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  1. #1
    Registered User nyyankees0191's Avatar
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    Oxycodone effects on protein synthesis

    Does Oxycodone negatively effect protein synthesis? I had a acl reconstruction done and that's what thy gave me. Thanks for the help.
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  2. #2
    Registered User rolandszi's Avatar
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    take it as prescribed!
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  3. #3
    MuscleLabs Supporter HATETANK's Avatar
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    Majoring in the minors buddy. Get better - don't get addicted, you will be good.

    FWIW I use dilaudid every so often which is a hydro on steroids because of migraines. I have never had a problem putting on muscle as long as my diet contributed to it. I do find it's harder to have an appetite when you are under the influence. Outside of that - there might be some study that points to fractions of percents of something - but who cares....
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  4. #4
    Slangin' Vitamins Jen0va's Avatar
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    one study I found stated this:

    "Our results indicate that Mor and M6G suppress tissue protein synthesis through central mechanisms, most likely mediated by opiate-induced respiratory depression in association with neural and hormonal alterations."
    -AJP - Regu Physiol September 1, 1996 vol. 271 no. 3 R619-R625

    Mor and M6G being Morphine and a morphone like opoid. Since Oxycodone is an opiate as well, this could have a similar effect. The study also involved rats so best not overthink it and just allow yourself a proper recovery before being concerned with muscle gain or maintenance.
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  5. #5
    MuscleLabs Supporter HATETANK's Avatar
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    Originally Posted by Jen0va View Post
    one study I found stated this:

    "Our results indicate that Mor and M6G suppress tissue protein synthesis through central mechanisms, most likely mediated by opiate-induced respiratory depression in association with neural and hormonal alterations."
    -AJP - Regu Physiol September 1, 1996 vol. 271 no. 3 R619-R625

    Mor and M6G being Morphine and a morphone like opoid. Since Oxycodone is an opiate as well, this could have a similar effect. The study also involved rats so best not overthink it and just allow yourself a proper recovery before being concerned with muscle gain or maintenance.
    and there it is..
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  6. #6
    Registered User tdrift's Avatar
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    I've had 2 ACL reconstructions now and, believe me, protein synthesis will be the least of your worries post-op...
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  7. #7
    Asian BBC Genetics Nexxus's Avatar
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    dude take oxycodone as prescribed and then when you don't need it anymore stop. You'll need it to recover but if you keep taking it recreationally may have negative effects on your hormones and liver.
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