Does CUTTING GEL work ?

[shap]

Hey all ,

I was wondering if a products called "CUTTING GEL" which is supposed to help with fatloss works. In your response please specify if you've actualy tried it out , and if so how long before you saw results.
Thnx...

[ÅnãBöL]

Aminophyline Gels are only good for removing localized water, not fat. A cheaper alternative is PrepH if you have water patches before a comp.

[marshdog]

I've been trying it over the past few weeks. So far, no apparent results. My target area looks exactly the same, and my body fat is exactly the same.

[Younggunz]

I've heard nothing but negative feedback about it. I would trash it.

[Par Deus]

Its active ingredient is aminophylline:

Aminophylline is a xanthine derivative, similar to caffeine, which is not a particularly potent fat burner. In rat studies, it has shown good thermogenic properties due to blockade of adenosine receptors (which provide one of the negative feedback mechanisms for catecholamine induced thermogenesis) and inhibition of phosphodiesterase (which degrade cyclic AMP) -- but this is at extremely high doses, which would kill a human, so it is not applicable (1,2). At therapuetic doses, only adenosine blockade occurs, which will act to increase norepinephrine levels (3)-- but norepinephrine stimulates alpha 2 receptors (bad) in addition to beta 2 receptors (good) -- and in stubborn fat, alpha 2's outnumber beta 2's (4).

Like caffeine, it is a good diuretic (5), which would account for the girth loss in the study they reference, which did not measure actual fat loss (6,7). One study did look at fat depth after use of an aminophylline cream, and no difference was found vs. control (8).

As a local diuretic, it seems to be effective, but as a true fat loss agent, it quite likely is not.

ParDeus
www.avantlabs.com

References

1. Dulloo AG; Seydoux J; Girardier L. Potentiation of the thermogenic antiobesity effects of ephedrine by dietary methylxanthines: adenosine antagonism or phosphodiesterase inhibition? Metabolism 1992 Nov;41(11):1233-41.

2. Lee TF; Li DJ; Jacobson KA; Wang LC. Improvement of cold tolerance by selective A1 adenosine receptor antagonists in rats. Pharmacol Biochem Behav 1990 Sep;37(1):107-12.

3. Tung CS, Kuan CJ, Tarng JL, Tseng CJ. Effect of adenosine blockade on plasma renin activity and catecholamines. Proc Natl Sci Counc Repub China B 1993 Jan;17(1):21-8

4. Millet L, Barbe M, Lafontan M, Berlan M, Galitzky J. Catecholamine effects on lipolysis and blood flow in human abdominal and femoral adipose tissue. J Appl Physiol 1998; 85(1):181-188.

5. Pretzlaff RK, Vardis RJ, Pollack MM Aminophylline in the treatment of fluid overload.Crit Care Med 1999 Dec;27(12):2782-5

6. Greenway FL, Bray GA, Heber D. Topical fat reduction. Obes Res 1995 Nov;3 Suppl 4:561S-568S

7. Greenway FL, Bray GA.Regional fat loss from the thigh in obese women after adrenergic modulation.Clin Ther 1987;9(6):663-9

8. Collis N, Elliot LA, Sharpe C, Sharpe DT. Cellulite treatment: a myth or reality: a prospective randomized, controlled trial of two therapies, endermologie and aminophylline cream. Plast Reconstr Surg 1999 Sep;104(4):1110-4; discussion 1115-7

[Big Cat]

I get the distinct feeling I've read that somewhere before ...

[Par Deus]

Originally posted by Big Cat
I get the distinct feeling I've read that somewhere before ...

I got the same feeling when I read "Does Cutting Gel work?".

Got it the time before that as well.

And the time before that.

[illustrious540]

When i was working at GNC my boss got a bott;e for free so he gave it a try, there was def noticable difference in his stomach, be carefull when u use it though, it stains your clothes

[Big Cat]

And Par, judging by the post above mine I don't think it really helped.

Illustrious, did you even bother reading par's post ?

[illustrious540]

NO

[Big Cat]

Ok, then kindly don't comment on the thread until you've read that its been fully explained.

[illustrious540]

My bAD!

Dont be mad at me CAT