There have been a couple of interesting threads on Ergopharm's 6-Oxo Extreme and 11-Oxo. In these threads the topic of Resveratrol has come up and a few discussions have taken place. I originally became interested in it for its potential for life extension via the SIRT-1 gene as well as its overall health benefits (the French Paradox).
However, Ergopharm incorporated it into its products mainly for its actions as an estrogen receptor antagonist which thereby increases testosterone. Very interesting, but this is where I became hesitant. I'm a man in my mid twenties and have been watching the hairline recede slowly for a few years. Thus, I try to avoid anything hormone related.
A quick search on resveratrol + hairloss strangely showed results using it for the prevention of hairloss via the following rationalization: "Resveratrol, from grape skins, is a lipase inhibitor. By decreasing the body's ability to absorb fat through the intestine walls, it reduces the total fat and calorie content of a person's diet." (http://answers.google.com/answers/threadview?id=757473) So the theory there is that less fat/calories will essentially reduce cholesterol which is the start for the synthesis of testosterone and then DHT via 5-alpha reductase (http://www.lib.mcg.edu/edu/eshuphysi...8img/page8.jpg)
But based on Ergopharm's studies it appears that the estrogen receptor antagonist actions of resveratrol far outweigh the disruption in the testosterone synthesis pathway via reduction in dietary cholesterol.
So while all this is interesting in and of itself, I'm trying to determine the cost/benefits of resveratrol and my questions are these:
How effective are the 5-alpha reductase inhibitors out there? Is saw palmetto the best? Has anyone had much success slowing hair loss with these?
Given the state of these inhibitors, how would they effectively stand up against largely elevated testosterone levels as shown in Ergopharms Resvertrol studies?
Any thoughts, comments, links, opinions, or questions on these and related topics would be much appreciated. Pat, I'm hoping you would be so kind as to chime in here if possible. Thanks.