Nizoral (ketoconazole)

[Jimmyp]

Hey guys, I recently purchased some Nizoral 1%ketoconazole shampoo because I've read several articles that it can be good for your skin. Apparently by acting as a topical anti - androgen, it can reduce the amount of DHT that can act on the androgen receptor and cause excess sebum and acne. So I just started using JW and I thought it would be wise to combat the likely increase in DHT with Nizoral.

My question is, how come when I try and search for information on ketoconazole I find info saying its a anti-fungal agent. How does its anti-androgen effects compare to its anti-fungal..or does anyone have any references about its anti-androgen effects.

Also, I just ordered some ketoconazole 2% shampoo from a online Canadian pharmacy, is the 2% strength a Rx Med. here in the states?

So far, this stuff seems to be working good on my skin...

[MaddenMuscle]

I never heard of the drugs anti androgen effects either. I was given that by rx once a while back.

[Jimmyp]

Well I've read a couple articles, one in Mind and Muscle..I believe it was written by Par Duex and he explained that it was an anti-androgen. I was just curious if anyone knew of any links to studies regarding its anti-androgen effects. Or does anyone know of any other TOPICAL anti-androgens that may work better?

[DJMctits]

Originally Posted by Jimmyp

Hey guys, I recently purchased some Nizoral 1%ketoconazole shampoo because I've read several articles that it can be good for your skin. Apparently by acting as a topical anti - androgen, it can reduce the amount of DHT that can act on the androgen receptor and cause excess sebum and acne. So I just started using JW and I thought it would be wise to combat the likely increase in DHT with Nizoral.

My question is, how come when I try and search for information on ketoconazole I find info saying its a anti-fungal agent. How does its anti-androgen effects compare to its anti-fungal..or does anyone have any references about its anti-androgen effects.

Also, I just ordered some ketoconazole 2% shampoo from a online Canadian pharmacy, is the 2% strength a Rx Med. here in the states?

So far, this stuff seems to be working good on my skin...

could you PM me the link to the store? i wanna check it out

[Jimmyp]

sure, will do shortly

[neuron]

Originally Posted by Jimmyp

Hey guys, I recently purchased some Nizoral 1%ketoconazole shampoo because I've read several articles that it can be good for your skin. Apparently by acting as a topical anti - androgen, it can reduce the amount of DHT that can act on the androgen receptor and cause excess sebum and acne. So I just started using JW and I thought it would be wise to combat the likely increase in DHT with Nizoral.

My question is, how come when I try and search for information on ketoconazole I find info saying its a anti-fungal agent. How does its anti-androgen effects compare to its anti-fungal..or does anyone have any references about its anti-androgen effects.

Also, I just ordered some ketoconazole 2% shampoo from a online Canadian pharmacy, is the 2% strength a Rx Med. here in the states?

So far, this stuff seems to be working good on my skin...

this stuff's anti-androgenic potential has been known for years. google "ketoconazole" and "alopecia". the idea that this agent could be used to combat acne has also been known for years (way before par deus and the like - i pointed this out before...). Ultimately however, its success in treating acne is very poor yet its ability to produce gyno is ever present.

[Jimmyp]

Originally Posted by triathelete04

this stuff's anti-androgenic potential has been known for years. google "ketoconazole" and "alopecia". the idea that this agent could be used to combat acne has also been known for years (way before par deus and the like - i pointed this out before...). Ultimately however, its success in treating acne is very poor yet its ability to produce gyno is ever present.

So, why is its success in treating acne poor?...It seemed to make the couple small pimples i had dissapear... And for gyno, I dont plan on rubbing this on my pecs....I assume It can't cause gyno from topical facial use, correct?

[neuron]

Originally Posted by Jimmyp

So, why is its success in treating acne poor?...It seemed to make the couple small pimples i had dissapear... And for gyno, I dont plan on rubbing this on my pecs....I assume It can't cause gyno from topical facial use, correct?

Systemic circulation will occur upon lathering ones skin with the lotion. This has been empirically shown with other topical agents such as Tea Tree Oil and lavender (both are also anti-androgenic).

[Fleshka]

Originally Posted by MaddenMuscle

I never heard of the drugs anti androgen effects either. I was given that by rx once a while back.

i have

[Jimmyp]

Originally Posted by triathelete04

Systemic circulation will occur upon lathering ones skin with the lotion. This has been empirically shown with other topical agents such as Tea Tree Oil and lavender (both are also anti-androgenic).

AHHH...to what extent will this circulate systemically? The article I had read said it WOULD NOT significantly change systemic blood concentrations of DHT or other androgens. How much is really absorbed into the blood if it's left on the skin for 30 seconds?? Does anyone else have any insight on this? I am somewhat alarmed now, I was under the impression this was very 'safe'.

[Jimmyp]

bump for some info on how much systemic blood concentration of androgens would be affected by topical Nizoral (anti-androgen).

[Skigazzi]

I have never seen anything suggesting that topical use of keto. can result in systemic delivery.

I HAVE seen warning about taking keto. internally in regards to it being a potent anti-androgenic substance.

I'll see If I can find anything worth posting.

[Skigazzi]

Ketoconazole binds to the human androgen receptor.

Title Ketoconazole binds to the human androgen receptor.
Author Eil C
Address Department of Internal Medicine, Naval Hospital, Bethesda, Maryland.
Source Horm Metab Res, 24: 8, 1992 Aug, 367-70
Abstract
Ketoconazole, an imidazole anti-fungal agent, has often produced features of androgen deficiency including decreased libido, gynecomastia, impotence, oligospermia, and decreased testosterone levels, in men being treated for chronic mycotic infections. Based on these potent effects on gonadal function in vivo as well as previous work in vitro demonstrating affinity of ketoconazole for receptor proteins for glucocorticoids and 1,25(OH)2 vitamin D3 and for sex steroid binding globulin (SSBG), the binding of ketoconazole to human androgen receptors (AR) in vitro was also examined. Ketoconazole competition with [3H]methyltrienolone (R1881) for androgen binding sites in dispersed, intact cultured human skin fibroblasts was determined at 22 degrees C. Fifty percent displacement of [3H]R1881 binding to AR was achieved by 6.4 +/- 1.8 (SE) x 10(-5) M ketoconazole. Additional binding studies performed with ketoconazole in the presence of increasing amounts of [3H]R1881 showed that the interaction of ketoconazole with AR was competitive when the data were analyzed by the Scatchard method. It should be noted, however, that the dose of ketoconazole required for 50% occupancy of the androgen receptor is not likely to be achieved in vivo, at least in plasma. Finally, androgen binding studies performed with other imidazoles, such as clotrimazole, miconazole, and fluconozole, revealed that in this class of compounds only ketoconazole appears to interact with the androgen receptor. Ketoconazole appears to be the first example of a non-steroidal compound which binds competitively to both SSBG and multiple steroid hormone receptors, suggesting that the ligand binding sites of these proteins share some features in common.

[Jimmyp]

Skigazzi, thanks for your time man...So by the sounds of that study, Ketoconazole is a good anti-androgen but its unlikely to reach significant concentrations in blood plasma., correct?..that's what i take away from this ~ "It should be noted, however, that the dose of ketoconazole required for 50% occupancy of the androgen receptor is not likely to be achieved in vivo, at least in plasma."...so this seems 'safe' to use, correct?

[Skigazzi]

Its safe to use externally (Topical Keto. has sides but nothing even remote to hormonal effects..just dont drink the shampoo ), ive used the shampoo multiple times and cannot even think for a second that there was any negative effect on my androgen levels.

[Jimmyp]

Thanks Ski, that reassuring to hear..thanks bro

[DaHooligan]

If your trying to reduce hair loss you have to leavet he shampoo on your scalp for 5-10 minutes 5 days a week and take saturday and sunday off. Make sure you have a timer. I also heard the first few weeks of taking Nizoral 2 percent you will experience some hair shedding.

nizoral is supposedly like rogaine but without the mess it takes 6 months I heard to see the benifits just like rogain and propecia, I am scared to take propecia cause of the impotence and gyno that is very evident with almost 60 percent of the users of propecia.

[pu12en12g]

Originally Posted by Jimmyp

So far, this stuff seems to be working good on my skin...

Love the stuff

[DaHooligan]

I notice I have been getting like a few pinkish bumps on my scalp is this normal? I use nizoral they dont itch at all should those bumps go away? I have lik 4 small pink bumps.

[LDragon]

Originally Posted by Jimmyp

Hey guys, I recently purchased some Nizoral 1%ketoconazole shampoo because I've read several articles that it can be good for your skin. Apparently by acting as a topical anti - androgen, it can reduce the amount of DHT that can act on the androgen receptor and cause excess sebum and acne. So I just started using JW and I thought it would be wise to combat the likely increase in DHT with Nizoral.

My question is, how come when I try and search for information on ketoconazole I find info saying its a anti-fungal agent. How does its anti-androgen effects compare to its anti-fungal..or does anyone have any references about its anti-androgen effects.

Also, I just ordered some ketoconazole 2% shampoo from a online Canadian pharmacy, is the 2% strength a Rx Med. here in the states?

So far, this stuff seems to be working good on my skin...

It blocks DHT and it's an anti-fungal. It was developed for anti-fungal issues.

[hooker]

Originally Posted by Jimmyp

Well I've read a couple articles, one in Mind and Muscle..I believe it was written by Par Duex and he explained that it was an anti-androgen. I was just curious if anyone knew of any links to studies regarding its anti-androgen effects. Or does anyone know of any other TOPICAL anti-androgens that may work better?

Actually, wasn't that article by me? Or did Par Deus write one also?

[VIDAPRETA]

Originally Posted by DaHooligan

If your trying to reduce hair loss you have to leavet he shampoo on your scalp for 5-10 minutes 5 days a week and take saturday and sunday off. Make sure you have a timer. I also heard the first few weeks of taking Nizoral 2 percent you will experience some hair shedding.

nizoral is supposedly like rogaine but without the mess it takes 6 months I heard to see the benifits just like rogain and propecia, I am scared to take propecia cause of the impotence and gyno that is very evident with almost 60 percent of the users of propecia.

This is what I read about NIZORAL maybee 10 years ago. I think it was Dan Duchaine or Bill PHILLIPS who were saying that people who were using certain steroids that were causing their hair to fall out(Testosterone,Anadrol)Were able to combat the hair loss using Nizoral just like this.

[DaHooligan]

Originally Posted by VIDAPRETA

This is what I read about NIZORAL maybee 10 years ago. I think it was Dan Duchaine or Bill PHILLIPS who were saying that people who were using certain steroids that were causing their hair to fall out(Testosterone,Anadrol)Were able to combat the hair loss using Nizoral just like this.

Some say hair will shed because its making way for new hair so just like rogaine and propecia you will have your 2-4 months of shed and possibly by the 6 month you will see some difference.

you just gotta stick with it I heard.

Also they say Saw palmetto is pretty good too.

[DejaBlue55]

I used this for acne back in the day. It worked well.

[kcb5150]

Every day is just not necessary according to most ppl the keto stays quite active in the scalp. The other thing is that it is a bit harsh and I could only imagine what your scalp would be like if you used that crap every day. The degreasing effect is potent.

[six sigma]

Originally Posted by triathelete04

Systemic circulation will occur upon lathering ones skin with the lotion. This has been empirically shown with other topical agents such as Tea Tree Oil and lavender (both are also anti-androgenic).

of tea tree oil and lavendar? ROTFLMAO

[DaHooligan]

Originally Posted by kcb5150

Every day is just not necessary according to most ppl the keto stays quite active in the scalp. The other thing is that it is a bit harsh and I could only imagine what your scalp would be like if you used that crap every day. The degreasing effect is potent.

lol no wonder i havea few pinkish bumps on my scalp? I used 2 percent 5 days straight and take saturday and sunday off and just use baby shampoo.

I think the 1 percent is the one you have to use 5 days on 2 days off and leave it in for like 10 minutes before you shower.

So should I just do it every other day instead of 5 days straight?

[Random907]

SKIZ, thanks bro!

These guys had me worried for a sec about systemic circulation of this stuff.

[CognitiveNutrition]

I should be getting mine in the mail anyday now 2% 120 ml.

[Random907]

Originally Posted by uniquenutrition

I should be getting mine in the mail anyday now 2% 120 ml.

How much was everything?