Myostatin blockers

[Dr.Dave1]

http :// www .ergo-log. com/creatinemyostatin .html

had to separate link to post

Interesting article but far from convincing. If you look at the original article I think you will appreciate that the website skews what the authors concluded as well. Myostatin levels dropped in strength training group compared to the no exercise group(duh); the strength training + creatinine group had a larger drop in myostatin than the strength training alone group (this would be expected with the larger increase in strength but could be a secondary effect). There was not a no exercise + creatinine group to see if creatinine alone decreased myostatin. The ergo folks put emphasis on GASP-1 levels increasing with resistance + creatinine which they did go up but not significantly more than resistance exercise alone . . . so this increase could be related to resistance training alone augmented by creatinine supplementation.

[nicesocks]

Interesting article but far from convincing. If you look at the original article I think you will appreciate that the website skews what the authors concluded as well. Myostatin levels dropped in strength training group compared to the no exercise group(duh); the strength training + creatinine group had a larger drop in myostatin than the strength training alone group (this would be expected with the larger increase in strength but could be a secondary effect). There was not a no exercise + creatinine group to see if creatinine alone decreased myostatin. The ergo folks put emphasis on GASP-1 levels increasing with resistance + creatinine which they did go up but not significantly more than resistance exercise alone . . . so this increase could be related to resistance training alone augmented by creatinine supplementation.

Good point.

I can't tell if that ergo website is legitimately unbiased or not...

[gspsilva]

I got chosen to do a log for Myo t-12.............that was in the summer, still waitin for it to be sent

[PaleoAyo]

any update lol

genetic doping is the future!!!!!

[timwake]

I would advise looking at some currently available anti cancer drugs for use as myostatin inhibitors. Myostatin is a small molecule that bonds to TGF-beta family receptors. There are several drugs on the market that inhibit the function of this receptor. I'm not sure how available these inhibitors are on the open market, but I Do know that certain drugs like novladex (used for breast cancer) can be easily obtained. It is therefore possible that the TGF-beta inhibitors can be obtained. Btw, novladex will not inhibit myostatin.

[Floorburn]

I would advise looking at some currently available anti cancer drugs for use as myostatin inhibitors. Myostatin is a small molecule that bonds to TGF-beta family receptors. There are several drugs on the market that inhibit the function of this receptor. I'm not sure how available these inhibitors are on the open market, but I Do know that certain drugs like novladex (used for breast cancer) can be easily obtained. It is therefore possible that the TGF-beta inhibitors can be obtained. Btw, novladex will not inhibit myostatin.

A multikinase inhibitor will have much broader effects than a targeted one, I would see what side effects are around before even starting to consider it. Cancer patients are generally okay with some wild side effects that other people are not okay with.

[rylacor]

FDA granted breakthrough therapy designation to Novartis' experimental drug bimagrumab ….. apparently a myostatin blocker that works out of gestation to address muscle wasting