Increasing Height Using AI and Test

[Redeem_Yourself]

My friend kept talking about this study he read wherein they increased the final height of teenagers using Aromatase Inhibitors and Testostrone.

Has anyone read such a study?

[factotum]

Testosterone? That seems to be a risky proposition and I haven't seen any studies confirming its use. AIs have a moderate breadth of documentation and anecdotal evidence does seem to support its merit to increase height.

1: J Clin Endocrinol Metab. 2008 Mar;93(3):823-31. Epub 2007 Dec 28.

Anastrozole increases predicted adult height of short adolescent males treated
with growth hormone: a randomized, placebo-controlled, multicenter trial for one
to three years.

Mauras N, Gonzalez de Pijem L, Hsiang HY, Desrosiers P, Rapaport R, Schwartz ID,
Klein KO, Singh RJ, Miyamoto A, Bishop K.

Nemours Children's Clinic, Division of Endocrinology, 807 Children's Way,
Jacksonville, Florida 32207, USA. nmauras@nemours.org

CONTEXT: The process of epiphyseal fusion during puberty is regulated by
estrogen, even in males. OBJECTIVE: Our objective was to investigate whether
anastrozole, a potent aromatase inhibitor, could delay bone age acceleration and
increase predicted adult height in adolescent boys with GH deficiency. METHODS:
Fifty-two adolescent males with GH deficiency treated with GH were randomized to
cotreatment with anastrozole or placebo daily for up to 36 months. RESULTS: Fifty
subjects completed 12 months, 41 completed 24 months, and 28 completed 36 months.
Linear growth was comparable between groups; however, there was a significantly
slower increase in bone age advancement from baseline in the anastrozole group
vs. placebo group after 2 yr (+1.8+/-0.1 vs. +2.7+/-0.1 yr, P<0.0001) and after 3
yr (+2.5+/-0.2 vs. +4.1+/-0.1 yr, P<0.0001). This resulted in a net increase in
predicted adult height of +4.5+/-1.2 cm in the anastrozole group at 24 months and
+6.7+/-1.4 cm at 36 months as compared with a 1-cm gain at both time points in
the placebo group. Estradiol and estrone concentrations increased less in the
anastrozole group compared with placebo group. All boys on the aromatase
inhibitor had normal tempo of virilization. Safety data, including glucose, and
plasma lipid concentrations were comparable between groups. CONCLUSIONS:
Anastrozole increases adult height potential of adolescent boys on GH therapy
while maintaining normal pubertal progression after 2-3 yr. This treatment offers
an alternative in promoting growth in GH-deficient boys in puberty. Long-term
follow up is needed to elucidate fully the safety and efficacy of this approach.

1: Pediatrics. 2008 Apr;121(4):e975-83.

Use of aromatase inhibitors in children and adolescents with disorders of growth
and adolescent development.

Shulman DI, Francis GL, Palmert MR, Eugster EA; Lawson Wilkins Pediatric
Endocrine Society Drug and Therapeutics Committee.

Collaborators: Misra M, Pacaud D, Petryk A, Solberg P, Speiser P, Rogol A.

All Children's Hospital, St Petersburg, Florida 33701, USA.
dshulman@health.usf.edu

Although treatment of children and adolescents who have disorders of growth and
adolescent development with aromatase inhibitors is increasingly common, data for
or against their use are extremely limited. Precocious puberty, short stature,
and gynecomastia are conditions for which inhibition of the enzyme aromatase
might prove beneficial to reduce clinical signs of estrogenization and/or
estrogen-mediated skeletal maturation. In this report, we summarize the published
data regarding the use of aromatase inhibitors in these conditions, and review
known and potential benefits, safety concerns, and shortcomings of the available
information.


PMID: 18381525 [PubMed - indexed for MEDLINE]

1: J Clin Endocrinol Metab. 2005 Dec;90(12):6396-402. Epub 2005 Sep 27.

Inhibition of estrogen biosynthesis with a potent aromatase inhibitor increases
predicted adult height in boys with idiopathic short stature: a randomized
controlled trial.

Hero M, Norjavaara E, Dunkel L.

Hospital for Children and Adolescents, University of Helsinki, Finland.

CONTEXT: In males as well as in females, estrogen is an essential regulator of
bone maturation, growth plate fusion, and cessation of longitudinal growth.
Therefore, an increase in predicted adult height (PAH) may be achieved in short
boys by blocking estrogen biosynthesis. OBJECTIVE: We tested the hypothesis that
a decrease in the rate of bone maturation and an increase in PAH can be achieved
in boys with idiopathic short stature (ISS) by the method of blocking estrogen
biosynthesis with an aromatase inhibitor. Secondarily, we investigated the
effects of aromatase inhibition on bone mineralization. DESIGN: This was a
prospective, double-blind, randomized, placebo (Pl)-controlled clinical study.
SETTING: The study was performed at a university hospital out-patient clinic.
PATIENTS: Thirty-one boys, aged 9.0-14.5 yr, with ISS were studied. INTERVENTION:
The boys were treated with the aromatase inhibitor letrozole (Lz; 2.5 mg/d) or Pl
for 2 yr. MAIN OUTCOME MEASURE: The main outcome measure was the change in PAH
after 24 months of treatment. RESULTS: PAH increased by 5.9 cm (P < 0.0001), and
height SD score for bone age increased by 0.7 SD score (P < 0.0001) in the
Lz-treated boys, whereas no changes occurred in the respective measures in
Pl-treated boys. Areal bone mineral density of the lumbar spine and femoral neck,
assessed by dual-energy x-ray absorptiometry, increased in a similar fashion in
both groups during the treatment, whereas bone mineral apparent density increased
only in those taking Lz (median increase, 4.3%; P = 0.009). CONCLUSIONS:
Treatment with the aromatase inhibitor Lz delays bone maturation and improves PAH
in boys with ISS. No adverse effects on bone mineralization were evident after 2
yr of treatment.


PMID: 16189252 [PubMed - indexed for MEDLINE]

[GTmauf]

Question: How did they know how tall they were going to get in the first place? They didn't...so how do they know they increased their final height?

[factotum]

Originally Posted by GTmauf

Question: How did they know how tall they were going to get in the first place? They didn't...so how do they know they increased their final height?

There's many methods of deducing predicted adult height. Even simpler methods relying on the heights of relatives seems fairly accurate. From my pediatric records at age 6 or 7 it stated a predicted adult height of 5'8"-5'10" and two decades later I fall right i nhte middle of that estimation.



The important thing to note is that they observed a decrease in the rate of bone maturation during the course of treatment. I'm not sure how the model be refined to yield results that are intuitively pleasing in more of a pragmatic sense.

[Redeem_Yourself]

would there be similar results with OTC AIs?

[GTmauf]

Originally Posted by factotum

There's many methods of deducing predicted adult height. Even simpler methods relying on the heights of relatives seems fairly accurate. From my pediatric records at age 6 or 7 it stated a predicted adult height of 5'8"-5'10" and two decades later I fall right i nhte middle of that estimation.



The important thing to note is that they observed a decrease in the rate of bone maturation during the course of treatment. I'm not sure how the model be refined to yield results that are intuitively pleasing in more of a pragmatic sense.

They are all guesses. I have a cousin whose parents were 5'6" and 5'8". He is now 6'7". There is just not a good way of determining someones height accurately, unless you knew what gene was used to determine this factor and read it off that.

Yes, I agree that the decreased bone maturation is interesting.

[Redeem_Yourself]

Originally Posted by Redeem_Yourself

would there be similar results with OTC AIs?

bump

[Guardian]

Estrogen is one of the primary causes for the growth plates to fuse, this is why women are shorter actually. It also at least imo is the primary reason for the steroids stunting growth scare, I would theorize steroids that do not convert to estrogen do not stunt growth, at least height wise. If you kept estrogen low for years and years I do believe the person may end up taller then they otherwise might have been. However having years of low estrogen may have other adverse health effects we as a society still have alot to learn about hormones, for example estrogen can play a significant role in serotonin balance. This may actually be one reason for "pms" its actually a sharp shift in serotonin which ultimatly is caused my shifts in estrogen.

[Roke]

Originally Posted by Guardian

Estrogen is one of the primary causes for the growth plates to fuse, this is why women are shorter actually. It also at least imo is the primary reason for the steroids stunting growth scare, I would theorize steroids that do not convert to estrogen do not stunt growth, at least height wise. If you kept estrogen low for years and years I do believe the person may end up taller then they otherwise might have been. However having years of low estrogen may have other adverse health effects we as a society still have alot to learn about hormones, for example estrogen can play a significant role in serotonin balance. This may actually be one reason for "pms" its actually a sharp shift in serotonin which ultimatly is caused my shifts in estrogen.

Then buy that same virture supplementing with estrogen will make men shorter and grow tits?

[Guardian]

Originally Posted by Roke

Then buy that same virture supplementing with estrogen will make men shorter and grow tits?

There is no such "supplement" I am aware of but yes if a young teen artificially raised his estrogen for prolonged period he would very likely end up short (maybe signficantly) then he should. Men never can grow full on "tits" like women because we do not have the genetic receptor capacity, but we can get pretty close lol!

[spectre86]

Originally Posted by Guardian

Estrogen is one of the primary causes for the growth plates to fuse, this is why women are shorter actually. It also at least imo is the primary reason for the steroids stunting growth scare, I would theorize steroids that do not convert to estrogen do not stunt growth, at least height wise. If you kept estrogen low for years and years I do believe the person may end up taller then they otherwise might have been. However having years of low estrogen may have other adverse health effects we as a society still have alot to learn about hormones, for example estrogen can play a significant role in serotonin balance. This may actually be one reason for "pms" its actually a sharp shift in serotonin which ultimatly is caused my shifts in estrogen.

interesting read. repped

[coofoostu]

Originally Posted by Guardian

There is no such "supplement" I am aware of but yes if a young teen artificially raised his estrogen for prolonged period he would very likely end up short (maybe signficantly) then he should. Men never can grow full on "tits" like women because we do not have the genetic receptor capacity, but we can get pretty close lol!

please elaborate on this statement

[Guardian]

Originally Posted by coofoostu

please elaborate on this statement

Generally speaking women have more receptors and better structural makeup for breats then males do just like males have more androgen receptors in muscle. There obviously is exceptions to this. But even if you take someone with full on gynocomastia, they will not look quite as full and normal as even a modestly developed female breast.