Read through some articles and gathered this...
When the body is fasted (hasn't eaten in several hours), certain hormones are elevated that promote the breakdown of fat. Also, in a fasted state, the body upregulates production of desnutrin, or ATGL. ATGL is a newly discovered/understood enzyme that helps to facilitate the breakdown of fat into usable energy. Not eating increases ATGL and other fat destroying enzymes/hormones. Eating, on the other hand, increases the amount/concentration of insulin in the body, which does two things- Turns "off" the production of ATGL, and turns "on" an enzyme known as AdPLA. Before we get into that tho, you have to know what PGE2 is. PGE2 is a molecule that slows down fat loss on a molecular level by degrading, or lowering levels of, a chemical called cAMP. cAMP is a chemical "messenger" that basically tells fat molecules within the fat cell to get the **** on and get useful somewhere. Now...PGE2 is produced by...yep, AdPLA (ughhhhh...molecule abbvs...) which starts producing the PGE2 when insulin concentrations are high (ie: after eating). So, I think it can be fair to say that someone wanting to lose fat would want a high level of cAMP as often as possible, which can only be maintained by keeping low level of PGE2.
"But Wubzy," you say, "what does all this really mean?"
Well reader...it's okay. Your cries are elaborated upon.
Well, basically, in theory it means that fasting, or NOT eating 5-6 small meals a day is an effective fat loss technique for 2 reasons.
1- ATG levels in the body remain at higher levels for longer periods of time
2- PGE2 stays at low levels and, adversely affects our good frend cAMP.
Idk....I'm no physician or nutritionist...or even a college grad, but after doing some reading I've decided that drinking alot of water and eating small amounts once a day would be pretty effective for someone really heavy to lose a good amount of fat without having to worry about eating a bit every 2-3 hours.
None of it matters tho, all that matters is CALORIES IN v.s. ENERGY OUT