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Thread: Prolactin?

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    Prolactin?

    I had some blood work done just make sure everything was ok and I found my prolactin was a little high,12.9(Ref: 4 - 15.2). The doctor said not to worry because it was still in range but is there anything to bring it down a bit?
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    Originally Posted by SenorRedGloves View Post
    I had some blood work done just make sure everything was ok and I found my prolactin was a little high,12.9(Ref: 4 - 15.2). The doctor said not to worry because it was still in range but is there anything to bring it down a bit?
    SNS makes a product for that, but these things arent meant to treat any medical condition and are only meant for short term use.

    If I was you Id probably just not worry about it especially if your doctor says your fine.
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    Disclaimer: All views and statements are my own opinion, and not a substitute or opinion for medical advice.
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    Originally Posted by KimJong-il View Post
    SNS makes a product for that, but these things arent meant to treat any medical condition and are only meant for short term use.

    If I was you Id probably just not worry about it especially if your doctor says your fine.
    This is fair advice, and we appreciate you mentioning our product.

    Consult with your doctor and get his opinion, sometimes simple fixes for things that are moderately out of the normal range are the most effective and safest and can yield long term results. Communicate with your physician openly and directly, and with his approval give Inhibit-P a shot. We believe it's the most effective prolactin control supplement on the market and it's definitely great to stack with other products such as DAA for anyone else that happens to stumble across this thread.

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    You could also try SAN Elixair, and get prolactin control with strong sleep and anti-catabolic support.

    ~ SAN Head Rep and Warlord ~

    Disclaimer: the above post is my personal opinion, and does not represent the official opinion of any company or entity. It does not constitute medical advice.
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    Originally Posted by UncleWade View Post
    Inhibit-P

    We believe it's the most effective prolactin control supplement on the market and it's definitely great to stack with other products such as DAA for anyone else that happens to stumble across this thread.
    Reducing prolactin --> at the cost of diminished testosterone concentrations seems counterproductive to me.

    Still trying to figure out SNS's implication that Inhibit-P will.... 'Naturally Boost Testosterone Levels'

    Treatment with dopaminergic agonists with high binding affinity such as Vitex agnus, inhibit HPG axis and decrease the density of testicular LH binding sites, while concomitantly decreasing testosterone secretion by leydig cells.

    http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum
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    counterproductive?

    Vitex agnus-induced [increase] in prolactin levels:

    Human data: In a placebo controlled crossover double-blind study of 20 healthy men, vitex had different effects on prolactin release at different concentrations. Men received doses of 120 mg, 240 mg or 480 mg of a special vitex extract (BP1095E1) daily for 14 days. There was a significant increase in prolactin level in men receiving the lowest dose, but a slight reduction in prolactin level in those receiving the higher doses 26. There were no significant dose-dependent changes in the 24-hour serum prolactin profile. The changes that occurred during the treatment period depended on the baseline prolactin levels of the individual subjects 7.

    Merz PG, Gorkow C, Schrodter A, Rietbrock S, Sieder C, Loew D, et al. The effects of a special Agnus castus extract (BP1095E1) on prolactin secretion in healthy male subjects. Exp Clin Endocrinol Diabetes 1996; 104:447-53.
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    All those silly supplements arent really going to bring down your prolactin levels. Also your prolactin could be just slightly high if youve ejaculated the night before. that has a sight effect on your levels.You might just have to retest if that was so.
    Also we would need more backround. What was your LH and FSH levels at? kind of hard to really give any sort of assessment without some more info and bloodwork posted. Hope you can figure it out. I know in the trt world high prolactin is a red flag you usually want to get an MRI to rule out any pituitary tumor. Just kind of spitting some stuff out you can further do some research on.
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    Originally Posted by NO HYPE View Post
    Reducing prolactin --> at the cost of diminished testosterone concentrations seems counterproductive to me.

    Still trying to figure out SNS's implication that Inhibit-P will.... 'Naturally Boost Testosterone Levels'

    Treatment with dopaminergic agonists with high binding affinity such as Vitex agnus, inhibit HPG axis and decrease the density of testicular LH binding sites, while concomitantly decreasing testosterone secretion by leydig cells.
    Vitex does puzzle me quite a bit. I assume mucuna pruriens is the testosterone booster. Do you have the FT on that study? This could have broad implications for many of us since we sure do love our dopaminergic compounds.

    Originally Posted by NO HYPE View Post
    Vitex agnus-induced [increase] in prolactin levels:

    Human data: In a placebo controlled crossover double-blind study of 20 healthy men, vitex had different effects on prolactin release at different concentrations. Men received doses of 120 mg, 240 mg or 480 mg of a special vitex extract (BP1095E1) daily for 14 days. There was a significant increase in prolactin level in men receiving the lowest dose, but a slight reduction in prolactin level in those receiving the higher doses 26. There were no significant dose-dependent changes in the 24-hour serum prolactin profile. The changes that occurred during the treatment period depended on the baseline prolactin levels of the individual subjects 7.

    Merz PG, Gorkow C, Schrodter A, Rietbrock S, Sieder C, Loew D, et al. The effects of a special Agnus castus extract (BP1095E1) on prolactin secretion in healthy male subjects. Exp Clin Endocrinol Diabetes 1996; 104:447-53.
    Yeah, but the product uses 300mg.
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    Originally Posted by NotThisAgain View Post
    Yeah, but the product uses 300mg.
    Indeed.

    So there was a significant rise in prolactin from a 120mg/kg dose, yet a 480mg/kg dose didn't affect 24-hour serum prolactin.



    Originally Posted by NotThisAgain View Post
    Do you have the FT on that study?
    check PM
    Last edited by NO HYPE; 08-28-2012 at 01:46 PM.
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    Originally Posted by NotThisAgain View Post
    I assume mucuna pruriens is the testosterone booster.
    When considering the possibility of Vitex-induced decrements in testosterone production.... maybe we should refer to the mucuna as the testosterone 'stabilizer'? I just don't see how this product is enhancing testosterone production.
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    Originally Posted by NotThisAgain View Post
    This could have broad implications for many of us since we sure do love our dopaminergic compounds.
    Not sure if the aforementioned decrements in testosterone are exclusive to the binding affinity of the labdane diterpenes in Vitex or not. Also, not sure if the presence of clerodadienols are a contributing factor.
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    Originally Posted by NO HYPE View Post
    Reducing prolactin --> at the cost of diminished testosterone concentrations seems counterproductive to me.

    Still trying to figure out SNS's implication that Inhibit-P will.... 'Naturally Boost Testosterone Levels'

    Treatment with dopaminergic agonists with high binding affinity such as Vitex agnus, inhibit HPG axis and decrease the density of testicular LH binding sites, while concomitantly decreasing testosterone secretion by leydig cells.

    http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum
    As always, if you have any question Tim you can always shoot one of us a PM. No issues with you posting your thoughts here though.

    I'll see about getting an answer to your question though.
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    Originally Posted by Daycrawler View Post
    As always, if you have any question Tim you can always shoot one of us a PM. No issues with you posting your thoughts here though.

    I'll see about getting an answer to your question though.
    Agreed - we welcome scholarly discussion, and it certainly gives us guidance in how we should adjust our products to meet 1) the desire of the consumer and 2) conform to the most accurate scientific information available to insure the most efficacious products possible.

    To be frank, such discussion is above my personal ability to answer and I will also work to get you some well-founded answers as expeditiously as possible. I'm just the training and nutrition guy here, it has been a long time since I've delved into pharmacology and related fields unfortunately.
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    Originally Posted by Daycrawler View Post
    As always, if you have any question Tim you can always shoot one of us a PM. No issues with you posting your thoughts here though. I'll see about getting an answer to your question though.
    Thanks for the response. I figured this was a topic that should be openly discussed.
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    Originally Posted by UncleWade View Post
    I will also work to get you some well-founded answers as expeditiously as possible.
    Thank you.
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    are we going to actually witness a logical discussion about supplement science?










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    The effects of vitex, in this study, were shown to be dose-dependent, and testosterone was only significantly lowered at the very high doses. Let’s take the 65 mg/kg dose of Vitex, which was found to have no statistical difference in testosterone levels when compared to control (in fact, it actually trended towards an increase in testosterone).
    The study used ~23g male mice.
    Let’s assume a 180 lb male human.

    HED = animal dose in mg/kg x (animal weight in kg/human weight in kg)^0.33
    HED=65* (0.023/81.82)^0.33
    HED = 4.3756231938 mg/kg
    For a 180 lb male, this equates to a dose of 360 mg Vitex Agnus Castus daily. Inhibit-P uses 300 mg daily, a dose which is lower than the dose that was found to have no significant effects. Couple this with inherent metabolic differences between humans and rats (decrements and increases in T in rats are manifested on a much lower scale in humans) and you’ll understand why Vitex will have no realistic effect on testosterone in males. Also, please note that a specific extract was used in this product, focusing on the key constituents in prolactin reduction.

    Last edited by Nom Z; 08-28-2012 at 02:15 PM.
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    Originally Posted by Nom Z View Post
    please note that a specific extract was used in this product, focusing on the key constituents in prolactin reduction.
    Nothing special about the extract that I could find --> i.e. dried Vitex fruit: 80% alcohol & 20% water



    Originally Posted by Nom Z View Post
    The effects of vitex, in this study, were shown to be dose-dependent, and testosterone was only significantly lowered at the very high doses.

    Inhibit-P uses 300 mg daily, a dose which is lower than the dose that was found to have no significant effects. Couple this with inherent metabolic differences between humans and rats (decrements and increases in T in rats are manifested on a much lower scale in humans) and you’ll understand why Vitex will have no realistic effect on testosterone in males.
    Aside from the DA2-receptor agonism from the Vitex in Inhibit-P, we're also dealing with the DA from Mucuna, as well as the DA cofactor; pyridoxal-5'-phosphate. Therefore, the degree of DA-agonism is considerably greater than just Vitex alone. Additionally, the threshold for Inhibit-P's suggested dose is 600mg of Vitex, and the biomarkers of steady-state concentrations of that magnitude have not been evaluated. So what do we really know?

    There is no available data suggesting Vitex 'enhances' testosterone production. The only effects observed [in rodents or humans] thus far, have been decrements in testosterone concentrations. In the absence of human data, if chronically administered Vitex does in fact suppress serum LH, then the theory of decreased testicular LH binding sites and reduced testosterone production could be supported. Nonetheless, the implication that testosterone production will be enhanced, is not supported [or even suggested] within the literature.
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    OP, if you're within normal range, that just might be your body's biochemical baseline. Did you get numbers before? Instead of fukking around with some crapass OTC supps that might work, and that's a very large assumption, wait for three to six months to see if it changes meanwhile do not change anything. If it's the same then don't worry about it. I'm facepalming at the micro managing some of you are trying to pull out of your ass when it won't matter in the end.
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    Originally Posted by thefleshlight View Post
    OP, if you're within normal range, that just might be your body's biochemical baseline. Did you get numbers before? Instead of fukking around with some crapass OTC supps that might work, and that's a very large assumption, wait for three to six months to see if it changes meanwhile do not change anything. If it's the same then don't worry about it. I'm facepalming at the micro managing some of you are trying to pull out of your ass when it won't matter in the end.
    I agree that taking supplements for the purpose of decreasing cortisol is a waste of time & money, especially when considering the degree of cortisol upregulation is likely non-significant from a clinical standpoint in almost all cases.

    I do like discussing the science though.
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    Just get some vitamin b6 instead of some ****ty over priced supplement.
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    Originally Posted by UncleWade View Post
    This is fair advice, and we appreciate you mentioning our product.

    Consult with your doctor and get his opinion, sometimes simple fixes for things that are moderately out of the normal range are the most effective and safest and can yield long term results. Communicate with your physician openly and directly, and with his approval give Inhibit-P a shot. We believe it's the most effective prolactin control supplement on the market and it's definitely great to stack with other products such as DAA for anyone else that happens to stumble across this thread.

    [center][IMG]http://i1185.photobucket.com/albums/z347/cclumberjack64/Inhibit-nter]
    You're a company shill trying to convince this poor guy to buy your company's crappy overpriced product that is essentially b6 and some other stuff.

    OP, just get some b6, or talk to your doctor about dostinex/cabergoline if you want to go down a prescription route. Dostinex is quite nice for general well being (nootropic, dopamine agonist)
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    Originally Posted by SenorRedGloves View Post
    I had some blood work done just make sure everything was ok and I found my prolactin was a little high,12.9(Ref: 4 - 15.2). The doctor said not to worry because it was still in range but is there anything to bring it down a bit?
    ever heard of Bromocriptine.

    Awesome all around, and especially for prolactin.
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