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  1. #1
    Registered User RashanCHarris's Avatar
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    Are Nitrates Carcinogenic? Help

    Can someone please explain to me if the new nitrate craze in the supplement industry is safe? Everything I have heard my whole life has told me that nitrates are bad and can cause all kinds if nasty problems in the long run. Any help would be greatly appreciated as I am looking into trying Condense by Purus Labs.
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  2. #2
    interact with me PinchTheBear's Avatar
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    Originally Posted by RashanCHarris View Post
    Everything I have heard my whole life has told me that nitrates are bad and can cause all kinds if nasty problems in the long run
    Epidemiologically, the contrary is actually evident in dietary research. The speculation that oral nitrates go on to form carcinogens does not take into account a few chemical principles about the nitrosation reaction, including:

    A) Extreme heat + extreme acidity accelerate the reaction. The former is why "people" erroneously generalize nitrate-based meat preservatives comparatively to oral nitrates.

    B) Although the gut is still a more favorable environment than neutral pH, there are a number of important antagonistic factors e.g. endogenous and supplementary reducing agents like ascorbate. Reducing agents take care of intermediates, because there are a number of ways the reaction could proceed.

    C) Free N-terminal substrate availability. Generally, it's low because the best conditions for the reaction are before a bunch of other potential reagents are thrown in the mix; concomitantly, this is also when the dietary protein you've ingested is still peptide bound and the electron pair on nitrogen is not kinetically vulnerable.

    So, no.
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  3. #3
    Team En Vivo thedarce's Avatar
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    Originally Posted by PinchTheBear View Post
    Epidemiologically, the contrary is actually evident in dietary research. The speculation that oral nitrates go on to form carcinogens does not take into account a few chemical principles about the nitrosation reaction, including:

    A) Extreme heat + extreme acidity accelerate the reaction. The former is why "people" erroneously generalize nitrate-based meat preservatives comparatively to oral nitrates.

    B) Although the gut is still a more favorable environment than neutral pH, there are a number of important antagonistic factors e.g. endogenous and supplementary reducing agents like ascorbate. Reducing agents take care of intermediates, because there are a number of ways the reaction could proceed.

    C) Free N-terminal substrate availability. Generally, it's low because the best conditions for the reaction are before a bunch of other potential reagents are thrown in the mix; concomitantly, this is also when the dietary protein you've ingested is still peptide bound and the electron pair on nitrogen is not kinetically vulnerable.

    So, no.
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  4. #4
    interact with me PinchTheBear's Avatar
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    Originally Posted by thedarce View Post
    welcome back!
    thanks buddy
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  5. #5
    Body by Nutella. cjwav34's Avatar
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    Originally Posted by PinchTheBear View Post
    thanks buddy
    Are/were you having issues with nitrate consumption personally?
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  6. #6
    Tachyphylaxis King PuZo's Avatar
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    Originally Posted by PinchTheBear View Post
    thanks buddy
    I would of said it first, but I didn't check here
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  7. #7
    interact with me PinchTheBear's Avatar
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    Originally Posted by cjwav34 View Post
    Are/were you having issues with nitrate consumption personally?
    Overconsumption. Completely my fault.
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  8. #8
    Body by Nutella. cjwav34's Avatar
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    Originally Posted by PinchTheBear View Post
    Overconsumption. Completely my fault.
    How many mg were you consuming per day do you estimate?
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