Likewise, non-solid-form extracts of muira puama, such as resin extracts, may be used in formulating pharmaceutical compositions within the scope of the invention, although these may be less convenient to produce or administer than the solid-form extracts.

The term "pharmaceutical composition" as used herein includes ingestible forms of the present muira puama extracts whether or not they are expressly medicinal, as for example forms designed or constituted as supplements, additives, nutrients or the like, and including bulk forms of such pharmaceutical compositions. Preferably, such pharmaceutical compositions are in a solid form, although liquid forms such as suspensions, syrups or elixirs may also be utilized. Most preferably, such compositions are in a unit dosage form (such as a tablet, capsule, pill, or apportioned powder or resin extract) containing a measured amount of the extract material per unit dose, combined with a pharmaceutically acceptable carrier. Suitable pharmaceutical additives and formulations are described in, for example, E. W. Martin, Remington's Pharmaceutical Sciences.

The amount of muira puama extract active ingredient in such pharmaceutical compositions may be adjusted to achieve an effective dosage unit. Preferably, the dosage units (e.g. capsule, pill, or other measured portion) are formulated so as to allow the convenient administration of an amount of muira puama active ingredient derived from about 0.025 grams to about 0.6 grams, more preferably about 0.075 grams to about 0.3 grams, and most preferably about 0.15 grams, of starting muira puama wood material per kilogram of subject weight per day. Thus, assuming a typical subject weight of 75 kilograms, each dosage unit may contain an amount of muira puama active ingredient derived from about 5.6 grams to about 22.5 grams, or preferably about 11.25 grams, of muira puama wood material, or some convenient measured fraction thereof. Alternatively, the amount of active ingredient is based directly on the weight of muira puama extract in the dosage unit, in which case the weight amount of extract will depend on the purity of the extract (e.g., a resin or washed resin form of the extract). In this case, each dosage unit may contain between about 10 mg and about 500 mg of muira puama extract, or some convenient fraction thereof, as measured based on the amount of muira puama active ingredient contained in the washed or crude resin form of the extract. More preferably, each unit dose will contain between about 25 mg and about 250 mg of the extract, and most preferably between about 50 mg and about 100 mg (again based on the concentration of active ingredient in the resin form of the extract), or some convenient fraction thereof. Smaller actual weight amounts of muira puama extract, or isolated or synthetic forms of the active ingredient, may be used in a unit dose to the extent the muira puama active ingredient is further purified, and are the equivalent of the resin-based dosages set forth above. Those skilled in the art will be able to ascertain the equivalent amounts to be used in these cases in order to achieve the functions and results taught herein.

Preferably, such compositions will be packaged in kits containing dosage units or other measured portions of the muira puama extract and instructions for the use of the composition in decreasing body fat, increasing muscle mass and/or lowering blood cholesterol levels. As explained hereinafter, suitable instructions for these purposes will specify that the composition be ingested in a repeated series of doses according to a regular schedule (preferably daily or twice daily) over an extended period (preferably at least one month, and more preferably at least three months or until a desired level of fat loss, lean mass gain or cholesterol lowering have been achieved).

[Rockyforever]

so whats the point of this post..for info or to enter a contest ?? and do we get samples to try first ???

[BluSilver]

Sounds like Methoxy and Ecdy, both of which sucked. Maybe this'll be good, though. IMO this product will be another herbal scam. The testing was probably bias in some way.

[BluSilver]

Bump

[sicosico]

Sounds like Methoxy and Ecdy, both of which sucked. Maybe this'll be good, though. IMO this product will be another herbal scam. The testing was probably bias in some way.

First this isn't a supplement, it is supposed to be a pharmaceutical drug. second the testings were done on humans and animals, ecdy studies were done on bugs, a complete 180 degrees difference, the compound is supposed to be a synthetic compound from the extract look at all the drugs that are made up from extracts !!


http://www.phytomedical.com/

press on plant derived drugs:

> 9-aminocamptothecin
> 9-Nitro-Camptothecin
> Aspirin
> Atropine
> Buprenorphine
> Butorphanol
> Caffeine
> Calanolide A
> Calanolide B
> Camptothecin
> *******
> Codeine
> Conocurovone
> Datura
> Digoxin
> Docetaxel
> Ephedrine
> Ergonovine
> Erythromycin
> Etoposide
> Flavopiridol
> Heroin
> Homoharringtonine
> Hydromorphone
> Irinotecan
> LSD
> Marijuana
> Mescaline
> Michellamine B
> Morphine
> Nicotine
> Oxycodone
> Oxymorphone
> Paclitaxel
> Papaverine
> Perillyl Alcohol
> Physostigmine
> Pilocarpine
> Prostratin
> Quinine
> Reserpine
> Teniposide
> Topotecan
> Tubocurarine
> Vinblastine
> Vincristine
> Vindesine
> Vinorelbine

[BluSilver]

Really? Well, this may be an exciting new addition to one's diet. I hope my previous post didn't put my foot in my mouth. I'm still skeptical. I mean, it's one of those too good to be true things. Everything has a downside. It may just be price in this case, or maybe side effects haven't been noted YET. I just don't know and won't pass further judgement.

[Iron___Stoner]

the best, and infact only "evidence" that something actually works is results. those studies dont prove sh!t. not trying to be a dick but im just skeptical, if it really works so well w/out side effects why hasnt someone mentioned it before? why arent top companies making products with it already?

[sicosico]

Really? Well, this may be an exciting new addition to one's diet. I hope my previous post didn't put my foot in my mouth. I'm still skeptical. I mean, it's one of those too good to be true things. Everything has a downside. It may just be price in this case, or maybe side effects haven't been noted YET. I just don't know and won't pass further judgement.

I am still wating for their official blinded studies, they claim no side effects what so ever , but come to think about it 15 lbs in 3 months is attainable naturally, but they said there was no change in diet or exercise, and also the 5% reduction in body fat which made the difference. I sent them a letter to get copies of the research, if they don't pass the fda testing as a drug in the us then it will be marketed for sure as a supplement as a plant extract or so.

[BluSilver]

Thanks, I can't wait for the studies.

[sicosico]

the best, and infact only "evidence" that something actually works is results. those studies dont prove sh!t. not trying to be a dick but im just skeptical, if it really works so well w/out side effects why hasnt someone mentioned it before? why arent top companies making products with it already?

This is one of the companies that does research, before viagra came out, why didn't another company do it ?

here is what the company states:

An estimated 300 new drugs of world-wide importance, worth over $150 billion, still remain to be discovered amongst the 250,000 species of higher plants found on earth, of which less than 15% have been investigated for bioactive compounds. Presently, twenty of the best selling drugs come from natural sources and 25% of all prescription drugs contain active compounds originally derived from or patterned after compounds derived from plants.

[Work]

After reading the first 4 posts, I was thinking of trying it, but I really need to read another 10 studies or so......
Seriously though, how can anyone read through all of that? I know it's what people ask for and is of good intent so I'm not knocking anyone for that.

How about a summary of what it purports to do?

[pu12en12g]

So has anyone actually used this muira puama extract ?

[neuron]

...wrote to a homeopathic medical scientist. This is what she replied :

Dear Matt,
Sorry, no. Natural muira puama bark, as well as our manufactured extract, will not reduce body fat or increase muscle. I'm not sure what this company extracted from muira puama or what kind of "ion channel modulators from natural sources" they mixed it with but natural muira puama won't provide these benefits. Since their "study" was only one person and it wasn't published in any peer reviewed medical journal, I don't believe they've made their case that their patented product will provide these results either. When filing a patent... no one at the patent office really verifies the "research" supporting a patent claim such as this one.

Best wishes,
Dr. Leslie Taylor, ND

[Rockyforever]

...wrote to a homeopathic medical scientist. This is what she replied :

Dear Matt,
Sorry, no. Natural muira puama bark, as well as our manufactured extract, will not reduce body fat or increase muscle. I'm not sure what this company extracted from muira puama or what kind of "ion channel modulators from natural sources" they mixed it with but natural muira puama won't provide these benefits. Since their "study" was only one person and it wasn't published in any peer reviewed medical journal, I don't believe they've made their case that their patented product will provide these results either. When filing a patent... no one at the patent office really verifies the "research" supporting a patent claim such as this one.

Best wishes,
Dr. Leslie Taylor, ND

well if thats a true letter and no one can say its a fake i say bullsh!t to the product. Siocisco(i cant spell) do ui work for them is that why u gave us the info to sell another false, crappy, and (my hard earned money) spent on this product when this Doctor says its bullsh!t ??? I aint going to research this product now.

[neuron]

PM me and I'll give you her e-mail address if you'd like to confirm it.

[sicosico]

...wrote to a homeopathic medical scientist. This is what she replied :

Dear Matt,
Sorry, no. Natural muira puama bark, as well as our manufactured extract, will not reduce body fat or increase muscle. I'm not sure what this company extracted from muira puama or what kind of "ion channel modulators from natural sources" they mixed it with but natural muira puama won't provide these benefits. Since their "study" was only one person and it wasn't published in any peer reviewed medical journal, I don't believe they've made their case that their patented product will provide these results either. When filing a patent... no one at the patent office really verifies the "research" supporting a patent claim such as this one.

Best wishes,
Dr. Leslie Taylor, ND

lol of course it won't the manufacture up is a phramacetical company, if they release it you'll need prescription, and guys quit BSing everything, this is a synthetic version of the extract lol, beside this guiys won't know **** about a pharmacetical company research ! and email the guy the link to the copany and ask him about it ad give him a link to http://www.phytomedical.com/ ! or why don't you email http://www.phytomedical.com/

Homeopathic is bs, just research. lol about a pharm company advertising in a supp forum, Rockyforever must be kidding or seriously don't know anything.

[pu12en12g]

Rockyforever must be kidding or seriously don't know anything.

He works at GNC . . . LMAO

[neuron]

"lol of course it won't the manufacture up is a phramacetical company"

The only thing I see here is that this company is trying to scam people out of money. This 'extract' is vague on research, and a little 'over the top' with the advertising - a clear sign of deceptive marketing.

"this is a synthetic version of the extract lol, beside this guiys won't know **** about a pharmacetical company research !"

Why are you so emotionally invested in this product?

"and email the guy the link to the copany and ask him about it ad give him a link to"

I sent that exact link to this doctor, and the above is her response. She wasn't amused.

"Homeopathic is bs, just research."

She has a doctorate in Naturopathy.

"Naturopathic Doctor - ND
What they do
Naturopathic medicine is a distinct profession of primary health care, emphasizing prevention, treatment and the promotion of optimal health through the use of therapeutic methods and modalities which encourage the self-healing process, the vis medicatrix naturae.

Typical training
A four-year graduate degree (ND) from an accredited naturopathic medical college or university

Philosophy
The person has an inherent ability to heal if supported properly. Naturopathic doctors emphasize prevention, self care and the use of natural treatments.

Tools used in the practice
Extensive medical history, lifestyle counseling, diagnostic testing including, pap smears, blood/urine tests, etc. ND’s refer patients for additional diagnosis (& treatment) as indicated. ND’s use several core treatments, including food and vitamin therapy, homeopathy, herbal medicine, osseous and cranio-sacral manipulation, massage and often soft tissue therapies, lifestyle and psychological counseling.

What to expect in first examination
You will complete an intensive medical intake and review it with your ND. He or she will conduct a thorough medical history, do a physical exam, and order diagnostic laboratory testing or imaging depending on your medical history and symptoms. Your treatment may include dietary changes, the use of vitamin / mineral supplements, herbal remedies and life style changes, including exercise or stress reduction. Your ND will consult with or refer you to specialists for co-management as appropriate."

- via http://www.bastyrcenter.org/health/key.asp?jump=3


Update : I TRIED to send her response to http://www.phytomedical.com/ but apparently there IS NO WAY TO CONTACT THE COMPANY. The 'Contact Us' feature on the website is 'under construction.' Innnnteresting.

[Matt96teg]

Muara Puama: 12:1 active extract 500mgs is found in Unleashed...FYI.

[sicosico]

"lol of course it won't the manufacture up is a phramacetical company"

The only thing I see here is that this company is trying to scam people out of money. This 'extract' is vague on research, and a little 'over the top' with the advertising - a clear sign of deceptive marketing.

"this is a synthetic version of the extract lol, beside this guiys won't know **** about a pharmacetical company research !"

Why are you so emotionally invested in this product?

"and email the guy the link to the copany and ask him about it ad give him a link to"

I sent that exact link to this doctor, and the above is her response. She wasn't amused.

"Homeopathic is bs, just research."

She has a doctorate in Naturopathy.

"Naturopathic Doctor - ND
What they do
Naturopathic medicine is a distinct profession of primary health care, emphasizing prevention, treatment and the promotion of optimal health through the use of therapeutic methods and modalities which encourage the self-healing process, the vis medicatrix naturae.

Typical training
A four-year graduate degree (ND) from an accredited naturopathic medical college or university

Philosophy
The person has an inherent ability to heal if supported properly. Naturopathic doctors emphasize prevention, self care and the use of natural treatments.

Tools used in the practice
Extensive medical history, lifestyle counseling, diagnostic testing including, pap smears, blood/urine tests, etc. ND’s refer patients for additional diagnosis (& treatment) as indicated. ND’s use several core treatments, including food and vitamin therapy, homeopathy, herbal medicine, osseous and cranio-sacral manipulation, massage and often soft tissue therapies, lifestyle and psychological counseling.

What to expect in first examination
You will complete an intensive medical intake and review it with your ND. He or she will conduct a thorough medical history, do a physical exam, and order diagnostic laboratory testing or imaging depending on your medical history and symptoms. Your treatment may include dietary changes, the use of vitamin / mineral supplements, herbal remedies and life style changes, including exercise or stress reduction. Your ND will consult with or refer you to specialists for co-management as appropriate."

- via http://www.bastyrcenter.org/health/key.asp?jump=3


Update : I TRIED to send her response to http://www.phytomedical.com/ but apparently there IS NO WAY TO CONTACT THE COMPANY. The 'Contact Us' feature on the website is 'under construction.' Innnnteresting.

Naturopathic or homeopathic is all BS

[sicosico]

Muara Puama: 12:1 active extract 500mgs is found in Unleashed...FYI.

I might give it a try

[Rushi]

Muara Puama: 12:1 active extract 500mgs is found in Unleashed...FYI.

the plant that is under discussion in this thread has been referred to as muira puama, not muara puama.

[pu12en12g]

the plant that is under discussion in this thread has been referred to as muira puama, not muara puama.

Hmm.. I wonder what the difference is

[LayneStaley]

Hmm.. I wonder what the difference is

No difference, its a typo on **************'s part. That alone stops me from buying their product. How can I take them seriously? Half the ingredients are libido enhancers, then they claim its just the result of your test production being upped. MY ASS.

[sicosico]

bumping an old thread, since we have lots of gurus in here, lets hear some science about it, if it is true, th future is here already.

and they also have new thing about cinnamon as insulin treatment !

http://www.phytomedical.com/IR/Press...0050110-1.html

[DejaBlue55]

Bump

[thanatopsis]

IIRC this herb is used in USP Labs PowerFULL.