D-Aspartic Acid - New Evidence Confirming Testosterone Boosting Effect

[ExDubio11]

http://www.google.com/url?sa=t&rct=j...eztide_IK1X2yQ

Yes, it's in largely infertile men, but it is a nice complement to the study done in healthy males.

[BigBoLuke93]

Nice find.

Conclusion:

In conclusion, in this study we demonstrated that sub-fertile men who consumed daily an oral dose of so- dium D-aspartate for 2 - 3 months, improved signify- cantly their sperm quality in terms of number and mobil- ity of the spermatozoa, and consequently they increased the possibility to fertilize the own partner. We do not know the exact molecular mechanism by which this phenomenon occurs, but we strongly hypothesize that this events is due to action of D-aspartate in inducing elevation of testosterone in the testis, which locally is involved in improving the spermatogenesis and in matu- ration of male gametes.

Also, if I'm reading this right, it looks like they used a daily dose of 2.66g DAA?

The dose of sodium D-aspartate consisted of 10 ml of 2.0 M sdium D-aspartate (composed of 2.66 g of D-aspartic acid neu- tralized with 0.46 g of NaOH in 10 ml distilled water, at final pH (6.5 - 7.0).

[ExDubio11]

Yes, 2.66 grams, and testosterone elevations on the order of those seen in the previous human study were observed. Unfortunately, this is not confirmation that a lower dose of DAA is effective in healthy males, since a 40% increase in T in sub-fertile males probably does not amount to much.

[ExDubio11]

Bump for more thoughts

[UncleWade]

I still think compounds like DAA and Bulbine show promise as testosterone boosting agents in the future, and I'm glad SNS is pursuing these [and other] ingredients.

With what I understand is in the works, we will be holding very true to our tagline of "Revolutionizing Sports Nutrition One Product At A Time."

[kevin1st]

lol and i thought DAA did nothing for me. i didn't notice any strength gains, libido boost or recovery benefits outside what's normal but i did get my gf pregnant towards the end of my DAA run after trying unsuccessfully for 4 months.

[Outside backer]

I still think compounds like DAA and Bulbine show promise as testosterone boosting agents in the future, and I'm glad SNS is pursuing these [and other] ingredients.

With what I understand is in the works, we will be holding very true to our tagline of "Revolutionizing Sports Nutrition One Product At A Time."

I agree We make Ergotest and it has bulbine natalensis in it and ive had blood work back showing it works. Looking forward to seeing what u guys come out with

[em-dubya]

A Researcher at Baylor Univ. is also currently conducting a study on DAA

[stevedm]

I think the article was fairly well written. They comment on p values relating to many things and considering there is no data table or p value comments when it comes to testosterone i think you can safely assume the results were not stastically significant or they would have said so....which i find surprising since they try to say the increased sperm numbers and activity are likely related to testosterone, this seems like a glaring hole. (i know they say the levels increased BUT this doesnt mean much unless it reaches stat sig)(unless i missed something in my quick scan). There is also a big difference between sub fertile people and regular people in regards to how they respond to drugs trying to manipulate the value in question.

All in all an interesting article. What i got out of this is for those of you on DAA, wear a condom tonight.

Thanks for posting.

[NO HYPE]

increased sperm numbers and activity

What i got out of this is for those of you on DAA, wear a condom tonight.

or just take bolus doses of ursolic acid

The spermatotoxic effects of ursolic acid warrant further research. In correlation to their findings in 1998, Akbarsha et al, 2000 revealed that an i.p. injection of ursolic acid 25 mg kg (-1) body weight per day to adult rats, resulted in the retention of the cytoplasmic droplet by spermatozoa, wich in turn negatively alters motility, epididymal function and reduces fertility.

[neddo]

A Researcher at Baylor Univ. is also currently conducting a study on DAA

What would RK say? EXPERIMENT ON YOURSELF AND FLUB THE RESULTS.

[snorkelman]

This study would be interesting to men between 27-43 years old who have a low concentration of and or motility of sperm.

This is the same group of researchers who did the 2009 DAA study showing a 42% increase in T.

I also find it interesting that this more recent 2012 study doesn't brag about the % increase in T. I am also left to assume it is not statistically relevant.

IMO it is a huge leap to assume that this study means anything to the athletic population desiring to elevate testosterone levels for the purpose of enhancing muscle gains in the gym.

A side-comment about guys with low sperm count elevating LH and T 1.3-1.6 times is not very relevant to most of us.

At most, this study may lay support that supplementing with DAA beyond 12 days (the length of time in the last DAA study these folks did) is safe. this study was 90 days.

[TrimLines]

Personally I have used DAA and like the results produced from it. Can I say that it was a huge boost or that it had no placebo effect what so ever, no. But I can say that I leaned out a bit and felt full of energy while using it. Id say it gives you a small kick, nothing major but there is something there.

[ExDubio11]

IMO it is a huge leap to assume that this study means anything to the athletic population desiring to elevate testosterone levels for the purpose of enhancing muscle gains in the gym.

no one has mentioned this. do you only do things in your life for the sake of body composition? how about natural energy, fertility, all that good stuff

[snorkelman]

no one has mentioned this. do you only do things in your life for the sake of body composition? how about natural energy, fertility, all that good stuff

Seriously? We are on a bodybuilding forum. I think it is safe to say that the vast majority of people reading this thread are either taking or thinking about taking DAA and are doing so with the hope that it will result in a clinically relevant testosterone boost for the purpose of LBM gains. I think it is relevant to discuss that. You are the one soliciting thoughts and comments.

I personally find it interesting that the same group of scientists decided to use DAA and specifically focus on fertility. I suppose that there is more money to be made from the sale of DAA targeting those unable to conceive and considering expensive IVF treatments, rather than bodybuilders.

[ExDubio11]

Seriously? We are on a bodybuilding forum. I think it is safe to say that the vast majority of people reading this thread are either taking or thinking about taking DAA and are doing so with the hope that it will result in a clinically relevant testosterone boost for the purpose of LBM gains. I think it is relevant to discuss that. You are the one soliciting thoughts and comments.

I personally find it interesting that the same group of scientists decided to use DAA and specifically focus on fertility. I suppose that there is more money to be made from the sale of DAA targeting those unable to conceive and considering expensive IVF treatments, rather than bodybuilders.

such studies are usually conducted with pharmacotherapy in mind. somehow i doubt testosterone elevation would matter at all when trt is available for those in need

[Enterococcusspp]

What would RK say? EXPERIMENT ON YOURSELF AND FLUB THE RESULTS.

* this post is protected under U.S. Patent No. 8,202,908

[snorkelman]

such studies are usually conducted with pharmacotherapy in mind. somehow i doubt testosterone elevation would matter at all when trt is available for those in need

I think that you may not realize just how many folks buy DAA, mistakenly believing it will have trt-like abilities. It is my observation that many bros who buy DAA think that they are just shy of riding a bike, and therefore, cool because it is legal. The reality of the current support for DAA has been stated succinctly by Lyle Mcdonald:

[ExDubio11]

I think that you may not realize just how many folks buy DAA, mistakenly believing it will have trt-like abilities. It is my observation that many bros who buy DAA think that they are just shy of riding a bike, and therefore, cool because it is legal. The reality of the current support for DAA has been stated succinctly by Lyle Mcdonald:

well that post of his is moronic. yes, for muscle growth you will T levels several times that of normal range. but basic elevations in testosterone within range can certainly have a physiological impact on mood, quality of life, drive, etc. you think people on some sort of hormone replacement therapy need to take 5000% the normal range to get the benefits?

[snorkelman]

I suppose we can debate the 2009 paper (The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats. by Topo E, et al. further, but really, this thread is about their October 2012 published paper concerning DAA and sperm concentration and motility. The study clearly was not intended to address athletes or bodybuilders who want higher T levels. There was no effort made to recruit trained males. No effort to ensure an effective resistance training program was in place. The paper clearly is focused on guys shooting blanks and getting them to knock up their women. The paper certainly seems to be exciting for that category of folks.

[digler84]

lol and i thought DAA did nothing for me. i didn't notice any strength gains, libido boost or recovery benefits outside what's normal but i did get my gf pregnant towards the end of my DAA run after trying unsuccessfully for 4 months.

I would say it worked!

[SwolenONE]

A Researcher at Baylor Univ. is also currently conducting a study on DAA

Very cool!

[TurdMuffin]

well that post of his is moronic. yes, for muscle growth you will T levels several times that of normal range. but basic elevations in testosterone within range can certainly have a physiological impact on mood, quality of life, drive, etc. you think people on some sort of hormone replacement therapy need to take 5000% the normal range to get the benefits?

show some data on this. show some data where the changed that he is talking about shows clinically significant changes in anything.

[Huzzah21]

I don't mean to hijack the thread, but will taking sodium-DAA also increase the overall levels of sodium in the body?

[snorkelman]

I don't mean to hijack the thread, ...

And yet you are. You already started an entire thread on your question. Just hang on and wait for the thread to develop.

http://forum.bodybuilding.com/showth...hp?t=149599773

[ncballa1011]

Saw daa makes you more fertile.... No more daa until married for this guy.... So may never use again... Good read ....

[zemzin]

I still think compounds like DAA and Bulbine show promise as testosterone boosting agents in the future, and I'm glad SNS is pursuing these [and other] ingredients.

With what I understand is in the works, we will be holding very true to our tagline of "Revolutionizing Sports Nutrition One Product At A Time."

Nah

Tribulus is the best.

[stevedm]

This study would be interesting to men between 27-43 years old who have a low concentration of and or motility of sperm.

This is the same group of researchers who did the 2009 DAA study showing a 42% increase in T.

I also find it interesting that this more recent 2012 study doesn't brag about the % increase in T. I am also left to assume it is not statistically relevant.

IMO it is a huge leap to assume that this study means anything to the athletic population desiring to elevate testosterone levels for the purpose of enhancing muscle gains in the gym.

A side-comment about guys with low sperm count elevating LH and T 1.3-1.6 times is not very relevant to most of us.

At most, this study may lay support that supplementing with DAA beyond 12 days (the length of time in the last DAA study these folks did) is safe. this study was 90 days.

I agree with your comments in this thread. Reps.

[ExDubio11]

show some data on this. show some data where the changed that he is talking about shows clinically significant changes in anything.

So are you just plain retarded? How about the study linked in the OP? You know, the one showing improved fertility, a physiological change in the spermatazoa? Holy **** some people here blow my mind

[ExDubio11]

I suppose we can debate the 2009 paper (The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats. by Topo E, et al. further, but really, this thread is about their October 2012 published paper concerning DAA and sperm concentration and motility. The study clearly was not intended to address athletes or bodybuilders who want higher T levels. There was no effort made to recruit trained males. No effort to ensure an effective resistance training program was in place. The paper clearly is focused on guys shooting blanks and getting them to knock up their women. The paper certainly seems to be exciting for that category of folks.

This post was not directed towards bodybuilders. I don't care if this is a bodybuilding forum by name, it is more of an active general forum (see misc, supp misc, nut misc). people spend all day talking about nootropics here. this is a supplement forum and i'm merely providing new information. you think people following 1,3 legality are using it for body composition? again, idc why people are using which ingredient, im just stimulating discussion