Bioavailability of creatine mono without carbs?

[ShogunRua]

Hey guys I tried search and got a million unrelated non sense threads. Does anybody have a link or anything to help me out here? Im aware it is very bioavailable on its own I just have never actually read it for myself and I would like to

[in10city]

Carbs really don't affect the bioavailabilty. Rather they enhance retention by influencing creatine transport into the muscle during creatine loading, assuming a certain insulin concentration is hit. Once you are near or at saturation, they don't do anything since muscle creatine can be maintained without co-ingestion with carbs.

http://www.ncbi.nlm.nih.gov/pubmed/17851680
http://www.ncbi.nlm.nih.gov/pubmed/8944667
http://www.ncbi.nlm.nih.gov/pubmed/10956365
http://www.ncbi.nlm.nih.gov/pubmed/20035494

[NO HYPE]

Clin Sci (Lond). 1992 Sep;83(3):367-74.

Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation.

Harris RC, Söderlund K, Hultman E.
SourceDepartment of Clinical Chemistry II, Karolinska Institute, Huddinge University Hospital, Sweden.



Abstract
1. The present study was undertaken to test whether creatine given as a supplement to normal subjects was absorbed, and if continued resulted in an increase in the total creatine pool in muscle. An additional effect of exercise upon uptake into muscle was also investigated. 2. Low doses (1g of creatine monohydrate or less in water) produced only a modest rise in the plasma creatine concentration, whereas 5g resulted in a mean peak after 1h of 795 (SD 104) mumol/l in three subjects weighing 76-87 kg. Repeated dosing with 5g every 2h sustained the plasma concentration at around 1000 mumol/l. A single 5g dose corresponds to the creatine content of 1.1 kg of fresh, uncooked steak. 3. Supplementation with 5g of creatine monohydrate, four or six times a day for 2 or more days resulted in a significant increase in the total creatine content of the quadriceps femoris muscle measured in 17 subjects. This was greatest in subjects with a low initial total creatine content and the effect was to raise the content in these subjects closer to the upper limit of the normal range. In some the increase was as much as 50%. 4. Uptake into muscle was greatest during the first 2 days of supplementation accounting for 32% of the dose administered in three subjects receiving 6 x 5g of creatine monohydrate/day. In these subjects renal excretion was 40, 61 and 68% of the creatine dose over the first 3 days. Approximately 20% or more of the creatine taken up was measured as phosphocreatine. No changes were apparent in the muscle ATP content.(ABSTRACT TRUNCATED AT 250 WORDS)

[powercage]

NH, personal thoughts on creatine cycling? * *

[NO HYPE]

Carbs really don't affect the bioavailabilty. Rather they enhance retention by influencing creatine transport into the muscle during creatine loading, assuming a certain insulin concentration is hit. Once you are near or at saturation, they don't do anything since muscle creatine can be maintained without co-ingestion with carbs.

http://www.ncbi.nlm.nih.gov/pubmed/17851680
http://www.ncbi.nlm.nih.gov/pubmed/8944667
http://www.ncbi.nlm.nih.gov/pubmed/10956365
http://www.ncbi.nlm.nih.gov/pubmed/20035494

^^^^ This. ^^^^

[BXR99]

A single 5g dose corresponds to the creatine content of 1.1 kg of fresh, uncooked steak.

cool study but I lold when I though of this, someone taking 5g of creatine or eating a 39 oz steak

[ShogunRua]

quick responses and awesome help. Thanks a ton guys

[NO HYPE]

NH, personal thoughts on creatine cycling? * *

There is some speculation as to the effects of long-term creatine supplementation on the creatine transporter and possible downregulated activity. I am of the opinion that physiological homeostasis [and low maintenence doses] would trump this concern however, I have no evidence to support this theory.

[powercage]

There is some speculation as to the effects of long-term creatine supplementation on the creatine transporter and possible downregulated activity. I am of the opinion that physiological homeostasis [and low maintenence doses] would trump this concern however, I have no evidence to support this theory.

That was my personal stance as well, still interested in others opinions since it is not fully substantiated