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  1. #1
    Registered User Dustin350z's Avatar
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    Question What is 2-phenyl-di-benzyl-benzopyran-4-one?

    What is 2-phenyl-di-benzyl-benzopyran-4-one? Is this the same thing as Androsterone? This is the main ingredient in my new bottle of LG T-911 that has a sticker saying "Updated Formula". bb.com says Androsterone is the main ingredient.
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    This is the naming of some complex chemical, maybe using the Abstract Chemical Service, but definitely not using IUPAC. Whoever wrote this on the label is absolutely misleading and I won't trust this chemist. Maybe it's androsterone, but it would take someone with at least a BSc majoring (Honours) in chemistry to draw this and compare it to the known structure of androsterone.
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    Originally Posted by Dustin350z View Post
    What is 2-phenyl-di-benzyl-benzopyran-4-one? Is this the same thing as Androsterone? This is the main ingredient in my new bottle of LG T-911 that has a sticker saying "Updated Formula". bb.com says Androsterone is the main ingredient.
    i just noticed this myself. i have a few sample packs and on the sample pack it has 2-phenyl-di-benzyl-benzopyran-4-one and on the webpage it has Androsterone.
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  5. #5
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    Originally Posted by quank View Post
    i just noticed this myself. i have a few sample packs and on the sample pack it has 2-phenyl-di-benzyl-benzopyran-4-one and on the webpage it has Androsterone.
    Could be some sort of stilebene.
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    It looks like a misprint, if you check LG Sciences website;

    T-911 contains:
    2-Phenyl-benzo(h)chromen-4-one

    I don't have any advanced chemisty knowledge to help out any further, but it's a start.
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    Originally Posted by Dustin350z View Post
    What is 2-phenyl-di-benzyl-benzopyran-4-one? Is this the same thing as Androsterone? This is the main ingredient in my new bottle of LG T-911 that has a sticker saying "Updated Formula". bb.com says Androsterone is the main ingredient.
    sounds like alpha-napthoflavone. also known as 7,8-benzoflavone

    it is a synthetic flavonoid with AI properties
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    How strong do you reckon is this AI?..thinking in terms of perhaps usage for pct...

    i know primordial uses something similar in sustain alpha..
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  10. #10
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    According to a blog on their LG website, it's an AI..one of a few AIs in their Methyl 1D product.. don't exactly know how strong it is..looks to be a in-house creation, so only they would the true strength, and I would guess it's not public information.
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  11. #11
    Freedom is Equality IrishCannon's Avatar
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    It is a 7,8-benz derivative.

    On paper, it's about 10x stronger than the AI in our original formula. Some don't report the same psychological effects as the first version, but strength gains and performance seem to be on par if not better.
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  12. #12
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    Originally Posted by IrishCannon View Post
    It is a 7,8-benz derivative.

    On paper, it's about 10x stronger than the AI in our original formula. Some don't report the same psychological effects as the first version, but strength gains and performance seem to be on par if not better.
    Any study on its oral bioavailability?
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  13. #13
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    Originally Posted by warugaki View Post
    How strong do you reckon is this AI?..thinking in terms of perhaps usage for pct...

    i know primordial uses something similar in sustain alpha..


    that all depends on its bioavailablity. in-vitro its pretty strong but in-vivo there are alot of factors to consider
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  14. #14
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    Originally Posted by ricka182 View Post
    According to a blog on their LG website, it's an AI..one of a few AIs in their Methyl 1D product.. don't exactly know how strong it is..looks to be a in-house creation, so only they would the true strength, and I would guess it's not public information.


    the research on alpha napthoflavone is public knowledge and over a decade old. this is not any supplement companies "in house" creation
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    Originally Posted by THEHUGE View Post
    Any study on its oral bioavailability?


    huge, i am guessing it probably has decent bioavailability. because it has no hydroxyl groups on it. nothing for the liver to readily conjugate and deactivate
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    Originally Posted by Patrick Arnold View Post
    huge, i am guessing it probably has decent bioavailability. because it has no hydroxyl groups on it. nothing for the liver to readily conjugate and deactivate
    Not sure about human pharmacokinetic data on alpha-NF however, [Wang X, Morris ME. J Pharm Sci. 2008] indicated a rather low bioavailability in rodents and that pharmacological practicality for breast cancer resistance protein treatment was entirely dose-dependent.
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    Originally Posted by NO HYPE View Post
    Not sure about human pharmacokinetic data on alpha-NF however, [Wang X, Morris ME. J Pharm Sci. 2008] indicated a rather low bioavailability in rodents and that pharmacological practicality for breast cancer resistance protein treatment was entirely dose-dependent.
    can you pm me some more info on this? thx
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    Originally Posted by Patrick Arnold View Post
    can you pm me some more info on this? thx
    Done.
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  19. #19
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    Pharmacokinetics and bioavailability of the flavonoid 7,8-benzoflavone in rats
    Xiaodong Wang, Marilyn E. Morris *
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, 517 Hochstetter Hall, Amherst, New York 14260

    email: Marilyn E. Morris (memorris@buffalo.edu)

    *Correspondence to Marilyn E. Morris, Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, 517 Hochstetter Hall, Amherst, New York 14260. Telephone: 1-716-645-2842 ext 230; Fax: 1-716-645-3693.


    Keywords
    7,8-benzoflavone • BCRP • bioavailability • oral absorption • pharmacokinetics • ADME • drug interaction


    Abstract
    The flavonoid 7,8-benzoflavone was recently identified as one of the most potent inhibitors of breast cancer resistance protein (BCRP); however, little is known of the in vivo disposition of 7,8-benzoflavone. The objective of this study was to investigate the pharmacokinetics and bioavailability of 7,8-benzoflavone in rats. Three intravenous (5, 10, and 25 mg/kg) and three oral (12.5, 25, and 50 mg/kg) doses were administered to female Sprague-Dawley rats. Plasma samples were analyzed by high-performance liquid chromatography. Pharmacokinetic analysis was conducted by WinNonlin and ADAPT II. The dose-normalized plasma concentration versus time curves did not superimpose with each other, indicating the nonlinear pharmacokinetics of 7,8-benzoflavone. 7,8-benzoflavone exhibited a large volume of distribution (Vss 1.5 L/kg) and rapid oral absorption (tmax < 30 min). The bioavailability of 7,8-benzoflavone was low (0.61-13.2%) and dose-dependent. A pharmacokinetic model with dose-dependent bioavailability, linear absorption and nonlinear elimination best described the pharmacokinetic profiles of 7,8-benzoflavone. Using a 50 mg/kg oral dose of 7,8-benzoflavone, we could significantly increase the AUC for the BCRP substrate nitrofurantoin, demonstrating the potential for BCRP-mediated drug interactions. ? 2008 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 97:4546-4556, 2008
    Last edited by warugaki; 02-04-2010 at 12:21 PM.
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  20. #20
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  21. #21
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    bump - Im not a science nerd - what does the descriptions above mean??

    does it mean since its not bio-available its not going to work well? LG science guys any help here?

    any information on this product would be helpful...

    is it only for PCT ?

    can you just use it as is?

    do you have to cycle it?

    thanks
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  22. #22
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    Not only is the BA low but it probably has a very short half life.
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    Registered User Runner710's Avatar
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    I was just browsing for related forums posts for my project research and I happened to discover yours. Thanks for the excellent information!
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