From what i have heard cortisone injections are a powerful anti-inflammatory medication. Also used as pain relieving medication in a the particular area of inflammation.
Is it true that it degrades muscle tissue in the area making it weaker, breaking down tissue, helping swelling that way?
For example: If i get a injection of cortisone would that certian muscle atrophy?
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09-21-2009, 03:23 AM #1
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Muscle atrophy caused by cortisone injection?
Last edited by JOSEF RAKICH; 09-21-2009 at 03:28 AM.
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09-21-2009, 03:28 AM #2
basically yes. have a read here what cortisone does http://en.wikipedia.org/wiki/Glucocorticoids
it's also worth noting that the cortisone will enter the blood stream and affect the entire body, not just the injection site. unless it's injected into a joint capsule or some other "sealed" area
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09-21-2009, 04:42 AM #3
No, this is incorrect.
Local corticosteroid injections will not cause local atrophy unless it's an enormous dose and given repeatedly. They do enter systemic circulation, but the dose is so tiny that it makes no difference. They are injected locally to avoid systemic side effects as you can give a smaller dose.The first rule of cheat club is you do not talk about cheat club. The second rule of cheat club is you DO NOT talk about cheat club. Third rule of cheat cub, someone yells stop!, goes limp, taps out, the cheat is over. Fourth rule, one cheat at a time, fellas. Fifth rule, cheats will go on as long as they have to. And the sixth and final rule, if this is your first night at cheat club, you have to cheat.
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09-21-2009, 05:55 AM #4
it depends on the dose rate and the type etc, you'll aways get some systemic affect just sometimes it's so low you dont notice and clinical affect (according to my lecture). and that "repeatedly" business also depends on the amount and type, a big hit of methylprednisolone acetate will certainly stay around for ages and cause some cushiod type affects.
vets use a lot more corticosteriods than the human world btw
end of the day, if you need cortisone, it's best to have it (atleast intially)
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09-21-2009, 06:51 AM #5
I refuse to believe that a local injection of steroid, no matter how strong, will cause Cushingoid side effects. In real life, that just doesn't happen. I'm not sure about animals, but certainly in people you would struggle to notice any systemic effects from steroids. Apart from children, but they are different physiologically and can get adrenal suppression from long term steroid inhalers.
Can you get Cushing's syndrome/disease in animals then? That's interesting. Although I doubt you would bother performing neurosurgery to remove the adenoma in Cushing's disease in a cow for example.The first rule of cheat club is you do not talk about cheat club. The second rule of cheat club is you DO NOT talk about cheat club. Third rule of cheat cub, someone yells stop!, goes limp, taps out, the cheat is over. Fourth rule, one cheat at a time, fellas. Fifth rule, cheats will go on as long as they have to. And the sixth and final rule, if this is your first night at cheat club, you have to cheat.
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09-21-2009, 06:58 AM #6
well i've certainly seen it, but we use a lot more steriods becuase we rely less on antihistamines, chemo drugs etc
yes, animals do get cushings, mainly dogs (its the most common metabolic disease in dogs) and horses. and no, we dont bother to do neurosurgery in animals becuase we have trilostane (and also mitotane). we do remove adrenal tumors though (bilateral sometimes too which is fun)
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09-21-2009, 08:54 AM #7
Fair enough. I've never seen it in humans though, so I guess we'll leave it at that.
I just looked up Trilostane. I can't imagine using a drug like that on people, seeing as you are effectively deliberately causing Addison's disease to treat Cushings. I guess dogs can handle it better than we can.The first rule of cheat club is you do not talk about cheat club. The second rule of cheat club is you DO NOT talk about cheat club. Third rule of cheat cub, someone yells stop!, goes limp, taps out, the cheat is over. Fourth rule, one cheat at a time, fellas. Fifth rule, cheats will go on as long as they have to. And the sixth and final rule, if this is your first night at cheat club, you have to cheat.
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09-21-2009, 09:37 AM #8
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09-21-2009, 11:11 PM #9
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09-21-2009, 11:25 PM #10
I have a friend who goes to piano school. She plays the piano hours each day.
she ended up getting tendonitis in her forearms from the overuse.
Her father a doctor injected her forearms with cortisone injections. Her muscles in her forearms wasted away.
She has not played the piano in months. Maybe its just her.Last edited by HALON; 09-21-2009 at 11:32 PM.
"In AUSTRALIA
Each year there are 470 000 adverse events, 18 000 deaths, and 50 000 permanent disabilities arising from medical error and negligence each year. This is four times higher compared to the USA." (Second oppinion, GERMOV quote, page 293)
353 fatal car crashes were recorded on Australian roads in 2008 (RTA, 2008). You are 50 TIMES more likely to die from medical negligence from a DOCTOR compared to being fatally injured in a car crash and they say driving is dangerous.
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09-22-2009, 12:11 AM #11
it will get into the rest of the body if it's injected into muscle/sub cut etc etc. However, as others noted, it probably wont have any affect on the rest of the body unless it's an extremely high dose etc etc.
but either way you probably need it
nah, you control the dose and only shut down the neoplastic tissue, the normal tissue works normally. it's actually highly effective and you need to montior blood cortisone levels to establish a dose for a bit though. and because it works on the enzyme it's completely reversable
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09-22-2009, 04:40 AM #12The first rule of cheat club is you do not talk about cheat club. The second rule of cheat club is you DO NOT talk about cheat club. Third rule of cheat cub, someone yells stop!, goes limp, taps out, the cheat is over. Fourth rule, one cheat at a time, fellas. Fifth rule, cheats will go on as long as they have to. And the sixth and final rule, if this is your first night at cheat club, you have to cheat.
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09-22-2009, 05:56 AM #13
No just one of the the many 470 000 examples of doctor stupidity, and
another stupid answer from our local fruit the melon.
My sig sums it all read it.
Yeah her forearms decided to atrophy by themselves. I think it was magic actually.
I know inject yourself with some cortisone injections in your forearms. Then come back and say anecdotal. First I have to ask her how many injections she had and the dosage.
Up for the challenge my fruit. I think it would be a good first hand (I should say forearm) learning experience for you. You do medicine right?. What better way to learn about the treatment you give patients by receiving it yourself.
You use the word anecdotal alot, espcially if you cant provide a definite answer or reason. If its not the cortisone injections then what else caused her attrophy?.Last edited by HALON; 09-22-2009 at 06:37 AM.
"In AUSTRALIA
Each year there are 470 000 adverse events, 18 000 deaths, and 50 000 permanent disabilities arising from medical error and negligence each year. This is four times higher compared to the USA." (Second oppinion, GERMOV quote, page 293)
353 fatal car crashes were recorded on Australian roads in 2008 (RTA, 2008). You are 50 TIMES more likely to die from medical negligence from a DOCTOR compared to being fatally injured in a car crash and they say driving is dangerous.
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09-22-2009, 10:44 PM #14
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09-22-2009, 11:10 PM #15
[QUOTE=JOSEF RAKICH;388363051]You serious?
Or you being sarcastic?
QUOTE]
No I am serious. This actually occured.
But I think its just an isolated incident. Maybe some people react differently to it."In AUSTRALIA
Each year there are 470 000 adverse events, 18 000 deaths, and 50 000 permanent disabilities arising from medical error and negligence each year. This is four times higher compared to the USA." (Second oppinion, GERMOV quote, page 293)
353 fatal car crashes were recorded on Australian roads in 2008 (RTA, 2008). You are 50 TIMES more likely to die from medical negligence from a DOCTOR compared to being fatally injured in a car crash and they say driving is dangerous.
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09-23-2009, 01:41 AM #16
How on earth am I supposed to tell you what happened to her arms from a few sentences of information. All I am saying is that pharmacologically, but in terms of how corticosteroids work and how they are absorbed and distributed around the body, a local injection should not cause muscle atrophy in the sense that a difference is noticed either visually or in terms of strength. There's certainly no way the muscle would become "wasted" with a single injection.
I'd rather not inject them into my own arms, as intramuscular injections are very painful. Plus, why should I, I didn't invent the drug so I have no reason to stand up for it in that way.
So you think doctors are stupid, that's your opinion. I guess you know better than we do from a few online articles you have read, no doubt written by another teenager who thinks they know everything.
We've had this argument before in a different thread so I know we're not going to agree. Do you really not know anybody that has seen benefit from treatment by a doctor?The first rule of cheat club is you do not talk about cheat club. The second rule of cheat club is you DO NOT talk about cheat club. Third rule of cheat cub, someone yells stop!, goes limp, taps out, the cheat is over. Fourth rule, one cheat at a time, fellas. Fifth rule, cheats will go on as long as they have to. And the sixth and final rule, if this is your first night at cheat club, you have to cheat.
Join us...
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09-23-2009, 02:49 AM #17"In AUSTRALIA
Each year there are 470 000 adverse events, 18 000 deaths, and 50 000 permanent disabilities arising from medical error and negligence each year. This is four times higher compared to the USA." (Second oppinion, GERMOV quote, page 293)
353 fatal car crashes were recorded on Australian roads in 2008 (RTA, 2008). You are 50 TIMES more likely to die from medical negligence from a DOCTOR compared to being fatally injured in a car crash and they say driving is dangerous.
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09-23-2009, 10:58 AM #18
This is a funny thread isn't it!? Let me try and set the record straight. A properly administered corticosteroid injection placed next to but not directly into an inflamed tissue will almost never result in a detrimental systemic effect or in local muscle atrophy. When administered orally, the same drug will almost certainly have a systemic effect and if administered repeatedly will almost certainly have a catabolic effect.
Josef asked 'If i get a injection of cortisone would that certain muscle atrophy?'. The answer is No - not if it is performed correctly. It should also be pointed out that the target tissue for most cortisone injections is not muscle itself. It is usually tendon or ligamentous tissue. I cannot think of a valid reason to inject a muscle with cortisone.
I hope this clears up any confusion!?
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01-10-2010, 01:44 PM #19
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01-10-2010, 06:22 PM #20
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01-17-2010, 09:03 PM #21
Question for you.
I accidentally came across this thread looking for reasons why a i have a huge new indention in my butt. About a month ago I got a cortisone shot. 1 single shot for back pain. Since then I have noticed a little bit of discoloration of the skin and a continuous "muscle ache feeling" in the site. Now I have a hole in the muscle exactly where I got the injection. I don't think it's coincidence, so please explain if you can. I completely believe I couldn't live without the help of my Dr's and modern medicine, but I am very disappointed in how quickly Dr's are giving out injections that can cause things like this. I'm also concerned about how much more of this muscle with go and if it will be able to be reversed. I mean, muscles don't regenerate....do they?
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09-06-2012, 07:39 AM #22
I just had a couple cortisone injections due to long term pain in hips and perifiormis muscle and the glutes atrophied, within 3 days it was almost gone! I freaked out... went back to my dr. said he's never seen anyhting like this. Doing everything I can to get built back up. I'm small and a hard gainer so it took a long time to get my glutes in good shape and put some size on them. now there gone and I'm scared, so maybe i'm just one of those odd cases but it does happen. I would not advise injections in large muscle groups, just in case. Had I been advised of this possible side affect I would not have done it I can only hope it I can get it back and that its only temperary ( keeping my fingers crossed) and hitting the gym. no advise from my dr. at this time. I read somewhere on line that it could be temperary and others have said theirs is permanent. I guess I should have checked all possible side affects before recieving the shots. shoulda, coulda, woulda, its bad. Hope this gives others food for thought. oh this just happened 2 week ago not much change yet.
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09-06-2012, 08:04 AM #23
you have my sympathy because I to am going through this myself right now. I also have the little dents on each of my hips at the injection site but it also took the whole muscle out out along with it and it happened within 3 days my glutes are mush and at first all I could do was cry and now I just have to try not to cant think to much about it. I just have to do what ever I can to try and get them back and pray that I can. My dr. has no clue as to why this happened I was at wits end with the pain and thats why I got the shot, now I wish I had left it alone but I had tried everything else an nothing helped, oh well I guess these things have to happen to someone in order to warn others but hang in there and just work a little harder to get it back. it took several years to build this butt and two mins to take it out I'm very upset gggrrrr but life goes on.
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09-06-2012, 12:26 PM #24
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03-18-2016, 12:39 PM #25
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04-30-2016, 02:55 PM #26
For those of you who don't think this can happen check out kenalog never again.Kenalog is a very powerful corticosteroid that is wreaking havoc on peoples lives. I am almost 4 years out and only in the past year started showing signs of recovery, very slow process and some never recover. Please do your research before allowing a Dr. to administer these types of drugs. They really need to know what their doing otherwise a lot can go wrong.
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03-18-2017, 07:24 PM #27
Yes!
Now first let me state this is not a common occurrence, at least not to a point that is highly noticeable or impactful.
I've had quite a few cortisone injections as I have arthritis quite young. I got into powerlifting and noticed that my arthritis in my knees were causing me a lot of pain. I went in for a routine cortisone injection and it ended up being my last I'll ever do. I have fat and muscle atrophy around my knee and it's made the pain more severe. It's been about 6 months. I've read and heard that this will actually resolve on its own but I'm going to see a doctor because it makes my movements very limited.
Cortisone injections absolutely help with pain and inflammation and I've never had a problem before. What's going on with me affects a very small percentage of people BUT you should still be informed before getting the injection.
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09-06-2018, 11:14 PM #28
Severe atrophy from cortisone shot
I received my first cortisone injection in my foot because of a neuroma. For 9 months two podiatrists mistreated me, causing greater pain. Both were ready to operate and remove the nerve. Fortunately, the third doctor did a high res MRI and it turns out I no longer have a neuroma. I have severe muscle atrophy and severe edema. Basically that cortisone shot melted the tiny interosseous muscles between my 2-3-4 metatarsals in my foot! I have started physical therapy to try and rebuild those
muscles and will receive a stem cell injection next month to try and help the growth and repair. It’s been a year of constant pain and no exercise; just trying to get by day to day. I’m keen to hear how those of you with a similar atrophy situation are doing. I know this is an old thread but I would very much appreciate hearing from you. Thanks!
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