6-OXO Raised Test levels!- and, Question for PA?

[LOWTESTOSTERONE]

http://www.ergopharm.net/page.php?pageID=17

6-OXO Research Update


6-OXO raises free testosterone levels 226%!


A study on 6-OXO was recently completed by a prestigious clinical research organization*. This study examined the blood hormone responses over a 3 week cycle of 600mg a day of 6-OXO. The study used 6 normal men aged 32-40, and in addition to tracking changes in sex hormone levels it also looked at common indicators of toxicity.

The results were very impressive. Total testosterone levels rose an average of 188%, while free testosterone levels rose an average of 226% over the course of the three weeks. The variability among the 6 subjects was quite low, and most of the testosterone increase was seen after only the first week. Results from two of the six subjects are demonstrated below.


Contrary to testosterone levels, changes in estradiol levels were slight but not statistically significant. The explanation for this is simple. 6-OXO acts to inhibit the aromatase enzyme and block the conversion of testosterone to estradiol. A consequence of this is a signal from the brain to increase production of testosterone to compensate for the blocked estradiol production. As testosterone levels increase, so do estradiol levels since more substrate has now become available for the aromatase enzyme. Basically, what has occurred is the establishment of a new baseline level of testosterone to maintain the body’s normal levels of estradiol.

This sort of hormonal response is very desirable. It is probably not healthy to lower estradiol levels below the physiologically normal range, so if we are able to raise testosterone without lowering estradiol this is great! Mind you, we don’t know what will happen if doses over 600mg a day are ingested. It could be that at higher dosages the aromatase inhibition becomes too great for increased testosterone production to overcome. In that case, a more dramatic lowering of estradiol will be seen. This is something that we probably want to avoid, at least for any longer than the short term.

No evidence of acute toxicity

A complete metabolic analysis was done examining changes in blood cells and lipids, liver function, kidney function, and immune function. No adverse changes were observed in any of these areas over the course of the three weeks. In fact, indications are that liver function actually improved slightly, and average cholesterol level dropped by about 26 points. That is an 11.6% reduction in cholesterol in 3 weeks! The explanation for this dramatic improvement is not known at this time.

Conclusion

The conclusion from all this is that 6-OXO appears to be a safe and effective way of raising the body’s own natural testosterone production. This makes it an excellent alternative to prohormones if one does not want to deal with the negatives associated with the use of these compounds. 6-OXO’s potent ability to stimulate natural testosterone production also makes it an excellent agent for bringing hormone levels back to normal after long term use of steroids or prohormones.

[LOWTESTOSTERONE]

"Contrary to testosterone levels, changes in estradiol levels were slight but not statistically significant. The explanation for this is simple. 6-OXO acts to inhibit the aromatase enzyme and block the conversion of testosterone to estradiol. A consequence of this is a signal from the brain to increase production of testosterone to compensate for the blocked estradiol production. As testosterone levels increase, so do estradiol levels since more substrate has now become available for the aromatase enzyme. Basically, what has occurred is the establishment of a new baseline level of testosterone to maintain the body’s normal levels of estradiol.

This sort of hormonal response is very desirable. It is probably not healthy to lower estradiol levels below the physiologically normal range, so if we are able to raise testosterone without lowering estradiol this is great! Mind you, we don’t know what will happen if doses over 600mg a day are ingested. It could be that at higher dosages the aromatase inhibition becomes too great for increased testosterone production to overcome. In that case, a more dramatic lowering of estradiol will be seen. This is something that we probably want to avoid, at least for any longer than the short term. "

============================

PA,

How long would you reccomend someone taking 6-OXO as a Test booster?

how long is it safe? Any long term side effects beyond say 4 weeks?

When does it stop raising Test levels?

What happens when you stop taking it? (effects on Test/ Est ratio?)

What is the reccemended dosage (how many pills) for taking it as a Test booster (not at end of cycle or anything- just start taking 6-OXO)

Does the dosage as a test booster differ from the label? Or compared to EST blocker at end of CYCLE?

[lakevillethor]

Originally posted by LOWTESTOSTERONE
http://www.ergopharm.net/page.php?pageID=17

6-OXO Research Update


6-OXO raises free testosterone levels 226%!


A study on 6-OXO was recently completed by a prestigious clinical research organization*. This study examined the blood hormone responses over a 3 week cycle of 600mg a day of 6-OXO. The study used 6 normal men aged 32-40, and in addition to tracking changes in sex hormone levels it also looked at common indicators of toxicity.

The results were very impressive. Total testosterone levels rose an average of 188%, while free testosterone levels rose an average of 226% over the course of the three weeks. The variability among the 6 subjects was quite low, and most of the testosterone increase was seen after only the first week. Results from two of the six subjects are demonstrated below.


Contrary to testosterone levels, changes in estradiol levels were slight but not statistically significant. The explanation for this is simple. 6-OXO acts to inhibit the aromatase enzyme and block the conversion of testosterone to estradiol. A consequence of this is a signal from the brain to increase production of testosterone to compensate for the blocked estradiol production. As testosterone levels increase, so do estradiol levels since more substrate has now become available for the aromatase enzyme. Basically, what has occurred is the establishment of a new baseline level of testosterone to maintain the body’s normal levels of estradiol.

This sort of hormonal response is very desirable. It is probably not healthy to lower estradiol levels below the physiologically normal range, so if we are able to raise testosterone without lowering estradiol this is great! Mind you, we don’t know what will happen if doses over 600mg a day are ingested. It could be that at higher dosages the aromatase inhibition becomes too great for increased testosterone production to overcome. In that case, a more dramatic lowering of estradiol will be seen. This is something that we probably want to avoid, at least for any longer than the short term.

No evidence of acute toxicity

A complete metabolic analysis was done examining changes in blood cells and lipids, liver function, kidney function, and immune function. No adverse changes were observed in any of these areas over the course of the three weeks. In fact, indications are that liver function actually improved slightly, and average cholesterol level dropped by about 26 points. That is an 11.6% reduction in cholesterol in 3 weeks! The explanation for this dramatic improvement is not known at this time.

Conclusion

The conclusion from all this is that 6-OXO appears to be a safe and effective way of raising the body’s own natural testosterone production. This makes it an excellent alternative to prohormones if one does not want to deal with the negatives associated with the use of these compounds. 6-OXO’s potent ability to stimulate natural testosterone production also makes it an excellent agent for bringing hormone levels back to normal after long term use of steroids or prohormones.

Thank you for posting this new revelation in the field of sports supplementation!!!

[wasntme]

Originally posted by lakevillethor
Thank you for posting this new revelation in the field of sports supplementation!!!

you have also made some great new revelations in the field of sports supplementation!!! it goes both ways.

[lakevillethor]

Originally posted by wasntme
you have also made some great new revelations in the field of sports supplementation!!! it goes both ways.

huh?
-AT

[exhortae]

6-OXO

800% more anabolic than test enanthate.



BS studies can say whatever they want, 6-OXO won't raise testosterone enough to have an impact on muscle gain.

[lakevillethor]

Originally posted by exhortae
6-OXO

800% more anabolic than test enanthate.



BS studies can say whatever they want, 6-OXO won't raise testosterone enough to have an impact on muscle gain.

I disagree - I saw decent gains on 6-OXO - nothing unreal but decent - 5 pounds in a couple weeks.
-AT

[LOWTESTOSTERONE]

Originally posted by exhortae
6-OXO

800% more anabolic than test enanthate.



BS studies can say whatever they want, 6-OXO won't raise testosterone enough to have an impact on muscle gain.

For someone with natural test level on the lower side of normal....

if it boosted it to the higher side of normal... it would produce some very reall benifits of a high test level.

[dio]

Originally posted by exhortae
6-OXO

800% more anabolic than test enanthate.



BS studies can say whatever they want, 6-OXO won't raise testosterone enough to have an impact on muscle gain.

Doubling levels would have a very noticeable result over time, especially for people who have low levels to begin with.

[LOWTESTOSTERONE]

Originally posted by dio
Doubling levels would have a very noticeable result over time, especially for people who have low levels to begin with.

This was my point- But you said it better?

[SPR1GGAN]

I believe this was sarcasm. ^_~

6-OXO is a good sup, has great uses post PH cycle as an estrogen suppresor. It's by no means NEW though.

Originally posted by lakevillethor
Thank you for posting this new revelation in the field of sports supplementation!!!

[Patrick Arnold]

Originally posted by LOWTESTOSTERONE
[B
PA,

How long would you reccomend someone taking 6-OXO as a Test booster?

how long is it safe? Any long term side effects beyond say 4 weeks?

When does it stop raising Test levels?

What happens when you stop taking it? (effects on Test/ Est ratio?)

What is the reccemended dosage (how many pills) for taking it as a Test booster (not at end of cycle or anything- just start taking 6-OXO)

Does the dosage as a test booster differ from the label? Or compared to EST blocker at end of CYCLE? [/B]

Good questions.

1) I am not sure how long 6-OXO can be used safely. I do know that after 3 weeks the toxicity profile was extremely good, and in fact some parameters improved (cholesterol, liver function).

NOw i have read of males taking aromatase inhibitors (atamastane i belive) for up to 48 weeks with no adverse effects. I cannot say for sure if 6-OXO would be safe for that time also, but there is a decent chance it might be given the fact that the short term toxicity was so good

2) Toxicity was only tested for 3 weeks. I encourage users on this board that want to take it for longer to get blood test results and report their findings here

3) It is likely that the testosterone elevation does not attenuate even after long term usage. Other aromatase inhibitors tested for long periods have all shown that the sex hormone response continues throughout the whole period of administration

4) If we can extapolate from the results from testing of other aromatase inhibitors, after discontinuation the hormone levels (test and estrogen) go back to the original baseline values. NO significant undersirable overcompensation (rebound effect) is observed

5) the only dose tested in our study was 600mg a day. As you can see from the results explained above the response was very impressive. These folks were normal men in their 30's who had not taken any hormone supplements previous to the clincial trial. I simply do not know if lower or higher doses are going to provide the same responses

6) The dosage on the bottle is probably suitable for both post cycle test recovery as well as straight up test elevation in clean athletes

[Patrick Arnold]

Originally posted by exhortae
6-OXO

800% more anabolic than test enanthate.



BS studies can say whatever they want, 6-OXO won't raise testosterone enough to have an impact on muscle gain.

This was a legitimate and well designed study. There was nothing BS about it.

I disagree that a doubling of testosterone won't help one in their training results. Yes, it may take a bit longer for an effect to be seen then with good doses of enanthate, but over the course of a few months I would be very surprised if a significant effect is not seen

6-OXO is not steroids, nor was it ever claimed to be. It is an alternative to steroids - a way to raise your own endogenous levels. This is a much safer and natural way to get the testosterone effect than prohormones or steroids. Of course it is not as potent in the short term. It is however, much better suited for long term usage than are steroid related products.

Oh, and 6-OXO actually makes your testicles bigger as opposed to prohormone and other steroidal products which can make them shrivel

Why do you have to be so antagonistic and offensive? I report facts and I make no claims beyond those that are reasonable here, do I??

[tomp]

I started 6-OXO a few days before my PH cycle was over because my nipples got puffy just in the nipple area only. I knew my E was starting to climb after approaching 50 days on this PH cycle of 1-test and 4AD.

Very next day after taking 6-OXO, I am horny as hell! Have not felt this way much even with 4AD in stack. Next day, same thing and puffy nipples starting to fade.

This stuff appears to actually work! This is one of those products that some people say will be hard to determine if it works. I am pretty convinced that it works because of the fact that my libido is coming back and puffiness is going away.

I am only taking 300mg since my cycle is still going. However, it ends tomorrow and I will bump it up to 600mg ED.

Patrick, please tell me if we should take all 6 capsules at same time with last meal or split them eqaully 12 hours apart?

[LOWTESTOSTERONE]

Originally posted by Patrick Arnold

5) the only dose tested in our study was 600mg a day. As you can see from the results explained above the response was very impressive. These folks were normal men in their 30's who had not taken any hormone supplements previous to the clincial trial. I simply do not know if lower or higher doses are going to provide the same responses

How many pills is 600mg ?

[dio]

Originally posted by LOWTESTOSTERONE
This was my point- But you said it better?

Didn't see your post. So now a good point was made twice.

[Stez]

"32-40 year olds"


Somehow I don't think it would have the same affect for 20-28 year olds...

[Patrick Arnold]

Originally posted by Stez
"32-40 year olds"


Somehow I don't think it would have the same affect for 20-28 year olds...

If anything 20-28 year olds would see more testosterone increases, as their HPTA likely are more responsive.

IN reality though, the results probably would be about the same

[tomp]

Patrick, what am I , chopped liver or somewthing? Can I please get a response to my question above. (I know the bottle says to take all 6 caps at once during last meal....)

[Patrick Arnold]

Originally posted by tomp
I started 6-OXO a few days before my PH cycle was over because my nipples got puffy just in the nipple area only. I knew my E was starting to climb after approaching 50 days on this PH cycle of 1-test and 4AD.

Very next day after taking 6-OXO, I am horny as hell! Have not felt this way much even with 4AD in stack. Next day, same thing and puffy nipples starting to fade.

This stuff appears to actually work! This is one of those products that some people say will be hard to determine if it works. I am pretty convinced that it works because of the fact that my libido is coming back and puffiness is going away.

I am only taking 300mg since my cycle is still going. However, it ends tomorrow and I will bump it up to 600mg ED.

Patrick, please tell me if we should take all 6 capsules at same time with last meal or split them eqaully 12 hours apart?

Either way is probably fine.

[tomp]

LOL, thanks Patrick!

[pu12en12g]

Originally posted by LOWTESTOSTERONE
How many pills is 600mg ?

6 pills

[MentalMuscle]

I'm not sure if I am overly impressed with 6OXO... I just finished up 2 bottles after a pretty heafty cycle of 1ad and 300 select.... I have dropped almost 7 to 8 pounds in bodyweight ( water i know) and have lost 20 to 30% of my strength.... To me, this was dissapointing..... I figured if 6 OXO was such a great test booster than how come I have lost so much???? Also I have had this pea sized rock hard tissue floating in my right nipple which hurts, to my belief, I would say this is a visible sign of gyno.... after 3 weeks of 6OXO, it has not got any smaller..... I am not trying to knock the product, cauz I have noticed that my balls have gone back to there orignal size and my sex drive has increased, but that could just be from being off the andro's for 3 weeks........ Who knows, but its safe to say that 6OXO did not do much for me...... I am a competitive bodybuilder year round so my diet in were it should be and so is my training..... I do however love all of the other products put out by Patrick and ergopharm... I just wish there where better ways of retaining gains coming of a prohormone stack......

[Dedicated1]

U should take a proven estrogen reducer and testosterone booster, after any cycle. To not take it would be stupid.

[LOWTESTOSTERONE]

Originally posted by Dedicated1
U should take a proven estrogen reducer and testosterone booster, after any cycle. To not take it would be stupid.

Yes.

Imagine if you did not take the 6-OXO

This stuff is not a miracle drug. It's a test booster/ estrogen suppressor and it works exactly as you would expect it to.

I always wondered why people bash it? What the **** do they expect it to do?

[Patrick Arnold]

Originally posted by LOWTESTOSTERONE
Yes.

Imagine if you did not take the 6-OXO

This stuff is not a miracle drug. It's a test booster/ estrogen suppressor and it works exactly as you would expect it to.

I always wondered why people bash it? What the **** do they expect it to do?

even the pharmaceutical estrogen blockers are not miracle drugs. The effects are subtle.

[Dedicated1]

I think people expect a tumor to grow out of their neck if there is a problem. That to them is a tangible problem they can see. They basically dont feel bad, so they assume everything is ok.

[LOWTESTOSTERONE]

Originally posted by Patrick Arnold
even the pharmaceutical estrogen blockers are not miracle drugs. The effects are subtle.

Then you must get frustrated when people play down your supplements as "non-effective" because they work exactly as designed and claimed.

Originally posted by Dedicated1
I think people expect a tumor to grow out of their neck if there is a problem. That to them is a tangible problem they can see. They basically dont feel bad, so they assume everything is ok.

And,

People expect miracles from supplements.

Even a hard long cycle of steroids won't product miracles if your training and diet is not good.

Most people need to re-align and reconsider thier expectations