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  1. #1
    Registered User ss4vegeta1's Avatar
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    Resveratrol what does the science say?

    Is it worth supplementing for anything? If anyone has any solid peer reviewed journals to post, will rep.
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  2. #2
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    Originally Posted by ss4vegeta1 View Post
    Is it worth supplementing for anything? If anyone has any solid peer reviewed journals to post, will rep.
    http://www.ncbi.nlm.nih.gov/pubmed/
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  3. #3
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    I think it is. Check out this study on people: cell.com/cell-metabolism/retrieve/pii/S155041311100386X

    Highlights
    Resveratrol reduced sleeping metabolic rate in human, mimicking calorie restriction
    Resveratrol improved mitochondrial metabolism through the AMPK-SIRT1-PGC-1α axis
    Resveratrol decreased hepatic and increased muscle lipid content
    Resveratrol reduced inflammation markers in plasma and muscle

    Summary

    Resveratrol is a natural compound that affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here, we treated 11 healthy, obese men with placebo and 150 mg/day resveratrol (resVida) in a randomized double-blind crossover study for 30 days. Resveratrol significantly reduced sleeping and resting metabolic rate. In muscle, resveratrol activated AMPK, increased SIRT1 and PGC-1α protein levels, increased citrate synthase activity without change in mitochondrial content, and improved muscle mitochondrial respiration on a fatty acid-derived substrate. Furthermore, resveratrol elevated intramyocellular lipid levels and decreased intrahepatic lipid content, circulating glucose, triglycerides, alanine-aminotransferase, and inflammation markers. Systolic blood pressure dropped and HOMA index improved after resveratrol. In the postprandial state, adipose tissue lipolysis and plasma fatty acid and glycerol decreased. In conclusion, we demonstrate that 30 days of resveratrol supplementation induces metabolic changes in obese humans, mimicking the effects of calorie restriction.

    The best comment is given by Husam Ghanim in the comments. He says:

    Our most current preliminary data (unpublished data), show that the intake of PC extract (600mg/ day) containing 20% RSV (120mg/day) but not pure resveratrol alone (500mg/day) for 12 weeks suppresses mediators of inflammation and improves HOMA-IR in insulin resistant obese subjects. Most of these reductions range between 20-30%. This is of interest since it demonstrates that resveratrol alone is not sufficient to induce metabolic changes even at a dose higher than when compared to that taken as part of the extract or with other polyphenols. It is possible that other components of the PC extract are necessary to either directly induce or mediate the changes observed. This might explain the lack of effect of many pure RSV supplements when used at low doses (1-10mg/kg/day) in animals and the need to use extremely high doses (200-500mg/kg/day) in order to achieve measurable metabolic changes.

    While resveratrol investigation in the human is still at an early stage, we need to be cautious in our enthusiasm since most studies, including our own, have not yielded clear cut results with pure preparations even when higher doses (2000mg/day) were used (4). On the other hand, changes observed with plant extracts containing resveratrol are impressive. However, more work is required to confirm these effects in larger studies and to identify the other active compounds in plant extracts.
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  4. #4
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    Product wise, take a look at PteroMax by Biotivia.
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  5. #5
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    One of the lead researchers of resveratrol was just implicated in some data fudging; I don't remember the details.
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    vvv excellent find!

    Originally Posted by bestbefore View Post
    Our most current preliminary data (unpublished data), show that the intake of PC extract (600mg/ day) containing 20% RSV (120mg/day) but not pure resveratrol alone (500mg/day) for 12 weeks suppresses mediators of inflammation and improves HOMA-IR in insulin resistant obese subjects. Most of these reductions range between 20-30%. This is of interest since it demonstrates that resveratrol alone is not sufficient to induce metabolic changes even at a dose higher than when compared to that taken as part of the extract or with other polyphenols. It is possible that other components of the PC extract are necessary to either directly induce or mediate the changes observed. This might explain the lack of effect of many pure RSV supplements when used at low doses (1-10mg/kg/day) in animals and the need to use extremely high doses (200-500mg/kg/day) in order to achieve measurable metabolic changes.
    ThermoLife scientific consultant
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  7. #7
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    Originally Posted by D3Baseball View Post
    One of the lead researchers of resveratrol was just implicated in some data fudging; I don't remember the details.
    Dipak K Das at UCONN.
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  8. #8
    ASSFUKKER6969 thefleshlight's Avatar
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    OP, resveratrol has essentially no bioavailability; with bioperene, it's marginally better, but still pretty damn shytty. Pteromax seems to be good because of the other goodies in it, not because of the resveratrol content.
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  9. #9
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    It's probably cheaper buying some cheap red wine than supplements
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    ASSFUKKER6969 thefleshlight's Avatar
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    Originally Posted by micahjfreedman View Post
    It's probably cheaper buying some cheap red wine than supplements
    It's known that the resveratrol has almost fully olimerized in red wine to a plethora of its 100 or so different natural products. The amount free resveratrol left in red wine to give legit benefits, coupled with the fact that it has horrid bioavailability, you will be very far beyond dead for any useful amount of resveratrol to make it through your digestion system.
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  11. #11
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    Originally Posted by thefleshlight View Post
    It's known that the resveratrol has almost fully olimerized in red wine to a plethora of its 100 or so different natural products. The amount free resveratrol left in red wine to give legit benefits, coupled with the fact that it has horrid bioavailability, you will be very far beyond dead for any useful amount of resveratrol to make it through your digestion system.
    Damn...I just wanted an excuse to drink lots of old grapes
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  12. #12
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    So basically resveratrol is a waste of $...???
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  13. #13
    Bringin the Synergy Back xR1pp3Rx's Avatar
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    no but it has poor absorbtion.. and may be expensive at an efficious dose.
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    Resveratrol isn't a waste of time I think. But in many things, don't take isolated supplements for the most part. Just as it is better to eat whole food to get your vitamins and minerals because of the synergy of all the ingredients together. Take Resveratrol as an extract with other polyphenols. Check out Country Life Resveratrol Plus.

    I would only use isolated supplements if you have a shortage of some kind of vitamin or mineral or you can't get the nutrient through food alone. Vitamin D3 or vitamin K2 are such supplements.

    And another thing, better absorption doesn't necessarily mean that it is going to work better.
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    I would like to see what the amount of resveratrol "bioavailability" Prototype Nutrition's R-spray has, to be honest. I think that would be a bit too costly for studies and specific bloodwork, but I'm sure Pat found a reason why it's good as a TD product.... Can't say I've personally gone on an internet quest to find his reasoning though.
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    A lot of the positives of resv supplementation exist even in low doses. I think the major issue is activating SIRT1 which would require better bioavialability to reach some of the levels shown in vitro. Example, super low dose improves insulin sensitivity...

    Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients. Brasnyó P, Molnár GA, Mohás M, Markó L, Laczy B, Cseh J, Mikolás E, Szijártó IA, Mérei A, Halmai R, Mészáros LG, Sümegi B, Wittmann I. 2011, The British Journal of Nutrition, pp. Mar 9:1-7.
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    Get Diesel Or Die Trying Younglifter16's Avatar
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    how much does piperine increase oral availability?
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    Originally Posted by Younglifter16 View Post
    how much does piperine increase oral availability?
    Mol Nutr Food Res. 2011 Aug;55(8):1169-76. doi: 10.1002/mnfr.201100117. Epub 2011 Jun 29.

    Enhancing the bioavailability of resveratrol by combining it with piperine.

    Johnson JJ, Nihal M, Siddiqui IA, Scarlett CO, Bailey HH, Mukhtar H, Ahmad N.


    Source

    Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA.


    Abstract

    SCOPE:

    Resveratrol (3,5,4'-trihydroxystilbene) is a phytoalexin shown to possess a multitude of health-promoting properties in pre-clinical studies. However, the poor in vivo bioavailability of resveratrol due to its rapid metabolism is being considered as a major obstacle in translating its effects in humans. In this study, we examined the hypothesis that piperine will enhance the pharmacokinetic parameters of resveratrol via inhibiting its glucuronidation, thereby slowing its elimination.

    METHODS AND RESULTS:

    Employing a standardized LC/MS assay, we determined the effect of piperine co-administration with resveratrol on serum levels resveratrol and resveratrol-3-O-β-D-glucuronide in C57BL mice. Mice were administered resveratrol (100 mg/kg; oral gavage) or resveratrol (100 mg/kg; oral gavage)+piperine (10 mg/kg; oral gavage), and the serum levels of resveratrol and resveratrol-3-O-β-D-glucuronide were analyzed at different times. We found that the degree of exposure (i.e. AUC) to resveratrol was enhanced to 229% and the maximum serum concentration (C(max)) was increased to 1544% with the addition of piperine.

    CONCLUSION:

    Our study demonstrated that piperine significantly improves the in vivo bioavailability of resveratrol. However, further detailed research is needed to study the mechanism of improved bioavailability of resveratrol via its combination with piperine as well as its effect on resveratrol metabolism.

    Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


    PMID: 21714124 [PubMed - indexed for MEDLINE]
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    Yes, but it should also be known that 229% of 3% is still pretty goddamn shytty.
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    Originally Posted by thefleshlight View Post
    Yes, but it should also be known that 229% of 3% is still pretty goddamn shytty.
    this is what Im refferring too. I remember the number was still pretty insignificant just like with curcumin. is it even worth it then?
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    Originally Posted by Younglifter16 View Post
    this is what Im refferring too. I remember the number was still pretty insignificant just like with curcumin. is it even worth it then?
    Well, 229% of 3% is roughly 7%. If you can get it cheap and megadose it, then, sure, why not try it. Meanwhile, I will use Na-R-ALA, Agmatine, vit c, vit e, etc and laugh all the way to the bank. I think just simple exercise/cardio and a good diet will negate any positive effects this has.... IMO, it's more gauged toward fatasses, sedentary people, and old fawkers. You would probably be better off running low dose test or GH for the kind of money you would need to drop to run Res; and I've never seen a consumer-friendly supplier of 'bulk' res, so you'll need to go to a manufacturer that has a product with res and hope you become friends with them so they can sell you some in bulk or go straight to chinatown for it. Either way, time saved >>>>> money spent IMO.

    Conversely, like I stated before, I would like to see support for TD use of resveratrol, like what Pat uses in his R-spry.
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    Originally Posted by thefleshlight View Post
    Yes, but it should also be known that 229% of 3% is still pretty goddamn shytty.
    A small amount, may actually be a significant amount when it comes to resv. See post #16.
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    Originally Posted by Right_Hook View Post
    A small amount, may actually be a significant amount when it comes to resv. See post #16.
    With regards to insulin sensitivity? Like I said, maybe in fatasses and old fawkers.

    and people who are unlucky since it's type 2 diabetes
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    Originally Posted by thefleshlight View Post
    With regards to insulin sensitivity? Like I said, maybe in fatasses and old fawkers.

    and people who are unlucky since it's type 2 diabetes
    That is just one reference. There are many more with low dose resv showing positive effects on various ailments.
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    Originally Posted by Right_Hook View Post
    That is just one reference. There are many more with low dose resv showing positive effects on various ailments.
    You know the answer to that....







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    Originally Posted by thefleshlight View Post
    You know the answer to that....







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    lol agreed
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    Yes, strong bump. I'm a STOKED person who uses it pretty much as a staple. So after reading this it appears as though the trans-resveratrol in it helps VERY little if any then with the availability/absorption problem...????
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    I iz a sad that fleshlight was banned.

    Having said that more research is beginning to look at resveratrol metabolites as the reason for in vivo effects. Also conversion back to the parent compound in vivo. A new good PD study out as well. Seems to be reaching adipose tissue.
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    I like pycnogenol which is kind of in the same genre.
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    Originally Posted by ss4vegeta1 View Post
    Is it worth supplementing for anything? If anyone has any solid peer reviewed journals to post, will rep.
    I hope that everyone on here knows that most of the affordable Resveratrol supplements are *NOT* made from grape skin.

    They are made from an invasive plant, Japanese Knotweed.

    Also, there is not enough science to judge the long term effects, and the little there is is far from conclusive.

    TLDR: Just eat real grapes instead.
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