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    Methylsynephrine & Isopropyloctopamine - What are we ACTUALLY ingesting????

    Apparently, isopropyloctopamine is being marketed as a fat loss supplement however, isopropyloctopamine [betaphrine] is an uncontrolled drug and is a non-DSHEA compliant ingredient, as evidenced by the FDA's ruling against Syntech Enterprises in 2004 when they tried to introduce betaphrine to the market as an NDI.

    "Isopropyloctopamine" (aka "Betaphrine"), a "synthetically produced substance that has not been approved by the FDA and is prohibited from being sold without authorization under the Federal Food, Drug, and Cosmetc Act."

    (Deary, et al. v. Vital Pharm., Inc., No. 2:12-cv-04314 (C.D. Cal. complaint filed on May 18, 2012)).


    Since we're on the subject of non-DSHEA compliance, methylsynephrine [which neuron has discussd ad nauseum] is also not found in nature and I am curious as to wether the "methylsynephrine" content from various manufacturers is actually the pharmacodynamically inferior beta-O-methylsynephrine.... or is it the uncontrolled drug oxilofrine. ---> *crickets jpg.*

    Any company representatives care to elaborate on this issue?
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    Originally Posted by TMac26 View Post
    I can mention that Methylsyn is no longer found in any of our products.
    Wonder why.

    Does VPX's isopropyloctopamine come from the isopropyl plant?
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    Subbing for responses
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    Don't hold your breath.

    Originally Posted by Corey_Ellis View Post
    Subbing for responses
    I woud not expect any valid and/or relevant responses, as there really are none. --> Nonetheless, the consumer needs to know exactly what they are ingesting, but unfortunately the aforementioned ingredient discrepancy remains elusive to say the least.
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    I am assuming if there were proof that the ingredient in question was available for use, it would have been posted by now.

    The lack of responses says much more than anything we can post about if.

    Assuming this ingredient is noncomplient, what happens next?
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    In for answers as well
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    I honestly don't care as long as it is on the label and it is safe.

    How about we talk about its safety, compared to other stimulants -- that's a worthy discussion. We don't have threads up about "DMAA - what are we ingesting?" despite the FDA declaring it a drug. Someone with knowledge should differentiate the safety concerns vs compliance BS. Being unsafe usually = non-compliant, but non-compliant does not = unsafe.

    It's also worth noting that iForce doesn't manufacture anything that isn't looked over and tested by the FDA, so it seems interesting that it would have made it to market if there were a problem.
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    That was my grandma just prior to taking an OTC supplement containing "Methylsynephrine".













































    She later tested positive for oxilofrine use, and got kicked off the bingo team. --> True story.
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  9. #9
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    Good thread NH. I ask "why do we care?"

    What I mean is this:
    Is the worry due to:
    1. Danger(most important IMO)
    2. Unlevel playing field
    3. More ridicule of the industry
    4. Bc the FDA says so(least important IMO)
    5. Other

    I agree with D3 with appreciation it is on the label so we can research and decide for ourselves. If there is danger that is a problem, if there is gonna be more ridicule and FDA back lash that is a problem, but the other reasons I don't care too much about as I think the FDA is corrupt and I am not an industry insider/competing product maker.

    If you know of ill effects please post sir.
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    Originally Posted by D3Baseball View Post
    I honestly don't care as long as it is on the label and it is safe.
    Compare the physiological effects of alpha-methylsynephrine to those of beta-O-methylsynephrine, and I bet your opinion will change.
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    what would bozz say
    Nope!
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    Originally Posted by rob112 View Post
    Good thread NH. I ask "why do we care?"
    Popping a positive on a drug screen for oxilofrine use for starters.....
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  13. #13
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    Originally Posted by NO HYPE View Post
    Compare the physiological effects of alpha-methylsynephrine to those of beta-O-methylsynephrine, and I bet your opinion will change.
    is this how VPX beat out the EC stack? with the OG meltdown... MS/MTTA version
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  14. #14
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    Originally Posted by NO HYPE View Post
    Popping a positive on a drug screen for oxilofrine use for starters.....
    Is there a article at high tower pharm on oxilofrine?
    I am gonna check.

    Oh, and I wasn't asking that to be a dick

    Edit: site isn't working for me
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  15. #15
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    Originally Posted by rob112 View Post
    Is there a article at high tower pharm on oxilofrine?
    I can't recall off-hand however, he discusses it briefly here --> http://forum.bodybuilding.com/showth...hp?t=144742671
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    Damn. I know neuron has been deleting posts lately but I missed what it was that got him sent to the banned-wagon?
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    If Beta-3 Agonists were so safe and splendid, esp for weight loss, we'd see the pharmaceutical drugs that were tested actual make it to market. However, we do not have any selective beta-3 agonists on the market, and therefore there is a reason.
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    Originally Posted by NO HYPE View Post
    Damn. I know neuron has been deleting posts lately but I missed what it was that got him sent to the banned-wagon?
    His blog isn't working either. ****! Will check link. Last posts I saw of him were in the "who wouldn't u rep for" thread. Maybe a request to be banned?
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  19. #19
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    yikes...
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    Originally Posted by NO HYPE View Post
    Even if it is properly identified, I highly doubt oxilofrine will remain on the shelves long [seeing how it's not found in nature/DSHEA compliant], plus it's definitely a compound they are looking for on the WADA ban list.

    Seems rather idiotic to me that a company would release this, after all of it's media coverage pertaining to athletes testing positive for oxilofrine. --> LINK for anyone unaware
    Still can't figure this out.
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    Who is still selling methylsynephrine?
    However beautiful the strategy, you should occasionally look at the results - Dr. John Berardi
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  23. #23
    Registered User _Smitty_'s Avatar
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    Originally Posted by D3Baseball View Post
    Who is still selling methylsynephrine?
    Synthetic Supplements... an off-shoot of PES.

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    Originally Posted by _Smitty_ View Post
    Synthetic Supplements... an off-shoot of PES.

    [img]http://syntheticsupplements.com/media/wysiwyg//Slider/Methyl-Syn_500x301.png[img]
    Interesting. I guess doing one run of something you know you're not allowed to do is an interesting way to make some money and say "oops, sorry!"
    However beautiful the strategy, you should occasionally look at the results - Dr. John Berardi
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    I snort that ****
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    Thumbs up

    Just found this in my user CP [I guess this is as close to an answer as we'll get]:

    "Octopamine is found naturally, and isopropyl octompamine HCL = Betaphrine"

    Response:

    1. Isopropyloctopamine is a synthetically-derived structural intermediate of octopamine.

    2. It's not naturally occurring.

    3. It's an uncontrolled drug.

    4. It's not DSHEA-compliant.
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  27. #27
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    so when is v.3 coming out
    Clear Muscle Log- http://forum.bodybuilding.com/showthread.php?t=162036483
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  28. #28
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    And I just purchased some iForce products a few days ago, including dexaprine v2. God damn it... Still awaiting VaughTrue's reply to the question regarding Isopropyloctopamine being a drug or not.
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  29. #29
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    Originally Posted by NO HYPE View Post
    Just found this in my user CP [I guess this is as close to an answer as we'll get]:

    "Octopamine is found naturally, and isopropyl octompamine HCL = Betaphrine"

    Response:

    1. Isopropyloctopamine is a synthetically-derived structural intermediate of octopamine.

    2. It's not naturally occurring.

    3. It's an uncontrolled drug.

    4. It's not DSHEA-compliant.
    That is what we all have been thinking. Curiously awaiting any type of response from said companies and I'm quite surprised this hasn't caused more of an uproar around here.
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  30. #30
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    Uproar = bans apparently.
    bodyrecomposition
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