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  1. #1
    Registered User Noahedwinbeach2's Avatar
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    loperamide(Immodium AD) and muscle gain(cortisol reducer)

    I was amazed at this study proving loperamide can be used for cortisol reduction. I currently take atleast 16mg a day of this stuff buying it from Costco in the generic version. This may sound strange to a bunch of you. I always seemed to have a problem absorbing a lot of the nutrients I would consume. I would increase my protein consumption and all that seemed to happen was I go to the bathroom more. Now I go like once or twice a day normal stools and my weight gain has shot up from 215 to 234 in the last 8 months. This drug has the ability to reduce cortisol which as we all know is one of the ways anabolic steroids work in the body. I would like to see more guys start taking 16mg or more of this stuff a day and eating about 15-20 calories per pound of bodyweight and then report your results. I really think this is something that could help most guys out there. If you take creatine and other suppplements that screw with your colon I think this could dramatically increase the absorption of those supplements.

    In 34 patients, in whom the suspect of hypercortisolism was ruled out, either loperamide or dexamethasone suppressed the pituitary-adrenal axis: cortisol and ACTH levels significantly fell from 417 +/- 24 nmol/L and 28.3 +/- 3.5 pg/ml to 60 +/- 6 nmol/L and 14.4 +/- 1.4 pg/ml after loperamide

    That is an 85% drop in cortisol!!!!

    This stuff is working for me and it is awsome something like this would make such a difference. Like I said though I think it is because I am absorbing more nutrients now combined with the reduction in cortisol. I hope other people on here will try it and report the results. Please keep this thread bumped!




    http://www.ncbi.nlm.nih.gov/sites/en...&dopt=Abstract

    AND

    http://www.ncbi.nlm.nih.gov/sites/en...&dopt=Abstract
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  2. #2
    Registered User Noahedwinbeach2's Avatar
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    I may be reporting the results wrong. I am not sure which value represents the cortisol drop the first or second number. Either way I would assume atleast a 50% drop.
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    Registered User Noahedwinbeach2's Avatar
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    Nimbus Nutrition Rep leonidas300's Avatar
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    Interesting post, will rep when recharged.
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    Registered User Tattedmama's Avatar
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    If you don't have bowel issues, will this cause constipation?
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    Registered User Noahedwinbeach2's Avatar
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    not if you eat fiber everyday..i eat around 30g a day
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    Banned lsimplydeepl's Avatar
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    bump for more opinions
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    ΛΦΕ AphtaLyfe's Avatar
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    Are there any studies showing what happens when you stop taking it? Would there be a cortisol rebound? I would imagine a cortisol rebound effect would be pretty terrible for your mental and physical health.

    Very interesting stuff though.

    I'm not taking it till there are more studies supporting its long term use.

    *Edit* There are reports of long term use resulting in addiction/withdrawl symptoms after trying to stop... I'll pass thanks =)
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    Registered User BrachioMorph's Avatar
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    Thumbs up

    Very interesting!
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  10. #10
    Registered User Yorob's Avatar
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    Originally Posted by AphtaLyfe View Post
    *Edit* There are reports of long term use resulting in addiction/withdrawl symptoms after trying to stop... I'll pass thanks =)
    could you link that
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  11. #11
    ΛΦΕ AphtaLyfe's Avatar
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    Originally Posted by Yorob View Post
    could you link that
    http://en.wikipedia.org/wiki/Loperamide

    However, loperamide can cause physical dependence. Symptoms of opiate withdrawal have been observed in patients abruptly discontinuing long-term therapy with loperamide. For this reason, the drug was briefly classified as a Schedule V controlled substance upon its introduction
    There is no source for that statement within wikipedia though. Just noticed that.
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  12. #12
    AKA: pachovia badbart's Avatar
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    I've used Immodium AD continuously for over 2 years and quit a month ago and experienced no withdrawal symptoms. In hose two years I've went from 155 pounds to 183 pounds. I assumed the Immodium AD helped control my minor IBS helping me to absorb more food, but maybe Immodium AD controlled cortisol helping me make my great gains. I'm 34 and have been lfting on and off since I was 14 but never was able to gain any meaningful amount of weight. Until I stared the Immodium AD.

    I'm guessing mt weight gain could be one of 3 things,

    1. Absorbing more food from Immodium AD slowing my digestive system.
    2. Immodium AD blocking cortisol
    3. Getting older and gaing weight easier.
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  13. #13
    Hero. Psycho. Insomniac. Skigazzi's Avatar
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    For the guys who have tried this...When you first started, regardless of fiber intake, did you become constipated?? and did your body adjust to it over time? or was there no major issue?

    I know if my stomache is bothering me, that 4mg of it pretty much seals me up for a few days...so 16mg a day, for a few days...Id imagine Id never go again! unless the body adjusts to it.
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    AKA: pachovia badbart's Avatar
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    Originally Posted by Skigazzi View Post
    For the guys who have tried this...When you first started, regardless of fiber intake, did you become constipated?? and did your body adjust to it over time? or was there no major issue?

    I know if my stomache is bothering me, that 4mg of it pretty much seals me up for a few days...so 16mg a day, for a few days...Id imagine Id never go again! unless the body adjusts to it.

    16mg seems huge, the most I've used is 8mg spread out through out the day.
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  15. #15
    Tao of Iron wild1poet2's Avatar
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    These studies involve pathological ACTH secretion. I wouldn't infer the same results in normal ACTH secreting athletes. Plus there may be other negative side effects to the anticholinergic effects. For example, weight gain might just be attributed to being "backed up" for a year. LOL
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  16. #16
    Registered User Noahedwinbeach2's Avatar
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    I take 30mg a day right now..I have upped the dose to this amount and I am not at 245 pounds at 5'10. I have put on some fat weight but also a very noticable amount of lean mass. Of course this is the result of 4000 plus calories per day. I still go to restroom 2 times per day minimum. However, this is normal considering the amount of food I am consuming. I can't help but notice how well I am growing as though I am on steroids. Before when I ate this much I **** a whole lot and didn't seem to put on the muscle I was before. I am not just saying this because I want to validate my theory which isn't really my theory. This drug has been shown to reduce cortisol levels in normal people already by drastic levels. I take such high amounts because I believe to benefit from the cortisol reduction such amounts have to be taken as shown in the testing. If I were going days without going to the restroom I obviously wouldn't be taking so much but because I still go regularly I will continue to take this much if not more. One thing I have noticed is I am able to consume creatine monohydrate now without the gastric problems I once had. I used to get bad runs off creatine monohydrate but now I get absolutely none. And my strength is flying through the roof. I am not getting any negative sides from doing this. I consume plenty of fluids along with my high calorie diet.

    8-10 hours sleep
    4000 calories per day(15-20 calories per pound of bw)
    30mg anti poop pills
    creatine(10-20g)

    =

    steroid like gains


    of course I am experimenting on myself but I don't care honestly. One day I will get my photo on here but I am getting fat so not right now
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  17. #17
    Your Body is a TEMPLE Feny's Avatar
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    Originally Posted by Noahedwinbeach2 View Post
    I take 30mg a day right now..I have upped the dose to this amount and I am not at 245 pounds at 5'10. I have put on some fat weight but also a very noticable amount of lean mass. Of course this is the result of 4000 plus calories per day. I still go to restroom 2 times per day minimum. However, this is normal considering the amount of food I am consuming. I can't help but notice how well I am growing as though I am on steroids. Before when I ate this much I **** a whole lot and didn't seem to put on the muscle I was before. I am not just saying this because I want to validate my theory which isn't really my theory. This drug has been shown to reduce cortisol levels in normal people already by drastic levels. I take such high amounts because I believe to benefit from the cortisol reduction such amounts have to be taken as shown in the testing. If I were going days without going to the restroom I obviously wouldn't be taking so much but because I still go regularly I will continue to take this much if not more. One thing I have noticed is I am able to consume creatine monohydrate now without the gastric problems I once had. I used to get bad runs off creatine monohydrate but now I get absolutely none. And my strength is flying through the roof. I am not getting any negative sides from doing this. I consume plenty of fluids along with my high calorie diet.

    8-10 hours sleep
    4000 calories per day(15-20 calories per pound of bw)
    30mg anti poop pills
    creatine(10-20g)

    =

    steroid like gains


    of course I am experimenting on myself but I don't care honestly. One day I will get my photo on here but I am getting fat so not right now
    very very interesting... repped on recharge
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  18. #18
    Your Body is a TEMPLE Feny's Avatar
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    also... just wondeirng... at the high doses your taking... do you experence any of the mild euphoria from taking this drug? wiki said something along thoes lines, and i was just curious
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    30mg a day...jesus...I think there are better ways to control cortisol (which has a purpose, its not just a 'bad' thing).

    Basically:
    I don't think megadosing an OTC anti-diarrheal as a way to control cortisol and make gains is a good thing.

    Just had to say that.
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    30mg and you go twice a day! Maybe you have a digestive problem, food allergy or IBS? If I took 8mg I was bound up for two days, and I had mild IBS!

    But since I've started taking 4mg I've had a real nice fat reduction around my waist and no weight loss.
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  21. #21
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    Just started taking 8mg a day split into two doses taken with my protein shakes (50-60 grams) Have increased fiber consumption a bit. Will report back with results.
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    Interesting, might not be the best bt for over-all health if used habitually but still interesting.
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    Originally Posted by Noahedwinbeach2 View Post
    I was amazed at this study proving loperamide can be used for cortisol reduction. I currently take atleast 16mg a day of this stuff buying it from Costco in the generic version. This may sound strange to a bunch of you. I always seemed to have a problem absorbing a lot of the nutrients I would consume. I would increase my protein consumption and all that seemed to happen was I go to the bathroom more. Now I go like once or twice a day normal stools and my weight gain has shot up from 215 to 234 in the last 8 months. This drug has the ability to reduce cortisol which as we all know is one of the ways anabolic steroids work in the body. I would like to see more guys start taking 16mg or more of this stuff a day and eating about 15-20 calories per pound of bodyweight and then report your results. I really think this is something that could help most guys out there. If you take creatine and other suppplements that screw with your colon I think this could dramatically increase the absorption of those supplements.

    In 34 patients, in whom the suspect of hypercortisolism was ruled out, either loperamide or dexamethasone suppressed the pituitary-adrenal axis: cortisol and ACTH levels significantly fell from 417 +/- 24 nmol/L and 28.3 +/- 3.5 pg/ml to 60 +/- 6 nmol/L and 14.4 +/- 1.4 pg/ml after loperamide

    That is an 85% drop in cortisol!!!!

    This stuff is working for me and it is awsome something like this would make such a difference. Like I said though I think it is because I am absorbing more nutrients now combined with the reduction in cortisol. I hope other people on here will try it and report the results. Please keep this thread bumped!




    http://www.ncbi.nlm.nih.gov/sites/en...&dopt=Abstract

    AND

    http://www.ncbi.nlm.nih.gov/sites/en...&dopt=Abstract
    Yeap it is proven that loperamide lowers basal Cortisol levels but i believe that your weight gain got nothing to do with muscle waste due to cortisol.
    I think too that the reduced bowel motility did all the work. Especially for an ectomorph this reduced bowel motility will do miracles.

    According to http://jcem.endojournals.org/cgi/con...tract/75/2/552
    Loperamide indeed lowers basal cortisol levels but it fails to reduce "stress" induced rise in cortisol levels and lead us to believe that it will fail to reduce exersise induced rise in cortisol levels too.
    And dont forget that cortisol is a key point in lipolysis and your weight gain could be some fat too.(and some pilled up ****s due to reduced bowel motility hehe)

    Originally Posted by Tattedmama View Post
    If you don't have bowel issues, will this cause constipation?
    inevitably !

    Originally Posted by AphtaLyfe View Post
    Are there any studies showing what happens when you stop taking it? Would there be a cortisol rebound? I would imagine a cortisol rebound effect would be pretty terrible for your mental and physical health.

    Very interesting stuff though.

    I'm not taking it till there are more studies supporting its long term use.

    *Edit* There are reports of long term use resulting in addiction/withdrawl symptoms after trying to stop... I'll pass thanks =)
    No cortisol rebound cause it aint act directly to the CRH-ACTH-CORTISOL system.
    It acts through the m-opioid receptor but only a small percentage of the drug can pass the blood-brain-barrier and it influences mainly the hypothalamus due to excessive m-opioid receptor concentrations that exist there.
    FFS you cant compare it with other opioid receptor agonists like morphine of codeine who pass the BBB easily and acts through all the opioid receptors everywhere in your brain.

    from wikipedia http://en.wikipedia.org/wiki/Mu_opioid_receptor
    "In contrast, chronic activation of MOR causes the collapse of dendritic spines via post-synaptic mechanisms "

    Imo to do that with loperamide you need supraphysiological doses for a long long time...
    Last edited by MMA_Greece; 08-18-2007 at 06:19 PM.
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    All of your concerns are good. This is something new as in really not many people probably thought of using this for muscle building. Even if it doesn't reduce exercise induced cortisol levels the increased benefit from nutrient absorption would be worth looking into. Fina (trenbelone) has the tremendous ability to increase nutrient uptake which is one reason it works. Steroids don't work entirely by cortisol reduction. It is just one way. My idea in all this was to increase calorie consumption and taking loperamide so that more of the food I was consuming would be utilized. In fact it is working. I am at 247 now and my strength has sky rocketed. I am still going 2 times per day. Loperamide doesnt completely keep you from going to the bathroom. Gravity still works against you. However it slows the motility down. If you are eating enough food your going to go to the restroom. Drink plenty of water and you will be fine. If you eat 1000 calories a day you may not go for a while but when you are eating 4500 calories or more per day the weight bearing on the colon alone seems to stimulate me to go to the restroom. Who else in here goes several times per day when you consume huge amounts of food? I am sure there are many. It is just a simple fact the more you eat the more you crap. But if you give the body enough time to absorb and use the nutrients you consume you optimize your body to grow. Cortisol is not the only answer. It is just one answer. Steroids don't work entirely through cortisol reduction and cortisol can be controlled by consuming large amounts of calories. I know this stuff is working because of my results. In the past large food consumption has results in lots of crapping and not near the weight gain I am getting now. And I am not storring 20 pounds of excess crap now. I would feel that kind of weight. I still consume fiber and it passes easily still so I know there isn't large blockage going on.
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    another thing..I am focusing my lifts on deep squats along with deadlifts...something like the following

    Monday
    Squats - warmup...1 set of 6, drop set to 10 reps
    Curls - 1 set 10

    Thursday
    Deadlift - warmup ..1 set of 8-10, drop set to 10 reps
    Flat Bench - 1 set 10
    Shoulder press - 1 set 10

    I realize this is a very simple workout but it is working. The heavy squats, deadlifting, and bench are increasing my testosterone along with consuming lots of calories are working tremendously. The loperamide is only helping in the way nutrients are being absorbed.
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    and I don't see the problem with 30mg...I am not getting a euphoric effect. I feel normal just not going to the restroom as much.
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    What about OTC cortisol reducing weight loss supplements like Cortislim or Relacore, wouldnt these have the same effect, but without the gastro-intestinal side effects?
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    they do not have the capability of slowing down the passage of food to increase nutrient uptake. I don't think people understand how important nutrient absorption is. If you consume 5000 calories and your colon absorbs 3500 calories you aren't going to grow at your potential. There are other reasons why this is such a great tool. One thing that may prevent cortisol from distroying your gains would be to absorb maximum amount of calories.

    This is all stupid anyways. The only way you will know if it works is to try it for yourself. consume 20 calories per pound of bodyweight..take 30mg a day and drink tons of fluid. Exercise and fluid alone will keep you from getting stopped up. All I can tell you is it is working for me. Speculating what it will do to you isn't the same as knowing what it will do for you.
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    I am now up to 255 pounds 5'11. Anyone had any success yet?
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    Any updates on this stuff. Seems pretty interesting.
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