Any good test boosters for 50+ with high blood pressure?

[rockbassist90]

I'm trying to figure this out for my father, he wanted to know if there are any testosterone boosters safe for someone 50+ with high blood pressure?

[jgoodson87]

Im 22 with HBP and i cycled T Bomb with no probs.

[Sldge]

Activate Xtreme will also work. Ive had Doctors email me about giving it to some of their patients above the age of 50 to help with total test, sex drive etc. Some have had high BP and obviously some have not but it worked extremely well for them including a 68 year old who was now "dating" more then 1 women in his retirement community.

[biggun_]

Activate Xtreme will also work.

what matt said.

[THEHUGE]

BioForge would be a safe buy. Both icariin and forskolin have a positive effect on blood pressure and circulation.

[Robboe]

Activate Xtreme will also work. Ive had Doctors email me about giving it to some of their patients above the age of 50 to help with total test, sex drive etc. Some have had high BP and obviously some have not but it worked extremely well for them including a 68 year old who was now "dating" more then 1 women in his retirement community.

We have also had several very successful journals ran by the over 35 folk in the over 35 forum.

[DR_P]

I'm trying to figure this out for my father, he wanted to know if there are any testosterone boosters safe for someone 50+ with high blood pressure?

No test booster for someone with high blood pressure and advanced age. regardless what the good bros are telling you on this board, all these substances that are used in popular test bosoters are NOT characterized in old people and even less in old people that suffer from diseases concerning their cardiovascular system.

[THEHUGE]

No test booster for someone with high blood pressure and advanced age. regardless what the good bros are telling you on this board, all these substances that are used in popular test bosoters are NOT characterized in old people and even less in old people that suffer from diseases concerning their cardiovascular system.

What's your opinion on theese findings?

Cardiovascular effects of forskolin (HL 362) in patients with idiopathic congestive cardiomyopathy--a comparative study with dobutamine and sodium nitroprusside.
Baumann G, Felix S, Sattelberger U, Klein G.

1st Medical Department, Technical University of Munich, Klinikum Rechts der Isar, West Germany.

Forskolin, a diterpene derivative of the Indian plant Coleus forskhohlii, proved to be a marked positive inotropic and vasodilatory compound in animal experiments with a mechanism of action distinct from catecholamines, cardiac glycosides, and phosphodiesterase-inhibiting compounds. The cardiovascular effects of forskolin seem to be mediated by a direct stimulatory action at the catalytic unit of sarcolemmal adenylate cyclase. The aim of the present study was to clarify the cardiovascular profile of this compound in 12 patients with stage III (NYHA) congestive cardiomyopathy. The effects of forskolin were investigated by invasive techniques using the thermodilution catheter method and compared to the beta 1-receptor agonist dobutamine and the vasodilator sodium nitroprusside in an intraindividual comparison. Forskolin dose-dependently reduced cardiac pre- and afterload values, and led to a reduction in systolic, diastolic, and mean pulmonary artery pressure as well as pulmonary wedge pressure by greater than 50% concomitant with an increase in cardiac output.

[Honkey_Kong]

I'm trying to figure this out for my father, he wanted to know if there are any testosterone boosters safe for someone 50+ with high blood pressure?

I don't think you're going to find one that's "safe" for a 50+ year old man with high blood pressure. Before you consider taking a test booster, you should have your old man make a real effort to lower his blood pressure. There are a lot of things that are quite effective. You know just switching from table salt to No Salt makes a difference in blood pressure? I'm sure you can spend a good hour or two googling many tricks to lower BP. spend a few months doing that, then if it's inside the safe range, start thinking about it.

[Sldge]

J Ethnopharmacol. 2002 Jun;81(1):105-9.
Cardiovascular effects of Urtica dioica L. (Urticaceae) roots extracts: in vitro and in vivo pharmacological studies.

Testai L, Chericoni S, Calderone V, Nencioni G, Nieri P, Morelli I, Martinotti E.

Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universit? di Pisa, via Bonanno 6, 56126 Pisa, Italy.

Urtica dioica (Urticaceae) is a plant principally used in the traditional medicine of oriental Marocco as antihypertensive remedy (J. Ethnopharmacol., 58 (1997), 45). The aim of this work was to evaluate a possible direct cardiovascular action of the plant and to investigate its mechanism of action. In aortic preparations with intact and functional endothelial layer, pre-contracted with KCl 20 mM or norepinephrine 3 microM, the crude aqueous and methanolic extracts of the plant roots, as well as purified fractions elicited a vasodilator action. Nevertheless, the vasodilator activity was not present in aortic rings without endothelial layer. In aortic rings with intact endothelial layer, the vasorelaxing effect was abolished by L-NAME, a NO-biosynthesis inhibitor, and ODQ, a guanylate cyclase inhibitor. Furthermore, potassium channel blockers (TEA, 4-aminopyridine, quinine, but not glybenclamide) antagonized the vasodilator action of the purified fraction F1W of U. dioica. The same fraction produced a marked decrease of inotropic activity, in spontaneously beating atria of guinea-pig, and a marked, but transient, hypotensive activity on the blood pressure of anaesthetized rats. It is concluded that U. dioica can produce hypotensive responses, through a vasorelaxing effect mediated by the release of endothelial nitric oxide and the opening of potassium channels, and through a negative inotropic action.

Life Sci. 2004 Jan 2;74(7):855-62.
Pycnogenol, French maritime pine bark extract, improves endothelial function of hypertensive patients.

Liu X, Wei J, Tan F, Zhou S, W?rthwein G, Rohdewald P.

Guang An Men Hospital of Chinese Medical Science Research Institute, Beijing, PR China.

A placebo-controlled, double-blind, parallel group study was performed with 58 patients to investigate effects of French maritime pine bark extract, Pycnogenol, on patients with hypertension. Supplementation of the patients with 100 mg Pycnogenol over a period of 12 weeks helped to reduce the dose of the calcium antagonist nifedipine in a statistically significant manner. The intake of Pycnogenol decreased endothelin-1 concentrations significantly compared to placebo while concentrations of 6-keto prostaglandin F1a in plasma were significantly higher compared to placebo. Values for nitric oxide (NO) in plasma increased in both groups, but the differences were not significant. Angiotensin II concentrations in plasma were lowered in the placebo group to a larger extent than in the Pycnogenol group. Heart rate, electrolytes and blood urea nitrogen were not changed during treatment in both groups of patients. Unwanted effects observed in both groups were of mild and transient nature, such as gastrointestinal problems, vertigo, headache and nausea. Differences in rate of side effects were not statistically significant between the two groups. Study results support a supplementation with Pycnogenol for mildly hypertensive patients.

PMID: 14659974 [PubMed - indexed for MEDLINE]

Phytomedicine. 2000 Oct;7(5):383-8.
PYCNOGENOL in chronic venous insufficiency.

Petrassi C, Mastromarino A, Spartera C.

Cattedra e Scuola di Specializzazione in Chirurgia Vascolare, Dipartimento di Scienze Chirurgiche, Universit? degli Studi di L'Aquila, Italy. chirvasc@cc.univaq.it

The aim of out study was to investigate the efficacy of Pycnogenol - a French maritime pine bark extract - in the treatment of chronic venous insufficiency (CVI). The study consisted of a double-blind phase - in which 20 patients were recruited and randomly treated with placebo or Pycnogenol (100 mg 2 3/day for 2 months) - and an open phase - in which other 20 patients were treated with Pycnogenol at the same dose schedule. In total, 40 patients were enrolled; 30 of them were treated with Pycnogenol and 10 with placebo. Pycnogenol significantly improved the legs' heaviness and subcutaneous edema; the venous pressure was also significantly reduced by the Pycnogenol treatment, thus adding further clinical evidence to its therapeutic efficacy in patients with CVI. Pycnogenol was effective, probably by either stabilizing the collagenous subendothelial basal membrane or scavenging the free radicals, or by a combination of these activities. Clinically, capillary leakage, perivascular inflammation and subcutaneous edema were all reduced. The safety of use of Pycnogenol is demonstrated by the lack of side effects or changes in blood biochemistry and hematologic parameters. Pycnogenol can be therefore recommended both for prevention and treatment of CVI and related veno-capillary disturbances.

PMID: 11081989 [PubMed - indexed for MEDLINE]

[DR_P]

J Ethnopharmacol. 2002 Jun;81(1):105-9.
Cardiovascular effects of Urtica dioica L. (Urticaceae) roots extracts: in vitro and in vivo pharmacological studies.

Testai L, Chericoni S, Calderone V, Nencioni G, Nieri P, Morelli I, Martinotti E.

Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universit? di Pisa, via Bonanno 6, 56126 Pisa, Italy.

Urtica dioica (Urticaceae) is a plant principally used in the traditional medicine of oriental Marocco as antihypertensive remedy (J. Ethnopharmacol., 58 (1997), 45). The aim of this work was to evaluate a possible direct cardiovascular action of the plant and to investigate its mechanism of action. In aortic preparations with intact and functional endothelial layer, pre-contracted with KCl 20 mM or norepinephrine 3 microM, the crude aqueous and methanolic extracts of the plant roots, as well as purified fractions elicited a vasodilator action. Nevertheless, the vasodilator activity was not present in aortic rings without endothelial layer. In aortic rings with intact endothelial layer, the vasorelaxing effect was abolished by L-NAME, a NO-biosynthesis inhibitor, and ODQ, a guanylate cyclase inhibitor. Furthermore, potassium channel blockers (TEA, 4-aminopyridine, quinine, but not glybenclamide) antagonized the vasodilator action of the purified fraction F1W of U. dioica. The same fraction produced a marked decrease of inotropic activity, in spontaneously beating atria of guinea-pig, and a marked, but transient, hypotensive activity on the blood pressure of anaesthetized rats. It is concluded that U. dioica can produce hypotensive responses, through a vasorelaxing effect mediated by the release of endothelial nitric oxide and the opening of potassium channels, and through a negative inotropic action.

That's not Divanil, to begin with.

[Sldge]

I want to be clear. Any supplements your father takes should be shown to or talked about with his doctor first. As should anyone who has any type of health issue.

[uhockey]

What's your opinion on theese findings?

Cardiovascular effects of forskolin (HL 362) in patients with idiopathic congestive cardiomyopathy--a comparative study with dobutamine and sodium nitroprusside.
Baumann G, Felix S, Sattelberger U, Klein G.

1st Medical Department, Technical University of Munich, Klinikum Rechts der Isar, West Germany.

Forskolin, a diterpene derivative of the Indian plant Coleus forskhohlii, proved to be a marked positive inotropic and vasodilatory compound in animal experiments with a mechanism of action distinct from catecholamines, cardiac glycosides, and phosphodiesterase-inhibiting compounds. The cardiovascular effects of forskolin seem to be mediated by a direct stimulatory action at the catalytic unit of sarcolemmal adenylate cyclase. The aim of the present study was to clarify the cardiovascular profile of this compound in 12 patients with stage III (NYHA) congestive cardiomyopathy. The effects of forskolin were investigated by invasive techniques using the thermodilution catheter method and compared to the beta 1-receptor agonist dobutamine and the vasodilator sodium nitroprusside in an intraindividual comparison. Forskolin dose-dependently reduced cardiac pre- and afterload values, and led to a reduction in systolic, diastolic, and mean pulmonary artery pressure as well as pulmonary wedge pressure by greater than 50% concomitant with an increase in cardiac output.

My read on this is that you're comparing a supplement delivered IV in TWELVE patients with NYHA Stage III HEart Failure who may need pressor therapy.....how in God's name does this relate in ANY way to an athlete taking ORAL Forskolin who doesn't have CHF?

This is absolutely assinine - that is my read.

[uhockey]

No test booster for someone with high blood pressure and advanced age. regardless what the good bros are telling you on this board, all these substances that are used in popular test bosoters are NOT characterized in old people and even less in old people that suffer from diseases concerning their cardiovascular system.

But what about Heart Failure patients in isolated studies?

[rocknout72]

tell your dad to go to the doctor and have a blood test to check his test level, he is old enugh that he can be put on testostarone replacement therapy. basicly the doctor will give a script for legal test injections and this will be 1,000,000 times better than some test booster would be


Brett

[DR_P]

But what about Heart Failure patients in isolated studies?

these heart failure patients actually can acutely benefit from a positive inotropic effect.

It needs to be noted however, that the intervention was just 60 minutes. So, we have an acute effect here.

Forskolin does indeed have an acute positive inotropic (=good for failing hearts) as well as a vasodilatory effect, this is undisputed. However, I am not aware of any CHRONIC studies of it. the problem is that forskolin may also influence water rentention and this could theoretically outperform its vasodilatory effect with questionable outcome on blood pressure.

I don't say forskolin will increase blood pressure, but its chronic effects on cardiovascular parameters are simply too poorly understood - at least from all I know.

Whatever is poorly udnerstood should - for ethical reasons - NEVER - be blindly / generally recommended to people who are at risk.

That's at least my stance and it applies equally to all products, being from Thermolife, or from any other company.

[uhockey]

I concur....additionally, I'm pretty sure we don't keep patients on dobutamine very long unless they're end stage.

[DR_P]

I concur....additionally, I'm pretty sure we don't keep patients on dobutamine very long unless they're end stage.

^^^^ this

[Phat Daddy]

... Whatever is poorly udnerstood should - for ethical reasons - NEVER - be blindly / generally recommended to people who are at risk. ...

Indeed. If you aren't sure, taking no action is better than doing harm to the innocent.

[DR_P]

Indeed. If you aren't sure, taking no action is better than doing harm to the innocent.

do you feel involved and do you feel innocent?

[Phat Daddy]

do you feel involved and do you feel innocent?

Do you, still?

[THEHUGE]

My read on this is that you're comparing a supplement delivered IV in TWELVE patients with NYHA Stage III HEart Failure who may need pressor therapy.....how in God's name does this relate in ANY way to an athlete taking ORAL Forskolin who doesn't have CHF?

This is absolutely assinine - that is my read.

You must be in the mood for fight today. I see.

I was merely discussing a MOA, smartass but you already know it.

[Bane]

Any supplement/drug that could alter BP BOTH ways(lower or increase it) should be used very carefully on a hypertensive patient that has his BP stabilized with his current medical regimen(that might include supplements). Keeping BP in the normal levels is of utmost importance. 100s of supplements can affect BP both ways and I have succesfully treated moderate hypertension patients with herbal/diet regimens but for severe hypertension cases you should ALWAYS keep your BP monitored and ALWAYS consult your physician/pharmacist.

[THEHUGE]

Any supplement/drug that could alter BP BOTH ways(lower or increase it) should be used very carefully on a hypertensive patient that has his BP stabilized with his current medical regimen(that might include supplements). Keeping BP in the normal levels is of utmost importance. 100s of supplements can affect BP both ways and I have succesfully treated moderate hypertension patients with herbal/diet regimens but for severe hypertension cases you should ALWAYS keep your BP monitored and ALWAYS consult your physician/pharmacist.

This is a sound advice.

[Supplement-Slut]

LuLz ITT