New Study links High Protein to death, cancer, disease.

[MollyBrah]

http://www.cell.com/cell-metabolism/...0062-X#Summary

Highlights:
-High protein intake is linked to increased cancer, diabetes, and overall mortality
-High IGF-1 levels increased the relationship between mortality and high protein
-Higher protein consumption may be protective for older adults
-Plant-derived proteins are associated with lower mortality than animal-derived proteins

Summary

Mice and humans with growth hormone receptor/IGF-1 deficiencies display major reductions in age-related diseases. Because protein restriction reduces GHR-IGF-1 activity, we examined links between protein intake and mortality. Respondents aged 50�65 reporting high protein intake had a 75% increase in overall mortality and a 4-fold increase in cancer death risk during the following 18 years. These associations were either abolished or attenuated if the proteins were plant derived. Conversely, high protein intake was associated with reduced cancer and overall mortality in respondents over 65, but a 5-fold increase in diabetes mortality across all ages. Mouse studies confirmed the effect of high protein intake and GHR-IGF-1 signaling on the incidence and progression of breast and melanoma tumors, but also the detrimental effects of a low protein diet in the very old. These results suggest that low protein intake during middle age followed by moderate to high protein consumption in old adults may optimize healthspan and longevity.

[shorkey]

Source: cell.com

No thanks molly

[MollyBrah]

Source: cell.com

No thanks molly

are you retarded? **** is all over the news and cell is a peer-reviewed journal you glorious winged *******.

[Nestoran]

Each year some studies says something is bad.

I bet for every food there is a study that will provide that a certain food is dangerous.


MEH

[Magnumtripod]

So what exactly doesn't lead to death, cancer and disease these days

[delinquent95]

so its got nothing to do with us youngins aye? sweet as

[Realityy]

First it was high fat diets, then high carbs, and now it's high protein.

Conflicting evidence and studies everywhere. Ignore and YOLO.

[Lexira]

Oooomaaaaaagaaaaad

[MollyBrah]

So what exactly doesn't lead to death, cancer and disease these days

most research points to a high carb and high protein intake. fats seem to be the safer evil of the two.

[MollyBrah]

so its got nothing to do with us youngins aye? sweet as

no, idiot what and how you eat now affects you later on.

>implying young people dont get cancer
>implying western diet doesnt have highest rates of disease

[wisdommaster1]

"Subjects with high protein consumption also had a 60% reduction in cancer mortality"


theres so many factors not accounted for that I cant take this credibly

I'm out

[MollyBrah]

"Subjects with high protein consumption also had a 60% reduction in cancer mortality"

only for 65 older, dont take **** out of context inbred.

hahaha misc arm-chair scientists think they are smarter than studies. im out.


>"High-protein" diet group more than 8 times as likely to report a history of diabetes
>"High-protein" diet group twice as likely to report they've changed their diet for health reasons
>"High-protein" diet group 10 times as likely to die due to diabetes

[RunAndPunch]

" carbohydrates (51%), followed by fat (33%) and protein (16%)

this was their diet

I would be more apt to think the increased mortality was a result of the high carb diets which everyone knows are **** "


this x1000

[wisdommaster1]

only for 65 older, dont take **** out of context inbred.

hahaha misc arm-chair scientists think they are smarter than studies. im out.

What were the subjects activity levels? Were they standard across the board? If subjects remained active (lifting) are they impacted differently from high protein diets than non-lifting no avi reds?

[sknot1454]

correlation =/= cause-effect

There are several cautions that authors themselves include that separate the actual study from the media hype and catch phrases:

1) Results showed that both the moderate and high protein intake groups had higher risks of diabetes mortality compared to participants in the low protein group.

2) We underline that our hazard ratios and confidence intervals may be inflated due to our sample size and the extremely low incidence of diabetes mortality in the low protein group.

In addition, things to consider are:

1) High protein-Cancer/Diabetes link is only correlative. Authors actual point is higher IGF1 serum levels to be associated with Cancer/Diabetes. There isn't a study that I could find where IGF1 levels have been systematically examined in human population of all ethinicities/age groups/genders, so in the end, this could simply be that IGF1 naturally increases with age...

2) Only first two figures of the paper are drawn from human data. The rest, based on authors' hypothesis that high protein diet increases serum IGF1, which in turn is linked to higher incidence of cancer and diabetes, and authors use a mouse and yeast model to prove their point. While their observations could be entirely true in mice and yeast, they may not have any relevance to human, as is many times the case with using model organisms.

3) Study uses a self reporting diet mechanism by the subjects, meaning it's not scientifically controlled, and highly subjective.

4) The population age with the highest incidence is 50 years or above. This is the age group that grew up in the 60s and 70s, when the awareness to hazards of, for example corn syrup and growth hormones on live stock, were not well unterstood, and their use not well regulated...


Oh, and nice appeal to authority fallacy you used against Wisdommaster.

Fuking ******* red.

[roccobladr]

" carbohydrates (51%), followed by fat (33%) and protein (16%)

this was their diet

I would be more apt to think the increased mortality was a result of the high carb diets which everyone knows are **** "


this x1000

That is not exactly a high carbohydrate diet. Carbs are recommended to be 45-65% of kcal's

[MollyBrah]

People buttmad itt:

>NO, I CANT GIVE UP MAH PROTEINS, I WOULD RATHER GET CANCER THAN GIVE UP CHEESE

[ANumber1]

I have a hard time believing that dietary changes at 65 could impact cancer mortality significantly. I would think that most of the genetic damage you're going to do has been done.

[wisdommaster1]

That is not exactly a high carbohydrate diet. Carbs are recommended to be 45-65% of kcal's

i deleted my post because I changed my thinking but I still consider 50% high carb. IMO fats should be higher than carbs but this is convo for another thread

[IllegalRage]

lmfao

[butwhowasfeel]

everything kills you nowadays

might as well get swole in the process

[Gabriel Anton]

People buttmad itt:

>NO, I CANT GIVE UP MAH PROTEINS, I WOULD RATHER GET CANCER THAN GIVE UP CHEESE

a life without steak, cheese, and eggs isn't a life worth living son

[sourcecode123]

Yolo

[MollyBrah]

a life without steak, cheese, and eggs isn't a life worth living son

post this again if you get cancer, then when ur on chemo with no hair withering away, let me know if that cheese was worth it.

[gtg]

yolo

[yudodistome]

probably tested some whales im sure if they tested healthy young athletic males such as the ones on this board the results would differ greatlyy...but i never read it so not sure

[Workid]

so its got nothing to do with us youngins aye? sweet as

Sweet as a nut m8

[MollyBrah]

correlation =/= cause-effect

There are several cautions that authors themselves include that separate the actual study from the media hype and catch phrases:

1) Results showed that both the moderate and high protein intake groups had higher risks of diabetes mortality compared to participants in the low protein group.

2) We underline that our hazard ratios and confidence intervals may be inflated due to our sample size and the extremely low incidence of diabetes mortality in the low protein group.

In addition, things to consider are:

1) High protein-Cancer/Diabetes link is only correlative. Authors actual point is higher IGF1 serum levels to be associated with Cancer/Diabetes. There isn't a study that I could find where IGF1 levels have been systematically examined in human population of all ethinicities/age groups/genders, so in the end, this could simply be that IGF1 naturally increases with age...

2) Only first two figures of the paper are drawn from human data. The rest, based on authors' hypothesis that high protein diet increases serum IGF1, which in turn is linked to higher incidence of cancer and diabetes, and authors use a mouse and yeast model to prove their point. While their observations could be entirely true in mice and yeast, they may not have any relevance to human, as is many times the case with using model organisms.

3) Study uses a self reporting diet mechanism by the subjects, meaning it's not scientifically controlled, and highly subjective.

4) The population age with the highest incidence is 50 years or above. This is the age group that grew up in the 60s and 70s, when the awareness to hazards of, for example corn syrup and growth hormones on live stock, were not well unterstood, and their use not well regulated...


Oh, and nice appeal to authority fallacy you used against Wisdommaster.

Fuking ******* red.

check it out guys, arm-chair phd research scientist lurks misc and thinks he debunked the 20 scientists with phd's because he learned in stat 101 about correlation.

[wisdommaster1]

check it out guys, arm-chair phd research scientist lurks misc and thinks he debunked the 20 scientists with phd's because he learned in stat 101 about correlation.

where is the mention of pre-existing health conditions of the groups, activity levels and other controls?

I could do a study showing people who eat high protein live longer if I neglect to mention that the low protein group is consisting of diabetic whales and the high protein group are world class athletes

[Chronys]

Were there any corrections, for things like smoking, activity level, weight and so forth?

edit: ^ wizard, repped