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07-30-2012, 03:54 PM #31
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07-30-2012, 03:56 PM #32
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07-30-2012, 04:01 PM #33
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08-24-2012, 11:50 AM #34
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08-24-2012, 02:04 PM #35
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11-29-2012, 08:55 PM #36
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11-30-2012, 07:14 AM #37
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There are a number of physiological inconsistencies between rodents and humans when you're examining such dynamic compound like ursolic acid. It's especially important to think about how large, hydroxylated compounds interact with ROS and how mammals and rodents adapt respectively. Based on some of the differences in other research e.g. antioxidant enzyme response to hypoxia, stress, and dietary antioxidants I wouldn't be too quick to weigh these results heavily in any sense. It's one of those cases in which anecdote prevails until we see human research.
Driven Sports
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11-30-2012, 02:14 PM #38
Read the full text.... there's not much cause for concern. They used castrated rats to exclude the influence of [intrinsic] testosterone, so no conclusions can be made reguarding UA's influence on circulating androgens in healthy subjects.
Nonetheless, the effects of UA closely resembled that of the finasteride-treated group suggesting that in addition to UA's prostate-specific apoptotic/antiproliferative effects in the BPH model, the primary MOA under such circumstances may include 5a-reductase inhibition.~
Wherever progression lacks.... regress can be found in abundance.
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