do any of the OTC GH boosters have any genuine data/bloods to support their claim?

[mark118]

There seems to be a small wave of GH boosters out at the mo, which if they work is great! but, i was wondering if any data or bloods have been taken pre and post these products to demonstrate they work. I know a 1 off GH level can't be taken like with test but it does worry me that these will be just like all the older generation of test boosters claiming 2000% increase in test without any hard data to back it up besides anecdotal opinions.

The claims for some products include;

'Every component of this revolutionary formula either directly or indirectly promotes testosterone and/or HGH production, while also triggering powerful fat-burning mechanisms.* The result? Everything you want: Massive increases in muscle size, strength, leanness and density!'

''* Increases the output of growth hormone and local IGF-1 levels
* Increases the duration/viability of growth hormone pulse mass
* Increases androgen receptor structure, function, and number
* Increases natural production of testosterone''

I'm not trying to bash these products but just wanting to know whether anyone seen any data for their claims.

[mark118]

bump

[gekkoboy14]

no.

[ericpad]

There seems to be a small wave of GH boosters out at the mo, which if they work is great! but, i was wondering if any data or bloods have been taken pre and post these products to demonstrate they work. I know a 1 off GH level can't be taken like with test but it does worry me that these will be just like all the older generation of test boosters claiming 2000% increase in test without any hard data to back it up besides anecdotal opinions.

The claims for some products include;

'Every component of this revolutionary formula either directly or indirectly promotes testosterone and/or HGH production, while also triggering powerful fat-burning mechanisms.* The result? Everything you want: Massive increases in muscle size, strength, leanness and density!'

''* Increases the output of growth hormone and local IGF-1 levels
* Increases the duration/viability of growth hormone pulse mass
* Increases androgen receptor structure, function, and number
* Increases natural production of testosterone''

I'm not trying to bash these products but just wanting to know whether anyone seen any data for their claims.

Check this out . . .
http://forum.bodybuilding.com/showth...hp?t=120491881

[gekkoboy14]

Check this out . . .
http://forum.bodybuilding.com/showth...hp?t=120491881

n=3.......
Not peer reviewed
Useless.

[mark118]

Check this out . . .
http://forum.bodybuilding.com/showth...hp?t=120491881

''Serum GH levels were measured via bloodwork (Lab Corp?) on two separate days, after an overnight fast. Serum GH levels were measured with (Test) and without (Baseline) having taken the supplement, with serum GH being measured at time (t)= -15, 45, 90, and 150 min''

well, its better than a 1 off reading but from my understand a day curve would be truly representative. The study is only in 3 men which doesnt really mean anything

HOWEVER, it is interesting and is definitely a step in the right direction to finally get some data on GH boosters and a big thanks for AppNut testing it

NB: not sure how safe it is to supplement with l-dopa

[ryanr623]

There seems to be a small wave of GH boosters out at the mo, which if they work is great! but, i was wondering if any data or bloods have been taken pre and post these products to demonstrate they work. I know a 1 off GH level can't be taken like with test but it does worry me that these will be just like all the older generation of test boosters claiming 2000% increase in test without any hard data to back it up besides anecdotal opinions.

The claims for some products include;

'Every component of this revolutionary formula either directly or indirectly promotes testosterone and/or HGH production, while also triggering powerful fat-burning mechanisms.* The result? Everything you want: Massive increases in muscle size, strength, leanness and density!'

''* Increases the output of growth hormone and local IGF-1 levels
* Increases the duration/viability of growth hormone pulse mass
* Increases androgen receptor structure, function, and number
* Increases natural production of testosterone''

I'm not trying to bash these products but just wanting to know whether anyone seen any data for their claims.

It was to my understanding, that it is very inaccurate to measure serum GH levels in blood.

[mark118]

It was to my understanding, that it is very inaccurate to measure serum GH levels in blood.

you are sort of correct, because of the time of day and pulsatile nature of GH release, 1 off or even 4-5 measurements within the 2 hour window dont mean much (eg it could lower even more so than normal after this surge, we dont know).

hence why a 24hr regular blood sampling would be most definitive to show that these products work and finally convince people like me that they actually have an effect on GH levels, and not just anecdotal viewpoints

[Bane]

you are sort of correct, because of the time of day and pulsatile nature of GH release, 1 off or even 4-5 measurements within the 2 hour window dont mean much (eg it could lower even more so than normal after this surge, we dont know).

hence why a 24hr regular blood sampling would be most definitive to show that these products work and finally convince people like me that they actually have an effect on GH levels, and not just anecdotal viewpoints

Finally yet another one who understands.

[atreyubeat]

Saw someone run a log on that HGHup supp, and it looked solid.
Here are a few:

http://forum.bodybuilding.com/showth...hp?t=120110811

http://forum.bodybuilding.com/showth...ighlight=HGHup

http://forum.bodybuilding.com/showth...ighlight=HGHup

Enjoy!

[mark118]

Saw someone run a log on that HGHup supp, and it looked solid.
Here are a few:

http://forum.bodybuilding.com/showth...hp?t=120110811

http://forum.bodybuilding.com/showth...ighlight=HGHup

http://forum.bodybuilding.com/showth...ighlight=HGHup

Enjoy!

thanks for the links, but i'm trying to get past the anecdotal evidence of whether a product works and actually see if it does what it claims

[Vitruvian]

n=3.......
Not peer reviewed
Useless.

Nobody peer reviewed your post either, eh?

It was to my understanding, that it is very inaccurate to measure serum GH levels in blood.

Where did you hear this exactly? Just curious.

you are sort of correct, because of the time of day and pulsatile nature of GH release, 1 off or even 4-5 measurements within the 2 hour window dont mean much (eg it could lower even more so than normal after this surge, we dont know).

hence why a 24hr regular blood sampling would be most definitive to show that these products work and finally convince people like me that they actually have an effect on GH levels, and not just anecdotal viewpoints

I believe the draws were every 15 minutes. We will most likely pursue further in depth testing in the future following the release of another product or 2 currently in the works. 24 hr sampling would be nice..... but very difficult to accomplish. I sure as hell am not fasting that long for it. lol

thanks for the links, but i'm trying to get past the anecdotal evidence of whether a product works and actually see if it does what it claims

Further details regarding our study will be released. Yes, only 3 subjects..... but it was a simple first step in the testing process. (GH was rising the entire 150 minute period, and PEAKED at the 150 minute mark. It probably continued rising). Data was positive enough to point us in the right direction on conducting further studies.

[UNCnate]

Nobody peer reviewed your post either, eh?


Where did you hear this exactly? Just curious.



I believe the draws were every 15 minutes. We will most likely pursue further in depth testing in the future following the release of another product or 2 currently in the works. 24 hr sampling would be nice..... but very difficult to accomplish. I sure as hell am not fasting that long for it. lol



Further details regarding our study will be released. Yes, only 3 subjects..... but it was a simple first step in the testing process. (GH was rising the entire 150 minute period, and PEAKED at the 150 minute mark. It probably continued rising). Data was positive enough to point us in the right direction on conducting further studies.

So youre saying that at each blood sample taken, GH levels were higher than each one before, and was highest at 150 minutes? And you assume that it would have just kept rising? Up to what point do you assume it would have kept increasing?

[Vitruvian]

So youre saying that at each blood sample taken, GH levels were higher than each one before, and was highest at 150 minutes? And you assume that it would have just kept rising? Up to what point do you assume it would have kept increasing?

Personally, I have no idea when it would have truly reached peak. That's a good question though..... I'll see if rms80 has any hypotheses on this.
The level at the 150 minute mark was impressive enough to ensure that once we get things squared away with our other upcoming products, we will go back and conduct further, in-depth testing. I am considering putting myself out there for a much longer fasting period in order to get a wider timeframe of sampling. It'll suck at the time, but will be worth it in the end.

[bclark22]

when were the samples taken at night? normal sleep time?

GH rises and falls throughout the day and spikes at night before you go to sleep/right when you are asleep

so really tests that are 150 mins are pretty useless imo

[Vitruvian]

when were the samples taken at night? normal sleep time?

GH rises and falls throughout the day and spikes at night before you go to sleep/right when you are asleep

so really tests that are 150 mins are pretty useless imo

Everyone is entitled to their own opinion.

[mark118]

Even though 2.5hrs of tests can suggest but not conclusively show whether a product works might be the case here... BUT I think the most important thing is that APP Nut has taken step that far too many supp companies wont, actually testing their products and reporting it

[Bane]

Just saying, acutely GABA and Glutamine(both dirt cheap) when taken during fasting can lead to GH excretion that can increase serum GH levels 600-700% easily. Now total daily GH production is another cookie.

[mark118]

Just saying, acutely GABA and Glutamine(both dirt cheap) when taken during fasting can lead to GH excretion that can increase serum GH levels 600-700% easily. Now total daily GH production is another cookie.

i completely agree. 2.5hrs of testing is not enough as we have no idea what happened in the rest of the day but i have yet to see another company at least try and test their product publicly like this.

[Bane]

i completely agree. 2.5hrs of testing is not enough as we have no idea what happened in the rest of the day but i have yet to see another company at least try and test their product publicly like this.

Yep. AN is the first with GH products to try something and this must be applauded.

[seanpreynolds1]

Good jobs guys this was very interesting.

[Skigazzi]

Can someone define 'overnight fast'?

I always consider that 12 hours, then plus the 2.5 hours of testing, thats 14.5 hours without food.

I (and many others) could never go 14.5 hours without food consistently and expect to hold my weight. (you try maintaining 999lbs!)

Having a shake or a meal / milk and cookies / etc prior to bed, then ingesting the supplement with a modest breakfast (shake / couple eggs / cheerios / etc) and dosing the product and testing to see how greatly the effects were blunted (or not) would be of massive interest to me. Plus that would show how it compares to the real deal (injected Hgh).

But I applaud the study despite its limited nature, its more than 99% of other supps have.

[BiggJohn]

NB: not sure how safe it is to supplement with l-dopa

Depends on the source, l-dopa from natural sources like Mucuna Pruriens and Velvet Beans is fine.

[mark118]

Depends on the source, l-dopa from natural sources like Mucuna Pruriens and Velvet Beans is fine.

this may sound like a naive question but what does the source matter if the end product of l-dopa is still the same?

[Bane]

If you gradually go up watching for sides, L-Dopa(on healthy individuals) can be considered quite safe. Many of the sides evaporate if taken in conjunction with an efficient peripheral dexarboxylase inhibitor.

[gekkoboy14]

Can someone define 'overnight fast'?

I always consider that 12 hours, then plus the 2.5 hours of testing, thats 14.5 hours without food.

I (and many others) could never go 14.5 hours without food consistently and expect to hold my weight. (you try maintaining 999lbs!)

Having a shake or a meal / milk and cookies / etc prior to bed, then ingesting the supplement with a modest breakfast (shake / couple eggs / cheerios / etc) and dosing the product and testing to see how greatly the effects were blunted (or not) would be of massive interest to me. Plus that would show how it compares to the real deal (injected Hgh).

But I applaud the study despite its limited nature, its more than 99% of other supps have.

Fasting will also increase GH, and catecholamines as well.

[BiggJohn]

this may sound like a naive question but what does the source matter if the end product of l-dopa is still the same?

What unknowns come along with it. Was a thread about this in the supplement science section some time ago, but I can't seem to find it ATM.

[Vitruvian]

Yep. AN is the first with GH products to try something and this must be applauded.

This is appreciated.

I hope we can have the full info on that study out soon for everyone to review.

[Vitruvian]

HGHup is now available in the BB.com store!

http://www.bodybuilding.com/store/app/hghup.html

[ryanr623]

HGHup is now available in the BB.com store!

http://www.bodybuilding.com/store/app/hghup.html

You know its funny, i was just coming into this thread to ask when it was gonna be available on here! soooooo nevermind