clen versus brycanil

[qazwe]

is there any difference between clen and brycanil(pump)?

[Manteca]

Originally posted by qazwe
is there any difference between clen and brycanil(pump)?

All I could find is that terbutalme (brycanil) is some sort of asthma drug, If you could give a more general chemical name that would be helpful cuz I can't find **** with these 2 names.

[raybravo]

lol , always looking into this arent u manteca .
either way , i dont think the pump will be effective , and i think he means either albuterol or salmeterol .

[Avatar of War]

I use brycanil, it IS for asthma :-)


AoW

[abid]

thats terbutaline, another b2 selective agonist, but salbutamol is better cause its half life is longer.....


also, i was reading my pharm book and it says that salmeterol has a pretty long half life....sounds interesting, might not have to dose it as often as the salbutamol,


ray, i think the pump is effective, if u take about 4-5 puffs, that delivers 50 micrograms per puff u can get the jittery feelings, cause there is no metabolism, goes straight in the bld stream,
but the pumps are more expensive than the tabs her in pakistan, plus is tasts like ****.

ill read more on that salmeterol.

[raybravo]

if u find info on the salmeterol , let me know bro .

[abid]

Salmeterol is similar in structure to salbutamol except that it has the addition of a long non-polar side chain. Salmeterol is a highly selective ß2-adrenoreceptor agonist, being at least as equipotent as isoprenaline as a bronchodilator. It is 15 times more potent than salbutamol at the ß2-receptor, but at the cardiac ß1-receptor, it is 4 times less potent than salbutamol and 10,000 times less potent than isoprenaline. Salmeterol has been shown to protect against bronchoconstriction caused by histamine, methacholine and exercise, and in suppressing late phase bronchoconstriction suggesting that it has some degree of anti-inflammatory activity in addition to its bronchodilator role. It has been shown to suppress the release of inflammatory mediators in the lung and the migration of inflammatory cells. It is postulated that the prolonged duration of action of salmeterol is due to the long side chain that may attach itself onto an exo-receptor site near to or within the ß2-receptor. This may allow the active phenylethanolamine head of salmeterol to oscillate in and out of the ß2-receptor site repeatedly stimulating it. The action of salmeterol can be competitively reversed by ß2-antagonists, but when the antagonist is removed, the muscle relaxant activity returns without further dosing with salmeterol, suggesting that it may be permanently anchored near the ß2-receptor site.






The side effect profile is similar to that of other ß2-agonists with tremor and palpitations being the most prominent, and there is a risk of hypokalaemia in overdosage. The incidence of side effects is dose related, and patients develop seem to develop tachyphylaxis to the unwanted side effects with time with no reduction in bronchodilator properties.




that tachyphylaxis isnt good....that means no tremors....downregulation of receptors in other words,
plus there isnt a pill form, twice daily dosing though....

[Osan_lifter]

Nice post, bro!