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  1. #1
    UCLA Rep bigguy66's Avatar
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    Grape Seed Extract

    Hey guys I was at my local supp store and they had this on sale so I picked some up. I have seen peopla on here saying that it is a good anti-estrogen. Is this true and what is the main reason for supping with it? Did I waste my money or can I benefit from supping with it? Thanks
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  2. #2
    nevigsawkufelgnisaton in10city's Avatar
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    Originally Posted by bigguy66 View Post
    Hey guys I was at my local supp store and they had this on sale so I picked some up. I have seen peopla on here saying that it is a good anti-estrogen. Is this true and what is the main reason for supping with it? Did I waste my money or can I benefit from supping with it? Thanks
    I don't know about the anti-estrogen impact, but I do know that it's a good anti-oxidant. So no, it's not a waste of money (but that depends on what else you are taking too).
    It is the mark of an educated mind to be able to entertain a thought without accepting it.
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    Originally Posted by bigguy66 View Post
    Hey guys I was at my local supp store and they had this on sale so I picked some up. I have seen peopla on here saying that it is a good anti-estrogen. Is this true and what is the main reason for supping with it? Did I waste my money or can I benefit from supping with it? Thanks
    I cannot speak highly enough about grape seed extract. It's a powerfull antioxidant as well as a very effective way to attenuate inflammation.

    GSE is also a potent suppressor of aromatase expression amongst other things.
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  4. #4
    UCLA Rep bigguy66's Avatar
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    Originally Posted by NO HYPE View Post
    I cannot speak highly enough about grape seed extract. It's a powerfull antioxidant as well as a very effective way to attenuate inflammation.

    GSE is also a potent suppressor of aromatase expression amongst other things.
    How much do you reccomend I take a day? And when, just in the morning, etc? Thanks
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    Originally Posted by bigguy66 View Post
    How much do you reccomend I take a day? And when, just in the morning, etc? Thanks
    I take anywhere between 250-500 mg a day (but I am using it to attenuate inflammation), usually taken twice.

    I would say around 250 mg a day would be sufficient for most.
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  6. #6
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    Originally Posted by NO HYPE View Post
    I take anywhere between 250-500 mg a day (but I am using it to attenuate inflammation), usually taken twice.

    I would say around 250 mg a day would be sufficient for most.
    Do you happen to know the reasoning behind some of the dosing recommendations that have the dosing higher initially, then reduced after a period of time?
    It is the mark of an educated mind to be able to entertain a thought without accepting it.
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    Originally Posted by in10city View Post
    Do you happen to know the reasoning behind some of the dosing recommendations that have the dosing higher initially, then reduced after a period of time?
    No.... but if you happen to find out why, could you please update this thread?

    I would like to hear the reasoning behind that theory.
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  8. #8
    Registered User LJ57's Avatar
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    It's most effective when taken with other anti-estrogenic ingredients.
    "From apes or sons of God, let every act be sacred. " Killing Joke
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  9. #9
    nevigsawkufelgnisaton in10city's Avatar
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    Originally Posted by NO HYPE View Post
    No.... but if you happen to find out why, could you please update this thread?

    I would like to hear the reasoning behind that theory.
    The only "bro-science" reasoning I've been able to find is that an initial loading phase is used to saturate the tissues with the Oligomeric Proanthocyanidins. It's water-soluble though...
    It is the mark of an educated mind to be able to entertain a thought without accepting it.
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  10. #10
    Lets Go Dbacks! sonicology's Avatar
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    Originally Posted by LJ57 View Post
    It's most effective when taken with other anti-estrogenic ingredients.
    I suggest taking it with resveratrol - this excellent NOW product contains grape seed extract, resveratrol and green tea extract at a very reasonable price;

    NOW Natural Resveratrol
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  11. #11
    Registered User dpihitithard's Avatar
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    Nice i need to get my hands on some anti's... How much does that grape seed cost BTW?
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  12. #12
    UCLA Rep bigguy66's Avatar
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    Originally Posted by sonicology View Post
    I suggest taking it with resveratrol - this excellent NOW product contains grape seed extract, resveratrol and green tea extract at a very reasonable price;

    NOW Natural Resveratrol
    Thanks!

    Originally Posted by dpihitithard View Post
    Nice i need to get my hands on some anti's... How much does that grape seed cost BTW?
    I got mine for $8 for 100 150mg tabs
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  13. #13
    UCLA Rep bigguy66's Avatar
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    Originally Posted by LJ57 View Post
    It's most effective when taken with other anti-estrogenic ingredients.
    Like what?
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  14. #14
    UCLA Rep bigguy66's Avatar
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    bump
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  15. #15
    nevigsawkufelgnisaton in10city's Avatar
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    An article I found with the uncited load-maintenance dose recommendation as well as GSE's other benefits including the AE effects ... Grape Expectations (Suppression of Estrogen Biosynthesis by Procyanidin Dimers in Red Wine and Grape Seeds) .

    Besides the "bro-science" reason, the dosing recommendation origin was probably born in part from research done by Bagchi with higher amounts and the maintenance weight-dose recommendation he's given.
    It is the mark of an educated mind to be able to entertain a thought without accepting it.
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  16. #16
    Alpha Red Catch39's Avatar
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    Guys I bought GSE and the bottle says to take two capsules daily (100 mg) but is it OK if I take about 6-8 capsules (300-400 mg) to reduce inflamation?
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    Originally Posted by Catch39 View Post
    Guys I bought GSE and the bottle says to take two capsules daily (100 mg) but is it OK if I take about 6-8 capsules (300-400 mg) to reduce inflamation?
    I have taken up to 400mg with no side effects, but I keep my maintenance dosage at around 250mg. What else are you taking to attenuate inflammation? Does your supplement contain 95% OPC's (Oligomeric Proanthocyanidin's)?
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    Originally Posted by NO HYPE View Post
    I have taken up to 400mg with no side effects, but I keep my maintenance dosage at around 250mg. What else are you taking to attenuate inflammation? Does your supplement contain 95% OPC's (Oligomeric Proanthocyanidin's)?
    ill double check, but I think it is 95 percent. Reps for your help, and also one more thing. If I'm taking 6 capsules a day, when should I take them, and should I spread them out? thanks alot
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    Originally Posted by Catch39 View Post
    ill double check, but I think it is 95 percent. Reps for your help, and also one more thing. If I'm taking 6 capsules a day, when should I take them, and should I spread them out? thanks alot
    Well.... that's 300mg, and I take 250mg twice a day (morning/night).

    Does that help?
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  20. #20
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    Since I have the research on hand (having put it into my latest product, CyoGenX), here's some cool stuff on GrapeSeedExtract (Procyanidin), from various human, in situ, in vitro, and in vivo studies:

    • Inhibits the Aromatase Enzyme (prevents testosterone from converting to estrogen at the genetic level, preventing both transcription and expression of Aromatase) [1-4]

    • Acts similarly to Letrozole (a prescription Aromatase Inhibitor), and can destroy breast tumor tissue (gynecomastia) [1]

    • Has anabolic properties (Inhibits the Glucocorticoid Receptor, thus allowing more muscle to be built)[4]

    • Has Anti-Hypertensive properties [5]

    • Improves Cognitive Function [5]

    • Lowers LDL Cholesterol [6]

    • Is a strong Anti-Oxidant (stronger than vitamin C or E) [6]

    . Grape seed extract is an aromatase inhibitor and a suppressor of aromatase expression. Cancer Res. 2006 Jun 1;66(11):5960-7.

    2. Suppression of Estrogen biosynthesis by procyanidin dimmers in red wine and grape seeds. Cancer Res. 2003 Dec 1;63(23):8516-22.

    3. Suppression of aromatase (estrogen synthetase) by red wine phytochemicals. Breast Cancer Res. Treat., 67: 133-146, 2001

    4. Modulation of aromatase gene expression by grape seed extract. Ikuko Kijima, et al. City of Hope, Durante, CA.

    5. Antihypertensive and cognitive effects of grape polyphenols in estrogen-depleted, female, spontaneously hypertensive rats. Am J Physiol Regul Integr Comp Physiol. 2005 Sep;289(3):R771-5.

    6. Concentrated red grape juice exerts antioxidant, hypolipidemic, and antiinflammatory effects in both hemodialysis patients and healthy subjects. Am J Clin Nutr. 2006 Jul;84(1):252-62.Am J Clin Nutr. 2006 Jul;84(1):252-62.
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  21. #21
    Registered User runningman4's Avatar
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    I always see GSE used as an antioxidant in NO products, and just assumed it was only used for cleaning up free radicals. So are you saying that all of us using NO products that contain GSE are also taking anti-estrogens?

    I am sort of worried about this actually. Is there any chance that once I cycle off of my current NO supplement (Animal Pump) that contain GSE, I could get a rebound and get Gyno?
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  22. #22
    Anthony Roberts hooker's Avatar
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    Originally Posted by sonicology View Post
    I suggest taking it with resveratrol
    As do I...

    I put Resveratrol and GSE into an anti-estrogen product with another AI (Stinging Nettle)...

    My advice is to figure out how much of each you want, and find the best product for the money. I didn't do the math, but hopefully the GSE/Res/SN product I put out with PF is priced competitively with others, and has what people are looking for, dosage-wise.
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  23. #23
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    Originally Posted by hooker View Post
    As do I...

    I put Resveratrol and GSE into an anti-estrogen product with another AI (Stinging Nettle)...

    My advice is to figure out how much of each you want, and find the best product for the money. I didn't do the math, but hopefully the GSE/Res/SN product I put out with PF is priced competitively with others, and has what people are looking for, dosage-wise.
    Found this too...

    http://www.ncbi.nlm.nih.gov/pubmed/16740737

    Any newer info on GSE as an AI? Would it be safe to take daily & not cycle it if used as an AI?
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  24. #24
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    Question for No_Hype

    Have you seen any studies regarding the anti-inflammatory effects of GSE on muscle growth, what is its MOA?

    I realize that even the issue of NSAIDs affecting muscle growth is a somewhat hotly debated topic, Input would be appreciated.
    CPT, CEO, R&D
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    Originally Posted by FoolontheHill View Post
    Have you seen any studies regarding the anti-inflammatory effects of GSE on muscle growth, what is its MOA?
    I honestly do not believe there are any.
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    Originally Posted by FoolontheHill View Post
    I realize that even the issue of NSAIDs affecting muscle growth is a somewhat hotly debated topic, Input would be appreciated.
    In terms of antioxidants and bodybuilding, while baseline ROS generation is of physiological benefit to muscle growth, the higher the level of ROS, the greater the dysruption of myogenic fusion and/or regeneration [1]. This suggests that ROS attenuation [via nutritional supplementation] aquires the ability to benefit and/or speed the recovery process.

    [1] Zaccagnini et al. (2007) J. Biol. Chem., Vol. 282, Issue 43, 31453-31459
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  27. #27
    The Olympian Myth Heracles25's Avatar
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    I have looked into the Now Foods product many times but never bought. It does look awesome. Now would it be cool to take this daily indefinitely? I am not looking for test boosting from TR but overall health. Also how would taking TR daily affect a natural test boosting product?
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    Originally Posted by Heracles25 View Post
    Now would it be cool to take this daily indefinitely?
    Well cycle everything on and off once in a while, but yeah.... definitely a beneficial nutrient worth taking.
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  29. #29
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    I have taken this stuff for a long time, just because it's such a powerful antioxidant that's extremely good for your overall health, especially your heart and blood vessels.

    I learned a while back that it helps stimulate collagen synthesis.

    Now I learn that it has anti-estrogenic properties? This **** keeps gettin better and better.

    I use nutra planet's grape seed extract powder.
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  30. #30
    The Olympian Myth Heracles25's Avatar
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    Originally Posted by NO HYPE View Post
    Well cycle everything on and off once in a while, but yeah.... definitely a beneficial nutrient worth taking.
    Nice. Thanks for the reply.
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