This should settle all those Melanotan threads that keep popping up. Im going to give as much info I can from other sources. Everything will be from http://melanotan.org/cgi-bin/yabb/YaBB.pl and for more info http://articles.muscletalk.co.uk/article-melanotan.aspx. For actual responses from people go there, but here I will list as much info as I can find. If anything posted under this is against the rules. I will remove it due to Mods authority.
*PRE-MIXED MELANOTAN PEPTIDES MAKE PEOPLE SICK*
*DO NOT BUY MELANOTAN PEPTIDES ADULTERATED WITH A FILLER LIKE MANNITOL - DEMAND HIGH PURITY >99%*
At no point in time will anything in Melanotan FAQs or forums override licensed medical practitioner to patient directives regarding matters of health. Direct doctor to patient counsels/advice ALWAYS takes precedence. Melanotan is not to be considered a legitimate source for direct medical advice. No individual is authorized to give direct medical advice on Melanotan. For direct medical matters always seek the assistance of licensed and qualified medical practitioners, NEVER rely upon Melanotan for such matters.
These WARNING / FAQ posts have been formulated both from information found in published clinical trials of the melanotan peptides and also from anecdotal reports.
Individuals considering using either of the as of yet unlicensed and unregulated melanotan peptides should know that there can be serious risks to one's health in doing so. Be aware of Governmental Health Agency Warnings specific to the melanotan peptides
against their usage outside of regulated clinical trials. Before reading this FAQ please review the entirety of the first post of this thread.
HEALTH CONCERNS - SEEK MEDICAL ASSISTANCE
If a health concern should present itself during a regimen do not automatically assume it stems from some aspect of the regimen. Instead, do not hesitate to be medically examined by a licensed health care practitioner. Be as upfront with the practitioner about your regimen as possible and know that generally speaking the more information doctors have the better they will be in a position to help you.
Section summary: It is strongly recommended to have one's skin examined by a dermatologist to check for any skin issues prior to starting usage of a melanotan peptide. This is also true if any skin issue should become apparent while using a melanotan peptide or after finishing a regimen.
Because usage of the melanotan peptides by people is a relatively new phenomenon (ie: the first human clinical trial of melanotan-1 was in 1991), it is advisable to visit a dermatologist to have a skin "check up" (physical) particularly for those who've never been able to tan previously. Request that the dermatologist do a thorough examination of your skin to check for any irregularities (ie: differences in skin tone, latent yeast/fungal infections, moles, etc.) Discuss with the dermatologist what are the aspects of skin tanning that individuals in general should be aware of in terms of how one's skin can be affected (besides becoming tan). Be aware that when developing a natural tan (natural - meaning based on melanin - and particularly for those who've never had a tan before) it is possible (for a relatively small population of individuals affected by various skin disorders) that certain areas of skin ("white spots"/patches) will not be able to tan and conversely certain areas may remain tanned ("brown spots"/patches) after completely ceasing a tanning regimen. There are many known causes (most of which are of an infectious <ie: yeast/fungal> nature) for these types of spots/patches and ordinarily this type of thing is not something that affected pale individuals in particular will become aware of until they can achieve a tan. If one is diagnosed with a dermal yeast infection (like tinea versicolor) they will generally be prescribed very effective and simple to use medicines (ie: Nizoral) for treatment. This is why it is a good idea to consult with a dermatologist to see if there are any issues that you may not be aware of. Additionally, you may want to see what information the dermatologist can share with you (if any) about the melanotan peptides. Such a checkup (ie: in the guise of a, "skin cancer screening") may be covered by your country's national healthcare system or your private/company healthcare plan in which case there will be either no charge for you or simply a small fee.
MOLES & FRECKLES
Section summary: Those with any moles (especially on the face) and/or freckles should know that they will almost certainly darken* and that additional not particularly visible moles will likely become more noticeable when tanning especially while using a melanotan peptide (initially), if such darkening will bother you then Melanotan.org strongly advises either not starting use of a melanotan peptide or having such moles and/or freckles removed and skin completely healed prior to starting a usage regimen.
Those with a prevalence of moles and/or prominent freckles should be aware that any sort of tanning of one's skin can affect them and in particular when tanning with the usage of the melanotan peptides (darkening - particularly moles). Indeed, previously latent (not noticeable) moles can become visible / more visible when one starts to tan (regardless of using the peptides or not). Moles and freckles are concentration points for melanin and accordingly they will very likely be the first places to accumulate melanin prior to other areas of the skin (which for some people at least in the initial stages of using one of the peptides can set up a disagreeable contrast - particularly if not slowly building up a tan with lower than normal doses of peptide*). It may be advisable to undergo simple and safe mole and/or freckle removal treatments with a well qualified dermatologist prior to starting any melanin tanning regimen. A good example of the appearance enhancing benefits of having moles removed can be found in the following log where a forum member underwent Radio Surgitron and Intense pulsed light mole removal treatments in correspondence with a desire to have a natural looking tan. These types of treatments may be covered by your healthcare plan (best to inquire). If scarring is likely to occur, do not have moles removed or undergo other potentially scar causing procedures while using a melanotan peptide see the "SCAR FORMATION" section below.
It is not currently definitively known how long it can take for melanotan peptide darkened moles to fade. The cosmetic ramifications of mole darkening and a progression of fading or not is an aspect of melanotan peptide usage about which no scientific studies are known to have been published.
*: There has been some speculation in the forums that at certain dosing levels (at least initially) and progression speed of tanning moles can darken disproportionately fast relative to surrounding skin and this is what has caused issues for folks who've experienced this. Correspondingly with this speculation there is a debate that if a person builds up their tan slower than normal with lower than normal dosing that such a disproportionate contrast will not occur and instead a more natural and even tanning across the skin (including moles/freckles) will happen. Another view is that this initial difference in contrast is unavoidable.
Section summary: For fair skinned peptide users limited UV exposure is likely necessary and helps both darker skinned and fair skinned individuals have a more natural looking tan. Never overexpose oneself to UV light. UV light overexposure is known to cause skin damage (particularly cumulatively) that can lead to skin cancers. Get only enough UV exposure to effectively tan and not more (start with low levels for short amounts of time).
While the administration of Melanotan peptides via injections has been clinically demonstrated to make it possible for people who ordinarily cannot tan or have difficulty doing so (type I/II individuals) to be able to as well as make it easier for type III and IVs to do so (even with no UV exposure) they will generally not be most effective and the resulting skin tones will not look most natural without some limited exposure to UV light (ie: sunlight).
Real sunlight is the best, but sunbeds work too.
The amount of UV exposure necessary to achieve good results differs for EVERY person.
Some people will see their skin darken after only one sunbed session, while it will take a few sessions for others.
Usage of melanotan-1 has been clinically demonstrated to reduce UV skin damage (not completely prevent it). While Melanotan II hasn't been clinically demonstrated to do this, because it allows one to tan in the same way, it is quite likely that this damage reduction effect is also found with its usage. Because UV light overexposure can negatively impact and damage skin it is best to limit exposure to a level that is just effective enough in producing a tanning effect but not more. Optimally (particularly when starting out) not more than 5 minutes in one session per day. Do not overexpose your skin to UV light, the melanotan peptides weren't designed to make skin capable of tolerating UV overexposure. Regardless of peptide usage, overexposure will damage your skin. Please know that UV skin damage is cumulative meaning that damage will build up over time. Cumulative damage has been shown to correlate with subsequent development of skin cancers and while scientists hypothesize that using the melanotan peptides can have a protective effect against skin cancers this has yet to be clinically demonstrated. Please note that melanin converts UV light into heat, as one becomes darker the skin will become noticeably warmer in the presence of the same tanning level of UV light as prior to being darker. This is a good sign and means that the increased level of melanin is providing additional photoprotection.
In clinical trials on melanotan-1 it was reported that areas of the skin that have been more chronically exposed to UV light (ie: face, back of the neck, arms, and hands) were found to respond more readily to the melanogenesis (melanin producing) effects of the peptide. This effect has been reported in logs on the site as well (for melanotan II usage). For proper tanning balance it is advisable that early in getting UV exposure to develop a melanotan peptide tan one uses a strong SPF sunblock (30+ SPF) or towels to cover areas most subject to daily UV exposure (ie: the face, back of the neck) to allow other less chronically sun exposed areas to tan first and then subsequently expose the face (and other areas) for less time (or as needed) to UV light to thereby achieve a well balanced tan.
When exposing oneself to UV light it is imperative to wear proper eye protection. Eyes are very sensitive to UV light and can be damaged irreparably from chronic and/or overexposure. If using sunbeds do not simply "scrunch up" your eyes during exposure but wear proper UV blocking protective eyewear (this is usually supplied by a salon). This cannot be emphasized enough.
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