SAM-e anti-inflammatory? Avoid circa workout?

[greenswimmer]

Hi,

(I would much appreciate NO HYPE's input on this, as I've seen a number of his posts on SAM-e.)

I'm considering using SAM-e to aid with depression symptoms. However, it seems that it is also an anti-inflammatory drug (aids with osteoarthritis and fibromyalgia). Should I avoid ingesting it close to workout time? Would certain dosages of SAM-e in any way interfere with muscle growth/recovery?

Thanks.

[NO HYPE]

Should I avoid ingesting it close to workout time? Would certain dosages of SAM-e in any way interfere with muscle growth/recovery?

I really don't think the use of SAMe will have any appreciable impact on muscle growth and/or recovery.

[powerhouse3434]

I really don't think the use of SAMe will have any appreciable impact on muscle growth and/or recovery.

Neither do i. You'd want to avoid dosing SAMe with hepatotoxic products but that's about it.

[NO HYPE]

On a side note, make sure the SAMe is enteric-coated.

[NO HYPE]

You'd want to avoid dosing SAMe with hepatotoxic products but that's about it.

I try to avoid ingesting hepatotoxic compounds altogether.

[powerhouse3434]

I try to avoid ingesting hepatotoxic compounds altogether.

Then you probably don't need to use SAMe

[NO HYPE]

Then you probably don't need to use SAMe

Well I don't normally use it anyway however, in the OP.... there were 3 other reasons to use it.

Nonetheless.... what hepatotoxic compounds were you refering to?

[Trans_Isomer]

I try to avoid ingesting hepatotoxic compounds altogether.

These are not teh superdrolz you are looking for...

[powerhouse3434]

Well I don't normally use it anyway however, in the OP.... there were 3 other reasons to use it.

Nonetheless.... what hepatotoxic compounds were you refering to?

USP Labs products. What else?

[00s4boy]

Well I don't normally use it anyway however, in the OP.... there were 3 other reasons to use it.

Nonetheless.... what hepatotoxic compounds were you refering to?

I believe he is referring to anything c17a methylated.

[NO HYPE]

I believe he is referring to anything c17a methylated.

Then that would be in opposition to his first statement. confused.jpg

[00s4boy]

Then that would be in opposition to his first statement. confused.jpg

I was too but I believe he is applying the milk thistle don't dose it with your methyl's because of possibly androgen receptor binding affinity to SAMe, while worded poorly I believe he is trying to say use it while on, but dose it at a different time.

[powerhouse3434]

Then that would be in opposition to his first statement. confused.jpg

No, it wouldn't.

C-17 alpha-alkylated oral agents cause hepatotoxicity and SAMe should be dosed away from said agent(s).

[00s4boy]

No, it wouldn't.

C-17 alpha-alkylated oral agents cause hepatotoxicity and SAMe should be dosed away from said agent(s).

No harm in dosing SAMe or TUDCA with you c17's.

[powerhouse3434]

No harm in dosing SAMe or TUDCA with you c17's.

TUDCA is fine. SAMe is not.

[NO HYPE]

C-17 alpha-alkylated oral agents cause hepatotoxicity and SAMe should be dosed away from said agent(s).

For what reason??

[UncleWade]

For what reason??

I personally cannot explain the science, but Dr. Dana Houser recommends this protocol on other online outlets.

[powerhouse3434]

For what reason??

It's how SAMe acts with methylation. SAMe actually blocks upstream methylation via feedback inhibition.

[NO HYPE]

IDr. Dana Houser recommends this protocol on other online outlets.

As in avoiding SAMe.... or using it with the compounds in question?

[NO HYPE]

It's how SAMe acts with methylation. SAMe actually blocks upstream methylation via feedback inhibition.

Something doesn't sound right. Could you possibly PM me a link to where this info originated?

[greenswimmer]

Something doesn't sound right. Could you possibly PM me a link to where this info originated?

thanks for all the replies!! excellent feedback. however, if you're going to PM him the link, please post it here too! i'd like to be aware of anything I should avoid.