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  1. #1
    Registered User htime's Avatar
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    pseudoephedrine and ephedrine

    What is the difference? I've been taking the cold tabs for years and never really notice the 'effects'. (high body temp, heart rate..etc)

    Thanks!
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  2. #2
    Registered User chris587's Avatar
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    Most cold tabs have such a low amount of pseudoephedrine so you never feel them.

    If you want an OTC "cold pill" that you will feel then get Vasopro ephedrine HCL.
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  3. #3
    Registered User htime's Avatar
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    Thanks.
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  4. #4
    Registered User MusclesFlyers's Avatar
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    Yes, Vasapro Ephedrine HCL is synthetically produced..Many people have reported a much smoother, cleaner, and actually stronger effect on ephedrine HCL..plus the price is unbeatable and tis not getting banned
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  5. #5
    Registered Broscientist Black_Spit's Avatar
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    Cold medicines do not have a small amount in them. They generally have 25 mg Pseudoephedrine Hcl per serving. I read a study(don't remember where I found it or where it was conducted) that stated that the pseudo form does not have the same cns effects as ephedra/ephedrine.
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  6. #6
    Registered User mimo's Avatar
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    i thought cold drugs were low in ephedrine. but i could be wrong
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  7. #7
    Registered User chris587's Avatar
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    Originally posted by Black_Spit
    Cold medicines do not have a small amount in them. They generally have 25 mg Pseudoephedrine Hcl per serving. I read a study(don't remember where I found it or where it was conducted) that stated that the pseudo form does not have the same cns effects as ephedra/ephedrine.
    Thanks for the clarification.
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  8. #8
    Registered User laz's Avatar
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    Psuedoephedrine and ephedrine effect the CNS differently! Psuedo is not a stimulant! Bada bing Bada boom.
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  9. #9
    Registered User |2e|3eL's Avatar
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    guys is there still a more powerful HCL product on the market (i.e. a pure ephedrine HCL w/o the guafinsin sp?)?
    I drank too much beer in college and now it is time to get back to business...
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  10. #10
    Registered Broscientist Black_Spit's Avatar
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    Originally posted by chris587
    Thanks for the clarification.
    You bet. I have 2 young kids that were sick a lot this winter(my wife, too), and I have a habit of reading every bottle I come across, so I got to know these very well.
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  11. #11
    Registered User htime's Avatar
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    Thanks for the info! Helps alot.
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  12. #12
    Senior Member factzone's Avatar
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    Let's clear things up here. There are numerous ephedrine alkaloids.
    (-) ephedrine
    (+) pseudoephedrine
    (-) methylephedrine
    (-) norephedrine
    (+) norpseudoephedrine
    (+) methylpseudoephedrine

    In nature, the order of content amount in total ephedrine group alkaloids found
    in various species of ephedra is normally 1-2-4-5-3-6.

    Of the 6 main ephedrine alkaloids, I am going to discuss the two most abundant
    and popular: Ephedrine and Pseudoephedrine

    1. Ephedrine - The Alkaloid ephedrine makes up 30% to 90% of total ephedrine
    group alkaloids in ephedra. Ephedrine is not as good as caffeine at stimulating
    the CNS, but when combined with caffeine, the two work in synergy because
    ephedrine prevents the break down of epinephrine released by the caffeine,
    enhancing caffeine's CNS stimulating effects.

    Ephedrine is probably the most effective herbal alkaloid at stimulating a
    non-active Sympathetic Nervous System (SNS). Obesity can be directly linked to
    an inactive SNS. Ephedrine has been proven to increase in weight loss for obese
    individuals, but has no effect by itself in lean individuals (lean individuals
    do not need SNS stimulation, they just need CNS stimulation- put more fat in the
    blood). Caffeine by itself keeps lean individuals lean by keeping circulating
    blood lipid levels higher than normal."

    My info is below...
    Pseudoephedrine causes headaches in ~15-20% of users regardless of the dose
    ingested orally..
    The evidence/research is more than adequate for me to occasionally use
    pseudo-ephedrine hcl at ~200mg orally, 45 minutes pre-workout for its POTENT,
    very safe - stimulant/strength/power elevating effects which equate to ~90-110mg
    of Ephedrine hcl, yet with half the side-effects of ephedrine hcl.

    IMO, the studies showing no benefits from pseudoephedrine alone pre-workout were
    planned to fail just like the 25mg of ephedrine hcl pre-workout studies on
    athletes have since the 1980's.

    Using pseudo-ephedrine at over 180mg pre-workout leads to at least 75% of
    subjects significantly increasing their 30 second peak power output by over 3%
    in double-blinded placebo-controlled-randomized research. Average
    Leg-press/Squat weight for 5 reps also consistently increases by well over 8%
    after ingestion of 180-200mg of pseudoephedrine pre-workout with little to no
    side-effects...
    Why others don't seem to utilize this safe stimulant responsibly is beyond
    me...IMO, any top athlete/PL'r would pay hundreds of $$$ for a pill that can
    easily add 30-50 pounds to their 1 Rep Squat or BP Max in less than an hour.
    First time I had a stuffed up nose during a cold I broke 5 PR's in the gym in 90
    minutes after only 90mg of pseudoephedrine hcl.
    Below is one out of many abstracts showing that doses that are way to low simply
    do not increase performance.

    "IMO, the studies showing no benefits from pseudoephedrine alone pre-workout
    were planned to fail..."

    Clin J Sport Med. 2002 Nov;12(6):387-90.

    A moderate dose of pseudoephedrine does not alter muscle contraction strength or
    anaerobic power.

    Chu KS, Doherty TJ, Parise G, Milheiro JS, Tarnopolsky MA.

    Department of Medicine (Rehabilitation and Neurology), McMaster University,
    Hamilton, Ontario, Canada.

    OBJECTIVE: To investigate the effect of an acute oral administration of
    pseudoephedrine (PSE) on muscle function, fatigue, and anaerobic power output.
    DESIGN AND MATERIALS: Healthy males (N = 10) and females (N = 10) were allocated
    to receive both a placebo and PSE (120 mg) using a randomized, double-blind,
    crossover experimental design. Each subject had their maximal voluntary
    contraction strength and fatigability measured for both handgrip and ankle
    dorsi-flexion. Following the strength measurements, a 30-second maximal cycle
    test was performed to determine lower extremity anaerobic power and fatigue.
    Plasma lactate was measured before and after exercise. RESULTS: There were no
    significant differences in any of the outcome variables between the placebo and
    PSE trials. CONCLUSIONS: These results demonstrated that a 120 mg dose of PSE
    did not enhance force production, time to fatigue, fatigue index, or power
    output in young men or women. Therefore, there does not appear to be an
    ergogenic benefit from the ingestion of 120 mg PSE in high-intensity exercise
    performance.

    Publication Types:
    Clinical Trial
    Randomized Controlled Trial

    PMID: 12466695 [PubMed - indexed for MEDLINE]
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