The Science of Fat

[thomps1523]

Great info!

[Aerdn]

Interesting

[TGT2]

Great information here. Thank you!

[TGT2]

To start off ->> A few links for those who want to learn more about adipose tissue on a physiological basis (how it works... and how to get rid of it)!

Fat Metabolism
The basics of fat storage

EndoText -Regulation of Energy Expenditure
"...Humans gain or lose weight when a mismatch exists between energy intake and energy expenditure (Figure 1). Due to the potentially important role of energy expenditure in controlling body weight, there has been much interest in processes which contribute to and regulate total body energy expenditure. This interest takes the form of three general questions. 1) Is obesity caused by deficiencies in energy expenditure, and if so, what mechanisms are nonfunctional in obese individuals? 2) How is energy expenditure regulated and what molecular mechanisms are responsible for this regulation? 3) Can energy expenditure be increased by pharmacologic agents and can this be used as a treatment for obesity? Towards addressing these questions, this chapter will explore the role of reduced energy expenditure in causing obesity and the molecular mechanisms which are thought to regulate energy expenditure..."

Encyclopedia of Sports Medicine and Science: Adipose Tissue
"...Adipose tissue is specialized connective tissue that functions as the major storage site for fat in the form of triglycerides. Adipose tissue is found in mammals in two different forms: white adipose tissue and brown adipose tissue. The presence, amount, and distribution of each varies depending upon the species. Most adipose tissue is white, the focus of this review..."

Medscape Article on Adipose Tissue: From Lipid Storage Compartment to Endocrine Organ
"...Adipose tissue, when carried around in excessive amounts, predisposes to a large number of diseases. Epidemiological data show that the prevalence of obesity has significantly increased over the past 20 years and continues to do so at an alarming rate. Here, some molecular aspects of the key constituent of adipose tissue, the adipocyte, are reviewed..."

International Journal of Obesity Article on: Integrative physiology of human adipose tissue
"....In this review we have attempted to illustrate the complexity of adipose tissue function, with an emphasis on the dynamic nature of this tissue... we will cover some aspects of the regulation of fat storage and mobilisation; the regulation of adipose tissue blood flow and the role of adipose tissue innervation; some aspects of the secretory functions of adipose tissue as they relate to regulation of fat balance; and finally, to demonstrate the integrative nature of adipose tissue function, possible oscillatory behaviour of the adipose tissue mass..."

Pharmacological Targeting of Adipocytes/Fat Metabolism for Treatment of Obesity and Diabetes
"...Obesity is now recognized as a rapidly increasing worldwide threat to health, largely as a result of causing diabetes. Thus, considerable efforts are underway in the pharmaceutical industry to find drugs to treat this condition. Target validation in various academic and industrial laboratories has revealed a number of potential molecular targets in fat cells or adipocytes. By definition, obesity is too much fat, and we here review efforts to treat obesity and, by proxy, diabetes by modulating the metabolic state of adipocytes...."


And a few other Random Things:

• Diurnal variation of the human adipose transcriptome and the link to metabolic disease
  
• Wiki on Adipose
  
• The Science of Fat Loss - Muscular Development
  
• Lyle McDonald on Fat

Very interested in the pharmacological targeting of adipocytes! I wonder if iricin and meteorin-like protein will ever make it to clinical use. I also wonder what the other possibilities are.

[patricia1987]

These are very helpful links! I'm a Biomedical Sciences major so I understand all the science behind these concepts which is very helpful.

These are very helpful links

[JacobVR]

These are very helpful links! Extremely informative, thank you very much.

[Abhibhava]

You should write a blog or post this in an edu site.

[rpmurrell]

Great post very informative!

These are very helpful links! I'm a Biomedical Sciences major so I understand all the science behind these concepts which is very helpful.

[supremeweb]

do you have english version of this website?
thanks

[dchris17]

Awesome!

[dchris17]

dead link

[supremeweb]

Yeah, Fat Metabolism - page not found!

[FrostbiteFitnes]

great info helped me out

[ReaperGuns]

I have a question regarding "The science of fat loss - Muscular devolpment" article. It seems he is suggesting that fasting is the prefered state for fat burning and when in a "fed" state, our body turns off most hormones that assist/promote/incite fat loss. Anyone care to elaborate?

In short, this is partially accurate. The fasting state leads to mostly fat oxidation (after all, this is why we have fat, to store our excess calories for use later), while after you eat (depending on what you eat) your blood sugar increases along with insulin levels, which helps promote sugar intake into your cells. Once your cells have that insulin signalling and sugar intake, they switch to glycolysis and start using those sugars to produce ATP instead of fats. Look up RER (Respiratory Exchange Ratio) aka RQ (Respiratory Quotient) to have a better understanding of what happens to your metabolic substrate utilization during the fasted and fed states. Usually during fasting, your RER will be about 0.70, indicating that you are burning almost purely fats. After eating, it will increase to about 0.85 indicating you are burning both fats AND glucose. During extreme exercise it will rise to 0.90-1.00 indicating you are burning almost purely sugars.

Is this the info you are looking for?

[Garfieldus]

I'm bit of science nerd so these were really helpful and insightful articles. It puts a lot of perspective with tip and tricks people been advising for so long.

[bri88col]

Thanks for this info

[ChampCraig]

Great read, thanks. Helps a ton with understanding

[NathanealB]

Losing Fat is one thing. Usually the idea is to Gain muscle! So instead of losing fat, how about turning what you can into muscle! and doing it with Scientifically proven methods?! Thats where you should be looking rather than dieting, or just "Losting Fat" Lets turn it into something We value!

[asmcriminal]

These are very helpful links! I'm a Biomedical Sciences major so I understand all the science behind these concepts which is very helpful.

The only science that matters in fat loss is burn more calories than you consume. Not more complicated than that.

[musclefitness11]

nice read! love the information

[austintip10]

Great information!

[jacksn7673]

Wow i love your sharing.Keep it up.

[Cidphan]

Very detailed and well organized. Thank for sharing.

[Criz98]

Great info thx man , educatibg us

[Criz98]

Very good reading !adioocytes!!

[IvanGregory]

First link's not working, OP!