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06-07-2012, 07:48 AM #61
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06-07-2012, 10:15 AM #62
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Methylsynephrine requires a much smaller dosage than regular synephrine with double the half life. I think it's 3-6 hours. Ephedrine's half life is around the same. They both stimulate the same receptors in your brain so the stim like affects are comparable. Ephedrine seems to increase the metabolic rate at a greater level.
Don't combine them. http://www.ncbi.nlm.nih.gov/pubmed/22408069- NOTICE: Not all posts represent my own opinion. I enjoy playing devil's advocate.
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06-07-2012, 01:45 PM #63
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06-07-2012, 02:06 PM #64
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06-07-2012, 02:46 PM #65
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In 2010 Nutrex was taken to court due to having the drug Oxilofrine in some of their products.
It has also caused many problems for athletes having failed drug tests. I have attached an example along with the Nutrex case.- NOTICE: Not all posts represent my own opinion. I enjoy playing devil's advocate.
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06-07-2012, 03:09 PM #66
First, methylsynephrine actually requires a larger dose to affect hemodynamic factors than synephrine (not for lipolysis, in which synephrine may as well be disregarded). Methylsynephrine is well-tolerated at doses of up to 120mg, whereas p-synephrine can be dangerous at much lower quantities.
Also, the study you cited elucidates the dangers of stacking p-synephrine with epehedrine and caffeine. While I still would not advocate co-administration of ephedrine, MS, and caffeine, MS' safety profile is far more favorable than p-synephrine and the likelihood of a toxic outcome is far lower.
I wouldn't be too concerned about ephedrine or methylsynephrine's effects in the brain, as the beta-hydroxyl on both compounds precludes significant CNS penetration.
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06-07-2012, 03:14 PM #67
Are you a competitive athlete? I'm not, and thus my opinion is selfishly limited to myself.
Back on topic, I believe answers to the original question have been provided with respect to methylsynephrine. What I am more curious about is whether or not the FDA's stance on betaphrine has changed in the past few years. For those who have full-text access to the study examining the effects of isopropylnorsynephrine on lipolysis relative to other constituents of Citrus aurantium, did the authors specifically state that the betaphrine was synthetic?
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06-07-2012, 03:29 PM #68
http://forum.bodybuilding.com/showth...hp?t=145500011
IForce's response!*RCSS Rep*
http://www.bodybuilding.com/store/ronnie-coleman-signature-series.html
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06-07-2012, 03:36 PM #69
The author clearly states "isopropyl derivative".
Additionally in terms of synthesis - Adamski et al. 1975, demonstrated that isopropyloctopamine is sythesized by reacting a ketone with a hydrochloride salt of an alkanolamine in the presence of hydrogen/palladium on a charcoal catalyst.~
Wherever progression lacks.... regress can be found in abundance.
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06-07-2012, 03:41 PM #70
Thanks for the information. I'm not too well-versed in the rules of this industry, but have you read the iForce response? They have a point with respect to creatine derivatives and the like, though again, I don't know if that is a broad-spectrum violation of DSHEA that is simply accepted at this point.
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06-07-2012, 03:42 PM #71
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06-07-2012, 03:58 PM #72
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The para-hydroxyl group would decrease the LogP even further. In humans, one would not expect any central activity at all, unlike ephedrine in which central effects (be them mild) are observable in humans despite the beta-hydroxyl group. http://www.ncbi.nlm.nih.gov/pmc/arti...00284-0075.pdf
Driven Sports
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06-07-2012, 04:03 PM #73
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06-07-2012, 04:20 PM #74
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This is unclear and can't be done in one step. Beginning with phenol, acylchloride (with another halogen terminus) with FeCl3 catalyst would produce the p-O-acyl and C-acyl derivative, from which you can remove the ester, add the substituted amine, reduce, and remove the quaternary amine in aqueous workup.
Driven Sports
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06-07-2012, 04:23 PM #75
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06-07-2012, 04:24 PM #76
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06-07-2012, 07:19 PM #77
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06-08-2012, 03:05 AM #78
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06-08-2012, 06:10 AM #79
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06-08-2012, 06:31 AM #80
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06-08-2012, 08:07 AM #81
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09-04-2012, 10:37 AM #82
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Thank you so much for this thread. I have been taking an EC stack off and on for a couple of years and was looking to try something new. I saw on another site they were talking about Methyl-Synephrine. Someone there said it was ok to take along with Bronkaid and caffeine but that worried me a bit so i wanted to come here and see what everyone was saying..
So you are saying that caffeine is okDaily Journal
http://forum.bodybuilding.com/showthread.php?t=172687201
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