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  1. #1
    Registered User shelisheli's Avatar
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    Garcinia Cambogia for fatloss?

    I'm curious if anyone has any experiences with Garcinia Cambogia. I'm watching Dr. Oz and he says that its the "Holy Grail" for weightloss. Supposed to be good for appetite suppression as well..?

    Anyone with real reviews?

    (edited because the search only has old posts.. wanting something more current)
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  2. #2
    I love BEEF Danes's Avatar
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    Here is something to read


    Evaluation of the safety and efficacy of hydroxycitric acid or Garcinia cambogia extracts in humans.

    Authors

    Márquez F,*et al.*Show all

    Journal

    Crit Rev Food Sci Nutr. 2012;52(7):585-94.

    Affiliation

    Human Nutrition Unit, Department of Biochemistry and Biotechnology, Faculty of Medicine and Health Sciences, Rovira i Virgili University, Reus, Spain.

    Abstract

    Several studies have shown that Garcinia cambogia plays an important role in the regulation of endogenous lipid biosynthesis. This effect is specially attributed to (-)-hydroxycitric acid (HCA) inhibiting the enzyme ATP-dependent citrate lyase, which catalyzes the cleavage of citrate to oxaloacetate and acetyl-CoA. Although several studies have found that the administration of G. cambogia extracts is associated with body weight and fat loss in both experimental animals and humans, we should be cautious when interpreting the results as other randomized, placebo-controlled clinical trials have not reported the same outcomes. Furthermore, most studies in humans have been conducted on small samples and mainly in the short term. None of them have shown whether these effects persist beyond 12 weeks of intervention. Therefore, there is still little evidence to support the potential effectiveness and long-term benefits of G. cambogia extracts. With regard to toxicity and safety, it is important to note that except in rare cases, studies conducted in experimental animals have not reported increased mortality or significant toxicity. Furthermore, at the doses usually administered, no differences have been reported in terms of side effects or adverse events (those studied) in humans between individuals treated with G. cambogia and controls.Investigations of botanicals on food intake, satiety, weight loss and oxidative stress: study protocol of a double-blind, placebo-controlled, crossover study.


    --------------------------------------------------


    Authors

    Anton SD,*et al.*Show all

    Journal

    Zhong Xi Yi Jie He Xue Bao. 2011 Nov;9(11):1190-8.

    Affiliation

    Department of Aging and Geriatric Research, University of Florida, Gainesville, Florida 32611, USA. santon@ufl.edu

    Abstract

    BACKGROUND:*Botanicals represent an important and underexplored source of potential new therapies that may facilitate caloric restriction and thereby may produce long-term weight loss. In particular, one promising botanical that may reduce food intake and body weight by affecting neuroendocrine pathways related to satiety is hydroxycitric acid (HCA) derived from Garcinia cambogia Desr.

    METHODS AND DESIGN:*The objective of this article is to describe the protocol of a clinical trial designed to directly test the effects of Garcinia cambogia-derived HCA on food intake, satiety, weight loss and oxidative stress levels, and to serve as a model for similar trials. A total of 48 healthy, overweight or obese individuals (with a body mass index range of 25.0 to 39.9 kg/m(2)) between the ages of 50 to 70 will participate in this double-blind, placebo-controlled, crossover study designed to examine the effects of two doses of Garcinia cambogia-derived HCA on food intake, satiety, weight loss, and oxidative stress levels. Food intake represents the primary outcome measure and is calculated based on the total calories consumed at breakfast, lunch, and dinner meals during each test meal day. This study can be completed with far fewer subjects than a parallel design.

    DISCUSSION:*Of the numerous botanical compounds, the compound Garcinia cambogia-derived HCA is selected for testing in the present study because of its potential to safely reduce food intake, body weight, and oxidative stress levels. We will review potential mechanisms of action and safety parameters throughout this clinical trial.Oral hydroxycitrate supplementation enhances glycogen synthesis in exercised human skeletal muscle.



    --------------------------------------------------



    Authors

    Cheng IS,*et al.*Show all

    Journal

    Br J Nutr. 2012 Apr;107(7):1048-55. Epub 2011 Aug 9.

    Affiliation

    Department of Physical Education, National Taichung University of Education, Taichung, Taiwan, ROC.

    Abstract

    Glycogen stored in skeletal muscle is the main fuel for endurance exercise. The present study examined the effects of oral hydroxycitrate (HCA) supplementation on post-meal glycogen synthesis in exercised human skeletal muscle. Eight healthy male volunteers (aged 22·0 (se 0·3) years) completed a 60-min cycling exercise at 70-75 % VO₂max and received HCA or placebo in a crossover design repeated after a 7 d washout period. They consumed 500 mg HCA or placebo with a high-carbohydrate meal (2 g carbohydrate/kg body weight, 80 % carbohydrate, 8 % fat, 12 % protein) for a 3-h post-exercise recovery. Muscle biopsy samples were obtained from vastus lateralis immediately and 3 h after the exercise. We found that HCA supplementation significantly lowered post-meal insulin response with similar glucose level compared to placebo. The rate of glycogen synthesis with the HCA meal was approximately onefold higher than that with the placebo meal. In contrast, GLUT4 protein level after HCA supplementation was significantly decreased below the placebo level, whereas expression of fatty acid translocase (FAT)/CD36 mRNA was significantly increased above the placebo level. Furthermore, HCA supplementation significantly increased energy reliance on fat oxidation, estimated by the gaseous exchange method. However, no differences were found in circulating NEFA and glycerol levels with the HCA meal compared with the placebo meal. The present study reports the first evidence that HCA supplementation enhanced glycogen synthesis rate in exercised human skeletal muscle and improved post-meal insulin sensitivity.
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  3. #3
    Banned Bacteroides's Avatar
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    Cambodia is definitely the "Holy Grail" of weight loss
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  4. #4
    VasKular...Pump Dominance GetRippedInc's Avatar
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    Every episode he has the holy grail of fat loss... Dude is tard
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  5. #5
    Molecular Nutrition Rep SwolenONE's Avatar
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    Originally Posted by GetRippedInc View Post
    Every episode he has the holy grail of fat loss... Dude is tard
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  6. #6
    Registered User shelisheli's Avatar
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    Originally Posted by Danes View Post
    Here is something to read

    cut.
    Thank you so much!
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  7. #7
    Registered User shelisheli's Avatar
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    Originally Posted by GetRippedInc View Post
    Every episode he has the holy grail of fat loss... Dude is tard
    yeah.. I don't watch his show often I've noticed he has a lot of that kind of stuff.. bummer.
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  8. #8
    Registered User naturalbb's Avatar
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    Originally Posted by Danes View Post
    Here is something to read


    Evaluation of the safety and efficacy of hydroxycitric acid or Garcinia cambogia extracts in humans.

    Authors

    Márquez F,*et al.*Show all

    Journal

    Crit Rev Food Sci Nutr. 2012;52(7):585-94.

    Affiliation

    Human Nutrition Unit, Department of Biochemistry and Biotechnology, Faculty of Medicine and Health Sciences, Rovira i Virgili University, Reus, Spain.

    Abstract

    Several studies have shown that Garcinia cambogia plays an important role in the regulation of endogenous lipid biosynthesis. This effect is specially attributed to (-)-hydroxycitric acid (HCA) inhibiting the enzyme ATP-dependent citrate lyase, which catalyzes the cleavage of citrate to oxaloacetate and acetyl-CoA. Although several studies have found that the administration of G. cambogia extracts is associated with body weight and fat loss in both experimental animals and humans, we should be cautious when interpreting the results as other randomized, placebo-controlled clinical trials have not reported the same outcomes. Furthermore, most studies in humans have been conducted on small samples and mainly in the short term. None of them have shown whether these effects persist beyond 12 weeks of intervention. Therefore, there is still little evidence to support the potential effectiveness and long-term benefits of G. cambogia extracts. With regard to toxicity and safety, it is important to note that except in rare cases, studies conducted in experimental animals have not reported increased mortality or significant toxicity. Furthermore, at the doses usually administered, no differences have been reported in terms of side effects or adverse events (those studied) in humans between individuals treated with G. cambogia and controls.Investigations of botanicals on food intake, satiety, weight loss and oxidative stress: study protocol of a double-blind, placebo-controlled, crossover study.


    --------------------------------------------------


    Authors

    Anton SD,*et al.*Show all

    Journal

    Zhong Xi Yi Jie He Xue Bao. 2011 Nov;9(11):1190-8.

    Affiliation

    Department of Aging and Geriatric Research, University of Florida, Gainesville, Florida 32611, USA. santon@ufl.edu

    Abstract

    BACKGROUND:*Botanicals represent an important and underexplored source of potential new therapies that may facilitate caloric restriction and thereby may produce long-term weight loss. In particular, one promising botanical that may reduce food intake and body weight by affecting neuroendocrine pathways related to satiety is hydroxycitric acid (HCA) derived from Garcinia cambogia Desr.

    METHODS AND DESIGN:*The objective of this article is to describe the protocol of a clinical trial designed to directly test the effects of Garcinia cambogia-derived HCA on food intake, satiety, weight loss and oxidative stress levels, and to serve as a model for similar trials. A total of 48 healthy, overweight or obese individuals (with a body mass index range of 25.0 to 39.9 kg/m(2)) between the ages of 50 to 70 will participate in this double-blind, placebo-controlled, crossover study designed to examine the effects of two doses of Garcinia cambogia-derived HCA on food intake, satiety, weight loss, and oxidative stress levels. Food intake represents the primary outcome measure and is calculated based on the total calories consumed at breakfast, lunch, and dinner meals during each test meal day. This study can be completed with far fewer subjects than a parallel design.

    DISCUSSION:*Of the numerous botanical compounds, the compound Garcinia cambogia-derived HCA is selected for testing in the present study because of its potential to safely reduce food intake, body weight, and oxidative stress levels. We will review potential mechanisms of action and safety parameters throughout this clinical trial.Oral hydroxycitrate supplementation enhances glycogen synthesis in exercised human skeletal muscle.



    --------------------------------------------------



    Authors

    Cheng IS,*et al.*Show all

    Journal

    Br J Nutr. 2012 Apr;107(7):1048-55. Epub 2011 Aug 9.

    Affiliation

    Department of Physical Education, National Taichung University of Education, Taichung, Taiwan, ROC.

    Abstract

    Glycogen stored in skeletal muscle is the main fuel for endurance exercise. The present study examined the effects of oral hydroxycitrate (HCA) supplementation on post-meal glycogen synthesis in exercised human skeletal muscle. Eight healthy male volunteers (aged 22·0 (se 0·3) years) completed a 60-min cycling exercise at 70-75 % VO₂max and received HCA or placebo in a crossover design repeated after a 7 d washout period. They consumed 500 mg HCA or placebo with a high-carbohydrate meal (2 g carbohydrate/kg body weight, 80 % carbohydrate, 8 % fat, 12 % protein) for a 3-h post-exercise recovery. Muscle biopsy samples were obtained from vastus lateralis immediately and 3 h after the exercise. We found that HCA supplementation significantly lowered post-meal insulin response with similar glucose level compared to placebo. The rate of glycogen synthesis with the HCA meal was approximately onefold higher than that with the placebo meal. In contrast, GLUT4 protein level after HCA supplementation was significantly decreased below the placebo level, whereas expression of fatty acid translocase (FAT)/CD36 mRNA was significantly increased above the placebo level. Furthermore, HCA supplementation significantly increased energy reliance on fat oxidation, estimated by the gaseous exchange method. However, no differences were found in circulating NEFA and glycerol levels with the HCA meal compared with the placebo meal. The present study reports the first evidence that HCA supplementation enhanced glycogen synthesis rate in exercised human skeletal muscle and improved post-meal insulin sensitivity.
    Thanks for posting these studies.
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  9. #9
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    Originally Posted by naturalbb View Post
    Thanks for posting these studies.
    You're welcome.
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  10. #10
    Registered User jsmith1975tx's Avatar
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    Thumbs up It is kind of like the holy grail

    I've tried Garcinia Cambogia and I lost weight with it. Yes it is an appetite suppressant that works and it burns fat too. Keep in mind that you do need to control your calorie intake and make sure you dont eat more than you burn off. I lost 2 pounds the first week I was on it and I didnt even exercise! the next two weeks I lost 10 pounds because I was also going to the gym. I've struggled in the past with my weight but with Garcinia cambogia it makes it easy to control your weight. Hope this sheds some light!
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  11. #11
    Registered User Lite_Weight's Avatar
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    Originally Posted by jsmith1975tx View Post
    I've tried Garcinia Cambogia and I lost weight with it. Yes it is an appetite suppressant that works and it burns fat too. Keep in mind that you do need to control your calorie intake and make sure you dont eat more than you burn off. I lost 2 pounds the first week I was on it and I didnt even exercise! the next two weeks I lost 10 pounds because I was also going to the gym. I've struggled in the past with my weight but with Garcinia cambogia it makes it easy to control your weight. Hope this sheds some light!
    So, you reduced your calories and you went to the gym. And, amazingly, you lost weight! That's incredible! I need to get a bottle of Garcinia Cambogia!!
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