Vicodene: The World’s Most Powerful Natural Painkiller
If you suffer from pain and inflammation and you want a natural anti- inflammatory and natural pain reliever, Vicodene is your ultimate solution. Vicodene is a revolutionary fast acting anti-inflammatory and natural pain killer that can deliver relief within 30 minutes. Read through the important information below and place an order today so you can enjoy a better tomorrow.
Inflammation is critical for our survival against a hostile world. Classical inflammation is usually associated with pain and can result from continuing wear of an overactive immune system that is constantly turned on so that the body attacks itself (rheumatoid arthritis, irritable bowel syndrome). Silent inflammation happens when the immune system continues to attck at the cellular level (heart, immune system and brain) without the perception of pain. These continued insults often result in heart disease, cancer and Alzeimer. Inflammation affects more than 43 million Americans or about 1 in 6 people. In the United States, by the year 2010, there may be about 50 to 75 million or more people with inflammatory metabolic syndrome X. Over 20 million clinical inflammation sufferers are under age 65.Most pharmaceutical therapies (Aspirin, NSAIDs, COX-2 inhibitors, and Corticosteroids) simply try to reduce inflammatories cytokines or inflammatory Protein such as iNOS or COX2. However, these usually do not solve the underlying problems of inflammation. In addition, long term use of drug therapies carry one or more of the following side-effects: dependency, heart failure, Liver toxicity, fevers, chills, sweating, muscle aches, ulcers, tiredness, increased symptoms, and death.
What is Vicodene ?
Vicodene is developed by a group of scientists from Chile who pioneered the research and development of Anti-inflammatory therapies. Vicodene® a patented, standardized extract of Andrographis Paniculata, a bicyclic Diterpenic Labdanes containing Andrographolide, 14-Deoxyandrographolides, and Neoandrographolides. Preliminary research has shown Vicodene®to stimulate immune response at low doses and to activate PPARγ to promote healthy inflammatory response at high doses. Vicodene naturally activates PPAR gamma, thereby inhibiting NFkappaB. When NFkB is inhibited, proinflammatory cytokines ( Interferon gamma, Interleukin 2) and proinflammatory agents (COX-2, iNOS) are reduced. Emerging research has shown NFkappaB and PPAR receptors to hold the key to many inflammatory related diseases as they are the key regulator of our immune system and inflammatory response. Research has shown that Non Steroidal Anti Inflammatory Drugs (NSAIDs) and Glucotoids also activate PPAR receptor and inhibit NFkappaB. The inhibition of NFkappaB and activation of PPARγ has been seen as possible new effective anti-inflammatory therapies for many inflammation related diseases. However, these drugs therapies often have many undesirable side effects. Approximately 20,000 Americans die each year from the proper use of non-steroidal over-the-counter and prescription anti-inflammatory drugs.
Vicodene is the natural alternative to NSAIDs and COX2 inhibitor. Vicodene is clinically proven to promote healthy inflammatory response by naturally activating PPAR gamma and inhibiting NF kappa B without toxicity or side effect. *
How does Vicodene Work?
Vicodene works by naturally invigorating the activation of Peroxisome Proliferator-Activated Receptor gamma (PPARγ ). When PPARγ is activated, Nuclear Factor kappa B (NFkB) is inhibited. Vicodene reduces the production of the inflammatory cytokines — interferon gamma (IFNγ), and Interleukin 2 (IL-2), COX-2, and iNOS. By supplementing the body’s ability to naturally activate PPARγ, Vicodene helps promote healthy inflammation response while maintaining normal cellular structure and activity in the joints, bones, and throughout the body.
PPAR gamma Regulates Inflammatory Response
Peroxisome proliferator-activated receptors (PPARs) are lipid-activated transcription factors that regulate lipid and lipoprotein metabolism, modulate the cells, control the inflammatory response, glucose homeostasis and and regulate inflammatory cytokine production.PPARγ when activated, results in inhibition of nuclear factor kappa B and T cell. PPARγ also reduce the release of pro-inflammatory cytokines such as IFNg, TNFγ, IL-6, IL-1b and IL-2. PPARg controls how certain cells heed insulin's instructions to lower blood sugar levels. Patients with a mutant version of the PPAR gamma gene have a 25% higher risk of developing adult-onset diabetes, in which cells stop responding to insulin's orders. Existing diabetes drugs such as Thiazolidinedione are found to be PPARg agonist. They resensitize the body to insulin by turning on the PPARgamma receptor. In turn, that can cut C-reactive Protein, a marker for inflammation, by up to 40%. However, these PPARgamma drugs make patients fatter and have undesirable side effects that include heart failure, Liver failure and even death. Other research has shown NSAIDs to be useful for Alzeimer as NSAIDs are PPARgamma agonist and can inhibit b-amyloid stimulated cytokines such as IL-6, TNF-a. Vicodene is the natural PPARgamma activator without side effects.
Nuclear Factor kappa B and Inflammation
Nuclear factor kappa B (NFkB) is a critical activator of genes for inflammation and immunity. It plays a central role in regulating proinflammatory mediators (COX-2, iNOS)and proinflammatory cytokines (Interferon gamma, Interleukin 2, TNF alpha). Recently, cellular and molecular mechanisms of inflammation have been the focus of designing new anti-inflammatory therapies. For example, Asprin (salicylates) and glucocorticoids, two widely usedanti-inflammatory drug classes, are now known to inhibit NFkB, a transcription factor that regulates a wide range of proinflammatory mediators and cytokines. Evidence from recent research demonstrates that by inhibiting NFkB, a wide range of diseases and conditions in which inflammation plays a critical role can be cured. Research now have shown that NFkB is activated in airway inflammation such as ashma and allergies. NFkB is also activated in rheumatoid synovium cells. Vicodene is the natural NF kappa B inhibitor without side effects.
Vicodene & Syndrome X
Syndrome X is a set of simultaneously occuring symptoms that includes abdominal weight gain with high blood sugar, high blood pressure, high triglycerides, and high cholesterol---all of which increase the odds of having a heart attack or a stroke. Today the condition may affect 25% of all adults in America, a direct result of our sugary, fatty diets. Existing drugs attack one risk factor at a time, curbing high blood pressure or lowering bad cholesterol or treating diabetes. Obesity is a risk factor for so many diseases--insulin resistance, hypertension, and cardiovascular disease. New emerging drugs aim at the peroxisome proliferator-activated receptors (PPARs), which are akin to master relay switches that control how the body uses sugar and fat. Researchers hope drugs that stimulate multiple PPARs at once could affect virtually every heart and diabetes risk factor.
Most syndrome X patients exhibit plenty of deactivated PPAR gamma in their adipose tissue. When PPAR gamma is deactivated, the adipose tissue binds to insulin and make them unavailable to the body to process the food we eat into energy. These in turns makes us hungrier and more tired; thus we increase our food intake and end up with even more fat storage. Over time, these result in obesity, type-2 diabetes, hypertension, and increased cardiovascular risk. Several published research suggest that the activation of PPARs as solution for metabolic syndrome X. Vicodene is the natural PPAR gamma activator without side effects.
How does it differ from Drug Therapies?
Vicodene is the first and only natural product clinically proven and patented to activate PPARγ, and to inhibit NFkB. Vicodene is not toxic and has no side effects. Unlike drug therapies, that attempt to stop inflammation by affecting 1 or 2 of the proteins, hormones, or cytokines involved in inflammatory response, Vicodene naturally activates PPARγ, which results in the inhibition of NFkB and reduction in the release of inflammatory cytokines such as IL-2 and IFNγ thereby promoting a healthy inflammatory response. Drug therapies such as Thiazolidinedione drugs—which also invigorate PPARγ can cause anemia, heart failure, Liver failure, and death. Many other drugs, which might inhibit cytokines and inflammatory agents - such as iNOS, COX-2, or IL-2 - have numerous side effects including fevers, chills, sweating, muscle aches, ulcers, and tiredness. Vicodene is patent pending for use in activating PPARγ, inhibiting NFkB, inhibiting T Cell activation, reducing pro-inflammatory cytokines IL-2 and IFNγ. Vicodene is the result of over 10 years of research and has passed numerous clinical trials and toxicology tests to insure safety and efficacy.
10-27-2010, 11:22 AM #1
Vicodene: the natural herbal pain killer!NCSA-CPT
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10-27-2010, 06:19 PM #2
Vicodene Maintains Healthy Brain Function
NSAIDs, thiazolidinediones, and PGJ2, all of which are PPARg agonists, were shown to inhibit the b-amyloid-stimulated expression of the genes for IL-6 and TNF-a. Patients with early stage of Alzheimer's disease (AD) were given either 250mg of Vicodene or placebo and undergone various Neuropsychological tests. Placebo group show a significant cognitive deterioration, which is the normal course of AD, while the Vicodene group is showing no change or improvement test scores suggesting that Vicodene may have application for maintaining healthy brain function by stimulates the PPAR-g receptor.
Vicodene Maintain Healthy Inflammatory Response
In vitro, Vicodene is shown to inhibit T cell proliferation, Interferon gamma, and Interleukin 2 (IL-2). Vicodene significantly delayed the onset and reduced the severity of Experimental Autoimmune Encephalomyelitis (EAE) by impairing T cell activation as well as antibody production against myelin antigens. After 3 weeks the Interferon gamma, Interleukin 2, and T Cells all return to normal.
Vicodene interferes with DNA binding of NF-kB
Nuclear factor kappa B (NF- kB) regulates our inflammatory and immune response. Vicodenecan be useful in maintaining healthy inflammatory response by inhibiting the NF-kB binding with DNA, and thus reducing the pro-inflammatory Protein expression, such as COX-2.
Vicodene reduces pro-inflammatory cytokines and protects against cell death
Vicodene reduces Pro-inflammatory cytokines Interferon gamma and Interleukin 2 production in murine T-cells and protects against cell apoptosis. The expression ICAM-1, iNOS, COX-2 and proinflammatory cytokine are controlled by mitogen-activated proteinkinase (MAPK) such as ERK1/2. Vicodene reduced ERK1/2 and could be useful in inhibiting ICAM-1, iNOS, COX-2, and other cytokines that are controlled by MARK.
Vicodene increase cellular immune response
The immunostimulatory effect of Vicodene at low doses has shown an increase of antigen specific and nonspecific immune response in mice. Vicodene can also be used for the prevention of common colds (a minimum of 15-25 mg of Vicodene corresponding to a dose of 0.3mg/Kg/day of Vicodene in healthy individuals. The increase in the cellular proliferation, IFN-g and IL-2 production in T-cells cultured with Vicodene indicate that Vicodene could be a stimulant of immune system, specifically through of Th1 response.
Vicodene as prevention of common cold
After 3 month treatment, volunteers receiving 15mg of Vicodene daily showed a significant lower incidence of common cold as compared to the placebo group indicating possible immunostimulating effect (29.63% vs. 63.3%). At low dosage, Vicodene were able to significantly increase the production of IFN gamma and IL-2 without modifying Th2 antibody (IL-2, IL-10 cytokines) production. In addition, RNA messenger for Interferon gamma was also increased. Interferon gamma is the first line of defense against viral infection such as Influenza, and is activated by T cell. In this study we have also found that at low dosage, Vicodene activates T cell, and increase Interleukin 2 (IL-2) cytokines. IL-2 assists T-cells to kill viral invaders and makes infection-fighting cells multiply and mature.
Interview with Dr Juan Hancke
Q. What is the historical use of Andrographis?
A. Andrographis has been used in Ayurveda and Traditional Chinese Medicine for over 3,000 years. Andrographis is reported to have various actions and indications. These include stimulating the immune system, reducing fever and inflammation, protecting
the Liver, reducing platelet aggregation, treating and preventing the common cold, and treating bacterial infections such as urinary tract infections. Andrographis is also used to treat diabetes, cough, throat infections, hepatitis, and gastrointestinal disorders such as diarrhea, indigestion, and loss of appetite. Andrographis protected the Liver from injury caused by alcohol, infectious organisms, and toxins.
Q. How did you get involved in the research?
A. 15 years ago, I was approached by a Swedish pharmaceutical company who were searching for a cure for the common cold. Andrographis was one of the herbal remedies that were being tested. Our research focuses on the immune boosting effects of the Andrographis plant, and how it can help to prevent and shorten the duration of common cold. In the last 5 years the University of Chile has received several grants from FONDEF and WHO that further fund our research. What we have found is that the active ingredients in the Andrographis plant is an immune–modulator, meaning in small dosage it boosts the immune system which helped prevent and shorten the duration of common cold, and at larger dosage it activates the PPAR gamma receptor, thereby inhibiting NF kappa B that regulates a range of cytokines and enzymes that causes pain and inflammation. With the advancement of extraction process, we have developed a patented blend for the bioactive compounds and created Vicodene.
Q. What were the results of the clinical studies on Vicodene
A. In a research published on Journal of Pharmacology & Exp Therapeutics, August 26 2004, titled “Paractin[Vicodene] interferes with T cell activation and reduces Experimental Autoimmune Encephalomyelitis in the Mouse”, Vicodene demonstrates the ability to interfere with T cell activation and reduces cytokines Interleukin 2 and Interferon gamma that causes inflammation and pain. In another research titled "PARACTIN®[Vicodene] interferes DNA binding of NF-kB in HL-60/Neutrophils cells” which was published on British Journal of Pharmacology (2005) 144, 680-686, showed that Vicodene effectively inhibits NF-kB which regulates a range of pro-inflammatory cytokines and reduces COX-2 expression.
Q. Does Vicodene works as an anti-inflammatory?
A. Yes. Several active compounds in Vicodene were found to have anti-inflammatory effects in some in vivo studies. They reduced inflammation significantly in several animal models, including a model of induced arthritis and multiple sclerosis. Other studies found the active compounds had analgesic activity, antipyretic effects, and prevented aspirin-induced ulcers in rats.
Q. How does Vicodene help relieve everyday pain and stiffness associated with overexertion?
A. As I mentioned earlier, several active compounds in Vicodene have shown anti-inflammatory effects and analgesic activity. Inflammation is the main cause of pain. When our body is under physical stress, the immune system responds by supplying defensive compounds such as cytokines and interleukins that causes pain and redness. Occasional overexertion from everyday activities can also lead to unwanted pain and stiffness. The active compounds in Vicodene help inhibit a multitude of substances that cause inflammation including COX-2, Interferon gamma, Interleukin 2, and iNOS. It does this by naturally invigorating the inhibition of Nuclear Factor kappa B (NFkB) which is key regulator of a range of cytokines and proteins that are responsible for causing pain and inflammation. By supplementing the body’s ability to naturally inhibiting NFkB, Vicodene helps promote healthy inflammation response while maintaining cellular structure and activity in the joints, bones, and throughout the body.
Q. Why is Vicodene preferred over Non Steroidal Anti-Inflammatory Drugs (NSAIDs) pain relievers?
A. Recent research has found that these NSAIDs also inhibits NF kappa B and are useful in anti-inflammatories therapies. However, long term use of these over-the-counter pain relievers, including aspirin, can cause stomach lining bleeding. Research has confirmed that Vicodene does not act on COX-1 that causes stomach lining bleeding.
Q. It was found that COX-2 is necessary for cardiovascular health and that the COX-2 inhibitors in many of the prescription drugs cause cardiovascular problems. Does Vicodene pose the same problems?
A. Absolutely not. The prescription COX-2 inhibitors decrease prostacyclin production to a radical level and sometimes cause disruption of the normal homeostatic balance, leading to increased cardiovascular risk. This is why a number of these prescriptions COX 2 were pulled from the market after reported deaths and increased cardiovascular risk of users. Vicodene reduces COX-2 naturally by turning off the NF kappa B, which regulates a range of cytokines that are involved in the inflammation process. In addition, the historical folk use for Andrographis includes improving cardiovascular health. There are several published animal studies that suggest that the active compounds in Vicodene significantly reduced blood pressure and may be beneficial in maintaining healthy cardiovascular function.
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