I want to be leaf.
http://www.dailymail.co.uk/health/ar...cientists.html
|
-
01-11-2016, 10:00 PM #1
-
01-11-2016, 10:05 PM #2
-
01-11-2016, 10:15 PM #3
-
01-11-2016, 10:19 PM #4
-
-
01-11-2016, 10:41 PM #5
- Join Date: Apr 2013
- Location: Kansas, United States
- Age: 40
- Posts: 22,368
- Rep Power: 97617
for some reason i'm reminded of when Olestra was supposed to be the great savior by being a fat substitute that the body doesn't digest, thus not adding calories!
but then it gave people explosive diarrhea, because if it can't get digested, the body wants it out...Domicron's Basement Gym and Fun House
http://forum.bodybuilding.com/showthread.php?t=652376&p=1451901723&viewfull=1#post1451901723
▪█─────█▪ Equipment Crew #60
-
01-11-2016, 10:50 PM #6
-
01-12-2016, 04:03 AM #7
http://www.pnas.org/content/early/20...75113.abstract
Significance
Glycerol-3-phosphate (Gro3P) lies at the crossroads of glucose, lipid, and energy metabolism in mammalian cells and is thought to participate in glycolysis or in gluconeogenesis, lipid synthesis, and Gro3P electron transfer shuttle to mitochondria. We now report a previously unidentified pathway of Gro3P metabolism in mammalian cells with the identification of Gro3P phosphatase (G3PP) that can directly hydrolyze Gro3P to glycerol. We observed that G3PP expression level controls glycolysis, lipogenesis, lipolysis, fatty acid oxidation, cellular redox, and mitochondrial energy metabolism in β-cells and hepatocytes, as well as glucose-induced insulin secretion and the response to metabolic stress in β-cells, and in gluconeogenesis in hepatocytes. G3PP is a previously unknown player in metabolic regulation and signaling and offers a potential target for cardiometabolic disorders.
Abstract
Obesity, and the associated disturbed glycerolipid/fatty acid (GL/FA) cycle, contribute to insulin resistance, islet β-cell failure, and type 2 diabetes. Flux through the GL/FA cycle is regulated by the availability of glycerol-3-phosphate (Gro3P) and fatty acyl-CoA. We describe here a mammalian Gro3P phosphatase (G3PP), which was not known to exist in mammalian cells, that can directly hydrolyze Gro3P to glycerol. We identified that mammalian phosphoglycolate phosphatase, with an uncertain function, acts in fact as a G3PP. We found that G3PP, by controlling Gro3P levels, regulates glycolysis and glucose oxidation, cellular redox and ATP production, gluconeogenesis, glycerolipid synthesis, and fatty acid oxidation in pancreatic islet β-cells and hepatocytes, and that glucose stimulated insulin secretion and the response to metabolic stress, e.g., glucolipotoxicity, in β-cells. In vivo overexpression of G3PP in rat liver lowers body weight gain and hepatic glucose production from glycerol and elevates plasma HDL levels. G3PP is expressed at various levels in different tissues, and its expression varies according to the nutritional state in some tissues. As Gro3P lies at the crossroads of glucose, lipid, and energy metabolism, control of its availability by G3PP adds a key level of metabolic regulation in mammalian cells, and G3PP offers a potential target for type 2 diabetes and cardiometabolic disorders.You can't get much done in life if you only work on the days when you feel good.
� Jerry West �
How to Upgrade Your Life: A Primer On Diet And Fitness
https://guavarilla.wordpress.com/fitness-guide/
Bookmarks