Honors chemistry project-creatine

[b0stonfan123]

For my honors college chemistry project I am explaining the chemistry of how creatine works. I am going to explain 2 topics.
1.) creatine lending a phosphate to ADP via the creator phosphate system to form cellular energy, ATP.
2.) creatine increasing intercellular water retention.

If anyone can answer or post articles/studies that can answer the following questions that would be fantastic:

-why is the bond between the 2nd and 3rd phosphate of ATP more favorable than the bond between creatine and its phosphate?
-how does creatine get into the muscle fiber?
-I assume it has something to do with osmosis, but how does creatine increase intracellular fluid retention?
-why is intracellular fluid retention anabolic?

Thank you very much

[Mr.Cooper69]

1. The bond isn't "more favorable." The reaction is dictated by thermodynamic principles. A fall in ATP engages Le Chatelier's principle -> more phosphocreatine dephosphorylation.

2. Current theory is the creatine transporter.

3. Yes, creatine is an osmolyte. Once it becomes phosphate bound, it is trapped intracellularly and hence disturbs the osmotic equilibrium.

4. More muscular water = more muscular weight (LBM) and more muscular size.

[b0stonfan123]

1. The bond isn't "more favorable." The reaction is dictated by thermodynamic principles. A fall in ATP engages Le Chatelier's principle -> more phosphocreatine dephosphorylation.

2. Current theory is the creatine transporter.

3. Yes, creatine is an osmolyte. Once it becomes phosphate bound, it is trapped intracellularly and hence disturbs the osmotic equilibrium.

4. More muscular water = more muscular weight (LBM) and more muscular size.

Great information. Thank you very much.
I must have worded the first question incorrectly, I understand le chatlier principle but I guess what I meant was what makes the production of ATP via the creatine phosphate system more favorable than another process (electron transport chain) under these conditions?

[Mr.Cooper69]

Great information. Thank you very much.
I must have worded the first question incorrectly, I understand le chatlier principle but I guess what I meant was what makes the production of ATP via the creatine phosphate system more favorable than another process (electron transport chain) under these conditions?

Sorry if I'm late, had to focus on school for a bit.

The electron transport chain (oxidative phosphorylation) requires oxygen and takes several minutes to become a significant metabolic force. While it is the most preferred source of energy production owing to its great ATP economy, it cannot meet the initial metabolic demand of exercise for a few reasons relating to both intrinsic cell machinery and external factors like bloodflow. So in the meantime, the body uses the most readily available ATP.

This means that it actually starts with free ATP in the cell, which is very low but still present. After that, it moves on to the equilbirium-based reactions (PCr, myokinase) to phosphorylate ADP. Further down the road, glycolysis and finally oxidative phosphorylation kick in.

[b0stonfan123]

Sorry if I'm late, had to focus on school for a bit.

The electron transport chain (oxidative phosphorylation) requires oxygen and takes several minutes to become a significant metabolic force. While it is the most preferred source of energy production owing to its great ATP economy, it cannot meet the initial metabolic demand of exercise for a few reasons relating to both intrinsic cell machinery and external factors like bloodflow. So in the meantime, the body uses the most readily available ATP.

This means that it actually starts with free ATP in the cell, which is very low but still present. After that, it moves on to the equilbirium-based reactions (PCr, myokinase) to phosphorylate ADP. Further down the road, glycolysis and finally oxidative phosphorylation kick in.

I was running on very little sleep but realized right after I posted that ETC requires oxygen. Thank you very much for the help, it is much appreciated.

[Mr.Cooper69]

No problem dude