Most potent/effective oral antioxidant product available

[Diab0lic]

My partner has rheumatoid arthritis, and after reading several studies confirming benefits of antioxidants, I'd like to get her to try something and was after advice on what would be the best single or combo product out there?

Things that spring to mind are EGCG, quercetin, sulfurophane, NAC, glutathione? I also saw a clinical trial in which pomegranate extract reduced disease activity scores significantly.

I do know these will not reverse or cure the disease but there is strong evidence for combining antioxidants with fish oil, magnesium and Vit D & B6 in RA patients which reduces pain and discomfort and need for NSAIDS, etc. Obviously there are other health benefits too,

What would you suggest?

[marcodeniro]

Alpha lipid acid from my understanding is a good antioxidant. Reservatrol is also good.

[cyneverdie]

My partner has rheumatoid arthritis, and after reading several studies confirming benefits of antioxidants, I'd like to get her to try something and was after advice on what would be the best single or combo product out there?

Things that spring to mind are EGCG, quercetin, sulfurophane, NAC, glutathione? I also saw a clinical trial in which pomegranate extract reduced disease activity scores significantly.

I do know these will not reverse or cure the disease but there is strong evidence for combining antioxidants with fish oil, magnesium and Vit D & B6 in RA patients which reduces pain and discomfort and need for NSAIDS, etc. Obviously there are other health benefits too,

What would you suggest?

Bioastin Supreme Astaxanthin 6mg x 2 (Most powerful antiox)

Boku's Matcha Tea (Super antiox) (Boku's super food is SUPER too)

Zyflamend® Whole Body x2

Take a good multi daily like Newchapter + Newchapter's fishoil

Take additional Vit D, Magnesium & zinc

OrganicIndia's Flexibility & Osteoseal Is awesome for arthritis too

[Mr.Cooper69]

My partner has rheumatoid arthritis, and after reading several studies confirming benefits of antioxidants, I'd like to get her to try something and was after advice on what would be the best single or combo product out there?

Things that spring to mind are EGCG, quercetin, sulfurophane, NAC, glutathione? I also saw a clinical trial in which pomegranate extract reduced disease activity scores significantly.

I do know these will not reverse or cure the disease but there is strong evidence for combining antioxidants with fish oil, magnesium and Vit D & B6 in RA patients which reduces pain and discomfort and need for NSAIDS, etc. Obviously there are other health benefits too,

What would you suggest?

There is no reason to believe antioxidant therapy will help rheumatoid arthritis. This isn't a disease of oxidative stress. It's autoimmune in nature and the treatment is centered on downregulating the immune response.

[cyneverdie]

There is no reason to believe antioxidant therapy will help rheumatoid arthritis. This isn't a disease of oxidative stress. It's autoimmune in nature and the treatment is centered on downregulating the immune response.

While I agree..inflammation factors need to be reduced...hence the products I suggested will help bigtime - as will general healthy living and a good hormone balance.
OP - Do do your research on the stuff I mentioned especially the OrganicINdia , Astaxanathin and Zyflamend

[Mr.Cooper69]

While I agree..inflammation factors need to be reduced...hence the products I suggested will help bigtime - as will general healthy living and a good hormone balance.
OP - Do do your research on the stuff I mentioned especially the OrganicINdia , Astaxanathin and Zyflamend

Antioxidants are not synonymous with anti-inflammatories. Don't give poor advice to someone with a fairly serious medical condition

[cyneverdie]

Antioxidants are not synonymous with anti-inflammatories. Don't give poor advice to someone with a fairly serious medical condition

I have not given poor advice. My dad has arthritis, my buddy has juvenile arthritis and my blood inflammation factors were sky high too.

Zyflamend is an awesome anti inflammatory...so is the organic india stuff so is the super antiox Astaxanthin !

The matcha tea is super good for you and is also kinda an anti inflammatory as are the newchapter products!

Dont comment without research too matey

[Mr.Cooper69]

I have not given poor advice. My dad has arthritis, my buddy has juvenile arthritis and my blood inflammation factors were sky high too.

Zyflamend is an awesome anti inflammatory...so is the organic india stuff so is the super antiox Astaxanthin !

The matcha tea is super good for you and is also kinda an anti inflammatory as are the newchapter products!

Dont comment without research too matey

Zyflamend is the only anti-inflammatory you listed, and I would kindly school you on rheumatoid arthritis if you'd like

[Mrsliz1724]

I have not given poor advice.

Yes you did. Very poor advice. Additionally, coop is not someone you want to enter a scientific debate with. Addtionally, neither am I... Although not at the same caliber as coop, neuron, pinch, nohype and so forth, I am one of the better informed individuals on these forums.

Again, rheumatoid is an issue of inflammation and immune disorder. Antioxidants can help general health issues but that will not effectively help with an immune disorder. When doctors and specialists at Children's in Boston actually discuss, respect, consider and make decisions with my opinion and research I do when it comes to my girlfriend and her rare, severe auto-immune disease (only 5 people in the country that have anything similar to what she has) it speaks to my knowledge on the issue. So, please understand, we are telling you the advice is not great advice in regards to the immune disorder in question and therefore, would ask you to reconsider providing said advice, especially when it comes to severe medical conditions.

[cyneverdie]

Yes you did. Very poor advice. Additionally, coop is not someone you want to enter a scientific debate with. Addtionally, neither am I... Although not at the same caliber as coop, neuron, pinch, nohype and so forth, I am one of the better informed individuals on these forums.

Again, rheumatoid is an issue of inflammation and immune disorder. Antioxidants can help general health issues but that will not effectively help with an immune disorder. When doctors and specialists at Children's in Boston actually discuss, respect, consider and make decisions with my opinion and research I do when it comes to my girlfriend and her rare, severe auto-immune disease (only 5 people in the country that have anything similar to what she has) it speaks to my knowledge on the issue. So, please understand, we are telling you the advice is not great advice in regards to the immune disorder in question and therefore, would ask you to reconsider providing said advice, especially when it comes to severe medical conditions.

Not claiming to have medical knowledge and I appreciate the knowledge- Thank you!...BUT as I said these products help. Astaxanthin is an anti inflammatory as is Organic India's Complete Flexibility. People I know even with terminal autoimmune issues aka rh arthritis have taken these products and it does help grip strength etc (to open doors!) and hence quality of life does improve.

Its safe its natural...speak to your Dr and try these out for 3 months...its a small price to pay.

[DR_P]

Skimming through a bunch of controlled clinical trials (=in humans), CLA and curcumin deemed somewhat promising. Trials using clssical "antioxidants", however, did not turn out favorable effects.
On a personal note, though, these "favorable" studies on CLA and curcumin were just one trial each, with small patient groups. Before drawing any conclusions, these results would thus first need to be confirmed by other scientific workgroups. Especially the finding that curcumin was more effective than a moderate dose of diclofenac made me raise an eyebrow... These results may encourage new studies but they are far from being conclusive.


CLA

Int J Rheum Dis. 2009 Apr;12(1):20-8. doi: 10.1111/j.1756-185X.2009.01374.x.
Effect of conjugated linoleic acids, vitamin E and their combination on the clinical outcome of Iranian adults with active rheumatoid arthritis.
Aryaeian N1, Shahram F, Djalali M, Eshragian MR, Djazayeri A, Sarrafnejad A, Salimzadeh A, Naderi N, Maryam C.
Author information
Abstract
BACKGROUND:

Despite beneficial effects of conjugated linoleic acids (CLAs) in animal studies, there is little information on their effects on human inflammatory and autoimmune diseases.
AIM:

To investigate the effects of CLAs as an adjuvant therapy on the clinical manifestations of rheumatoid arthritis (RA) in adults with an active disease.
METHODS:

In a randomized, double-blind placebo-controlled trial, 87 patients with active RA were divided into four groups receiving one of the following daily supplements for 3 months: group C: CLAs 2.5 g equivalent to 2 g mixture of cis 9-trans 11 and trans 10-cis12 CLAs at a rate of 50/50; group E: vitamin E: 400 mg; group CE: CLAs and vitamin E at above doses; group P: placebo. Serum alpha-tocopherol was determined by high-performance liquid chromatography. Clinical data was determined by physician examination and filling the questionnaire by interview. Complete blood count (CBC), erythrocyte sedimentation rate (ESR), C-Reactive protein (CRP) and rheumatoid factor (RF) were measured in each patient. DAS28 (diseases activity score) was also determined.
RESULTS:

A 3-month supplementation resulted significant reduction in DAS28, pain and morning stiffness in the groups C and CE compared with group P (P < 0.05). Compared with the baseline, ESR levels decreased significantly in the groups C (P < or = 0.05), E (P < or = 0.05) and CE (P < or = 0.001). Group CE had significantly lower ESR levels than group P (P v 0.05). CRP dropped non-significantly in all four groups (P > 0.1). The reduction of white blood cell count was significant in group CE compared with other groups (P < 0.05). Decrease in platelet count was non-significant in groups CE, C, and E. Changes in RF, body mass index, red blood cell count and hemoglobin were not significant in four groups, while RF decreased non-significantly in groups CE and E. In comparison with the baseline, alpha-tocopherol increased significantly in groups C (P < or = 0.05), E (P < or = 0.01) and CE (P < or = 0.001) and in groups E and CE compared with group P.
CONCLUSION:

CLA supplementation resulted in significant improvement in clinical manifestation among RA patients and may be useful in their treatments.

CURCUMIN

Phytother Res. 2012 Nov;26(11):1719-25. doi: 10.1002/ptr.4639. Epub 2012 Mar 9.
A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis.
Chandran B1, Goel A.
Author information
Abstract

Curcumin is known to possess potent antiinflammatory and antiarthritic properties. This pilot clinical study evaluated the safety and effectiveness of curcumin alone, and in combination with diclofenac sodium in patients with active rheumatoid arthritis (RA). Forty-five patients diagnosed with RA were randomized into three groups with patients receiving curcumin (500 mg) and diclofenac sodium (50 mg) alone or their combination. The primary endpoints were reduction in Disease Activity Score (DAS) 28. The secondary endpoints included American College of Rheumatology (ACR) criteria for reduction in tenderness and swelling of joint scores. Patients in all three treatment groups showed statistically significant changes in their DAS scores. Interestingly, the curcumin group showed the highest percentage of improvement in overall DAS and ACR scores (ACR 20, 50 and 70) and these scores were significantly better than the patients in the diclofenac sodium group. More importantly, curcumin treatment was found to be safe and did not relate with any adverse events. Our study provides the first evidence for the safety and superiority of curcumin treatment in patients with active RA, and highlights the need for future large-scale trials to validate these findings in patients with RA and other arthritic conditions.

ANTIOXIDANTS

J Am Coll Nutr. 2009 Feb;28(1):56-62.
Effects of antioxidant supplements intervention on the level of plasma inflammatory molecules and disease severity of rheumatoid arthritis patients.
Bae SC1, Jung WJ, Lee EJ, Yu R, Sung MK.
Author information
Abstract
OBJECTIVE:

Excess generation of reactive oxygen species in damaged joints accelerates inflammatory responses in RA (rheumatoid arthritis) patients. The complementary effects of dietary antioxidant supplementation on the blood level of inflammatory mediators and the severity of the disease in RA patients were evaluated. Study Design and Settings: The study was conducted as a randomized, placebo-controlled, double-blind, three-treatment cross-over design trial. The participants visited the hospital as outpatients.
SUBJECTS:

Twenty patients meeting the 1987 criteria for the classification of rheumatoid arthritis completed the study.
INTERVENTIONS:

The subjects were randomized in three groups to receive one of following supplementation; quercetin+vitamin C (166 mg+133 mg/capsule), alpha-lipoic acid (300 mg/capsule) or placebo for 4 weeks (3 capsules/day). Each treatment period consisted of 4 weeks with 2 weeks of wash-out period before the subject starts next supplementation. Outcome Parameters: Serum levels of tumor necrosis factor-alpha(TNF-alpha), interleukin-1beta(IL-1beta), interleukin -6(IL-6), and C-reactive protein (CRP) were measured. The severity of disease was evaluated using Korean Health Assessment Questionnaire(KHAQ) and Visual Analogue Scale(VAS). Nutrient intake was measured at baseline and at the end of each intervention period.
RESULTS:

The mean energy and nutrient intakes remained constant during study period. No significant differences were found in the serum concentrations of pro-inflammatory cytokines and CRP between treatments. The scores of disease severity measurements were not significantly different between treatments, although quercetin supplementation had a tendency to reduce VAS.
CONCLUSIONS:

Dietary supplementation of antioxidants at 900 mg/day for 4 weeks did not change the blood biomarkers of inflammation and disease severity of RA patients under conventional medical treatments. Further considerations for dose-response relationships, duration of supplementation, and susceptible biomarkers are required.

There are also trials on Vitamin E and fish oil, all of which were fairly disappointing.

[j.hov85]

Zyflamend is the only anti-inflammatory you listed, and I would kindly school you on rheumatoid arthritis if you'd like

out of curiosity, i've read several studies stating that Fish oil (high in EPA and DHA from a high quality low heavy metal source) has shown to be a potent natural anti-inflammatory; is this not accurate?

Hundreds of studies suggest that omega-3s may provide some benefits to a wide range of diseases: cancer, asthma, depression, cardiovascular disease, ADHD, and autoimmune diseases, such as rheumatoid arthritis.

Source

[Mr.Cooper69]

out of curiosity, i've read several studies stating that Fish oil (high in EPA and DHA from a high quality low heavy metal source) has shown to be a potent natural anti-inflammatory; is this not accurate?



Source

The metabolism of omega 3s promotes reduced inflammation and reduced triglycerides. But it is more of a balance-type thing. Consuming an excess of fish oil will yield no benefit; rather, gradual chronic intake (with balanced intake of opposing fatty acids) is the key.

[_NimbusTim_]

Yes you did. Very poor advice. Additionally, coop is not someone you want to enter a scientific debate with. Addtionally, neither am I... Although not at the same caliber as coop, neuron, pinch, nohype and so forth, I am one of the better informed individuals on these forums.

Again, rheumatoid is an issue of inflammation and immune disorder. Antioxidants can help general health issues but that will not effectively help with an immune disorder. When doctors and specialists at Children's in Boston actually discuss, respect, consider and make decisions with my opinion and research I do when it comes to my girlfriend and her rare, severe auto-immune disease (only 5 people in the country that have anything similar to what she has) it speaks to my knowledge on the issue. So, please understand, we are telling you the advice is not great advice in regards to the immune disorder in question and therefore, would ask you to reconsider providing said advice, especially when it comes to severe medical conditions.

Not claiming to have medical knowledge and I appreciate the knowledge- Thank you!...BUT as I said these products help. Astaxanthin is an anti inflammatory as is Organic India's Complete Flexibility. People I know even with terminal autoimmune issues aka rh arthritis have taken these products and it does help grip strength etc (to open doors!) and hence quality of life does improve.

Its safe its natural...speak to your Dr and try these out for 3 months...its a small price to pay.

As MrSliz said, it's just not the case. He could have easily agreed with you about the Astaxanthin as he works for a Company (Nimbus Nutrition) who just released a very scientifically based product called Cadence which is comprised of AstaReal which is the best Astaxanthin product on the market. Instead, he chose not to as it just doesn't fit into what the opening poster needs. Nick is very knowledgeable in this respect as his girlfriend deals with these issues daily.

With that said, Coop and Nick both mean no harm with their post.

[Diab0lic]

I currently have her taking the best quality I can find of the following, which has definitely helped her with her symptoms and emergency medication requirements. I know I am not going to cure her, I am just trying to reduce her symptoms and need for medications. There is evidence for all of these either in directly alleviating the symptoms and even underlying processes of RA, or the progressive and/or extra-articular symptoms and bone health. In addition they should provide some benefit against adverse effects of some medications and are generally considered good for overall health and reducing many general risk factors anyway.

EGCG (green tea extract)
Fish Oil
Calcium/Vit D/Mg/Zn
Curcumin (with bioperine)
Probiotics
B complex

I've found studies for all of these and while the evidence for some is not robust in directly treating RA symptoms/disease, it's not a bad stack to be taking. I've also got her into resistance and aerobic exercise more as this has been shown to be beneficial in treating most of the symptoms of RA with no deleterious effect on disease progression noted anywhere I can see.

Working on her diet now