Legal Gear's new product "Receptor" is a Fraud

[Conciliator]

Legal Gear/LG Sciences is releasing a product called "Receptor". Their page for this product can be found here: http://www.lgsciences.com/items/-ana...tor-detail.htm

They state the following:

Do you ever wish you could go back in time when your receptors were "clean"? Why don't your second, third and fourth cycles "feel like your first time"? This is because of "dirty receptors" or better known as down-regulated androgen receptor syndrome.

Doing a cycle of steroids like Sustenon, Deca or D-Bol will make your androgen receptor down-regulate over time. Which is why your other cycles NEVER feel like " the first time". Even potent prosteroids like Superdrol, M1T and Pheraplex suffer from this same problem. LG Sciences UNLEASHES ANOTHER BOMB, by bringing you RECEPTOR, the only patent pending product that UPREGULATES the androgen receptor and makes every cycle feel like your first. If you suffer from AR down regulation syndrome, from too many cycles, clean out your receptors with the only product backed by science!

Now anyone who knows anything about androgens knows that the claims of this product are blatantly incorrect. It's marketing hogwash. In fact, they've gone so far as to invent a new medical condition: "down-regulated androgen receptor syndrome." That really made me laugh. Nice try guys. The research shows that androgens do EXACTLY THE OPPOSITE, not down-regulating, but UP-REGULATING the androgen receptor (AR). In other words, androgens increase the density or quantity of the receptor that it binds to.

First, understand that androgens are far different from beta-adrenoceptor agonists like clenbuterol. Clenbuterol has been shown in research to down-regulate the beta-2 receptor by decreasing the half life of receptor proteins. This is why it's used for such short durations. Unknowing bodybuilders might suspect that the same is true with androgens and the androgen receptor. Unscupulous supplement companies who don't have your best interests in mind might try and take advantage of that. However, androgen receptors are much different than beta-adrenergic receptors. Reseach has shown that the half-life and stability of androgen receptors are actually INCREASED in the presence of androgens, in many tissues. Yes, that's right, the AR is up-regulated and the density of androgen receptors INCREASES in response to anabolic steroids. There are no "dirty-receptors" to clean out. There are actually more "clean" receptors. This is very well established. But don't take my word for it. I've compiled some of the research so that you can see it for yourself:

This 1992 study (the full text is free), entitled "Androgen Receptor Phosphorylation, Turnover, Nuclear Transport, and Transcriptional Activation" concluded:

Androgen increased the amount of AR [androgen receptor] phosphorylation simply by slowing the rate of degradation of the AR protein. AR stabilization by androgen was observed previously in binding studies on tissue cytosols (34). Moreover, in a ductus deferens smooth muscle tumor cell line, endogenous AR stabilization increased about 2-fold with androgen, from t1/2 3.1 h without androgen to t1/2 6.6 h with R1881 (55). The mechanism of receptor stabilization by androgen is not known but the striking specificity for androgen suggests it may be closely linked with receptor functional activity. Although other groups have reported on steroidinduced phosphorylation of AR (25) and the glucocorticoid and progesterone receptors (21-24), no androgen-dependent enhancement of recombinant AR phosphorylation was detected in the present study. While the AR is clearly a phosphoprotein, the specific role of phosphorylation in receptor function is unclear. AR sites of phosphorylation are currently being mapped, and it is conceivable that androgen binding may increase phosphorylation of a single site not detectable in our assay system.

This 1996 study (the full text is free), entitled "Testosterone Up-Regulates Androgen Receptors... of Porcine Myogenic Satellite Cells in Vitro" concluded:

In summary, we demonstrate that cultured satellite cells and myotubes possess AR [androgen receptors], which are up-regulated in response to testosterone.

This 1999 paper, entitled "Effects of anabolic steroids on the muscle cells of strength-trained athletes" stated:

Enhanced satellite cells stimulation would provide more nuclei to the muscle fibers. Because androgen receptors are located in the myonucleus (23,38,47), the increased nuclear number would also give rise to an elevation of the number of androgen binding sites, thus making the muscle more susceptible to the anabolic compounds.

This 1999 study (free text), entitled "Effects of castration and androgen treatment on androgen-receptor levels in rat skeletal muscles" spoke to bodybuilders saying:

It is intriguing to speculate that the upregulation of AR levels via the administration of pharmacological amounts of androgens might convert some muscles that normally have a minor or no response to muscles with enhanced androgen responsiveness.

Because athletes may self administer synthetic androgens for many months or years at even higher doses than used in this study (17), it is possible that upregulation of AR levels might be an important part in the anabolic effects of androgen abuse.

In this 2004 study (free full text), the title says it all: "Androgen Receptor in Human Skeletal Muscle and Cultured Muscle Satellite Cells: Up-Regulation by
Androgen Treatment". They concluded:

In summary, although multiple cell types within the human skeletal muscle express AR protein, satellite cells, and myonuclei are the predominant sites of AR expression. ARs aggregate within the nucleoli of satellite cells and myonuclei. Testosterone and DHT up-regulate AR expression in vivo and in vitro.

And finally, this 2005 paper (free full text), entitled "Androgen regulation of satellite cell function" couldn't have made it any more explicit:

Increase in AR levels: Up-regulation of AR levels is one of the documented responses to androgens in target tissues or organs. Up-regulation of AR levels by androgen treatment in skeletal muscle has been observed in rat and human (Antonio et al. 1999, Kadi et al. 2000, Lee et al. 2003). The auto-regulation of AR levels by androgens may occur through stabilizing existing receptors or by increasing de novo receptor synthesis (Kadi et al. 2000). Up-regulation of AR levels by androgens could be one mechanism by which androgens have effects on muscle.

The increase in AR levels with androgen treatment has been demonstrated in satellite cells in pig (Doumit et al. 1996). This study clearly demonstrated the presence and auto-regulation of AR in satellite cells and also myotubes. Immunoblot analysis revealed that AR expression in satellite cells and myotubes was up-regulated in response to testosterone. Moreover, immunocytochemical staining for AR was more intense in the nuclei of satellite cells and myotubes from androgen-treated cells. Because the AR is
located in the myonucleus, the increased nuclear number could potentially give rise to an elevation in the number of androgen binding sites (Kadi et al. 1999). Taken together, these data suggest that androgens may have effects on satellite cells through up-regulation of AR levels in satellite cells, which could enhance the sensitivity of satellite cells to androgens.

I'm sure if I looked around I could find more references, but that should get my point across. So what do you think? Legal Gear tells us that "Doing a cycle of steroids like Sustenon, Deca or D-Bol will make your androgen receptor down-regulate over time." Are they being honest with you? Do anabolic steroids down-regulate the androgen receptor? Or are they just completely ignorant of the research? Either way, it doesn't look very good for them. They were certainly right when they said "LG Sciences UNLEASHES ANOTHER BOMB, by bringing you RECEPTOR." But this bomb is going off in their face, for using dishonest marketing. Shameful...

Discuss.

[Uninspired123]

Pwned!

[Shal]

wow nice catch! Love to hear what LG have to say about this

[212121]

All companys have products that are a fraud

[m1k3g0rd]

A supplement company misrepresenting their products? No way....

[hooker]

It was even better a decade ago when Bill Roberts was the first person to point this out.

[seven11]

something tells me that this thread will be delete or the company will threaten to sue.....

[samsam12341]

Great thread Conc. News to me! Thanks for pointing all that info out. Reps!

Sam

[Conciliator]

Originally Posted by seven11

something tells me that this thread will be delete or the company will threaten to sue.....

I'd love to go to court with them. I'll file a counter lawsuit for false advertising.

[Uninspired123]

nice thrad

[dan7681]

Yeah I've seen this mentioned several times.. think there were a couple threads on this a while back

[mudbug45]

Great post Conciliator... What do you expect from company that have "legal" somewhere in the name. Its all a fraud!

[bredfan]

Good post. Although I can't say I'm surprised.

I pretty much stopped paying attention to LG once VS started carrying their products.

Not that VS carrying a product is a bad thing. It's because if LG's products were actually close to what they claim them to be, they wouldn't be carried at VS.

That, and I really despise their marketing. The "bonus newspaper" packed with this month's MD was beyond pathetic.

[Conciliator]

Originally Posted by hooker

It was even better a decade ago when Bill Roberts was the first person to point this out.

And it was even better than that before AR started disseminating his bull**** across the boards.

And no, I'm not talking about the androgen receptor.

[G.W. Hayduke]

lmao

[Uninspired123]

Originally Posted by hooker

It was even better a decade ago when Bill Roberts was the first person to point this out.

lol anthony roberts haha you're a moron

ok continue thread

[dangetinthere]

You know Legal Gear doesn't come here anymore. Form my understanding they are used to people talking bad about their products but yet their sales are still high, so they don't care. Thats coming from my lips though.(which doesn't mean much)

[deserusan]

pwned!

[Eightpak]

Originally Posted by m1k3g0rd

A supplement company misrepresenting their products? No way....

This is more than mis-representing. They're saying the complete opposite of what science says. You got to be kidding me. I will never touch a LG supp.

[Xc]

Interesting. I would like to hear what LG has to say in response.

[deserusan]

Originally Posted by Xc

Interesting. I would like to hear what LG has to say in response.

We are still waiting for the MHP rep to bring those studies he promised us too.

[Uninspired123]

Originally Posted by Xc

Interesting. I would like to hear what LG has to say in response.

lol LG's response


*tumbleweed rolls by

[DrnkMnky]

Originally Posted by 212121

All companys have products that are a fraud

False.

[GeneGnomeX]

Originally Posted by hooker

It was even better a decade ago when Bill Roberts was the first person to point this out.

Yeah I pointed his article out in the original Receptor thread: http://www.mesomorphosis.com/article...regulation.htm

LG stated that it was out of date.

[deserusan]

Originally Posted by Uninspired123

*tumbleweed rolls by

http://www.youtube.com/watch?v=awskKWzjlhk

I love the soundtrack to this!

[Conciliator]

Originally Posted by fitnecise

Yeah I pointed his article out in the original Receptor thread: http://www.mesomorphosis.com/article...regulation.htm

LG stated that it was out of date.

Oh, that's a good link. I haven't seen that. Thanks.

[Conciliator]

Originally Posted by fitnecise

LG stated that it was out of date.

I wonder if they'd try to claim that the 2005 research I posted above is out of date as well. Regardless, they'll need some counter evidence. You don't just discount research you don't like by saying "it's too old."

[Deja_Entendu]

Good thread and very interesting. I've always has my doubts about LG products.

[OUTLAW210]

AWESOME Thread... Of course they dont care what this board thinks.. they are onto bigger and better things..

The one thing they should remember is that LG was built by bb.com, how soon they forget. 3 or 4 years...

Nice research..

[Conciliator]

Originally Posted by OUTLAW210

AWESOME Thread... Of course they dont care what this board thinks.. they are onto bigger and better things..

The one thing they should remember is that LG was built by bb.com, how soon they forget. 3 or 4 years...

Nice research..

Thanks.

What do you mean "LG was built by bb.com"?