Gplc

[caffeinecowboy]

I've read a lot lately about GPLC (Glycine-Propionyl-L-Carnitine). Its being touted as the latest and greatest NO precursor available. As it starts to make it's way into more NO and pre-workout products I'd like to know if there are any studies available where it was compared to AAKG for effectiveness. I have not found any negitives on this product (marketed by Sigma-tau of Italy as GlycoCarn). Would it need to be cycled like arginine based products? I would just like some input from the scientific community. Thanks.

[__AM__]

GlycoCarn (GPLC) - A Novel Compound

[caffeinecowboy]

Originally Posted by __AM__

GlycoCarn (GPLC) - A Novel Compound

Thanks, AM. I appreciate your expertise.

[spoch]

There's really no studies that support this as a great NO ingredient. I've seen studies, and the levels werent really affected...and then Pat Jacobs and Rick Bloomer published a study on GPLC most recently, without any real evidence of NO...perhaps fat metabolization, but from then way I read it, it may not even be more valuable then regular carnitine.
If I'm wrong I would like to see a concrete HUMAN study on this and its elevation of NO....I would love to be wrong.

[__AM__]

Originally Posted by caffeinecowboy

Thanks, AM. I appreciate your expertise.

You're welcome.

Originally Posted by spoch

There's really no studies that support this as a great NO ingredient. I've seen studies, and the levels werent really affected...and then Pat Jacobs and Rick Bloomer published a study on GPLC most recently, without any real evidence of NO...perhaps fat metabolization, but from then way I read it, it may not even be more valuable then regular carnitine.
If I'm wrong I would like to see a concrete HUMAN study on this and its elevation of NO....I would love to be wrong.

Did you read my article?I cited 2 studies from Bloomer et al. showing statistically significant increases in NO production by GPLC in both trained & untrained human subjects (Int J Vitam Nutr Res. & J Int Soc Sports Nutr. 2007; 4: 22).

[spoch]

This study does not really show unequivically that it does increase NO.....Which is why Im still curious as to the overall veracity of Glycocarn. Is there anything concrete that proces this stuff works?

[ATHLETIC EDGE NUTRITION]

Originally Posted by spoch

This study does not really show unequivically that it does increase NO.....Which is why Im still curious as to the overall veracity of Glycocarn. Is there anything concrete that proces this stuff works?

No study is absolute and it is just one study and certainly more research is needed to get a more accurate picture. However, it is the single strongest/most credible and relevant study looking at an ingredient, taken orally in HEALTHY individuals, shown to increase NO. There's no more credible study out there I have seen on any other ingredient that can match the study done on GPLC affecting NO.

[methodice]

Why do you want to increase NO anyway?

[NO HYPE]

Originally Posted by caffeinecowboy

I've read a lot lately about GPLC (Glycine-Propionyl-L-Carnitine). Its being touted as the latest and greatest NO precursor available.

If that were true.... the use of clinical nitrate therapy would have been replaced by GPLC.

[NO HYPE]

Originally Posted by methodice

Why do you want to increase NO anyway?

http://forum.bodybuilding.com/showpo...91&postcount=7

[UNCnate]

Is there ANY evidence to show that this is more effective than the other carnitine salts?

[ATHLETIC EDGE NUTRITION]

Originally Posted by UNCnate

Is there ANY evidence to show that this is more effective than the other carnitine salts?

I've never seen a comparison but I've never seen a study on any of the other forms of carnitine directly looking at NO either.

[UNCnate]

Originally Posted by ATHLETIC EDGE NUTRITION

I've never seen a comparison but I've never seen a study on any of the other forms of carnitine directly looking at NO either.

Would be interesting to see.