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    Can BCAAs get converted to glucose?

    I'm doing intermittent fasting and take BCAAs peri workout after having fasted usually 14-16 hours. But the other day it occurred to me that maybe the body will just convert them to glucose if their is not enough muscle glycogen - wouldn't that defeat the whole purpose? Would the body use fat stores as energy before it converted the BCAAs or does it want to avoid using the fat for some retarded reasons.
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    nevigsawkufelgnisaton in10city's Avatar
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    Leucine cannot, but isoleucine and valine can. Little would be converted to glucose.
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    Registered User peteyboy1015's Avatar
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    Originally Posted by in10city View Post
    Leucine cannot, but isoleucine and valine can. Little would be converted to glucose.
    Carbs are more readily converted to glucose, from what I've read. Is that correct?
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    Originally Posted by peteyboy1015 View Post
    Carbs are more readily converted to glucose, from what I've read. Is that correct?
    Yeah i just thought after being in a fasted state maybe the BCAA could be converted to glucose which would be ironic given that the BCAA are taken to prevent protein breakdown. Just taking some simple carbs could have the same effect of sparing the muscle protein.
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    Registered User misterguyx's Avatar
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    Not ironic, that's more or less their purpose. My understanding is they are recommended there to replenish what's getting lost during oxidation of fat and catabolism of muscle. IF just seems to be a way of encouraging a mini-ketosis state during fasted training, and then eating properly the rest of the day without having to follow a strict keto diet.
    The choice between cutting and bulking should be made based on facial and chest hollows.
    The choice between eating more or eating less should be made based eating sufficient protein sources first, and energy levels second.
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    as in10city said, some aminos are glucogenic.
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    The controversial aspect is whether BCAA's really help in the long term, or is it simply for convenience and/or safety.
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    Registered User lauhpurush's Avatar
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    Also, is it important to take BCAA's if you're just doing some LISS like Brisk walking for 40 minutes and you'll be having the first meal like 6 hours later?
    Or are they only needed during intense weightlifting in fasted state?
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    Originally Posted by lauhpurush View Post
    Also, is it important to take BCAA's if you're just doing some LISS like Brisk walking for 40 minutes and you'll be having the first meal like 6 hours later?
    Or are they only needed during intense weightlifting in fasted state?
    They are "needed" to make your numbers at the end of the day, and because eventually you may need the boost of energy from not being COMPLETELY fasted to get through your lifts. If you're able to finish, and you're going to eat sufficient protein to repair before your next set of exercise, then eat them if they make you happy, and not otherwise.
    The choice between cutting and bulking should be made based on facial and chest hollows.
    The choice between eating more or eating less should be made based eating sufficient protein sources first, and energy levels second.
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    Originally Posted by peteyboy1015 View Post
    Carbs are more readily converted to glucose, from what I've read. Is that correct?
    glucose is a carb
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    Originally Posted by misterguyx View Post
    Not ironic, that's more or less their purpose.
    So their purpose is to be turned into glucose to spare muscle protein being broken down in a catabolic state? As I said in that case why not just ingest some simple carbs pre workout then and save the money and the net result will be the same.
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    Originally Posted by in10city View Post
    Leucine cannot, but isoleucine and valine can. Little would be converted to glucose.
    Thanks. When you say that "little would be converted to glucose" could you explain the reason for it.?
    Is it because stored fat would be a preferential energy source rather than the body converting amino acids? Or is it that you feel muscle glycogen levels are not that far depleted from training after a 14-16 hour fast?
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    nevigsawkufelgnisaton in10city's Avatar
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    Originally Posted by PimpedHerOut View Post
    Thanks. When you say that "little would be converted to glucose" could you explain the reason for it.?
    Is it because stored fat would be a preferential energy source rather than the body converting amino acids? Or is it that you feel muscle glycogen levels are not that far depleted from training after a 14-16 hour fast?
    The reason has to do with the metabolic pathways that leucine, isoleucine and valine flow through. At least the beginning of BCAA catabolism primarily begins in the muscle since the activities of the first two enzymes involved in BCAA catabolism - branched-chain amino acid aminotransferase (BCAAAT) and the branched-chain keto acid dehydrogenase complex (BCKD) - are highest there 50%+ (and muscle BCAA uptake and BCKD activity are increased by exercise, particularly endurance). If you have a 2:1:1 BCAA mix, only 38% could possibly end up as glucose since leucine is not glucogenic and only half of isoleucine is glucogenic. Since muscle isn't gluconeogenic, in order to create glucose, metabolism needs to begin in gluconeogenic tissue (liver or kidneys) or the carbon from partial catabolism needs to be released and taken up by gluconeogenic tissue. Some carbon is released, but not all is, in the form of glutamine, alanine and beta-hydroxyisobutyrate among others. Not all of the carbon is taken up by gluconeogenic tissue and not all that is taken up by gluconeogenic tissue is used for gluconeogenesis.
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